8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline and primaquine

8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline has been researched along with primaquine in 26 studies

Compound Research Comparison

Studies (8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline)	Trials (8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline)	Recent Studies (post-2010) (8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline)	Studies (primaquine)	Trials (primaquine)	Recent Studies (post-2010) (primaquine)
26	3	12	2,196	196	711

Protein Interaction Comparison

Protein	Taxonomy	primaquine (IC50)
Cytochrome P450 1A2	Homo sapiens (human)	0.1824
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	7.5
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.016
Serine hydroxymethyltransferase, mitochondrial	Homo sapiens (human)	0.4365
Thiosulfate sulfurtransferase	Homo sapiens (human)	2.9
60 kDa chaperonin	Escherichia coli	6.2
10 kDa chaperonin	Escherichia coli	6.2

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (15.38)	18.7374
1990's	8 (30.77)	18.2507
2000's	2 (7.69)	29.6817
2010's	9 (34.62)	24.3611
2020's	3 (11.54)	2.80

Authors

Authors	Studies
Ni, YC; Wang, MJ; Xu, YQ	1
Endoh, YS; Inoue, Y; Ishihara, Y; Nakamura, S; Nishikawa, M; Sasaki, H; Sasaki, N; Yoshimura, H	1
Back, DJ; Bangchang, KN; Karbwang, J	1
Ahmad, T; Frischer, H; Mellovitz, RL; Nora, MV	1
Ahmad, T; Carson, PE; Chow, HS; Frischer, H; Kaizer, H; Mellovitz, R; Nora, MV; Parkhurst, GW; Ptak, L; Sivarajan, M	1
Breckenridge, AM; Edwards, G; Mihaly, GW; Orme, ML; Ward, SA	1
Baker, JK; Clark, AM; Hufford, CD; McChesney, JD; Quinones, IN	1
Baker, JK; Clark, AM; Hufford, CD; McChesney, JD	1
Bartlett, MS; Black, J; Dean, RA; Dumaual, NG; Ochieng, W; Queener, SF	1
Davis, TM; Edwards, G; McGrath, CS; Pukrittayakamee, S; Supanaranond, W; Ward, SA; White, NJ	1
Dua, VK; Kar, PK; Sarin, R; Sharma, VP	1
Constantino, L; Cravo, P; do Rosário, VE; Iley, J; Moreira, R; Pinto, J; Portela, MJ; Rosa, R; Valente, E	1
Chung, WC; Kang, MW; Kim, MY; Kim, SI; Kim, YR; Kim, YS; Kuh, HJ	1
Bonato, PS; Bortocan, R	1
Avula, B; Khan, IA; Khan, SI; McChesney, JD; Nanayakkara, NP; Tekwani, BL; Walker, LA	1
Batty, KT; Betuela, I; Davis, TM; Ilett, KF; Page-Sharp, M	1
Ashley, EA; Charunwatthana, P; Day, NP; Hanboonkunupakarn, B; Hanpithakpong, W; Jittamala, P; Lawpoolsri, S; Lee, SJ; Pukrittayakamee, S; Tarning, J; White, NJ	1
Ashley, EA; Blessborn, D; Chairat, K; Day, NP; Hanboonkunupakarn, B; Jittamala, P; Lee, SJ; Nosten, F; Panapipat, S; Pukrittayakamee, S; Tarning, J; Thana, P; White, NJ	1
Avula, B; Chaurasiya, ND; ElSohly, MA; Fasinu, PS; Herath, HM; Jain, S; Khan, IA; Khan, SI; McChesney, JD; Nanayakkara, NP; Sahu, R; Stanford, D; Tekwani, BL; Walker, LA; Yates, TW	1
Avula, B; Bandara Herath, HM; Elsohly, MA; Fasinu, PS; Khan, IA; Khan, SI; Marcsisin, SR; McChesney, JD; Nanayakkara, NP; Reichard, GA; Tekwani, BL; Walker, LA; Wang, YH	1
Baresel, PC; Campo, B; Marcsisin, SR; Reichard, GA; Rochford, R; Sousa, J; Tekwani, BL; Vuong, CT; Walker, LA; Wickham, KS	1
Bancone, G; Carrara, VI; Chu, CS; Gilder, ME; Hanpithakphong, W; Hilda, N; Hoglund, RM; McGready, R; Nosten, F; Singhasivanon, P; Tarning, J; White, NJ; Win, HH	1
Grisólia, DPA; Mello, AGNC; Paixão, TPD; Pinto, ACG; Sena, LWP; Silva, MT; Vieira, JLF; Vieira, MVDF	1
Catchings, Z; Chaurasiya, ND; ElSohly, MA; Fasinu, PS; Herath, HMTB; Khan, IA; Khan, S; Khan, W; McChesney, JD; Nanayakkara, NPD; Tekwani, BL; Walker, LA; Wang, YH	1
Aung, AA; Blessborn, D; Chu, CS; Hanpithakpong, W; Imwong, M; Kraft, K; Ling, C; Nosten, FH; Phyo, AP; Proux, S; Soe, NL; Tarning, J; Thinraow, S; Watson, JA; White, NJ; Wilaisrisak, P; Win, HH; Yotyingaphiram, W	1
Day, NPJ; Hanpithakpong, W; Tarning, J; White, NJ	1

