8-chloro-cyclic adenosine monophosphate has been researched along with 8-bromo cyclic adenosine monophosphate in 256 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 98 (38.28) | 18.7374 |
| 1990's | 85 (33.20) | 18.2507 |
| 2000's | 40 (15.63) | 29.6817 |
| 2010's | 29 (11.33) | 24.3611 |
| 2020's | 4 (1.56) | 2.80 |
| Authors | Studies |
|---|---|
| Boswell, KH; Christensen, LF; Meyer, RB; Miller, JP; Robins, RK | 1 |
| Abe, K; Fujiwara, Y; Kubota, N; Miki, K; Morikage, T; Nishio, K; Ohmori, T; Saijo, N; Takeda, Y | 1 |
| Cho-Chung, YS | 4 |
| Aldinucci, D; Budillon, A; Cho-Chung, YS; Gattei, V; Pinto, A; Tortora, G; Zagonel, V | 1 |
| Cho-Chung, YS; Szekeres, T; Weber, G | 1 |
| Heimans, JJ; Jongenelen, CA; Langeveld, CH; Stoof, JC | 2 |
| Taylor, CW; Yeoman, LC | 1 |
| Cho-Chung, YS; Clair, T; Greiner, JW; Guadagni, F; Roselli, M; Schlom, J; Tortora, G | 1 |
| Cho-Chung, YS; Marti, GE; Noguchi, PD; Pepe, S; Tortora, G; Washington, GC | 1 |
| Ally, S; Cho-Chung, YS; Ciardiello, F; Clair, T; Kim, N; Salomon, DS; Tortora, G | 1 |
| Abe, K; Miki, K; Saito, D; Tahara, E; Takanashi, A; Urakami, K; Yasui, W; Yokozaki, H; Yoshida, K | 1 |
| Greiner, JW; Guadagni, F; Roselli, M; Schlom, J | 1 |
| Jastorff, B; Kessin, RH; Van Lookeren Campagne, MM; Villalba Díaz, F | 1 |
| Endo, K; Hakomori, S; Igarashi, Y; Nisar, M; Zhou, QH | 1 |
| Cho-Chung, YS; Clair, T; Pepe, S; Tortora, G; Yokozaki, H | 1 |
| Bourke, JR; Huxham, GJ; Manley, SW; Matainaho, T; Murdoch, S; Waters, MJ | 1 |
| Cho-Chung, YS; Meissner, S; Pepe, S; Tortora, G; Yokozaki, H | 1 |
| Avery, TL; Finch, RA; Parandoosh, Z; Robins, RK; Rubalcava, B | 1 |
| Chabaud, O; Chambard, M; Depetris, D; Gonzalvez, S; Gruffat, D; Mauchamp, J | 1 |
| Grisoli, F; Gunz, G; Jaquet, P; Pellegrini, I | 1 |
| Ally, S; Cho-Chung, YS; Clair, T; Mednieks, MI; Merlo, GR; Tahara, E; Tortora, G; Yokozaki, H | 1 |
| Ally, S; Cho-Chung, YS; Ciardiello, F; Clair, T; Salomon, DS; Tortora, G | 1 |
| Ally, S; Avery, TL; Cho-Chung, YS; Clair, T; Finch, RA; Katsaros, D; Tortora, G; Yokozaki, H | 1 |
| Tahara, E; Takanashi, A; Yoshida, K | 1 |
| Chabaud, O; Chambard, M; Gaudry, N; Mauchamp, J | 1 |
| Gerard, C; Mauchamp, J; Verrier, B | 1 |
| Ally, S; Cho-Chung, YS; Clair, T; Døskeland, SO; Grieco, D; Jahnsen, T; Katsaros, D; Merlo, G; Ogreid, D; Tortora, G | 1 |
| Budillon, A; Cereseto, A; Cho-Chung, YS; Clair, T; Kondrashin, A; Merlo, G; Nesterova, M | 1 |
| Bianco, AR; Bianco, C; Ciardiello, F; Damiano, V; Davies, SL; Harris, AL; Hickson, ID; North, PS; Pepe, S; Tortora, G | 1 |
| Bates, SE; Budillon, A; Cho-Chung, YS; Jefferson, J; Scala, S; Tsokos, M; Zhan, Z | 1 |
| Actis, AM; Caruso, SP; Levin, E | 1 |
| Bøe, R; Døskeland, SO; Gjertsen, BT; Vintermyr, OK | 1 |
| Burns, DJ; Langdon, SP; Miller, WR; Ramage, AD; Ritchie, AA | 1 |
| Fang, W; Wu, B; Zhang, J | 1 |
| Aakvaag, A; Brustugun, OT; Bøe, R; Døskeland, SO; Maronde, E; Vintermyr, OK | 1 |
| Borsellino, N; Crescimanno, M; D'Alessandro, N; Leonardi, V | 1 |
| Cummings, J; Fielding, H; Miller, WR | 1 |
| Glazer, RI; Rohlff, C | 2 |
| Baldassarre, G; Bianco, AR; Bianco, C; Ciardiello, F; Pepe, S; Ruggiero, A; Selvam, MP; Tortora, G | 1 |
| Afanasjev, GG; Buraczewska, I; Szumiel, I; Zagórski, S | 1 |
| Budillon, A; Cho-Chung, YS; Clair, T; Merlo, G; Pepe, S; Rohlff, C; Tortora, G; Yokozaki, H | 1 |
| Cummings, J; Leonard, RC; Miller, WR | 1 |
| Gerard, C; Penel, C; Rigot, V | 1 |
| Botham, KM; Cho-Chung, YS; Lambert, MS; Martinez, MJ; Mayes, PA; Ochoa, B | 1 |
| Lange-Carter, CA; Malkinson, AM; Vuillequez, JJ | 1 |
| Demura, H; Emoto, N; Isozaki, O; Murakami, H; Ohmura, E; Onoda, N; Robins, RK; Shizume, K; Tsushima, T; Wakai, K | 1 |
| Cho-Chung, YS; Glazer, RI; Klecker, RW; Rahman, A; Rohlff, C; Safa, B | 1 |
| Chatterjee, D; Han, Z; Wyche, JH | 1 |
| Botham, KM; Cho-Chung, YS; Hoang, VQ; Suckling, KE | 1 |
| Cho-Chung, YS; Clair, T; Rohlff, C | 1 |
| Kim, YS; Lamprecht, SA; Niv, Y; Polak-Charcon, S; Schwartz, B | 1 |
| Chatterjee, D; Early, J; Han, Z; Hendrickson, EA; Pantazis, P; Wyche, JH | 1 |
| Keast, JR; Manley, SW; Stevenson, BR; Waters, MJ; Yap, AS | 1 |
| Bronte, V | 1 |
| van den Berg, J; van Rijn, J | 1 |
| Avella, M; Botham, KM; Stevens, L | 1 |
| Burns, DJ; Cummings, J; Langdon, SP; Leonard, RC; Mackay, J; Miller, WR; Ritchie, AA; Stockman, P | 1 |
| Budillon, A; Cho-Chung, YS; Clair, T; Nesterova, M; Pepe, S | 1 |
| Nicolaï, S; Slegers, H; Van Mechelen, E; Willems, J; Zwijsen, A | 1 |
| Botham, KM; Hoang, VQ; Jones, AK; Martinez, MJ; Ochoa, B; Suckling, KE | 1 |
| Bianco, AR; Bianco, C; Bianco, R; Ciardiello, F; Damiano, V; De Laurentiis, M; De Placido, S; Fontanini, G; Mendelsohn, J; Tortora, G | 1 |
| Baak, JP; Heimans, JJ; Jongenelen, CA; Langeveld, CH; Peters, GJ; Stoof, JC; Theeuwes, JW | 1 |
| Bauch, H; Brix, K; Graebert, KS; Herzog, V; Neumüller, W | 1 |
| Bell, PB; Bosanquet, AG; Burlton, AR; Harris, AL | 1 |
| Bond, M; McConnell, BK; Morano, I; Moravec, CS | 1 |
| Bianco, AR; Bianco, R; Ciardiello, F; di Isernia, G; Pepe, S; Pomatico, G; Sandomenico, C; Tortora, G | 1 |
| Albini, A; Aluigi, MG; Cai, T; Fassina, G; Gentleman, S; Noonan, DM; Wong, P | 1 |
| Harris, AL; Long, L; Mawer, EB; O'Byrne, KJ; Salisbury, AJ; Saunders, MP; Talbot, DC; Whitehouse, RM | 1 |
| Actis, AM; Caruso, SP; Dorfman, VB; Levin, E | 1 |
| Arteaga, CL; Bianco, AR; Bianco, R; Ciardiello, F; Damiano, V; di Isernia, G; Dixit, M; Tortora, G | 1 |
| Caruso, G; Cassarà, D; Dolo, V; Ginestra, A; Lucania, G; Miele, M; Vittorelli, ML | 1 |
| Cho-Chung, YS; Srivastava, AR; Srivastava, RK | 1 |
| Ciardiello, F; Tortora, G | 1 |
| Krystosek, A | 1 |
| Dodds, M; Howie, AF; Langdon, SP; Leonard, RC; Miller, WR; Muir, M; Ritchie, AA; Stockman, PK | 1 |
| Halgren, RG; Heller, KF; Krett, NL; Pillay, S; Rosen, ST; Traynor, AE; Zell, JL | 1 |
| Halgren, RG; Krett, NL; Pillay, S; Rosen, ST; Traynor, AE; Zell, JL | 1 |
| Baldassarre, G; Bianco, AR; Bianco, C; Caputo, R; Chinè, S; Ciardiello, F; Fontanini, G; Tortora, G | 1 |
| Baselga, J; Bianco, AR; Bianco, C; Caraglia, M; Ciardiello, F; Damiano, V; di Isernia, G; Mendelsohn, J; Ruggiero, A; Tagliaferri, P | 1 |
| Cho-Chung, YS; Murata, T; Noguchi, K | 1 |
| Su, J; Wang, LX; Xu, B; Yang, XB; Zhang, LH | 1 |
| Joksimović, J; Juranić, I; Juranić, Z; Radulović, S | 1 |
| Johnston, PG; McDaid, HM | 1 |
| Fang, W; Zhang, J; Zheng, J | 1 |
| Cho-Chung, YS; Longo, DL; Srivastava, AR; Srivastava, RK | 2 |
| Abbruzzese, A; Barbarulo, D; Budillon, A; Caraglia, M; Di Gennaro, E; Marra, M; Tagliaferri, P | 1 |
| Braybrooke, JP; Dowsett, M; Ganesan, TS; Harris, AL; Long, L; O'Byrne, KJ; Propper, DJ; Salisbury, AJ; Saunders, MP; Talbot, DC; Taylor, M | 1 |
| Abbruzzese, A; Barbarulo, D; Budillon, A; Caraglia, M; Di Gennaro, E; Tagliaferri, P | 1 |
| Cho-Chung, YS; Srivastava, RK; Srivastave, AR | 1 |
| Jankovic, V; Maksimovic, D; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V | 1 |
| Allen, PD; Jia, L; Kelsey, SM; MacEy, MG; Newland, AC; Yin, Y | 1 |
| Cho-Chung, YS; Hong, SH; Kim, SG; Kim, SN; Lee, MA; Park, JH; Park, SD | 1 |
| Caputo, R; Chiariello, M; Ciardiello, F; Di Lorenzo, E; Indolfi, C; Leccia, A; Rapacciuolo, A; Stabile, E; Stingone, AM; Torella, D; Tortora, G | 1 |
| Fagan, TE; Romani, A | 1 |
| Drabek, K; Medić-Mijacević, L; Pesić, M; Pietrzkowski, Z; Piperski, V; Rakić, L; Ruzdijić, S | 1 |
| Davydova, NN; Glisic, J; Wainer, IW | 1 |
| Allen, PD; Jia, L; Kelsey, SM; Newland, AC; Yin, Y | 1 |
| Burnham, LL; Carlson, CC; Dransfield, DT; Shanks, RA | 1 |
| Colic, M; Jandric, D; Medic-Mijacevic, L; Rakic, L; Vucevic, D | 1 |
| Ahn, YH; Cho-Chung, YS; Hong, SH; Kim, SG; Kim, SN; Park, SD | 1 |
| Ayres, M; Gandhi, V; Halgren, RG; Krett, NL; Newman, RA; Rosen, ST | 1 |
| Breitman, TR; Taimi, M; Takahashi, N | 1 |
| Harris, AL; Houlbrook, S; Priddle, JD; Robbins, SK | 1 |
| Abe, T; Kamei, C; Mio, M; Shimada, K | 1 |
