8-chloroadenosine has been researched along with 8-chloro-cyclic adenosine monophosphate in 20 studies
| Studies (8-chloroadenosine) | Trials (8-chloroadenosine) | Recent Studies (post-2010) (8-chloroadenosine) | Studies (8-chloro-cyclic adenosine monophosphate) | Trials (8-chloro-cyclic adenosine monophosphate) | Recent Studies (post-2010) (8-chloro-cyclic adenosine monophosphate) |
|---|---|---|---|---|---|
| 60 | 0 | 15 | 269 | 3 | 30 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taylor, CW; Yeoman, LC | 1 |
| Heimans, JJ; Jongenelen, CA; Langeveld, CH; Stoof, JC | 1 |
| Borsellino, N; Crescimanno, M; D'Alessandro, N; Leonardi, V | 1 |
| Cummings, J; Leonard, RC; Miller, WR | 1 |
| Lange-Carter, CA; Malkinson, AM; Vuillequez, JJ | 1 |
| Chatterjee, D; Han, Z; Wyche, JH | 1 |
| Baak, JP; Heimans, JJ; Jongenelen, CA; Langeveld, CH; Peters, GJ; Stoof, JC; Theeuwes, JW | 1 |
| Bell, PB; Bosanquet, AG; Burlton, AR; Harris, AL | 1 |
| Halgren, RG; Heller, KF; Krett, NL; Pillay, S; Rosen, ST; Traynor, AE; Zell, JL | 1 |
| Allen, PD; Jia, L; Kelsey, SM; Newland, AC; Yin, Y | 1 |
| Ayres, M; Gandhi, V; Halgren, RG; Krett, NL; Newman, RA; Rosen, ST | 1 |
| Harris, AL; Houlbrook, S; Priddle, JD; Robbins, SK | 1 |
| Lamb, D; Steinberg, RA | 1 |
| Choe, J; Choo, HJ; Kim, MK; Park, GH; Park, YG; Sohn, J | 1 |
| Ahn, YH; Hong, SH; Jung, JM | 2 |
| Janković, D; Kanazir, S; Marković, I; Marković, J; Pesić, M; Rakić, L; Ruzdijić, S | 1 |
| Bauer, A; Greene, E; Hsiao, HP; Krett, NL; Leitner, WW; Nesterova, M; Robinson-White, AJ; Stratakis, CA | 1 |
| Ayres, ML; Dennison, JB; Gandhi, V; Kaluarachchi, K; Plunkett, W | 1 |
| Borghi, MO; Caraglia, M; Dicitore, A; Gaudenzi, G; Grassi, ES; Hofland, LJ; Persani, L; Vitale, G | 1 |
20 other study(ies) available for 8-chloroadenosine and 8-chloro-cyclic adenosine monophosphate
| Article | Year |
|---|---|
Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Biotransformation; Blood; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Prodrugs; Tumor Cells, Cultured | 1992 |
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Adenylyl Cyclases; Cell Division; Chromatography, High Pressure Liquid; Glioma; Humans; Receptors, Purinergic; Tumor Cells, Cultured | 1992 |
Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Doxorubicin; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Tumor Cells, Cultured | 1994 |
Sensitive determination of 8-chloroadenosine 3',5'-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Quality Control; Sensitivity and Specificity | 1994 |
8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Cell Division; Cell Survival; Cyclic AMP; Epithelium; Gene Expression; Lung; Lung Neoplasms; Mice; Protein Kinases; RNA, Messenger | 1993 |
Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP.
Topics: 2-Chloroadenosine; 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Biotransformation; Blood; Cattle; Cell Division; Cells, Cultured; Humans; Mice; Rats | 1993 |
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Cycle; Cell Division; DNA; Flow Cytometry; Humans; RNA; Tumor Cells, Cultured | 1997 |
Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Drug Evaluation; Drug Resistance; Humans; Neoplasms | 1997 |
8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Biotransformation; Cattle; Culture Media; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Interleukin-6; Multiple Myeloma; Phosphoric Diester Hydrolases; Prodrugs; Thioinosine; Tumor Cells, Cultured | 1998 |
8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Growth Inhibitors; Humans; I-kappa B Proteins; Leukemia, T-Cell; NF-kappa B; NF-KappaB Inhibitor alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vinblastine | 2001 |
8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Adenosine Triphosphate; Antineoplastic Agents; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Time Factors; Tumor Cells, Cultured | 2001 |
8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chlorine Compounds; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Temperature | 2001 |
Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Animals; Antineoplastic Agents; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Humans; Mice; Mutation; Protein Subunits; Tumor Cells, Cultured | 2002 |
Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Blotting, Western; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation | 2002 |
8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Division; Cyclin B; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Mice; NIH 3T3 Cells; Protein Kinase C; Signal Transduction | 2004 |
8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HL-60 Cells; Humans; K562 Cells; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases | 2005 |
The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Neuroblastoma; Purine Nucleosides; Time Factors | 2006 |
Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Humans; Signal Transduction; Thyroid Neoplasms | 2008 |
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Line, Tumor; Citric Acid Cycle; Dose-Response Relationship, Drug; Energy Metabolism; Fumarates; Humans; Hypoglycemic Agents; Lymphoma, Mantle-Cell; Metformin; Oligomycins; Purines; Succinic Acid; Uncoupling Agents | 2010 |
The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Amines; Antineoplastic Agents; Apoptosis; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; MAP Kinase Signaling System; Piperidines; Proto-Oncogene Mas; Thyroid Neoplasms | 2016 |