Trials

3 trial(s) available for 8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline and primaquine

Article	Year
Pharmacokinetic interactions between primaquine and chloroquine. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6 Topics: Adult; Antimalarials; Chloroquine; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Malaria; Malaria, Vivax; Male; Middle Aged; Plasmodium vivax; Primaquine; Young Adult	2014
Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:1 Topics: Administration, Oral; Adult; Antimalarials; Artemisinins; Artesunate; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Naphthyridines; Primaquine; Thailand; Young Adult	2015
Determinants of Primaquine and Carboxyprimaquine Exposures in Children and Adults with Plasmodium vivax Malaria. Antimicrobial agents and chemotherapy, 2021, 10-18, Volume: 65, Issue:11 Topics: Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Malaria, Vivax; Primaquine	2021

Other Studies

23 other study(ies) available for 8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline and primaquine

Article	Year
Rat liver microsomal and mitochondrial metabolism of primaquine in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:5 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Microsomes, Liver; Mitochondria, Liver; Primaquine; Rats	1992
High-performance liquid chromatographic determination of pamaquine, primaquine and carboxy primaquine in calf plasma using electrochemical detection. Journal of chromatography, 1992, Aug-07, Volume: 579, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Calibration; Cattle; Chromatography, High Pressure Liquid; Electrochemistry; Primaquine; Reproducibility of Results	1992
Primaquine metabolism by human liver microsomes: effect of other antimalarial drugs. Biochemical pharmacology, 1992, Aug-04, Volume: 44, Issue:3 Topics: Antimalarials; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Kinetics; Microsomes, Liver; NADP; Primaquine	1992
The conversion of primaquine into primaquine-aldehyde, primaquine-alcohol, and carboxyprimaquine, a major plasma metabolite. The Journal of laboratory and clinical medicine, 1991, Volume: 117, Issue:6 Topics: Alcohols; Aldehydes; Biotransformation; Blood; Bone Marrow; Bone Marrow Cells; Carmustine; Chromatography; Chromatography, High Pressure Liquid; Embryo, Mammalian; Humans; Leukemia, Erythroblastic, Acute; Liver; Primaquine; Tumor Cells, Cultured	1991
Biotransformation of primaquine in vitro with human K562 and bone marrow cells. The Journal of laboratory and clinical medicine, 1987, Volume: 109, Issue:4 Topics: Biotransformation; Bone Marrow; Carmustine; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Primaquine	1987
Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite. British journal of clinical pharmacology, 1984, Volume: 17, Issue:4 Topics: Adult; Biotransformation; Half-Life; Humans; Kinetics; Male; Middle Aged; Primaquine	1984
Microbial metabolism studies on the major microbial and mammalian metabolite of primaquine. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:1 Topics: Bacteria; Biotransformation; Fermentation; Magnetic Resonance Spectroscopy; Primaquine	1983
High-performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite. Journal of chromatography, 1982, Jun-11, Volume: 230, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Male; Primaquine; Rats; Rats, Inbred Strains; Reference Values; Time Factors	1982
Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications, 1994, Apr-22, Volume: 655, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; Drug Combinations; Electrochemistry; Humans; Indicators and Reagents; Primaquine	1994
Interactions among primaquine, malaria infection and other antimalarials in Thai subjects. British journal of clinical pharmacology, 1993, Volume: 35, Issue:2 Topics: Acute Disease; Administration, Oral; Adult; Drug Interactions; Humans; Malaria, Falciparum; Male; Mefloquine; Primaquine; Quinine; Thailand	1993