| Bollag, WB; Dransfield, DT; Griner, RD; Keskintepe, M; Ray, S | 1 |
| Lamb, D; Steinberg, RA | 1 |
| Becker, KG; Cheadle, C; Cho, YS; Cho-Chung, YS; Kim, MK; Lee, YN; Neary, C; Nesterova, M; Park, YG; Srivastava, R | 1 |
| Choe, J; Choo, HJ; Kim, MK; Park, GH; Park, YG; Sohn, J | 1 |
| Blank, JL; Bos, JL; Christensen, AE; de Rooij, J; Døskeland, SO; Enserink, JM; Genieser, HG; Schwede, F; van Triest, M | 1 |
| Grbovic, O; Jovic, V; Kanazir, S; Pejanovic, V; Rakic, L; Ruzdijic, S | 1 |
| Actis, A; Bergoc, R; Croci, M; Levin, E | 1 |
| SWEENEY, JS | 1 |
| RADOJICIC, MM | 1 |
| PARRY, SC | 1 |
| HEFFNER, GP; HENSON, WC | 1 |
| CRISMER, R; LAMBERMONT, J | 1 |
| PARAD, HJ; YOUNG, RA | 1 |
| DOERFLER, LG; SIEGENTHALER, BM | 1 |
| BARDOS, V | 1 |
| BIAGI, F | 2 |
| BIRCHER, R | 1 |
| DAENEN, P | 1 |
| MORSE, WC | 1 |
| FURCOLOW, ML; NISHIO, J; SALVIN, SB | 1 |
| MORALES CISNEROS, A | 1 |
| SCHULTHESS, L | 1 |
| DINGLE, JH; FELLER, AE; FURCOLOW, ML; LANGMUIR, AD; LARSH, HW | 1 |
| KORP, W; SWOBODA, W; ZWEYMULLER, E | 1 |
| PONOMAREV, LE | 1 |
| REILLY, JJ | 1 |
| REBHAN, AW | 1 |
| PURINA, EA | 1 |
| MELKUMIAN, BG | 1 |
| MORSE, WC; SMALL, ER | 1 |
| ERMAKOV, VV; STAROBINSKII, IM | 1 |
| CADITZ, SB | 1 |
| GREEN, CE; HASSLER, FR | 1 |
| IOSIFOV, I; PETKOV, D | 1 |
| KNOX, JS | 1 |
| KOEHLER, W | 1 |
| WATKINS, WW | 1 |
| BESSEL-LORCK, C | 1 |
| BOGOIAVLENSKII, NA | 1 |
| HARE, RL; PAGE, OC; STEPHENS, JW | 1 |
| WOLFSOHN, H | 1 |
| SMART, PE | 1 |
| LUGER, MJ | 1 |
| MEERLOO, JA | 1 |
| AITKEN, W; ANDREW, HG; FOLEY, DP; HICKS, CS; WILLIMOT, SG | 1 |
| BACKER, M | 1 |
| SCANNELL, RF | 1 |
| VERVEN, N | 1 |
| CARY, LJ | 1 |
| DESMOND, M | 1 |
| SHEPARD, MC | 1 |
| HORDERO, G; NIKOLIC, M; POIOVIC, R | 1 |
| POPOV, GA | 1 |
| YONIS, Z | 2 |
| HEFFNER, GP; MILLER, AP | 1 |
| GERRITZEN, F | 1 |
| MARBLE, A; STEPHENS, JW | 1 |
| BURNS, KF; LONG, AP | 1 |
| MILLER, L; VERVEN, N; YOUNG, RA | 1 |
| BUCHNER, BK; COONS, DO; DEMPSTER, G | 1 |
| FURCOLOW, ML; LARSH, HW | 1 |
| Keck, C; Pietrowski, D; Witt, PS | 1 |
| Dammann, E; Dangers, M; Evans, C; Ganser, A; Genieser, HG; Kolb, HJ; Kolch, W; Mischak, H; Oettrich, K; Schwede, F; Weissinger, EM | 1 |
| Ahn, YH; Hong, SH; Jung, JM | 2 |
| COLE, MM; SMITH, CN | 1 |
| POLAKOVA, Z | 1 |
| Gupte, RS; Lee, MY; Liu, L; Weng, Y | 1 |
| Demajo, MA; Korićanac, LB; Popović, NM; Ristić-Fira, AM; Ruzdijić, SD; Todorović, DV | 1 |
| Janković, D; Kanazir, S; Marković, I; Marković, J; Pesić, M; Rakić, L; Ruzdijić, S | 1 |
| Cho-Chung, YS; Nesterova, MV | 1 |
| Ahn, YH; Han, JH; Hong, SH | 1 |
| Arnaldi, G; Beck-Peccoz, P; Bondioni, S; Bosari, S; Ferrero, S; Lania, AG; Mantovani, G; Pedroni, C; Pellegrini, C; Peverelli, E; Spada, A; Vicentini, L | 1 |
| Adzić, M; Nićiforović, A; Radojcić, MB; Ruzdijić, S; Vucić, V | 1 |
| Bauer, A; Greene, E; Hsiao, HP; Krett, NL; Leitner, WW; Nesterova, M; Robinson-White, AJ; Stratakis, CA | 1 |
| Cheng, YM; Hu, JP; Jia, PM; Zhu, Q | 1 |
| Bajić, V; Djelić, N; Milićević, Z; Spremo-Potparević, B; Zivković, L | 1 |
| Ahn, YH; Choi, KY; Han, JH; Hong, SH | 1 |
| SCHIEVE, JF | 1 |
| MILNOR, JP; RUBENSTEIN, AD | 1 |
| COOPERSTOCK, M; MORSE, E | 1 |
| WOODRUFFE, MF | 1 |
| Pesić, M; Podolski, A; Rakić, L; Ruzdijić, S | 1 |
| Bossis, I; Hsiao, HP; Leitner, WW; Nesterova, M; Robinson-White, AJ; Stratakis, CA | 1 |
| Ayres, ML; Dennison, JB; Gandhi, V; Kaluarachchi, K; Plunkett, W | 1 |
| Bertherat, J; Bouizar, Z; Hortane, M; Ragazzon, B; Rizk-Rabin, M; Viou, L | 1 |
| STEFANINI, M | 1 |
| DAVIS, WA; SIGEL, MM | 1 |
| MICKLE, WA | 1 |
| RICHET, C | 1 |
| SMITH, DA | 2 |
| SEFTON, L | 1 |
| REDL, F | 1 |
| ALLEN, GV; MacGREGOR, RG | 1 |
| WILLIAMS, CD | 1 |
| PEARSON, EF | 2 |
| DEKKING, HM | 1 |
| MARKOWITZ, J | 1 |
| SYDENHAM, A | 2 |
| FEINSTEIN, M; MARKS, JL; YESNER, R | 1 |
| HIBBS, RE | 1 |
| PHILLIPS, HA | 1 |
| KRAEMER, M | 1 |
| BROWN, BH | 1 |
| GOLDBLOOM, AA; SCHANTZ, BA | 1 |
| BEHENNA, D | 1 |
| ROSENBLUM, P | 1 |
| JAY, AN | 1 |
| COATES, AE | 1 |
| Borghi, MO; Calebiro, D; de Filippis, T; Grassi, ES; Lucchi, S; Persani, L | 1 |
| Enyeart, JA; Enyeart, JJ; Liu, H | 1 |
| Cisneros-Mejorado, A; Sánchez Herrera, DP | 1 |
| Ahn, HW; Ahn, YH; Cho, YJ; Choi, KY; Hong, SH | 1 |
| Anini, Y; Gagnon, J | 1 |
| Prakash, P; Tripathi, O | 1 |
| Anoopkumar-Dukie, S; Grant, GD; Hempenstall, A; Johnson, PJ | 1 |
| El Hachmane, MF; Komai, AM; Olofsson, CS | 1 |
| Borghi, MO; Caraglia, M; Dicitore, A; Gaudenzi, G; Grassi, ES; Hofland, LJ; Persani, L; Vitale, G | 1 |
| Ahn, YH; Cho, YJ; Choi, KY; Hong, SH; Kim, JS | 1 |
| Saegusa, Y; Yoshimura, K | 1 |
| Cai, B; Fan, J; Fu, BM; Yang, J; Zeng, M; Zhang, L | 1 |
| Cao, L; Cao, YX; Li, S; Mi, YN; Ping, NN | 1 |
| Han, L; Li, Y; Liu, D; Wang, H; Yang, X; Zhuang, C | 1 |
| Bauer, R; Homma, MK; Kazami, M; Kenerson, HL; McKnight, GS; Riehle, KJ; Riggle, KM; Samelson, B; Scott, JD; Turnham, R; Yeung, RS | 1 |
| Alon, U; Bren, A; Dekel, E; Park, JO; Rabinowitz, JD; Towbin, BD | 1 |
| Chen, Y; Liu, QS; Liu, X; Lu, Y; Penzes, P; Proudfoot, SC; Qi, J; Reynolds, AM; Tong, J | 1 |
| Jiang, Y; Niu, YL; Wang, XF; Xia, JH | 1 |
| Borghi, MO; Dicitore, A; Grassi, ES; Negri, I; Persani, L; Vitale, G | 1 |
| Barbuskaite, D; Brown, D; Christensen, HL; Damkier, HH; Matchkov, V; Păunescu, TG; Praetorius, J | 1 |
| Cai, J; Chen, F; Chen, W; Chen, Y; Chen, Z; Cheng, S; Gao, M; Gu, J; Hu, J; Li, K; Li, Y; Liang, J; Lin, Y; Liu, D; Lu, B; Lu, W; Luan, Y; Mai, J; Qiu, P; Sai, K; Sheng, L; Su, X; Tan, Y; Wang, J; Wu, S; Xiao, X; Xie, Z; Xing, F; Yan, G; Yin, W; Zhang, H; Zhu, S; Zhu, W | 1 |
| Hogstrand, C; Luo, Z; Pan, YX; Song, YF; Wei, CC; Wu, K | 1 |
| Chen, R; Jia, Y; Lei, L; Liu, J; Liu, L; Lu, HAJ; Su, L; Yang, B; Zhou, H; Zhu, S | 1 |
| Fan, Y; Peng, Z; Qi, Y; Qiao, X; Su, X; Wang, L; Wang, Y | 1 |
| Baumgardner, K; Firtel, RA; Lacal, J; Lin, C | 1 |
| Goldberg, AL; Lokireddy, S; VerPlank, JJS; Zhao, J | 1 |
| Brzezinska, P; Burke-Kleinman, J; MacKeil, JL; Maurice, DH; Nicol, CJB; Ormiston, ML; Theilmann, AL | 1 |
| Chen, W; He, M; Huang, Q; Liu, H; Nie, H; Nie, L; Xiao, Y | 1 |
| Dong, Y; Ge, RS; Huang, T; Li, H; Li, X; Liu, S; Wang, Y; Wu, S; Zhu, Q | 1 |
| Ceballos, NR; Czuchlej, SC; Scaia, MF; Volonteri, MC | 1 |
| Ikeda, T; Ishigaki, Y; Saito-Takatsuji, H; Yonekura, H; Yoshitake, Y; Yoshitomi, Y | 1 |
10 review(s) available for 8-chloro-cyclic adenosine monophosphate and 8-bromo cyclic adenosine monophosphate
| Article | Year |
|---|---|
Suppression of malignancy targeting cyclic AMP signal transducing proteins.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cells; Cyclic AMP; Female; Humans; Macromolecular Substances; Neoplasm Metastasis; Neoplasms; Oligonucleotides, Antisense; Protein Kinases; Receptors, Cyclic AMP; RNA, Messenger; Signal Transduction | 1992 |
Regulation of human tumor antigen expression by biological response modifiers (BRMs).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Immunologic Factors; Interferon-gamma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Recombinant Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 1991 |
Site-selective 8-chloro-cyclic adenosine 3',5'-monophosphate as a biologic modulator of cancer: restoration of normal control mechanisms.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Antineoplastic Agents; Cell Differentiation; Gene Expression Regulation; Growth Inhibitors; Humans; In Vitro Techniques; Neoplasms, Experimental; Nuclear Proteins; Receptors, Cyclic AMP; Transcription Factors; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
[Stomach cancer and growth factors].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Division; Depression, Chemical; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Receptors, Estrogen; Stomach Neoplasms; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
