Page last updated: 2024-09-03

7-propyl spirolactone and spironolactone

7-propyl spirolactone has been researched along with spironolactone in 28 studies

Compound Research Comparison

Studies (7-propyl spirolactone)	Trials (7-propyl spirolactone)	Recent Studies (post-2010) (7-propyl spirolactone)	Studies (spironolactone)	Trials (spironolactone)	Recent Studies (post-2010) (spironolactone)
31	0	0	7,222	960	1,923

Protein Interaction Comparison

Protein	Taxonomy	spironolactone (IC50)
Chain A, Mineralocorticoid receptor	Homo sapiens (human)	0.049
Chain A, Mineralocorticoid receptor	Homo sapiens (human)	0.049
Estrogen receptor	Homo sapiens (human)	5.702
Glucocorticoid receptor	Homo sapiens (human)	4.0745
Progesterone receptor	Homo sapiens (human)	1.675
Glycine receptor subunit alpha-1	Rattus norvegicus (Norway rat)	1.9025
Mineralocorticoid receptor	Homo sapiens (human)	0.0315
Androgen receptor	Homo sapiens (human)	0.3585
Androgen receptor	Rattus norvegicus (Norway rat)	0.406
Glycine receptor subunit beta	Rattus norvegicus (Norway rat)	1.9025
Glycine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	1.9025
Glycine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	1.9025
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	6.92
Cytochrome P450 2C19	Homo sapiens (human)	3

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (25.00)	18.7374
1990's	16 (57.14)	18.2507
2000's	5 (17.86)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Agarwal, MK; Mirshahi, M	1
Agarwal, MK; Mirshahi, A; Mirshahi, M; Nato, A	1
Agarwal, MK; Lazar, G; Mirshahi, M; Pagano, M; Razaghi, A	1
Hayashi, T; Miyabo, S; Nakai, T	1
Agarwal, MK; Lazar, G; Pagano, M	1
Agarwal, M; Corley, K; Kalimi, M; Opoku, J	1
Agarwal, MK; Kalimi, M	4
Davda, MM; Luttge, WG; Rupp, ME	1
Davda, MM; Kang, CG; Luttge, WG; Rupp, ME	1
Agarwal, MK; Lazar, G	1
Boadle-Biber, MC; Corley, KC; Krieg, RJ; Phan, TH; Singh, VB	1
Ricketts, ML; Stewart, PM; Whorwood, CB	1
Agarwal, MK; Mirshahi, F; Mirshahi, M; Rostene, W	1
Agarwal, MK; Braq, S; Guern, J; Jullienne, A; Leblanc, N; Mirshahi, M; Stibon, F	1
Brooke, S; Jacobson, L; Sapolsky, R	1
Agarwal, MK; d'Hermies, F; Faure, JP; Hecquet, C; Mirshahi, A; Mirshahi, M; Nicolas, C	1
Couette, B; Fagart, J; Rafestin-Oblin, ME; Souque, A	1
Agarwal, MK; Faure, JP; Hecquet, C; Mirshahi, A; Mirshahi, M; Sedighian, R	1
Ben Rhouma, K; Felix, JM; Sakly, M; Schimchowitsch, S; Stoeckel, ME	1
Barker, KS; Davis, AT; Rollins-Smith, LA	1
Agarwal, MK; Golestaneh, N; Mirshahi, M; Valamanesh, F	1
Cluzeaud, F; Le Menuet, D; Lombès, M; Penfornis, P; Viengchareun, S; Zennaro, MC	1
Coca-Prados, M; Hewison, M; Hughes, SV; Murray, PI; Rauz, S; Stewart, PM; Walker, EA	1
Pitt, B; Rajagopalan, S	1
Blot-Chabaud, M; Capurro, C; Cluzeaud, F; Farman, N; Fay, M; Jaisser, F; Le Moëllic, C; Ouvrard-Pascaud, A	1

Reviews

1 review(s) available for 7-propyl spirolactone and spironolactone

Article	Year
Aldosterone as a target in congestive heart failure. The Medical clinics of North America, 2003, Volume: 87, Issue:2 Topics: Aldosterone; Cardiovascular Agents; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Plasminogen Activator Inhibitor 1; Progesterone; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome	2003

Article

Year

Aldosterone as a target in congestive heart failure.

