Page last updated: 2024-08-21

8-aminoquinoline and primaquine

8-aminoquinoline has been researched along with primaquine in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (16.67)	18.7374
1990's	6 (16.67)	18.2507
2000's	2 (5.56)	29.6817
2010's	17 (47.22)	24.3611
2020's	5 (13.89)	2.80

Authors

Authors	Studies
Bartlett, MS; Berman, JD; Dean, RA; Ellis, WY; Milhous, WK; Queener, SF; Smith, JW	1
Baskin, SI; Fricke, RF; Scharf, BA	1
Baskin, SI; Clark, JH; Kirby, SD; Steinhaus, RK	1
Berman, JD; Lee, LS	1
Brewer, TG; Idowu, OR; Peggins, JO	1
Bartlett, MS; Goheen, MP; Queener, SF; Shaw, MM; Smith, JW	1
Jiang, Q; Li, G; Shi, Y; Zhong, J	1
WINCKEL, CW	1
ALVING, AS; BREWER, GJ; CARSON, PE; JOHNSON, CF; KELLERMEYER, RW; TARLOV, AR	1
ALVING, AS; BREWER, GJ; TARLOV, AR	1
CLYDE, DF	1
SCHMIDT, IG; SCHMIDT, LH	1
White, NJ	1
Gomes, P; Matos, J; Moreira, R; Vale, N	1
Croft, SL; Gamarro, F; Yardley, V	1
Doerksen, RJ; Liu, H; Walker, LA	1
Baird, JK; Berman, J; Melendez, V; Myint, HY; Ohrt, C; Pybus, B; Walker, L	1
Chaurasiya, ND; Dias, LR; Ganesan, S; Nanayakkara, NP; Tekwani, BL; Walker, LA	1
Barnhart, R; Christian, RE; Ferguson, JA; Jin, X; Kozar, MP; Melendez, V; Ohrt, C; Pybus, BS; Reichard, GA; Sciotti, RJ; Sousa, JC; Vuong, C; Walker, LA	1
Gomes, MS; Gomes, P; Matos, J; Moreira, R; Tomás, A; Vale, N; Vale-Costa, S	1
Loughlin, WA; Reynolds, KA; Young, DJ	1
Amnuaysirikul, J; Caridha, D; Gao, X; Grogl, M; Hickman, M; Ishida, H; Li, Q; Magill, AJ; O'Neil, MT; Ohrt, C; Ray, P; Weina, PJ; Zhang, P	1
Baresel, PC; Campo, B; Magill, AJ; Ohrt, C; Rochford, R; Sampath, A; Tekwani, BL; Walker, LA	1
Doerksen, RJ; Liu, H; Nanayakkara, NP; Tekwani, BL; Walker, LA	1
Clarke, A; Garner, P; Gelband, H; Graves, P; Saunders, R; Sinclair, D; Uthman, OA	1
Bancone, G; Bansil, P; Charunwatthana, P; Chowwiwat, N; Chu, CS; Domingo, GJ; McGray, S; Nosten, FH; Somsakchaicharoen, R; Wilaisrisak, P	1
Franken, G; Holtfreter, MC; Labisch, A; Mehlhorn, H; Richter, J; Walter, S	1
Kaewpruk, N; Mungthin, M; Sitthichot, N; Suwandittakul, N; Tan-ariya, P; Ward, SA	1
Azhari, A; Blake, LD; Kemp, MT; Kyle, DE; Larsen, RW; Manetsch, R; McGaha, TW; McQueen, A; Namelikonda, N	1
Advani, N; Cohen, J; Domingo, GJ; Kalnoky, M; Kelley, M; Parker, M; Rowley, E; Satyagraha, AW; Sibley, CH	1
Alano, P; Baker, DA; Bhatia, SN; Biagini, GA; Camarda, G; Jirawatcharadech, P; Leung, S; March, S; Miller, AB; O'Neill, PM; Paine, MJI; Priestley, RS; Saif, A; Ward, SA; Wong, MHL	1
Bancone, G; Brummaier, T; Chotivanich, K; Chu, CS; Gilder, ME; Gornsawun, G; McGready, R; Nosten, F; Pimanpanarak, M	1
Burke, PA; Chavas, TEJ; Flaherty, SM; Ho, DK; Huber, HE; Jackson, C; LeGuyader, CLM; Li, Q; Lin, H; Maktabi, M; Pottenger, A; Pybus, B; Rochford, R; Roy, D; Srinivasan, S; Stayton, PS; Strauch, P; Vlaskin, V; Wesche, D; Zhang, J	1
Flaherty, S; Maktabi, M; Pybus, BS; Reichard, G; Rochford, R; Strauch, P; Walker, LA	1
Shanks, GD	1
Boonyuen, U; Chamchoy, K; Krudsood, S; Patrapuvich, R; Sudsumrit, S; Thita, T	1