Transcriptional regulation of multidrug resistance in breast cancer.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cyclic AMP-Dependent Protein Kinases; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
cAMP-dependent protein kinase: role in normal and malignant growth.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Binding Sites; Cell Cycle; Cell Differentiation; Cell Nucleus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Induction; Genetic Vectors; Growth Inhibitors; Isoenzymes; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasms; Oligonucleotides, Antisense; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Receptors, Cell Surface; Signal Transduction; Subcellular Fractions; Tumor Cells, Cultured | 1995 |
Antisense DNA toward type I protein kinase A produces sustained inhibition of tumor growth.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA, Antisense; Epithelial Cells; Humans; Leukemia; Neoplasms, Experimental; Tumor Cells, Cultured | 1997 |
Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Genes, ras; Humans; Neoplasms; Transforming Growth Factor alpha | 1998 |
Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Neoplasms; Oligodeoxyribonucleotides, Antisense; Oligonucleotide Array Sequence Analysis; Protein Subunits; Second Messenger Systems; Signal Transduction; Transcription Factors | 2002 |
Tumor reversion: protein kinase A isozyme switching.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Therapy; Humans; Neoplasms; Oligonucleotide Array Sequence Analysis; Oligonucleotides, Antisense; Phenotype; Protein Isoforms | 2005 |
3 trial(s) available for 8-chloro-cyclic adenosine monophosphate and 8-bromo cyclic adenosine monophosphate
| Article | Year |
|---|---|
Pharmacokinetics, metabolism and tumour disposition of 8-chloroadenosine 3',5'-monophosphate in breast cancer patients and xenograft bearing mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Humans; Infusions, Intravenous; Mice; Mice, Nude; Prodrugs; Tissue Distribution; Transplantation, Heterologous | 1996 |
A novel cyclic adenosine monophosphate analog induces hypercalcemia via production of 1,25-dihydroxyvitamin D in patients with solid tumors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Antineoplastic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Hypercalcemia; Neoplasms; Parathyroid Hormone; Vitamin D | 1997 |
Phase I study of the novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: toxicity, hormonal, and immunological effects.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adult; Aged; Antineoplastic Agents; Cytokines; Female; Hormones; Humans; Hypercalcemia; Kidney; Liver; Lymphocyte Subsets; Male; Middle Aged; Nausea; Neoplasms; Treatment Outcome; Vomiting | 1999 |
243 other study(ies) available for 8-chloro-cyclic adenosine monophosphate and 8-bromo cyclic adenosine monophosphate
| Article | Year |
|---|---|
Synthesis and enzymatic and inotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain; Cats; Cattle; Cyclic AMP; Dogs; Enzyme Activation; Female; In Vitro Techniques; Kidney; Male; Myocardial Contraction; Papillary Muscles; Protein Kinases; Rabbits | 1980 |
Alteration of type II regulatory subunit of cAMP-dependent protein kinase in human cisplatin-resistant cells as a basis of collateral sensitivity to 8-chloro-cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cisplatin; Cyclic AMP; Drug Hypersensitivity; Drug Resistance; Humans; Lung Neoplasms; Macromolecular Substances; Protein Kinases; Sensitivity and Specificity; Tumor Cells, Cultured | 1992 |
Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Affinity Labels; Antigens, Surface; Antineoplastic Agents; Azides; Blast Crisis; Cell Survival; Culture Techniques; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia, Myeloid, Acute; Receptors, Cyclic AMP; Tumor Cells, Cultured | 1992 |
Action of tiazofurin and 8-Cl-cAMP in human colon and pancreatic cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Synergism; Humans; IMP Dehydrogenase; Pancreatic Neoplasms; Ribavirin; Signal Transduction; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1992 |
8-Chloro-cyclic adenosine monophosphate, a novel cyclic AMP analog that inhibits human glioma cell growth in concentrations that do not induce differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Glioma; Humans; Kinetics; Neuroglia; Rats; Rats, Inbred Strains; Thionucleotides; Tumor Cells, Cultured | 1992 |
Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Biotransformation; Blood; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Prodrugs; Tumor Cells, Cultured | 1992 |
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Adenylyl Cyclases; Cell Division; Chromatography, High Pressure Liquid; Glioma; Humans; Receptors, Purinergic; Tumor Cells, Cultured | 1992 |
Carcinoembryonic antigen regulation in human colorectal tumor cells by a site-selective cyclic AMP analogue: a comparison with interferon-gamma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Bucladesine; Carcinoembryonic Antigen; Cell Line; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Kinetics; Mice; Mice, Nude; Radioimmunoassay; Recombinant Proteins; Rectal Neoplasms; Transplantation, Heterologous | 1991 |
Effects of 8-chloroadenosine 3',5'-monophosphate and N6-benzyl-cyclic adenosine 5'-monophosphate on cell cycle kinetics of HL-60 leukemia cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Cycle; Cyclic AMP; Drug Synergism; Flow Cytometry; Humans; Leukemia, Promyelocytic, Acute; Resting Phase, Cell Cycle; Time Factors; Tumor Cells, Cultured | 1991 |
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Epithelium; Isoenzymes; Mammary Glands, Animal; Mice; Protein Kinases; Radioimmunoassay; Radioligand Assay; RNA; RNA, Messenger; Transforming Growth Factors | 1990 |
Inhibitory effect of 8-chloro-cyclic adenosine 3',5'-monophosphate on cell growth of gastric carcinoma cell lines.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Division; Cell Line; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Genes, myc; Humans; Kinetics; Molecular Sequence Data; Oligonucleotide Probes; RNA, Messenger; Stomach Neoplasms; Transcription Factors; Tumor Necrosis Factor-alpha | 1991 |
Correspondence Re: Michiel M. Van Lookeren Campagne et al., 8-chloroadenosine 3',5'-monophosphate inhibits the growth of Chinese hamster ovary and molt-4 cells through its adenosine metabolite. Cancer Res., 51: 1600-1605, 1991.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; CHO Cells; Cricetinae; Tumor Cells, Cultured | 1991 |
8-Chloroadenosine 3',5'-monophosphate inhibits the growth of Chinese hamster ovary and Molt-4 cells through its adenosine metabolite.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Deaminase; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Cricetinae; Protein Kinases | 1991 |
Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Body Weight; Cell Membrane; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Protein Kinase C; Signal Transduction; Sphingosine; Transplantation, Heterologous; Tumor Cells, Cultured | 1991 |
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Base Sequence; Cell Differentiation; Cell Division; Cell Line; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Macromolecular Substances; Molecular Sequence Data; Oligonucleotides, Antisense; Protein Kinases; Tetradecanoylphorbol Acetate | 1991 |
Epidermal growth factor (EGF) inhibits the secretomotor response of the thyroid: effects of EGF on radioiodine turnover and fluid transport in cultured porcine thyroid cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Calcimycin; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Epidermal Growth Factor; Iodine Radioisotopes; Swine; Thyroid Gland; Thyrotropin | 1991 |
Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Base Sequence; Cell Differentiation; Cell Division; Cell Line; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Molecular Sequence Data; Monocytes; Oligonucleotides, Antisense; Protein Kinases; Recombinant Proteins | 1991 |
