8-11-14-eicosatrienoic-acid has been researched along with 4-7-10-13-eicosatetraynoic-acid* in 1 studies
1 other study(ies) available for 8-11-14-eicosatrienoic-acid and 4-7-10-13-eicosatetraynoic-acid
Article | Year |
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Inactivation of 15-lipoxygenases by acetylenic fatty acids.
The inactivation of soybean lipoxygenase-1 and of rabbit reticulocyte lipoxygenase by five selected acetylenic fatty acids was studied. In all cases the inactivation was time-consuming and depended on the concentration of the inactivator. The inactivation kinetics was measured and the data were fitted to a kinetic model based on the assumption of catalytic self-inactivation. The kinetic constants (Km-value and inactivation rate k2) calculated indicated that 7,10,13-eicosatrienoic acid was the most powerful inactivator for the soybean enzyme followed by 8,11,14-eicosatrienoic acid. The occurrence of an additional triple bond between C-4 and C-5 or between C-5 and C-6 strongly reduced the suicidal rate. With the reticulocyte enzyme, only small differences in the reactivities towards various acetylenic fatty acids have been observed. Topics: 5,8,11,14-Eicosatetraynoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Glycine max; Kinetics; Lipoxygenase; Lipoxygenase Inhibitors; Rabbits; Reticulocytes | 1991 |