Reviews

4 review(s) available for 8-aminoquinoline and primaquine

Article	Year
The role of anti-malarial drugs in eliminating malaria. Malaria journal, 2008, Dec-11, Volume: 7 Suppl 1 Topics: Aminoquinolines; Animals; Antimalarials; Artemisinins; Drug Therapy, Combination; Health Policy; Humans; Malaria; Plasmodium; Primaquine; Treatment Outcome	2008
Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations. The American journal of tropical medicine and hygiene, 2011, Volume: 85, Issue:6 Topics: Aminoquinolines; Antimalarials; Drug Interactions; Drug Therapy, Combination; Humans; Malaria; Plasmodium; Primaquine	2011
Quinolines as chemotherapeutic agents for leishmaniasis. Mini reviews in medicinal chemistry, 2013, Apr-01, Volume: 13, Issue:5 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Imiquimod; Leishmania; Leishmaniasis; Primaquine; Quinolines; Structure-Activity Relationship	2013
Clinical implications of a gradual dormancy concept in malaria. Parasitology research, 2016, Volume: 115, Issue:6 Topics: Aminoquinolines; Antimalarials; Humans; Liver; Malaria; Parasitemia; Plasmodium; Plasmodium falciparum; Plasmodium knowlesi; Plasmodium malariae; Plasmodium ovale; Plasmodium vivax; Primaquine; Recurrence; Species Specificity	2016

