8-aminoguanosine has been researched along with 2-nitropropane* in 1 studies
1 other study(ies) available for 8-aminoguanosine and 2-nitropropane
| Article | Year |
|---|---|
2-Nitropropane-induced liver DNA and RNA base modifications: differences between Sprague-Dawley rats and New Zealand white rabbits.
2-Nitropropane (2-NP), a hepatocarcinogen in male Sprague-Dawley rats but not, under the same conditions, in male New Zealand White rabbits, induces characteristic base modifications in rat liver DNA and RNA including increases in 8-oxoguanine and the formation of 8-aminoguanine. We compared the levels of these modifications in the two animal species at 6, 18 and 42 h after a single i.p. treatment with 1.12 mmol/kg 2-NP. Significantly less nucleic acid base modifications were found to be produced in rabbit liver than in rat liver. Thus, the relative resistance of the rabbit to the hepatocarcinogenicity of 2-NP correlates with decreased levels of 2-NP-induced liver DNA and RNA base damage. Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Guanosine; Liver; Male; Mutagens; Nitroparaffins; Nucleic Acids; Nucleosides; Propane; Rabbits; Rats; Rats, Sprague-Dawley; RNA; Species Specificity | 1993 |