Changes in diacylglycerol and membrane associated protein kinase C activity reflect the growth status of xenografted human mammary carcinoma treated with 8-Cl-cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adult; Animals; Antineoplastic Agents; Cell Membrane; Diglycerides; Female; Glycerides; Humans; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Protein Kinase C; Transplantation, Heterologous | 1990 |
Thyrotrophin regulation of apical and basal exocytosis of thyroglobulin by porcine thyroid monolayers.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholera Toxin; Culture Media; Dose-Response Relationship, Drug; Exocytosis; Kinetics; Swine; Thyroglobulin; Thyroid Gland; Thyrotropin | 1990 |
Different pathways of secretion for glycosylated and nonglycosylated human prolactin.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biological Transport; Female; Humans; Immunosorbent Techniques; Kinetics; Monensin; Pituitary Neoplasms; Prolactin; Prolactinoma; Tumor Cells, Cultured | 1990 |
Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Binding Sites; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; DNA, Neoplasm; Humans; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Transformation, Viral; Cyclic AMP; Gene Expression Regulation; Genes, ras; In Vitro Techniques; Protein Kinases; Rats; Receptors, Cyclic AMP; Transforming Growth Factors | 1989 |
Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Blotting, Western; Carcinoma; Cell Division; Cell Nucleus; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Isoenzymes; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Oncogenes; Protein Kinases; Receptors, Cyclic AMP; RNA, Messenger; RNA, Neoplasm | 1989 |
Thyrotrophin and cyclic AMP regulation of thyroglobulin gene expression in cultured porcine thyroid cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholera Toxin; Cyclic AMP; Gene Expression Regulation; RNA, Messenger; Swine; Thyroglobulin; Thyroid Gland; Thyrotropin | 1988 |
Effects of prostaglandin E2 and cholera toxin on apical sodium uptake in thyroid epithelial cells: role of cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Epithelium; Prostaglandins E; Sodium; Swine; Thyroid Gland; Time Factors | 1985 |
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Division; Cell Line; Cell Nucleus; Colonic Neoplasms; Humans; Isoenzymes; Protein Kinases; Receptors, Cyclic AMP; Transcription, Genetic | 1988 |
Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Base Sequence; Cell Compartmentation; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Sorting Signals | 1995 |
Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Bleomycin; Cell Division; CHO Cells; Cisplatin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Drug Screening Assays, Antitumor; Etoposide; Teniposide | 1994 |
Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Breast Neoplasms; Cell Differentiation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Drug Resistance, Multiple; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Isoenzymes; Keratins; Molecular Sequence Data; Neoplasm Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Vinblastine | 1995 |
Opposite effect of a cAMP analogue on tumoral growth related to hormone dependence of a murine mammary tumor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Cyclic AMP-Dependent Protein Kinases; Female; Mammary Neoplasms, Experimental; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction | 1995 |
8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Adenosine Deaminase; Amino Acid Sequence; Apoptosis; Biotransformation; Breast Neoplasms; Chromatin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Damage; Ethers, Cyclic; Female; Humans; Marine Toxins; Microvilli; Molecular Sequence Data; Necrosis; Okadaic Acid; Organelles; Oxazoles; Phosphoprotein Phosphatases | 1995 |
Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Humans; Immunosuppression Therapy; Mice; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured | 1995 |
[Effects of site-selective 8-Cl-cAMP on the growth regulation of human lung giant cell cancer].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Carcinoma, Giant Cell; Cell Division; Cyclic AMP; Humans; Immunologic Factors; Lung Neoplasms; Tumor Cells, Cultured | 1995 |
Cyclic adenosine monophosphate (cAMP) analogs 8-Cl- and 8-NH2-cAMP induce cell death independently of cAMP kinase-mediated inhibition of the G1/S transition in mammary carcinoma cells (MCF-7).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cell Death; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Female; G1 Phase; Humans; Protein Conformation; Protein Serine-Threonine Kinases; S Phase; Thymidine; Tumor Cells, Cultured | 1995 |
Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Doxorubicin; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Tumor Cells, Cultured | 1994 |
Pharmaceutical analysis of 8-chloroadenosine 3',5'-monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Immunologic Factors; Spectrophotometry, Ultraviolet | 1994 |
Reduction of RI alpha subunit of cAMP-dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF-alpha, c-Ha-ras, and c-erbB-2 genes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Base Sequence; Breast; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Epithelium; ErbB Receptors; Female; Genes, ras; Humans; Macromolecular Substances; Molecular Sequence Data; Oligonucleotides, Antisense; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Receptor, ErbB-2; Transforming Growth Factor alpha | 1993 |
Effects of 8-chloroadenosine-3',5'-monophosphate in combination with irradiation in L5178Y mouse lymphoblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; Immunologic Factors; Lymphoma; Mice; Tumor Cells, Cultured | 1994 |
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Topics: 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Allosteric Site; Animals; Cadmium; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Isoenzymes; Leukemia, Promyelocytic, Acute; Metallothionein; Mice; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins; Retroviridae; Signal Transduction; Tumor Cells, Cultured | 1994 |
Sensitive determination of 8-chloroadenosine 3',5'-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Quality Control; Sensitivity and Specificity | 1994 |
Chloride channel blockers inhibit the Na+/I- symporter in thyroid follicles in culture.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carrier Proteins; Cells, Cultured; Chloride Channels; Diphenylamine; Furosemide; Hypochlorous Acid; Iodides; Iodine Radioisotopes; Kinetics; Membrane Proteins; Nitrobenzoates; Probenecid; Sodium; Sulfobromophthalein; Swine; Symporters; Thyroid Gland | 1994 |
The effect of cyclic AMP analogues on cholesterol metabolism in cultured rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bile Acids and Salts; Cells, Cultured; Cholesterol; Cyclic AMP; Cytosol; Liver; Male; Microsomes, Liver; Rats; Rats, Wistar; Sterol Esterase; Sterol O-Acyltransferase; Thionucleotides | 1993 |
8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Cell Division; Cell Survival; Cyclic AMP; Epithelium; Gene Expression; Lung; Lung Neoplasms; Mice; Protein Kinases; RNA, Messenger | 1993 |
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Humans; Immunologic Factors; Insulin-Like Growth Factor I; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Differentiation; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; DNA, Neoplasm; Down-Regulation; Doxorubicin; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Promyelocytic, Acute; Protein Kinases; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tumor Cells, Cultured | 1993 |
Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP.