The Medical clinics of North America, 2003, Volume: 87, Issue:2

Topics: Aldosterone; Cardiovascular Agents; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Plasminogen Activator Inhibitor 1; Progesterone; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome

2003

Other Studies

27 other study(ies) available for 7-propyl spirolactone and spironolactone

Article	Year
Rat lung possesses the mineralocorticoid receptor. Biochemical and biophysical research communications, 1992, Mar-16, Volume: 183, Issue:2 Topics: Animals; Cross-Linking Reagents; Cytosol; Lung; Male; Promegestone; Rats; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Ultraviolet Rays	1992
Mineralocorticoid hormone action in plant cells. Biochemical and biophysical research communications, 1992, Jul-31, Volume: 186, Issue:2 Topics: Aldosterone; Animals; Chlamydomonas reinhardtii; Chromatography, Ion Exchange; Cytosol; DNA-Binding Proteins; Immunoglobulin G; Molecular Weight; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1992
Immunophotochemical analysis of mineralocortin by polyclonal antibodies against the native receptor from rat kidney. Biochemical medicine and metabolic biology, 1992, Volume: 47, Issue:2 Topics: Adrenalectomy; Animals; Antibodies; Cattle; Cytosol; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunoglobulin G; Immunohistochemistry; Kidney; Male; Mineralocorticoids; Molecular Weight; Photochemistry; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1992
Glucocorticoids increase Ca2+ uptake and [3H]dihydropyridine binding in A7r5 vascular smooth muscle cells. The American journal of physiology, 1991, Volume: 261, Issue:1 Pt 1 Topics: Amiloride; Analysis of Variance; Androstanols; Animals; Calcium; Calcium Channels; Cell Count; Cell Line; Cycloheximide; Dactinomycin; Dexamethasone; Dihydropyridines; Electric Conductivity; Glucocorticoids; Indomethacin; Kinetics; Muscle, Smooth, Vascular; Potassium; Proteins; Rats; Receptors, Glucocorticoid; Spironolactone; Water	1991
Purification and characterization of the activated mineralocorticoid receptor from rat myocardium. Biochimica et biophysica acta, 1990, Jan-29, Volume: 1033, Issue:1 Topics: Aldosterone; Animals; Cellulose; Chromatography; Cytosol; DNA; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Magnesium Chloride; Male; Molecular Weight; Myocardium; Potassium Chloride; Promegestone; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1990
Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1 Topics: Aldosterone; Animals; Blood Pressure; Hypertension; Male; Nephrectomy; Rats; Rats, Inbred Strains; Reference Values; Spironolactone; Urine	1990
Analysis of the mineralocorticoid receptor in rat heart with the aid of two new spirolactone derivatives. Biochemical medicine and metabolic biology, 1989, Volume: 41, Issue:1 Topics: Animals; Chromatography, Ion Exchange; Kinetics; Male; Mineralocorticoids; Myocardium; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1989
Aldosterone-stimulated down-regulation of both type I and type II adrenocorticosteroid receptors in mouse brain is mediated via type I receptors. Endocrinology, 1989, Volume: 125, Issue:2 Topics: Aldosterone; Androstanols; Animals; Brain; Corticosterone; Dexamethasone; Female; Mice; Mice, Inbred Strains; Receptors, Corticotropin; Receptors, Pituitary Hormone; Spironolactone; Time Factors	1989
High affinity binding and regulatory actions of dexamethasone-type I receptor complexes in mouse brain. Endocrinology, 1989, Volume: 125, Issue:3 Topics: Aldosterone; Animals; Brain; Cytosol; Dexamethasone; DNA-Binding Proteins; Estrenes; Female; Glucocorticoids; Kinetics; Mice; Mifepristone; Organ Specificity; Receptors, Glucocorticoid; Spironolactone	1989
Paradoxical differences in the receptor binding of two new antimineralocorticoids. Biochimica et biophysica acta, 1988, Jan-12, Volume: 964, Issue:1 Topics: Adrenalectomy; Aldosterone; Animals; Cytosol; Hot Temperature; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Thermodynamics	1988
Different mechanisms for the receptor mediated antimineralocorticoid action of two new spirolactone derivatives. Biochemical and biophysical research communications, 1988, Jan-15, Volume: 150, Issue:1 Topics: Animals; Binding, Competitive; Centrifugation, Density Gradient; Cytosol; Hot Temperature; Kidney; Kinetics; Liver; Lung; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Molybdenum; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1988
Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochemical and biophysical research communications, 1986, Jan-14, Volume: 134, Issue:1 Topics: Aldosterone; Animals; Binding, Competitive; Chromatography, Ion Exchange; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1986
Activation of mineralocorticoid agonist and antagonist specific receptors from rat kidney. Biochemical and biophysical research communications, 1987, Feb-27, Volume: 143, Issue:1 Topics: Aldosterone; Animals; Cytosol; Kidney; Kinetics; Male; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1987
Sound stress activation of tryptophan hydroxylase blocked by hypophysectomy and intracranial RU 38486. European journal of pharmacology, 1994, Apr-21, Volume: 256, Issue:2 Topics: Acoustic Stimulation; Animals; Cerebral Cortex; Dexamethasone; Enzyme Activation; Hypophysectomy; Hypothalamo-Hypophyseal System; Injections, Intraventricular; Male; Mesencephalon; Mifepristone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spironolactone; Stress, Psychological; Tryptophan Hydroxylase	1994