Other Studies

32 other study(ies) available for 8-aminoquinoline and primaquine

Article	Year
Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats. The Journal of infectious diseases, 1992, Volume: 165, Issue:4 Topics: Aminoquinolines; Animals; Clindamycin; Disease Models, Animal; Drug Administration Schedule; Female; Pneumonia, Pneumocystis; Primaquine; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms; Trimethoprim, Sulfamethoxazole Drug Combination	1992
Comparison of methemoglobin formers in protection against the toxic effects of cyanide. General pharmacology, 1992, Volume: 23, Issue:1 Topics: Aminoquinolines; Aniline Compounds; Animals; Dose-Response Relationship, Drug; Hemoglobins; Ketones; Lethal Dose 50; Male; Methemoglobin; Mice; Mice, Inbred ICR; Motor Activity; Oxidation-Reduction; Primaquine; Propiophenones; Sodium Cyanide	1992
Formation of methemoglobin and metmyoglobin using 8-aminoquinoline derivatives or sodium nitrite and subsequent reaction with cyanide. Journal of applied toxicology : JAT, 1990, Volume: 10, Issue:5 Topics: Aminoquinolines; Chemical Phenomena; Chemistry, Physical; Cyanides; Humans; Indicators and Reagents; Kinetics; Methemoglobin; Metmyoglobin; Oxidation-Reduction; Primaquine; Protein Binding; Sodium Nitrite	1990
Activity of antileishmanial agents against amastigotes in human monocyte-derived macrophages and in mouse peritoneal macrophages. The Journal of parasitology, 1984, Volume: 70, Issue:2 Topics: Aminoquinolines; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Ascitic Fluid; Cells, Cultured; Drug Evaluation, Preclinical; Gluconates; Humans; Ketoconazole; Leishmania; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Pentamidine; Primaquine	1984
Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Formic Acid Esters; Hydroxylation; Male; Mass Spectrometry; Primaquine; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1995
Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii. International journal of experimental pathology, 1993, Volume: 74, Issue:4 Topics: Aminoquinolines; Humans; Microscopy, Electron; Pneumocystis; Primaquine	1993
[Synthesis of primaquine analogues and their antimalarial activity in mice]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:3 Topics: Aminoquinolines; Animals; Antimalarials; Malaria; Mice; Plasmodium yoelii; Primaquine	1998
When to use the 8-aminoquinolines in the treatment of malaria, especially primaquine. Documenta de medicina geographica et tropica, 1954, Volume: 6, Issue:3 Topics: Aminoquinolines; Antimalarials; Malaria; Primaquine; Quinolines; Uricosuric Agents	1954
Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report. Bulletin of the World Health Organization, 1960, Volume: 22 Topics: Adult; Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Malaria, Vivax; Male; Primaquine	1960
Methaemoglobin reduction test: a new, simple, in vitro test for identifying primaquine-sensitivity. Bulletin of the World Health Organization, 1960, Volume: 22 Topics: Aminoquinolines; Antimalarials; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Malaria; Methemoglobin; Primaquine	1960
Mass administration of an antimalarial drug combining 4-aminoquinoline and 8-aminoquinoline in Tanganyika. Bulletin of the World Health Organization, 1962, Volume: 27 Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Culicidae; Humans; Malaria; Primaquine; Tanzania	1962
Neurotoxicity of the 8-aminoquinolines. III. The effects of pentaquine, isopentaquine, primaquine, and pamaquine on the central nervous system of the rhesus monkey. Journal of neuropathology and experimental neurology, 1951, Volume: 10, Issue:3 Topics: Aminoquinolines; Animals; Macaca mulatta; Nervous System; Primaquine; Quinolines	1951
Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives. European journal of mass spectrometry (Chichester, England), 2009, Volume: 15, Issue:5 Topics: Aminoquinolines; Antimalarials; Imidazolidines; Peptides; Primaquine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2009
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Female; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Primaquine; Trypanosoma cruzi	2010
DFT study on the radical anions formed by primaquine and its derivatives. Chemical research in toxicology, 2011, Sep-19, Volume: 24, Issue:9 Topics: Aminoquinolines; Anions; Antimalarials; Electrons; Free Radicals; Models, Molecular; Primaquine; Quantum Theory	2011
Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs. Bioorganic & medicinal chemistry letters, 2012, Feb-15, Volume: 22, Issue:4 Topics: Aminoquinolines; Antimalarials; Enzyme Activation; Humans; Inhibitory Concentration 50; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenols; Primaquine	2012
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine. Malaria journal, 2012, Aug-02, Volume: 11 Topics: Aminoquinolines; Antimalarials; Cytochrome P-450 Enzyme System; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Primaquine; Recombinant Proteins	2012
Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Cell Culture Techniques; Cell Survival; Inhibitory Concentration 50; Leishmania infantum; Leishmaniasis, Visceral; Macrophages; Mice; Mice, Inbred BALB C; Organometallic Compounds; Parasitic Sensitivity Tests; Peptidomimetics; Phosphorylcholine; Primaquine	2012
An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines. The American journal of tropical medicine and hygiene, 2013, Volume: 88, Issue:6 Topics: Acute Disease; Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genotype; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Haptoglobins; Hemolytic Agents; Male; Mefloquine; Mice; Phenotype; Primaquine; Reticulocyte Count	2013
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43 Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; Dapsone; Dose-Response Relationship, Drug; Doxycycline; Drug Evaluation, Preclinical; Erythrocyte Count; Erythrocyte Transfusion; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Mefloquine; Mice; Mice, Inbred NOD; Mice, SCID; Primaquine; Pyrimethamine; Reproducibility of Results; Sensitivity and Specificity; Transplantation, Heterologous	2013
Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine. Chemical research in toxicology, 2013, Dec-16, Volume: 26, Issue:12 Topics: Aminoquinolines; Methemoglobin; Molecular Dynamics Simulation; Molecular Structure; Primaquine; Quantum Theory	2013
Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies. BMJ open, 2014, May-14, Volume: 4, Issue:5 Topics: Aminoquinolines; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Primaquine; Prospective Studies; Research Design; Systematic Reviews as Topic	2014
Suitability of capillary blood for quantitative assessment of G6PD activity and performances of G6PD point-of-care tests. The American journal of tropical medicine and hygiene, 2015, Volume: 92, Issue:4 Topics: Aminoquinolines; Antimalarials; Capillaries; Clinical Enzyme Tests; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Vivax; Male; Point-of-Care Systems; Primaquine; Sensitivity and Specificity; Veins	2015
PFMDR1 POLYMORPHISMS INFLUENCE ON IN VITRO SENSITIVITY OF THAI PLASMODIUM FALCIPARUM ISOLATES TO PRIMAQUINE, SITAMAQUINE AND TAFENOQUINE. The Southeast Asian journal of tropical medicine and public health, 2016, Volume: 47, Issue:3 Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Primaquine; Thailand	2016
Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine. Bioorganic & medicinal chemistry letters, 2017, 10-15, Volume: 27, Issue:20 Topics: Aminoquinolines; Antimalarials; Erythrocytes; Fluorescent Dyes; Hep G2 Cells; Humans; Life Cycle Stages; Malaria, Falciparum; Microscopy, Fluorescence; Plasmodium falciparum; Primaquine	2017
Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities. International health, 2019, 01-01, Volume: 11, Issue:1 Topics: Africa; Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Health Knowledge, Attitudes, Practice; Humans; Malaria, Vivax; Male; Primaquine; Risk Factors; Sex Factors	2019
Antimalarial activity of primaquine operates via a two-step biochemical relay. Nature communications, 2019, 07-19, Volume: 10, Issue:1 Topics: Aminoquinolines; Antimalarials; Bone Marrow; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Liver; Malaria, Falciparum; NADP; Pharmacokinetics; Plasmodium falciparum; Primaquine	2019
Vivax malaria in pregnancy and lactation: a long way to health equity. Malaria journal, 2020, Jan-22, Volume: 19, Issue:1 Topics: Adolescent; Aminoquinolines; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Female; Fetal Growth Retardation; Glucosephosphate Dehydrogenase Deficiency; Health Equity; Humans; Infant, Small for Gestational Age; Lactation Disorders; Malaria, Vivax; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Primaquine	2020
Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure. Journal of controlled release : official journal of the Controlled Release Society, 2021, 03-10, Volume: 331 Topics: Aminoquinolines; Animals; Antimalarials; Liver; Malaria; Malaria, Vivax; Mice; Mice, Inbred NOD; Mice, SCID; Polymers; Primaquine; Prodrugs	2021
Mechanisms of 8-aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model. Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:13 Topics: Aminoquinolines; Animals; Antimalarials; Disease Models, Animal; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Malaria, Vivax; Mice; Primaquine	2022
Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together. The American journal of tropical medicine and hygiene, 2022, 11-14, Volume: 107, Issue:5 Topics: Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Primaquine; Quinine	2022
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure. PLoS neglected tropical diseases, 2022, Volume: 16, Issue:12 Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis; Humans; Malaria; Malaria, Vivax; Primaquine; Southeast Asian People	2022