High-performance liquid chromatographic determination of primaquine and carboxyprimaquine concentrations in plasma and blood cells in Plasmodium vivax malaria cases following chronic dosage with primaquine. Journal of chromatography. B, Biomedical applications, 1996, Jan-12, Volume: 675, Issue:1 Topics: Adolescent; Adult; Antimalarials; Chromatography, High Pressure Liquid; Humans; Malaria, Vivax; Middle Aged; Primaquine; Reproducibility of Results; Spectrophotometry, Ultraviolet	1996
Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates. Pharmaceutical research, 1999, Volume: 16, Issue:6 Topics: Acylation; Animals; Antimalarials; Dipeptides; Liver; Mice; Mice, Inbred BALB C; Plasmodium berghei; Primaquine; Rats; Rats, Sprague-Dawley	1999
Pharmacokinetics of primaquine and carboxyprimaquine in Korean patients with vivax malaria. Archives of pharmacal research, 2004, Volume: 27, Issue:5 Topics: Adult; Antimalarials; Humans; Korea; Malaria, Vivax; Male; Primaquine	2004
Enantioselective analysis of primaquine and its metabolite carboxyprimaquine by capillary electrophoresis. Electrophoresis, 2004, Volume: 25, Issue:16 Topics: Animals; Buffers; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Molecular Structure; Polysaccharides; Primaquine; Rats; Rats, Wistar; Stereoisomerism	2004
Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification. Biomedical chromatography : BMC, 2011, Volume: 25, Issue:9 Topics: Animals; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Mice; Primaquine; Stereoisomerism	2011
Simultaneous determination of primaquine and carboxyprimaquine in plasma using solid phase extraction and LC-MS assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Aug-01, Volume: 902 Topics: Child; Chromatography, Liquid; Female; Humans; Male; Primaquine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization	2012
Enantioselective pharmacokinetics of primaquine in healthy human volunteers. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:4 Topics: Administration, Oral; Adult; Antimalarials; Cells, Cultured; Chromatography, High Pressure Liquid; Healthy Volunteers; Hepatocytes; Humans; Middle Aged; Molecular Structure; Primaquine; Primary Cell Culture; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship	2015
Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes. Malaria journal, 2016, Apr-19, Volume: 15 Topics: Carbon Isotopes; Chromatography, High Pressure Liquid; Half-Life; Hepatocytes; Humans; Kinetics; Primaquine; Stereoisomerism; Tandem Mass Spectrometry	2016
Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:10 Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocyte Transfusion; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Mice, SCID; Primaquine	2016
Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 09-14, Volume: 67, Issue:7 Topics: Adolescent; Adult; Antimalarials; Area Under Curve; Breast Feeding; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Lactation; Malaria, Vivax; Male; Milk, Human; Primaquine; Young Adult	2018
Levels of primaquine and carboxyprimaquine in patients with malaria vivax from the Brazilian Amazon basin. Revista do Instituto de Medicina Tropical de Sao Paulo, 2018, Oct-25, Volume: 60 Topics: Adult; Antimalarials; Brazil; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Humans; Malaria, Vivax; Male; Primaquine; Prospective Studies	2018
Quantitative determination of primaquine-5,6-ortho-quinone and carboxyprimaquine-5,6-ortho-quinone in human erythrocytes by UHPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Jan-15, Volume: 1163 Topics: Chromatography, High Pressure Liquid; Erythrocytes; Humans; Limit of Detection; Linear Models; Primaquine; Reproducibility of Results; Tandem Mass Spectrometry	2021
Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry. Malaria journal, 2022, Jun-03, Volume: 21, Issue:1 Topics: Acetonitriles; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Primaquine; Reproducibility of Results; Tandem Mass Spectrometry	2022