Page last updated: 2024-09-03

7-propyl spirolactone and aldosterone

7-propyl spirolactone has been researched along with aldosterone in 17 studies

Compound Research Comparison

Studies (7-propyl spirolactone)	Trials (7-propyl spirolactone)	Recent Studies (post-2010) (7-propyl spirolactone)	Studies (aldosterone)	Trials (aldosterone)	Recent Studies (post-2010) (aldosterone)
31	0	0	25,333	1,517	4,169

Protein Interaction Comparison

Protein	Taxonomy	7-propyl spirolactone (IC50)	aldosterone (IC50)
Mineralocorticoid receptor	Homo sapiens (human)		0.0048
Mineralocorticoid receptor	Rattus norvegicus (Norway rat)		0.043

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (29.41)	18.7374
1990's	7 (41.18)	18.2507
2000's	5 (29.41)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Agarwal, MK; Mirshahi, A; Mirshahi, M; Nato, A	1
Agarwal, MK; Lazar, G; Pagano, M	1
Agarwal, M; Corley, K; Kalimi, M; Opoku, J	1
Davda, MM; Luttge, WG; Rupp, ME	1
Davda, MM; Kang, CG; Luttge, WG; Rupp, ME	1
Agarwal, MK; Kalimi, M	2
Agarwal, MK; Lazar, G	1
Agarwal, MK; Mirshahi, F; Mirshahi, M; Rostene, W	1
Couette, B; Fagart, J; Rafestin-Oblin, ME; Souque, A	1
Ben Rhouma, K; Felix, JM; Sakly, M; Schimchowitsch, S; Stoeckel, ME	1
Barker, KS; Davis, AT; Rollins-Smith, LA	1
Agarwal, MK; Golestaneh, N; Mirshahi, M; Valamanesh, F	1
Cluzeaud, F; Le Menuet, D; Lombès, M; Penfornis, P; Viengchareun, S; Zennaro, MC	1
Coca-Prados, M; Hewison, M; Hughes, SV; Murray, PI; Rauz, S; Stewart, PM; Walker, EA	1
Pitt, B; Rajagopalan, S	1
Blot-Chabaud, M; Capurro, C; Cluzeaud, F; Farman, N; Fay, M; Jaisser, F; Le Moëllic, C; Ouvrard-Pascaud, A	1

Reviews

1 review(s) available for 7-propyl spirolactone and aldosterone

Article	Year
Aldosterone as a target in congestive heart failure. The Medical clinics of North America, 2003, Volume: 87, Issue:2 Topics: Aldosterone; Cardiovascular Agents; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Plasminogen Activator Inhibitor 1; Progesterone; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome	2003

Article

Year

Aldosterone as a target in congestive heart failure.

The Medical clinics of North America, 2003, Volume: 87, Issue:2

Topics: Aldosterone; Cardiovascular Agents; Endothelium, Vascular; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Plasminogen Activator Inhibitor 1; Progesterone; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome

2003

Other Studies

16 other study(ies) available for 7-propyl spirolactone and aldosterone

Article	Year
Mineralocorticoid hormone action in plant cells. Biochemical and biophysical research communications, 1992, Jul-31, Volume: 186, Issue:2 Topics: Aldosterone; Animals; Chlamydomonas reinhardtii; Chromatography, Ion Exchange; Cytosol; DNA-Binding Proteins; Immunoglobulin G; Molecular Weight; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1992
Purification and characterization of the activated mineralocorticoid receptor from rat myocardium. Biochimica et biophysica acta, 1990, Jan-29, Volume: 1033, Issue:1 Topics: Aldosterone; Animals; Cellulose; Chromatography; Cytosol; DNA; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Magnesium Chloride; Male; Molecular Weight; Myocardium; Potassium Chloride; Promegestone; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1990
Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1 Topics: Aldosterone; Animals; Blood Pressure; Hypertension; Male; Nephrectomy; Rats; Rats, Inbred Strains; Reference Values; Spironolactone; Urine	1990
Aldosterone-stimulated down-regulation of both type I and type II adrenocorticosteroid receptors in mouse brain is mediated via type I receptors. Endocrinology, 1989, Volume: 125, Issue:2 Topics: Aldosterone; Androstanols; Animals; Brain; Corticosterone; Dexamethasone; Female; Mice; Mice, Inbred Strains; Receptors, Corticotropin; Receptors, Pituitary Hormone; Spironolactone; Time Factors	1989
High affinity binding and regulatory actions of dexamethasone-type I receptor complexes in mouse brain. Endocrinology, 1989, Volume: 125, Issue:3 Topics: Aldosterone; Animals; Brain; Cytosol; Dexamethasone; DNA-Binding Proteins; Estrenes; Female; Glucocorticoids; Kinetics; Mice; Mifepristone; Organ Specificity; Receptors, Glucocorticoid; Spironolactone	1989
Paradoxical differences in the receptor binding of two new antimineralocorticoids. Biochimica et biophysica acta, 1988, Jan-12, Volume: 964, Issue:1 Topics: Adrenalectomy; Aldosterone; Animals; Cytosol; Hot Temperature; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone; Thermodynamics	1988
Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochemical and biophysical research communications, 1986, Jan-14, Volume: 134, Issue:1 Topics: Aldosterone; Animals; Binding, Competitive; Chromatography, Ion Exchange; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1986
Activation of mineralocorticoid agonist and antagonist specific receptors from rat kidney. Biochemical and biophysical research communications, 1987, Feb-27, Volume: 143, Issue:1 Topics: Aldosterone; Animals; Cytosol; Kidney; Kinetics; Male; Mineralocorticoids; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone	1987
Immunochemical detection of the mineralocorticoid receptor in rat brain. Neuroendocrinology, 1993, Volume: 58, Issue:5 Topics: Adrenalectomy; Aldosterone; Animals; Blotting, Western; Brain Chemistry; Cell Aggregation; Cytosol; Electrophoresis, Polyacrylamide Gel; Immunoenzyme Techniques; Immunohistochemistry; Male; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone	1993
Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor. The Journal of steroid biochemistry and molecular biology, 1996, Volume: 57, Issue:5-6 Topics: Aldosterone; Cell-Free System; Cysteine; Humans; Kinetics; Methyl Methanesulfonate; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Protein Binding; Receptors, Mineralocorticoid; Recombinant Proteins; Spironolactone; Sulfhydryl Reagents	1996
[Implication of type II glucocorticoid receptors in aldosterone induced apoptosis of rat thymocytes]. Archives of physiology and biochemistry, 1997, Volume: 105, Issue:2 Topics: Aldosterone; Animals; Apoptosis; Dexamethasone; Glucocorticoids; Rats; Rats, Wistar; Receptors, Glucocorticoid; Spironolactone; Thymus Gland	1997
Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis. Developmental immunology, 1997, Volume: 5, Issue:2 Topics: Aldosterone; Animals; Apoptosis; Corticosterone; Glucocorticoids; Hormone Antagonists; Lymphocyte Activation; Lymphocytes; Metamorphosis, Biological; Mifepristone; Spironolactone; Spleen; Thymus Gland; Xenopus laevis	1997
Paradoxical effects of mineralocorticoids on the ion gated sodium channel in embryologically diverse cells. Biochemical and biophysical research communications, 2000, Apr-21, Volume: 270, Issue:3 Topics: Aldosterone; Animals; Cattle; Cell Division; Cells, Cultured; Cornea; Embryo, Mammalian; Epithelial Sodium Channels; Fibroblasts; Humans; Ion Channel Gating; Leukemia, Erythroblastic, Acute; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Pigment Epithelium of Eye; Receptors, Mineralocorticoid; Sodium Channels; Spironolactone; Tumor Cells, Cultured	2000
The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:2 Topics: Adipose Tissue, Brown; Aldosterone; Animals; Carrier Proteins; Cell Differentiation; Dose-Response Relationship, Drug; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Hormone Antagonists; Lipoma; Lipoprotein Lipase; Mice; Mifepristone; Mineralocorticoid Receptor Antagonists; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Transcription Factors; Transcription, Genetic; Triglycerides; Tumor Cells, Cultured	2000
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium. Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:4 Topics: Aldosterone; Blotting, Northern; Cell Line; Ciliary Body; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Epithelial Sodium Channels; Gene Expression Regulation; Glucocorticoids; Hormone Antagonists; Humans; Immediate-Early Proteins; In Situ Hybridization; Isoenzymes; Mifepristone; Mineralocorticoid Receptor Antagonists; Nuclear Proteins; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channels; Spironolactone	2003
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:5 Topics: Aldosterone; Animals; Biological Transport; Cell Line; Kidney Tubules, Collecting; Mineralocorticoid Receptor Antagonists; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptor Cross-Talk; Receptors, Mineralocorticoid; Serum Albumin, Bovine; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; Spironolactone; Transcription, Genetic	2004