Topics: 2-Chloroadenosine; 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Biotransformation; Blood; Cattle; Cell Division; Cells, Cultured; Humans; Mice; Rats | 1993 |
The effect of cyclic AMP analogues and glucagon on cholesteryl ester synthesis and hydrolysis in cultured hamster hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholesterol Esters; Cricetinae; Cyclic AMP; Glucagon; Hydrolysis; Liver; Male; Mesocricetus; Oleic Acid; Oleic Acids; Theophylline; Thionucleotides; Triglycerides | 1993 |
8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Differentiation; Cell Division; Chromatography, High Pressure Liquid; Down-Regulation; Humans; Isoenzymes; Leukemia, Promyelocytic, Acute; Protein Kinases; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 1993 |
Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Benzylidene Compounds; Cell Differentiation; Cell Line; Colonic Neoplasms; Colorectal Neoplasms; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Microscopy, Electron, Scanning; Nitriles; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Subcellular Fractions; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1995 |
Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Cycloheximide; HL-60 Cells; Humans; Molecular Sequence Data; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 1996 |
Vinculin localization and actin stress fibers differ in thyroid cells organized as monolayers or follicles.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Actins; Animals; Cadherins; Cell Count; Cell Polarity; Cells, Cultured; Cytochalasin D; Cytoskeleton; Epithelial Cells; Epithelium; Heat-Shock Proteins; Immunohistochemistry; Immunologic Factors; Intercellular Junctions; Membrane Proteins; Microscopy, Confocal; Phosphoproteins; Swine; Thyroid Gland; Vinculin; Zonula Occludens-1 Protein | 1995 |
Molecular genetics of cancer. Gene therapy and other novel therapeutic approaches.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; CD40 Antigens; Genetic Therapy; Humans; Neoplasms | 1995 |
Effect of adenosine 3':5'-cyclic monophosphate and inhibition of protein kinase A on heat sensitivity in H35 hepatoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cyclic AMP; Hyperthermia, Induced; Immunologic Factors; Liver Neoplasms, Experimental; Rats; Signal Transduction; Tumor Cells, Cultured | 1996 |
Neutral cholesteryl ester hydrolase activity in rat peritoneal macrophages: regulation by cyclic AMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arteriosclerosis; Bucladesine; Cyclic AMP; Foam Cells; In Vitro Techniques; Macrophages, Peritoneal; Male; Rats; Rats, Wistar; Sterol Esterase; Thionucleotides | 1995 |
Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cell Differentiation; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Extracellular Space; Glial Fibrillary Acidic Protein; Glioma; Isoquinolines; Kinetics; Rats; RNA, Messenger; Sulfonamides; Superoxide Dismutase; Transcription, Genetic | 1996 |
Comparison of the effects of cyclic AMP analogues on cholesterol metabolism in cultured rat and hamster hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bile Acids and Salts; Cells, Cultured; Cholesterol; Cholesterol Esters; Cricetinae; Cyclic AMP; Hydrolysis; Liver; Male; Mesocricetus; Rats; Rats, Wistar; Thionucleotides | 1996 |
Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Humans; Immunoenzyme Techniques; Immunologic Factors; Mice; Mice, Nude | 1996 |
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Cycle; Cell Division; DNA; Flow Cytometry; Humans; RNA; Tumor Cells, Cultured | 1997 |
Epithelial folding in vitro: studies on the cellular mechanism underlying evagination of thyrocyte monolayers.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Actins; Alkaloids; Animals; Calcium; Carbazoles; Cell Membrane; Cell Size; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Epithelium; Hydrogen-Ion Concentration; Indoles; Microscopy, Electron; Myosin-Light-Chain Kinase; Protein Kinase Inhibitors; Staurosporine; Swine; Temperature; Thyroid Gland; Thyrotropin | 1997 |
Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Drug Evaluation; Drug Resistance; Humans; Neoplasms | 1997 |
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Heart; Heart Ventricles; Hypertension; Isoproterenol; Marine Toxins; Myocardial Contraction; Myocardium; Myosin Light Chains; Norepinephrine; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Troponin I | 1997 |
Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cisplatin; Drug Synergism; Female; G2 Phase; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitosis; Neoplasm Transplantation; Paclitaxel; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Apoptosis; Bucladesine; Cell Differentiation; Cell Division; Child; Cyclic AMP-Dependent Protein Kinases; DNA Fragmentation; Eye Neoplasms; Humans; Kinetics; Macromolecular Substances; Phosphopyruvate Hydratase; Retinoblastoma; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP-Dependent Protein Kinases; Doxorubicin; Drosophila; Drug Resistance, Multiple; Genes, MDR; Phenotype; Promoter Regions, Genetic; Sp1 Transcription Factor; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Effects on mouse uterus of three antitumoral drugs acting upon estrogen and progesterone receptors directly and through other transduction pathways.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Female; Medroxyprogesterone Acetate; Mice; Mice, Inbred BALB C; Organ Size; Ovary; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; Tamoxifen; Uterus | 1998 |
Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cyclic AMP-Dependent Protein Kinases; DNA, Antisense; Down-Regulation; ErbB Receptors; Female; Humans; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1998 |
Modulation of vesicle shedding in 8701 BC human breast carcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cell Differentiation; Cell Division; Cell Membrane; Extracellular Matrix; Female; Humans; Microscopy, Electron; Neoplasm Invasiveness; Phospholipases A; Quercetin; Second Messenger Systems; Signal Transduction; Tretinoin; Tumor Cells, Cultured | 1998 |
Synergistic effects of 8-chlorocyclic-AMP and retinoic acid on induction of apoptosis in Ewing's sarcoma CHP-100 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Division; Cell Survival; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Humans; Nucleosomes; Sarcoma, Ewing; Tretinoin; Tumor Cells, Cultured | 1998 |
Repositioning of human interphase chromosomes by nucleolar dynamics in the reverse transformation of HT1080 fibrosarcoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Binding Sites; Cell Division; Cell Nucleolus; Cell Transformation, Neoplastic; Chromosome Mapping; Chromosomes; DNA Probes; Fibrosarcoma; Humans; In Situ Hybridization, Fluorescence; Interphase; Kinetochores; Phenotype; Repetitive Sequences, Nucleic Acid; Tumor Cells, Cultured | 1998 |
Antitumour activity and schedule dependency of 8-chloroadenosine-3',5'-monophosphate (8-ClcAMP) against human tumour xenografts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypercalcemia; Infusions, Intravenous; Male; Mice; Neoplasm Transplantation; Ovarian Neoplasms; Prostatic Neoplasms; Transplantation, Heterologous; Weight Loss | 1998 |
8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Biotransformation; Cattle; Culture Media; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Interleukin-6; Multiple Myeloma; Phosphoric Diester Hydrolases; Prodrugs; Thioinosine; Tumor Cells, Cultured | 1998 |
Cyclic adenosine-3',5'-monophosphate-mediated cytotoxicity in steroid sensitive and resistant myeloma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Butyrates; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Drug Resistance, Neoplasm; Enzyme Activation; Glucocorticoids; Humans; Interleukin-6; Multiple Myeloma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amphiregulin; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Colorectal Neoplasms; EGF Family of Proteins; Endothelial Growth Factors; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Glycoproteins; GPI-Linked Proteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Proteins; Neovascularization, Pathologic; Transforming Growth Factor alpha; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Cooperative antiproliferative effects of 8-chloro-cyclic AMP and 528 anti-epidermal growth factor receptor monoclonal antibody on human cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Division; DNA Fragmentation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Tumor Cells, Cultured | 1995 |
8-chloroadenosine 3',5'-monophosphate (8-Cl-cAMP) selectively eliminates protein kinase A type I to induce growth inhibition in c-ras-transformed fibroblasts.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Fibroblasts; Genes, ras; Mice; Oncogene Protein p21(ras) | 1998 |
[(Sp)-8-chloroadenosine 3',5'-cyclophosphate induced differentiation on human leukemia HL-60 cells].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; HL-60 Cells; Humans | 1996 |
The mechanism of 8-Cl-cAMP action.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Blood; Cell Division; Cell Survival; Culture Media; Dipyridamole; Enzyme Inhibitors; HeLa Cells; Humans; K562 Cells; Kinetics; Melanoma, Experimental; Mice; Ribavirin; Tumor Cells, Cultured | 1998 |
Synergistic interaction between paclitaxel and 8-chloro-adenosine 3',5'-monophosphate in human ovarian carcinoma cell lines.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Humans; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1999 |
[Regulatory effects of cAMP analogs on growth and differentiation of metastatic human lung cancer cells].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Bucladesine; Carcinoma, Giant Cell; Cell Division; Chromogranins; Humans; Lung Neoplasms; Phosphopyruvate Hydratase; Tumor Cells, Cultured | 1997 |
Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Apoptosis; Caspase 3; Caspases; Cell Cycle; Cell Survival; Cytochrome c Group; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Female; Humans; Molecular Sequence Data; Nuclear Proteins; Ovarian Neoplasms; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured | 1999 |
Up-regulated EGF receptors undergo to rapid internalization and ubiquitin-dependent degradation in human cancer cells exposed to 8-Cl-cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Neoplasms; Signal Transduction; Tumor Cells, Cultured; Ubiquitins | 1999 |
Synergistic effects of retinoic acid and 8-chloro-adenosine 3',5'-cyclic monophosphate on the regulation of retinoic acid receptor beta and apoptosis: involvement of mitochondria.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Survival; Cytochrome c Group; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Synergism; Gene Expression Regulation, Neoplastic; Hormones; Humans; Mitochondria; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Protein Serine-Threonine Kinases; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured | 1999 |
8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Squamous Cell; Cell Division; DNA, Neoplasm; Enzyme Activation; Epidermal Growth Factor; Humans; Mitogen-Activated Protein Kinases; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured | 1999 |
Synergistic effects of 8-Cl-cAMP and retinoic acids in the inhibition of growth and induction of apoptosis in ovarian cancer cells: induction of retinoic acid receptor beta.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Division; Drug Synergism; Female; Humans; Ovarian Neoplasms; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured | 2000 |
Differential regulation of nitric oxide production by increase of intracellular cAMP in murine primary fibroblasts and L929 fibrosarcoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Catalysis; Cells, Cultured; Cyclic AMP; Fibroblasts; Fibrosarcoma; Interferon-gamma; Intracellular Fluid; Mice; Mice, Inbred CBA; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Rolipram; Tumor Cells, Cultured | 2000 |
Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Isoquinolines; Leukemia; NF-kappa B; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Dual anticancer activity of 8-Cl-cAMP: inhibition of cell proliferation and induction of apoptotic cell death.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Division; Cell Line; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Genes, bcl-2; Humans; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2000 |
8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Aorta, Thoracic; Arterial Occlusive Diseases; Blood Pressure; Catheterization; Cell Division; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Heart Rate; Injections, Intraperitoneal; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Tunica Intima; Up-Regulation | 2000 |
Activation of Na(+)- and Ca(2+)-dependent Mg(2+) extrusion by alpha(1)- and beta-adrenergic agonists in rat liver cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Amiloride; Animals; Calcium; Diuretics; Epinephrine; Glucagon; Glucose; Hepatocytes; Imipramine; Isoproterenol; Liver; Magnesium; Male; Phenylephrine; Phloretin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Sodium; Stimulation, Chemical | 2000 |
8-Cl-cAMP and tiazofurin affect vascular endothelial growth factor production and glial fibrillary acidic protein expression in human glioblastoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Differentiation; Cell Division; Endothelial Growth Factors; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Lymphokines; Ribavirin; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Determination of 8-chloroadenosine 3',5'-monophosphate in dog plasma by capillary electrophoresis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Dogs; Female; Male; Reference Standards | 2001 |
8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Growth Inhibitors; Humans; I-kappa B Proteins; Leukemia, T-Cell; NF-kappa B; NF-KappaB Inhibitor alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vinblastine | 2001 |
8-Cl-adenosine induces differentiation in LS174T cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Cell Differentiation; Cell Division; Colorectal Neoplasms; Humans; Oncogene Protein p21(ras); Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
8-Chloro-cAMP modulates apoptosis of thymocytes and thymocyte hybridoma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibodies, Monoclonal; Apoptosis; CD4 Antigens; CD8 Antigens; Cell Death; Cell Division; Cysteine Proteinase Inhibitors; Female; Humans; Hybridomas; Immunologic Factors; Ovarian Neoplasms; Rats; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Thymidine | 2001 |
8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells.
