8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine and 8-(4-sulfophenyl)theophylline

8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine has been researched along with 8-(4-sulfophenyl)theophylline in 3 studies

Compound Research Comparison

Studies (8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine)	Trials (8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine)	Recent Studies (post-2010) (8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine)	Studies (8-(4-sulfophenyl)theophylline)	Trials (8-(4-sulfophenyl)theophylline)	Recent Studies (post-2010) (8-(4-sulfophenyl)theophylline)
16	0	3	324	1	25

Protein Interaction Comparison

Protein	Taxonomy	8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine (IC50)	8-(4-sulfophenyl)theophylline (IC50)
Adenosine receptor A1	Rattus norvegicus (Norway rat)		0.448
Adenosine receptor A1	Bos taurus (cattle)		0.0219

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (33.33)	18.2507
2000's	2 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE	1
Dunwiddie, TV; Thümmler, S	1

Reviews

1 review(s) available for 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine and 8-(4-sulfophenyl)theophylline

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992

Other Studies

2 other study(ies) available for 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine and 8-(4-sulfophenyl)theophylline

Article	Year
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines	2002
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines	2000

Article

Year

Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.

Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11

Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines

2002

Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.

Journal of neurophysiology, 2000, Volume: 83, Issue:4

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines

2000