8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine and adenosine-5'-(n-ethylcarboxamide)

8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine has been researched along with adenosine-5'-(n-ethylcarboxamide) in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.86)	18.7374
1990's	18 (51.43)	18.2507
2000's	11 (31.43)	29.6817
2010's	5 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Jacobson, KA; Kim, J; Schöneberg, T; van Rhee, AM; Wess, J	1
Bertin, B; Freissmuth, M; Hohenegger, M; Jockers, R; Linder, ME; Marullo, S; Nanoff, C; Strosberg, AD	1
Jacobson, KA; Olah, ME; Stiles, GL	1
Jacobson, MA; Johnson, RG; Linden, J; Salvatore, CA; Taylor, HE	1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C	1
Glashofer, M; Jacobson, KA; Jiang, Q; Lee, BX; van Rhee, AM	1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C	1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T	1
Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K	1
Barili, PL; Betti, L; Ferrarini, PL; Giannaccini, G; Lucacchini, A; Manera, C; Martinelli, A; Mori, C; Mori, F; Saccomanni, G; Trincavelli, L	1
Beukers, MW; Brouwer, J; den Dulk, H; Ijzerman, AP; van Tilburg, EW	1
Ahern, DG; Jacobson, KA; Ji, X; Kim, YC; Linden, J	1
Barak, D; Chen, A; Gao, ZG; Jacobson, KA; Kim, SA; Lee, K; Liang, BT; Link, A; Rompaey, PV; van Calenbergh, S	1
Castelhano, AL; Ma, C; MacLennan, SJ; McKibben, B; Song, JP; Steinig, AG; Stewart, M	1
Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K; Oyanagi, K	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Abe, T; Ishiyama, H; Kobayashi, J; Nakata, H; Ohshita, K	1
Ishiyama, H; Kobayashi, J; Nakajima, H; Nakata, H	1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L	1
Handa, C; Momose, T; Muranaka, H; Ozawa, T	1
Gobran, LI; Griese, M; Rooney, SA	3
Jacobson, KA; Ji, XD; Stiles, GL	1
Holtzman, SG; Mante, S; Minneman, KP	1
Bealer, SL; Proctor, KG; Stojanov, I	1
Klotz, KN; Lohse, MJ; Schwabe, U	1
Prostran, M; Varagić, VM	1
Nakata, H; Saitoh, O; Saitoh, Y	1
Basavappa, S; Fitz, JG; Mangel, AW; McGill, JM; Middleton, JP; Shimokura, GH	1
Bourgoin, S; Cesselin, F; Hamon, M; Mauborgne, A; Poliénor, H	1
Briddon, SJ; Hill, SJ; May, LT	1
Adams, L; Baker, JG; Briddon, SJ; Hill, SJ; Kellam, B; May, LT; Middleton, R	1
Briddon, SJ; Bridge, LJ; Hill, SJ; May, LT; Stoddart, LA	1

Reviews

2 review(s) available for 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1	2013