Topics: 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Female; G2 Phase; HeLa Cells; HL-60 Cells; Humans; K562 Cells; Mice; Mitosis; Neuroblastoma; Ovarian Neoplasms; Receptors, Cyclic AMP; S Phase; Tumor Cells, Cultured | 2001 |
8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Adenosine Triphosphate; Antineoplastic Agents; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Time Factors; Tumor Cells, Cultured | 2001 |
Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Affinity Labels; Azides; Breast Neoplasms; Cell Differentiation; Cell Division; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Female; HL-60 Cells; Humans; Immunoblotting; Isoenzymes; Tumor Cells, Cultured | 2001 |
8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chlorine Compounds; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Temperature | 2001 |
The influence of the protein kinase A system in differentiation of HL-60-Eo cells to eosinophils induced by histamine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Eosinophils; Histamine; HL-60 Cells; Humans; Indoles; Oligonucleotides, Antisense; Protein Subunits; Pyrroles; Thymidine | 2001 |
8-Cl-adenosine induces growth arrest without differentiation of primary mouse epidermal keratinocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Biomarkers; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Epidermal Cells; G1 Phase; Keratinocytes; Keratins; Mice; Mice, Inbred ICR; Resting Phase, Cell Cycle; Transglutaminases | 2001 |
Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Animals; Antineoplastic Agents; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Humans; Mice; Mutation; Protein Subunits; Tumor Cells, Cultured | 2002 |
Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Blotting, Western; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation | 2002 |
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Humans; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Protein Structure, Tertiary; rap1 GTP-Binding Proteins; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Transfection | 2002 |
8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cyclin B; Cyclin B1; DNA Primers; Flow Cytometry; G2 Phase; Glioma; Humans; In Situ Nick-End Labeling; Kinetics; Mutation; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
8-Chloro-cAMP-related changes on mice uteri.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Endometrial Hyperplasia; Endometrium; Estrus; Female; Medroxyprogesterone; Mice; Mice, Inbred BALB C; Organ Size; Pregnancy; Pseudopregnancy; Tamoxifen; Uterus | 2002 |
The Sweeney Diabetic Foundation camp for diabetic children.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Diabetes Mellitus; Infant | 1952 |
[Two epidemics of leptospirosis caused L. pomona and L. sejroe in a camp A and in a camp B].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Epidemics; Humans; Leptospirosis | 1952 |
Some medical problems at a camp for displaced persons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Transients and Migrants | 1953 |
West Virginia's camp for juvenile diabetics.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Child; Diabetes Mellitus; Humans; Infant; West Virginia | 1953 |
[Nutritional cirrhosis in an old prisoner of the camp of Buchenwald].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Liver Cirrhosis; Prisoners; Starvation | 1953 |
Recording practices in a therapeutic camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Medical Records; Psychotherapy | 1953 |
Camp Easter Seal Hearing Program for pre-school hearing-handicapped children.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Disabled Children; Hearing; Hearing Disorders; Hearing Tests; Humans; Infant | 1953 |
[Organization of health services at a youth camp, 1950-51].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Health Services; Humans; Occupational Health; Organizations | 1953 |
[Coproparasitic index in Escarega, Camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Parasitic Diseases | 1953 |
[Harmful fruits; the newest excitement in the health reform camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Fruit; Health; Health Care Reform; Humans | 1953 |
[Correction in ametropies for the study of visual camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Refractive Errors | 1953 |
[Intradermal tuberculin and toxoplasmin reactions in Escarcega, Camp.; transmission of toxoplasmosis].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Immune Sera; Toxoplasmosis; Tuberculin; Tuberculosis | 1953 |
The development of a mental hygiene milieu in a camp program for disturbed boys.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Humans; Male; Mental Health | 1953 |
Serologic studies on outbreak of pulmonary disease at Camp Gruber, okla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease Outbreaks; Histoplasmosis; Humans; Lung Diseases; Pneumonia | 1954 |
[Diethylcarbamazine in onchocerciasis: notes on dosing in the treatment of camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Diethylcarbamazine; Onchocerciasis | 1954 |
[Experiments with a salve protecting against frostbite in a winter camp of mountain troops].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease; Frostbite; Humans; Military Personnel; Ointments | 1955 |
Outbreak of unusual form of pneumonia at Camp Gruber, Oklahoma, in 1944; follow-up studies implicating Histoplasma capsulatum as the etiologic agent.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease Outbreaks; Follow-Up Studies; Histoplasma; Histoplasmosis; Humans; Oklahoma; Pneumonia | 1956 |
[First Austrian summer camp for diabetic children. I. Course of diabetes mellitus prior to arrival at camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Diabetes Mellitus; Infant | 1956 |
[Medical and sanitary care in a drifting polar camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cold Temperature; Humans | 1957 |
An exceptional camp for exceptional children.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Child, Exceptional; Education of Intellectually Disabled; Humans | 1957 |
An outbreak of Asian in fluenza in a girls' camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Asian People; Disease Outbreaks; Humans; Influenza, Human | 1957 |
[Sanitary education at a pioneer camp in prevention of ascariasis in children].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Ascariasis; Biomedical Research; Child; Humans | 1957 |
[Utilization of camp tents for development of a Divisional Medical Center].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Hospitals, Military; Humans; Military Medicine; Military Personnel; Naval Medicine; United States | 1958 |
Group life space interviewing in a therapeutic camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Psychotherapy | 1959 |
[Specialization and postgraduate education in countries in the socialist camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Education, Medical; Humans; Socialism; Specialization | 1959 |
Effects of a forestry camp experience on the personality of delinquent boys.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Forestry; Humans; Juvenile Delinquency; Male; Personality; Personality Disorders | 1961 |
A football camp outbreak of aseptic meningitis due to Echo 9 virus.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease Outbreaks; Echovirus 9; Football; Meningitis; Meningitis, Aseptic; Virus Diseases | 1960 |
[Our experience with the treatment of stuttering in a treatment-logopedic camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Speech Disorders; Speech Therapy; Stuttering | 1960 |
The inadequate psychopath at Camp Hill Prison.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antisocial Personality Disorder; Humans; Prisons | 1960 |
[Typing of hemolyzing streptococci of group A. III. On distribution of Streptococcus A and Staphylococcus aureus in a children's camp and their typing].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Hemolysis; Humans; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Streptococcus | 1961 |
Humor and pathos of physicians practice in a Mexican mining camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Anecdotes as Topic; Humans; Mexico; Physicians | 1960 |
[Common cold prophylaxis in young people at a ski-camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Ascorbic Acid; Biomedical Research; Common Cold; Humans; Vitamins | 1959 |
[Sanitary conditions and aid to sick and wounded in the rebel camp in the twelfth century in Lianshan'bo (China)].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; China; History of Medicine; Humans | 1960 |
Gales Creek Camp--a summer camp for diabetic children.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Diabetes Mellitus; Infant | 1960 |
[A diabetic children's camp in Israel].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Diabetes Mellitus; Infant; Israel | 1959 |
Migrant labor camp sanitation in Washington.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Sanitation; Transients and Migrants; Washington | 1962 |
Extending the work camp concept.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Juvenile Delinquency; Occupational Therapy | 1962 |
Neurologism and denial of psychic trauma in extermination camp survivors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Neurology; Prisons; Survivors | 1963 |
Nutrition and beriberi in a Japanese prisoner-of-war camp: a study of 500 daily food intakes in 35 months.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Beriberi; Humans; Nutrition Surveys; Nutritional Status; Prisoners; Prisons; Warfare | 1961 |
Extermination-camp syndrome.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Ethics, Medical; Humans; Violence | 1963 |
The place of individual counseling in the work camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Counseling; Humans; Juvenile Delinquency; Occupational Therapy; Psychotherapy | 1962 |
The technique of therapeutic intervention in a treatment camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Juvenile Delinquency; Occupational Therapy; Psychotherapy | 1962 |
