8-bromo-2--deoxyguanosine and 8-5--cyclo-2--deoxyguanosine

8-bromo-2--deoxyguanosine has been researched along with 8-5--cyclo-2--deoxyguanosine* in 1 studies

Other Studies

1 other study(ies) available for 8-bromo-2--deoxyguanosine and 8-5--cyclo-2--deoxyguanosine

Article	Year
(5'S)- and (5'R)-5',8-cyclo-2'-deoxyguanosine: mechanistic insights on the 2'-deoxyguanosin-5'-yl radical cyclization. Chemical research in toxicology, 2007, Volume: 20, Issue:12 The two diastereomeric forms (5'S) and (5'R) of 5',8-cyclo-2'-deoxyguanosine have been synthesized and fully characterized. They have been used as references for the investigation of gamma-irradiation of 2'-deoxyguanosine and photolysis of 8-bromo-2'-deoxyguanosine in aqueous solutions. The observed (5'R)/(5'S) ratio of 8:1 was obtained in both sets of experiments. The mechanism of the cyclization reaction is discussed in some detail, and the diastereomeric outcome is rationalized in terms of favorable hydrogen-bonded structures in the pro-(5'R) conformation. Topics: Cyclization; Deoxyguanosine; Gamma Rays; Molecular Structure; Photolysis; Stereoisomerism	2007

Article

Year

(5'S)- and (5'R)-5',8-cyclo-2'-deoxyguanosine: mechanistic insights on the 2'-deoxyguanosin-5'-yl radical cyclization.

Chemical research in toxicology, 2007, Volume: 20, Issue:12

The two diastereomeric forms (5'S) and (5'R) of 5',8-cyclo-2'-deoxyguanosine have been synthesized and fully characterized. They have been used as references for the investigation of gamma-irradiation of 2'-deoxyguanosine and photolysis of 8-bromo-2'-deoxyguanosine in aqueous solutions. The observed (5'R)/(5'S) ratio of 8:1 was obtained in both sets of experiments. The mechanism of the cyclization reaction is discussed in some detail, and the diastereomeric outcome is rationalized in terms of favorable hydrogen-bonded structures in the pro-(5'R) conformation.

Topics: Cyclization; Deoxyguanosine; Gamma Rays; Molecular Structure; Photolysis; Stereoisomerism

2007