Regulation of sodium-potassium adenosine triphosphate subunit gene expression by corticosteroids and 11 beta-hydroxysteroid dehydrogenase activity. Endocrinology, 1994, Volume: 135, Issue:3 Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Animals; Gene Expression Regulation; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hydroxysteroid Dehydrogenases; Kidney; Male; Mifepristone; Rats; Rats, Wistar; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Spironolactone	1994
Immunochemical detection of the mineralocorticoid receptor in rat brain. Neuroendocrinology, 1993, Volume: 58, Issue:5 Topics: Adrenalectomy; Aldosterone; Animals; Blotting, Western; Brain Chemistry; Cell Aggregation; Cytosol; Electrophoresis, Polyacrylamide Gel; Immunoenzyme Techniques; Immunohistochemistry; Male; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone	1993
Nicotiana tabacum contains a putative mineralocorticoid receptor. Biochemical and biophysical research communications, 1994, May-16, Volume: 200, Issue:3 Topics: Blotting, Western; Gene Expression; Genes, Plant; Nicotiana; Plants, Toxic; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone	1994
Corticosterone is a preferable ligand for measuring rat brain corticosteroid receptors: competition by RU 28362 and RU 26752 for dexamethasone binding in rat hippocampal cytosol. Brain research, 1993, Oct-15, Volume: 625, Issue:1 Topics: Androstanols; Animals; Binding, Competitive; Brain; Corticosterone; Cytosol; Dexamethasone; Hippocampus; Ligands; Male; Osmolar Concentration; Rats; Receptors, Steroid; Spironolactone	1993
The mineralocorticoid hormone receptor and action in the eye. Biochemical and biophysical research communications, 1996, Feb-06, Volume: 219, Issue:1 Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Eye; Fluorescent Antibody Technique; Humans; Kidney; Molecular Weight; Myocardium; Organ Specificity; Pigment Epithelium of Eye; Radioligand Assay; Rats; Receptors, Mineralocorticoid; Retina; Spironolactone; Tritium	1996
Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor. The Journal of steroid biochemistry and molecular biology, 1996, Volume: 57, Issue:5-6 Topics: Aldosterone; Cell-Free System; Cysteine; Humans; Kinetics; Methyl Methanesulfonate; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Protein Binding; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Sulfhydryl Reagents	1996
Immunochemical demonstration of the mineralocorticoid receptor in ocular tissues. Neuroendocrinology, 1997, Volume: 65, Issue:1 Topics: Animals; Autoradiography; Blotting, Western; Cattle; Cell Nucleus; Ciliary Body; Cornea; Cytosol; Eye; Fluorescent Antibody Technique; Immunohistochemistry; Iris; Pigment Epithelium of Eye; Rats; Receptors, Mineralocorticoid; Retina; Spironolactone; Ultraviolet Rays	1997
[Implication of type II glucocorticoid receptors in aldosterone induced apoptosis of rat thymocytes]. Archives of physiology and biochemistry, 1997, Volume: 105, Issue:2 Topics: Aldosterone; Animals; Apoptosis; Dexamethasone; Glucocorticoids; Rats; Rats, Wistar; Receptors, Glucocorticoid; Spironolactone; Thymus Gland	1997
Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis. Developmental immunology, 1997, Volume: 5, Issue:2 Topics: Aldosterone; Animals; Apoptosis; Corticosterone; Glucocorticoids; Hormone Antagonists; Lymphocyte Activation; Lymphocytes; Metamorphosis, Biological; Mifepristone; Spironolactone; Spleen; Thymus Gland; Xenopus laevis	1997
Paradoxical effects of mineralocorticoids on the ion gated sodium channel in embryologically diverse cells. Biochemical and biophysical research communications, 2000, Apr-21, Volume: 270, Issue:3 Topics: Aldosterone; Animals; Cattle; Cell Division; Cells, Cultured; Cornea; Embryo, Mammalian; Epithelial Sodium Channels; Fibroblasts; Humans; Ion Channel Gating; Leukemia, Erythroblastic, Acute; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Pigment Epithelium of Eye; Receptors, Mineralocorticoid; Sodium Channels; Spironolactone; Tumor Cells, Cultured	2000
The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:2 Topics: Adipose Tissue, Brown; Aldosterone; Animals; Carrier Proteins; Cell Differentiation; Dose-Response Relationship, Drug; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Hormone Antagonists; Lipoma; Lipoprotein Lipase; Mice; Mifepristone; Mineralocorticoid Receptor Antagonists; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Transcription Factors; Transcription, Genetic; Triglycerides; Tumor Cells, Cultured	2000
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium. Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:4 Topics: Aldosterone; Blotting, Northern; Cell Line; Ciliary Body; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Epithelial Sodium Channels; Gene Expression Regulation; Glucocorticoids; Hormone Antagonists; Humans; Immediate-Early Proteins; In Situ Hybridization; Isoenzymes; Mifepristone; Mineralocorticoid Receptor Antagonists; Nuclear Proteins; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channels; Spironolactone	2003
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:5 Topics: Aldosterone; Animals; Biological Transport; Cell Line; Kidney Tubules, Collecting; Mineralocorticoid Receptor Antagonists; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptor Cross-Talk; Receptors, Mineralocorticoid; Serum Albumin, Bovine; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Transcription, Genetic	2004