History of the work camp as a method of treating delinquents.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Juvenile Delinquency; Occupational Therapy | 1962 |
Crutches and courage at camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Courage; Crutches; Health Resorts; Humans; Nursing Care | 1955 |
Non-gonococcal urethritis in the Camp Lejeune area.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Urethritis | 1959 |
[Recollections on a typhus epidemic in a German camp for prisoners of war during the years 1942-43 and 1943-44].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Prisoners of War; Prisons; Typhus, Epidemic Louse-Borne; Warfare | 1961 |
[6th conference of ministers of public health of countries from the socialist camp].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Clergy; Humans; International Cooperation; Public Health; Public Health Administration; Socialism | 1961 |
The course of measles in a repatriation camp (in Hebrew; English summary).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Humans; Language; Measles | 1950 |
West Virginia's first camp for diabetic children. (A report on Camp Kno-Koma).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Child Welfare; Diabetes Mellitus; Humans; West Virginia | 1951 |
[First cycle of the Netherlands Diabetics Association's childrens camp at its settlement house Bijsterbosch in Epe, 7-26 July 1950].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Diabetes Mellitus; Humans; Netherlands | 1950 |
Data on infant feeding in a repatriation camp [Hebrew text; English summary].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Dietetics; Ethnicity; Humans; Infant; Infant Nutritional Physiological Phenomena; Language; Nutritional Sciences | 1950 |
Place and value of summer camps in management of juvenile diabetes; observations and a report of activities at a camp for diabetic boys in 1950.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Disease Management; Humans; Infant | 1951 |
Report of an isolated outbreak of influenza type B, Camp Haugen, Japan, 1950.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biometry; Disease Outbreaks; Humans; Influenza, Human; Japan | 1951 |
Treatment techniques in a therapeutic camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Psychotherapy; Psychotherapy, Group | 1951 |
An outbreak of epidemic influenza at Camp Borden, Ontario.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Biometry; Disease Outbreaks; Humans; Influenza, Human; Ontario | 1952 |
Direct isolation of Histoplasma capsulatum from soil: probable etiological relationship to Camp Gruber pneumonitis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Histoplasma; Humans; Lung Diseases; Pneumonia; Soil | 1952 |
PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Angiopoietin-2; Benzyl Alcohols; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Indoles; Luteal Cells; Maleimides; Protein Kinase C; RNA, Messenger; Thionucleotides | 2004 |
Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Bone Marrow Cells; Bone Marrow Purging; Bone Marrow Transplantation; Cyclic AMP-Dependent Protein Kinases; DNA; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Transplantation, Autologous; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2004 |
8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Division; Cyclin B; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Mice; NIH 3T3 Cells; Protein Kinase C; Signal Transduction | 2004 |
Investigations of tick repellents at Camp Bullis, Texas, 1948.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Texas; Ticks | 1949 |
Rehabilitation camp for physically handicapped children at Svoj6sice near Prague.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Disabled Persons; Humans; Public Health; Rehabilitation | 1950 |
The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Line; Cell Line, Tumor; Cell Survival; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoprecipitation; Multiprotein Complexes; Protein Interaction Mapping; Replication Protein C; Two-Hybrid System Techniques | 2005 |
Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3',5'-monophosphate and tiazofurin.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Cell Line, Tumor; DNA Primers; Melanoma, Experimental; Mice; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin | 2004 |
8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HL-60 Cells; Humans; K562 Cells; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases | 2005 |
The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Neuroblastoma; Purine Nucleosides; Time Factors | 2006 |
Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells.
Topics: 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Enzyme Activation; Fibroblasts; Immunologic Factors; Mice; p38 Mitogen-Activated Protein Kinases; rap1 GTP-Binding Proteins; Signal Transduction | 2006 |
Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Base Sequence; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydrocortisone; Up-Regulation | 2008 |
The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Gamma Rays; Humans; Male; Prostatic Neoplasms | 2008 |
Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Humans; Signal Transduction; Thyroid Neoplasms | 2008 |
[Apoptosis of multiple myeloma cells induced by 8-Cl-cAMP in vitro].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin E; Cyclin-Dependent Kinase 2; Humans; Multiple Myeloma | 2007 |
A study on the genotoxic effects of 8-Cl-cAMP on human lymphocytes in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adult; Antineoplastic Agents; Cell Survival; Cells, Cultured; Centromere; Chromosome Aberrations; Humans; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Mutagenicity Tests | 2008 |
Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; HeLa Cells; HL-60 Cells; Humans; Imidazoles; K562 Cells; Mutation; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Ribonucleotides; Signal Transduction | 2009 |
Complications encountered among cholera cases treated in Ismailia isolation camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cholera; Humans | 1948 |
A report of 62 cases of infectious hepatitis occurring in 1946, Station Hospital, Camp Lee, Virginia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colubridae; Hepatitis A; Hospitals; Virginia | 1948 |
A study of virus carriers from a poliomyelitis outbreak at a boys' camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease Outbreaks; Humans; Male; Poliomyelitis; Transplants; Viruses | 1948 |
Nutritional status of children; nutritional conditioning in a health camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Child Nutritional Physiological Phenomena; Humans; Nutritional Sciences; Nutritional Status | 1948 |
A study in adaptation, being an account of some experiences as a medical officer in a Japanese prisoner-of-war camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Prisoners; Prisons; Warfare | 1947 |
Purine analogs sensitize the multidrug resistant cell line (NCI-H460/R) to doxorubicin and stimulate the cell growth inhibitory effect of verapamil.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Growth Inhibitors; Humans; Purine Nucleosides; Verapamil | 2010 |
8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; Electrophoresis; Flow Cytometry; Humans; Multiple Endocrine Neoplasia; Mutation; Syndrome | 2009 |
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Line, Tumor; Citric Acid Cycle; Dose-Response Relationship, Drug; Energy Metabolism; Fumarates; Humans; Hypoglycemic Agents; Lymphoma, Mantle-Cell; Metformin; Oligomycins; Purines; Succinic Acid; Uncoupling Agents | 2010 |
8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit; Cyclin-Dependent Kinase 2; DNA Replication; Humans; Proliferating Cell Nuclear Antigen; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2010 |
Observations on a series of cases of sprue in a prison camp in India.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Celiac Disease; Humans; India | 1947 |
Influenza at an Army camp in 1945-1946.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Influenza, Human; Military Personnel | 1947 |
Studies on the causation of an unusual pulmonary disease at Camp Gruber, Okla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Lung Diseases | 1947 |
[Medical Notes on Camp Buchenwald in 1944-45].
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Prisoners; Prisoners of War; Warfare | 1946 |
Nutritional neuropathies in the civilian internment camp, Hong Kong, January, 1942-August, 1945.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Deficiency Diseases; Food Supply; Hong Kong; Humans; Nervous System Diseases; Prisoners; Prisoners of War; Warfare | 1946 |
Some experiences in a skin department of a prisoner-of-war camp hospital in Singapore, 1942-1945.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Dermatology; Hospitals; Humans; Military Medicine; Prisoners; Prisoners of War; Singapore; Warfare | 1947 |
Psychopathologic risks of camp life.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antisocial Personality Disorder; Humans; Personality; Psychopathology | 1947 |
Nutritional conditions and diseases in the civilian internment camp, Hong Kong.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Food Supply; Hong Kong; Humans; Nutritional Sciences; Nutritional Status; Prisoners; Prisoners of War; Warfare | 1946 |
Experiences in the civilian camp at Singapore.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Food Supply; Humans; Nutritional Sciences; Nutritional Status; Prisoners; Prisoners of War; Singapore; Warfare | 1946 |
Nutritional conditions among women and children in internment in the civilian camp at Singapore.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Female; Food Supply; Humans; Nutritional Status; Prisoners; Prisoners of War; Singapore; Warfare | 1946 |
Observations on malnutrition in Santo Tomas Internment Camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Deficiency Diseases; Food Supply; Humans; Malnutrition; Nutritional Status; Prisoners of War; Warfare | 1947 |
Tropical nutritional amblyopia ("camp eyes").
