8-11-14-eicosatrienoic-acid and baicalein

8-11-14-eicosatrienoic-acid has been researched along with baicalein* in 2 studies

Other Studies

2 other study(ies) available for 8-11-14-eicosatrienoic-acid and baicalein

Article	Year
Identification and association of recurrent ALOXE3 mutation with non-bullous congenital ichthyosiform erythroderma in two ethnically distinct Pakistani families. Congenital anomalies, 2019, Volume: 59, Issue:3 Non-bullous congenital ichthyosiform erythroderma (NCIE) is characterized by skin scaling with erythema. In this study, two Pakistani families with NCIE are genetically characterized through Whole Exome and Sanger sequencing to identify molecular basis of the disease. We identified a nonsense homozygous c.2026C>T mutation of ALOXE3, causing premature termination of the eLOX3 protein (p.Q676X). In silico studies predicted impaired enzymatic activity of the premature truncated eLOX3, leading to abnormal synthesis of specific hepoxilin derivatives, essential for epidermal barrier formation. It is the first ever study reporting homozygotes of p.Q676X mutation in ethnically distinct two Pakistani families; otherwise, heterozygotes of the said mutation have been reported in South Asian population only. Hence, mutation seems to be region-specific and may be useful for molecular diagnosis of NCIE. Moreover, our findings should help in genetic counseling and career screening. Topics: 8,11,14-Eicosatrienoic Acid; Adolescent; Adult; Base Sequence; Case-Control Studies; Child; Child, Preschool; Codon, Nonsense; Ethnicity; Exome Sequencing; Female; Flavanones; Gene Expression; Homozygote; Humans; Ichthyosis, Lamellar; Lipoxygenase; Male; Middle Aged; Molecular Docking Simulation; Pakistan; Pedigree; Protein Binding; Protein Structure, Secondary; Skin	2019
Epoxyeicosatrienoic acids stimulate the growth of vascular smooth muscle cells. Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Division; Epoprostenol; Epoxy Compounds; Flavanones; Flavonoids; Indomethacin; Ketoconazole; Mesenteric Veins; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Thymidine	1995

Article

Year

Identification and association of recurrent ALOXE3 mutation with non-bullous congenital ichthyosiform erythroderma in two ethnically distinct Pakistani families.

Congenital anomalies, 2019, Volume: 59, Issue:3

Non-bullous congenital ichthyosiform erythroderma (NCIE) is characterized by skin scaling with erythema. In this study, two Pakistani families with NCIE are genetically characterized through Whole Exome and Sanger sequencing to identify molecular basis of the disease. We identified a nonsense homozygous c.2026C>T mutation of ALOXE3, causing premature termination of the eLOX3 protein (p.Q676X). In silico studies predicted impaired enzymatic activity of the premature truncated eLOX3, leading to abnormal synthesis of specific hepoxilin derivatives, essential for epidermal barrier formation. It is the first ever study reporting homozygotes of p.Q676X mutation in ethnically distinct two Pakistani families; otherwise, heterozygotes of the said mutation have been reported in South Asian population only. Hence, mutation seems to be region-specific and may be useful for molecular diagnosis of NCIE. Moreover, our findings should help in genetic counseling and career screening.

Topics: 8,11,14-Eicosatrienoic Acid; Adolescent; Adult; Base Sequence; Case-Control Studies; Child; Child, Preschool; Codon, Nonsense; Ethnicity; Exome Sequencing; Female; Flavanones; Gene Expression; Homozygote; Humans; Ichthyosis, Lamellar; Lipoxygenase; Male; Middle Aged; Molecular Docking Simulation; Pakistan; Pedigree; Protein Binding; Protein Structure, Secondary; Skin

2019

Epoxyeicosatrienoic acids stimulate the growth of vascular smooth muscle cells.

Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Division; Epoprostenol; Epoxy Compounds; Flavanones; Flavonoids; Indomethacin; Ketoconazole; Mesenteric Veins; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Thymidine

1995