Other Studies

33 other study(ies) available for 8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. The Journal of biological chemistry, 1995, Jun-09, Volume: 270, Issue:23 Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Histidine; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Purinergic P1; Structure-Activity Relationship	1995
Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. The Journal of biological chemistry, 1994, Dec-23, Volume: 269, Issue:51 Topics: Animals; Base Sequence; Brain; Cattle; DNA Primers; Escherichia coli; GTP-Binding Proteins; Humans; Molecular Sequence Data; Protein Binding; Receptors, Purinergic P1; Recombinant Proteins; Species Specificity	1994
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors. The Journal of biological chemistry, 1994, Oct-07, Volume: 269, Issue:40 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Binding Sites; Cattle; Cells, Cultured; Molecular Sequence Data; Rats; Receptors, Purinergic P1; Recombinant Fusion Proteins; Structure-Activity Relationship; Xanthines	1994
Molecular cloning and characterization of the human A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: Adenosine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Consensus Sequence; Corpus Striatum; Cricetinae; DNA Primers; Gene Expression; Humans; Iodobenzenes; Kinetics; Liver; Lung; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Sheep; Transfection	1993
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles	1997
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors. Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; COS Cells; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Iodobenzenes; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Biogenic Amine; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines	1997
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines	1998
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines	1999
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Molecular pharmacology, 2000, Volume: 57, Issue:5 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium	2000
A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: Adenylyl Cyclases; Animals; Cattle; Cerebral Cortex; Corpus Striatum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Naphthyridines; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Structure-Activity Relationship	2000
Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine. Molecular pharmacology, 2000, Volume: 58, Issue:6 Topics: Adenosine; Alkynes; Amino Acid Sequence; Animals; Asparagine; COS Cells; Cyclic AMP; Molecular Sequence Data; Mutation; Point Mutation; Protein Conformation; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Transfection; Tyrosine	2000
[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochemical pharmacology, 2001, Mar-15, Volume: 61, Issue:6 Topics: Acetamides; Cells, Cultured; Humans; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Radiopharmaceuticals; Receptor, Adenosine A2B; Tritium	2001
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. Journal of medicinal chemistry, 2001, Nov-22, Volume: 44, Issue:24 Topics: Adenosine; Amines; Animals; Cell Line; Cerebral Cortex; Cyclic AMP; GTP-Binding Proteins; Humans; In Vitro Techniques; Ligands; Models, Molecular; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1	2001
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochemical pharmacology, 2004, Jul-15, Volume: 68, Issue:2 Topics: Adenosine A2 Receptor Antagonists; Cells, Cultured; Humans; Pyrimidines; Pyrroles; Radioligand Assay; Time Factors; Tritium	2004
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9 Topics: Binding Sites; Caffeine; Carbolines; Cell Line; Humans; Ligands; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Carbolines; Cell Line; Humans; Molecular Structure; Receptors, Purinergic P1; Structure-Activity Relationship	2008
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13 Topics: Binding, Competitive; Caffeine; Carbolines; Cell Line; Humans; Ligands; Protein Binding; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	2009
Photoaffinity Labeling of the Human A ACS medicinal chemistry letters, 2017, Jun-08, Volume: 8, Issue:6 Topics:	2017
Cibacron blue stimulation of surfactant secretion in rat type II pneumocytes. British journal of pharmacology, 1992, Volume: 106, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; L-Lactate Dehydrogenase; Lung; Phosphatidylcholines; Protein Synthesis Inhibitors; Pulmonary Surfactants; Rats; Second Messenger Systems; Stimulation, Chemical; Suramin; Terbutaline; Triazines; Xanthines	1992
Chemical modification and irreversible inhibition of striatal A2a adenosine receptors. Molecular pharmacology, 1992, Volume: 42, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Amino Acid Sequence; Animals; Corpus Striatum; Diethyl Pyrocarbonate; Drug Antagonism; Hydroxylamine; Hydroxylamines; Molecular Sequence Data; Phenethylamines; Purinergic Antagonists; Rabbits; Radioligand Assay; Receptors, Purinergic; Theophylline; Xanthines	1992
A2 and P2 purine receptor interactions and surfactant secretion in primary cultures of type II cells. The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 1 Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); AMP Deaminase; Animals; Cells, Cultured; Cyclic AMP; Inositol 1,4,5-Trisphosphate; Lung; Phosphatidylcholines; Pulmonary Surfactants; Receptors, Purinergic; Terbutaline; Theophylline; Thionucleotides; Xanthines	1991
Role of adenosine receptors in caffeine tolerance. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Administration, Oral; Animals; Binding Sites; Brain; Caffeine; Cyclic AMP; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Male; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Time Factors; Tritium; Xanthines	1991
Activation of brain adenosine receptors evokes vasodilation in skin arterioles. The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Brain; Cricetinae; Injections, Intraventricular; Male; Mesocricetus; Receptors, Purinergic; Skin; Theophylline; Vasodilation; Vasodilator Agents; Xanthines	1991
Mechanism of A2 adenosine receptor activation. I. Blockade of A2 adenosine receptors by photoaffinity labeling. Molecular pharmacology, 1991, Volume: 39, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Alprostadil; Azides; Blood Platelets; Humans; Kinetics; Membranes; Phenylisopropyladenosine; Purinergic Antagonists; Radioligand Assay; Receptors, Purinergic; Tritium; Vasodilator Agents; Xanthines	1991
The effect of 5'-N-ethylcarboxamideadenosine on the isolated hemidiaphragm of the rat during direct and indirect electrical stimulation. Fundamental & clinical pharmacology, 1989, Volume: 3, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminophylline; Animals; Diaphragm; Dipyridamole; Electric Stimulation; Female; In Vitro Techniques; Isometric Contraction; Male; Neuromuscular Blocking Agents; Rats; Receptors, Purinergic; Respiratory Muscles; Tubocurarine; Xanthines	1989
Regulation of A2a adenosine receptor mRNA expression by agonists and forskolin in PC12 cells. Neuroreport, 1994, Jun-27, Volume: 5, Issue:11 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cyclic AMP; Gene Expression Regulation, Neoplastic; PC12 Cells; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; RNA, Messenger; Second Messenger Systems; Xanthines	1994
Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. Gastroenterology, 1994, Volume: 107, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Bile Duct Neoplasms; Bile Ducts; Calcium; Cell Membrane Permeability; Cells, Cultured; Chlorides; Cholangiocarcinoma; Humans; Iodine Radioisotopes; Ion Transport; Male; Potassium; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Tumor Cells, Cultured; Uridine Triphosphate; Xanthines	1994
Signal-transduction mechanisms of ATP-stimulated phosphatidylcholine secretion in rat type II pneumocytes: interactions between ATP and other surfactant secretagogues. Biochimica et biophysica acta, 1993, Mar-17, Volume: 1167, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Drug Interactions; Ionomycin; Isoquinolines; L-Lactate Dehydrogenase; Lung; Male; Phosphatidylcholines; Piperazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Terbutaline; Tetradecanoylphorbol Acetate; Xanthines	1993
Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord. European journal of pharmacology, 2002, Apr-19, Volume: 441, Issue:1-2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuropeptides; Pain; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Substance P; Xanthines	2002
Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Molecular pharmacology, 2010, Volume: 77, Issue:4 Topics: Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Animals; Azo Compounds; Calcium; CHO Cells; Cricetinae; Cricetulus; Humans; Receptor, Adenosine A1; Receptor, Adenosine A3; Xanthines	2010
Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. British journal of pharmacology, 2010, Volume: 159, Issue:4 Topics: Adenosine-5'-(N-ethylcarboxamide); Alkaline Phosphatase; Animals; Boron Compounds; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dansyl Compounds; Fluorescent Dyes; Genes, Reporter; GPI-Linked Proteins; Humans; Isoenzymes; Ligands; Microscopy, Confocal; Molecular Imaging; Molecular Probe Techniques; Molecular Structure; Radioligand Assay; Receptor, Adenosine A1; Response Elements; Transfection; Xanthines	2010
Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:10 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Gene Expression Regulation; Humans; Kinetics; Protein Binding; Receptor, Adenosine A3; Xanthines	2011