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amblyopia; Blindness; Deficiency Diseases; Eye; Humans; Nutrition Disorders; Tropical Medicine | 1947 |
Experiences with cholera in a jungle camp in Thailand.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cholera; Thailand | 1946 |
Period of internment in Stanley Camp, Hong Kong, January 1941 to September 1945.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Hong Kong; Humans; Prisoners of War; Warfare | 1946 |
Morbidity and mortality in Santo Tomas Internment Camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Prisoners; Prisoners of War; Warfare | 1946 |
Amenorrhoea at Stanley Camp, Hong Kong, during internment.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amenorrhea; Female; Gynecology; Hong Kong; Humans; Military Medicine; Military Personnel; Prisoners of War; Warfare | 1946 |
Epidemics of Q fever among troops returning from Italy in the spring of 1945; clinical aspects of the epidemic at Camp Patrick Henry, Virginia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Epidemics; Italy; Q Fever; Rickettsia Infections; Virginia | 1946 |
Beriberi in Japanese prison camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Beriberi; Humans; Prisoners; Prisoners of War; Prisons; Warfare | 1946 |
Genito-urinary disorders occurring in Singapore prisoner-of-war camp, with special reference to polyuria and non-specific inflammations.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Disease; Humans; Inflammation; Polyuria; Prisoners; Prisoners of War; Singapore; Urinary Tract Infections; Urination; Urination Disorders; Urogenital System; Warfare | 1946 |
Clinical findings in American soldiers released from a German prison camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Ethnicity; Gastroenterology; Humans; Military Medicine; Military Personnel; United States | 1946 |
A detailed report on the weights and weight losses of twenty-four men in Santo Tomas Internment Camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Body Height; Humans; Male; Prisoners; Prisoners of War; Thinness; Warfare; Weight Loss | 1946 |
The management of the emotionally maladjusted soldier at a staging camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Military Medicine; Military Personnel; Psychiatry | 1946 |
In a Japanese internment camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Prisoners; Prisoners of War; Warfare | 1945 |
Physical activity of children with rheumatic heart disease; experience at Sunset Camp.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Child; Exercise; Heart Diseases; Humans; Rheumatic Fever; Rheumatic Heart Disease | 1946 |
Resumé of medical activities at German Prisoner of War Camp, Fort Lewis, Washington, August, 1944-August 1945.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Humans; Military Medicine; Prisoners; Prisoners of War; Warfare; Washington | 1946 |
The practice of surgery in Japanese prison camp hospitals in Burma and Siam.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Hospitals, Military; Humans; Military Medicine; Military Personnel; Prisoners; Prisoners of War; United States; Warfare | 1946 |
8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Kinase; Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Fragmentation; Drug Screening Assays, Antitumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Subunits; Proto-Oncogene Proteins c-akt; Signal Transduction | 2011 |
8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Animals; Calcium Channels, T-Type; Cattle; Cells, Cultured; Cyclic AMP; Drug Evaluation, Preclinical; Gene Expression Regulation, Enzymologic; Hydrocortisone; Models, Biological; Signal Transduction; Steroid Hydroxylases; Thionucleotides; Up-Regulation | 2011 |
cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Drug Resistance; Male; Membrane Potentials; Mice; Sperm Capacitation; Spermatozoa | 2012 |
Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; HeLa Cells; Humans; MCF-7 Cells; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Ribonucleotides | 2013 |
Glucagon stimulates ghrelin secretion through the activation of MAPK and EPAC and potentiates the effect of norepinephrine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Caproates; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Ghrelin; Glucagon; Guanine Nucleotide Exchange Factors; Male; MAP Kinase Kinase Kinases; Norepinephrine; Rats; Receptors, Glucagon; RNA, Messenger; Stomach | 2013 |
Modulation of spontaneous electrical activity of freshly isolated 3-day embryonic chick ventricle by cAMP and cGMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Chick Embryo; Cyclic GMP; Heart Ventricles; Ventricular Function | 2005 |
Pyocyanin inhibits both nitric oxide-dependent and -independent relaxation in porcine coronary arteries.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Diethylamines; Dinoprost; Female; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Pseudomonas aeruginosa; Pyocyanine; Swine; Vasodilation | 2015 |
Cooling reduces cAMP-stimulated exocytosis and adiponectin secretion at a Ca2+-dependent step in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adiponectin; Animals; Calcium; Cold Temperature; Cyclic AMP; Exocytosis; Ionomycin; Mice; Models, Biological | 2015 |
The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Amines; Antineoplastic Agents; Apoptosis; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; MAP Kinase Signaling System; Piperidines; Proto-Oncogene Mas; Thyroid Neoplasms | 2016 |
SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Kinase; Cell Division; Cell Line, Tumor; Humans; Mass Spectrometry; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Signal Transduction | 2015 |
cAMP controls the balance of the propulsive forces generated by the two flagella of Chlamydomonas.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Axoneme; Chlamydomonas; Cilia; Cyclic AMP; Flagella; Second Messenger Systems | 2015 |
Reinforcing endothelial junctions prevents microvessel permeability increase and tumor cell adhesion in microvessels in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Breast Neoplasms; Capillaries; Capillary Permeability; Cell Adhesion; Cell Line, Tumor; Cyclic AMP; Endothelial Cells; Endothelium, Vascular; Female; Humans; Mesentery; Microvessels; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Venules | 2015 |
H2S induces vasoconstriction of rat cerebral arteries via cAMP/adenylyl cyclase pathway.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcium Channel Agonists; Calcium Channels, L-Type; Cerebral Arteries; Colforsin; Cyclic AMP; Endothelium; Hydrogen Sulfide; Isoproterenol; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sulfides; Vasoconstriction | 2015 |
The immunotoxicity of aluminum trichloride on rat peritoneal macrophages via β2-adrenoceptors/cAMP pathway acted by norepinephrine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aluminum Chloride; Aluminum Compounds; Animals; Cells, Cultured; Chlorides; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Macrophages, Peritoneal; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Adrenergic, beta-3; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |
Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Hepatocellular; Catalytic Domain; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Cirrhosis; Liver Neoplasms; Lymphatic Metastasis; Mutation; Neoplasm Recurrence, Local | 2016 |
Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carbohydrate Metabolism; Carbohydrates; Carbon; Citric Acid Cycle; Cyclic AMP; Energy Metabolism; Escherichia coli; Glucose; Ketoglutaric Acids | 2016 |
Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cocaine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Excitatory Postsynaptic Potentials; Female; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Receptors, AMPA; Reward; Synapses; Thionucleotides; Ventral Tegmental Area | 2016 |
The effects of MCA-MAO on cAMP pathway in rats with cerebral hemorrhage.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cerebral Hemorrhage; Cyclic AMP-Dependent Protein Kinases; Male; Monoamine Oxidase; Rats | 2016 |
8-Cl-cAMP and PKA I-selective cAMP analogs effectively inhibit undifferentiated thyroid cancer cell growth.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP; Humans; Phosphorylation; Signal Transduction; Thyroid Gland; Thyroid Neoplasms | 2017 |
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain; Cell Membrane; Cerebrospinal Fluid; Choroid Plexus; Cyclic AMP; Enzyme Inhibitors; Flow Cytometry; Hydrogen-Ion Concentration; Intracellular Fluid; Macrolides; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Sodium; Thionucleotides; Vacuolar Proton-Translocating ATPases | 2017 |
The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Astrocytes; Brain Neoplasms; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Gene Expression Profiling; Glial Fibrillary Acidic Protein; Glioblastoma; Glycolysis; Humans; Organelle Biogenesis; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proteomics; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Endoplasmic reticulum (ER) stress and cAMP/PKA pathway mediated Zn-induced hepatic lipolysis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Catfishes; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Hazardous Substances; Homeostasis; Lipid Metabolism; Lipolysis; Liver; Signal Transduction; Sulfonamides; Thiophenes; Zinc | 2017 |
Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Differentiation; Cell Line; Cell Proliferation; Colforsin; Cysts; Disease Models, Animal; Down-Regulation; Epithelial Cells; Ganoderma; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; ras Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; TRPP Cation Channels | 2017 |
Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenomedullin; Aldehydes; Animals; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Ethidium; Fibrosis; Gene Transfer Techniques; Isoquinolines; Kidney; Kidney Diseases; Lipid Peroxidation; Male; NADPH Oxidase 4; Neuropeptides; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Transforming Growth Factor beta1; Up-Regulation | 2017 |
Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates in Dictyostelium that contribute to chemotaxis towards cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Cycle Proteins; Chemotaxis; Cyclic AMP; Dictyostelium; Gene Expression Regulation; Glycogen Synthase Kinase 3; Kelch Repeat; Phosphoric Diester Hydrolases; Protozoan Proteins; Signal Transduction | 2018 |
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epinephrine; Glucagon; Hepatocytes; Humans; Kidney; Male; Mice; Muscle, Skeletal; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Proteostasis Deficiencies; Rats; Rats, Sprague-Dawley; Rats, Wistar; Ubiquitinated Proteins | 2019 |
Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; Phosphodiesterase 3 Inhibitors | 2019 |
A crosstalk between c-di-GMP and cAMP in regulating transcription of GcsA, a diguanylate cyclase involved in swimming motility in Pseudomonas putida.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bacterial Proteins; Conserved Sequence; Cyclic GMP; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Phosphoric Diester Hydrolases; Phosphorus-Oxygen Lyases; Promoter Regions, Genetic; Pseudomonas putida; Second Messenger Systems | 2020 |
Acephate interferes with androgen synthesis in rat immature Leydig cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Androgens; Animals; Apoptosis; Cells, Cultured; Leydig Cells; Luteinizing Hormone; Male; Multienzyme Complexes; Organothiophosphorus Compounds; Phosphoramides; Progesterone; Progesterone Reductase; Rats; Rats, Sprague-Dawley; Receptors, LH; Steroid Isomerases; Testis | 2020 |
Characterization of StAR protein of Rhinella arenarum (Amphibia, Anura).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Androgens; Animals; Anura; Chorionic Gonadotropin; Male; Phosphoproteins; Phylogeny; RNA, Messenger; Tissue Distribution | 2020 |
EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Movement; Cell Shape; Cells, Cultured; Collagen; Drug Combinations; Endothelial Cells; Endothelium, Vascular; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Laminin; Morphogenesis; Proteoglycans; Pseudopodia | 2021 |