7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine has been researched along with topotecan in 1 studies
| Studies (7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine) | Trials (7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine) | Recent Studies (post-2010) (7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine) | Studies (topotecan) | Trials (topotecan) | Recent Studies (post-2010) (topotecan) |
|---|---|---|---|---|---|
| 6 | 1 | 3 | 2,392 | 626 | 792 |
| Protein | Taxonomy | 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine (IC50) | topotecan (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 1.5211 | |
| DNA topoisomerase 1 | Homo sapiens (human) | 0.8525 | |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | 0.605 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.605 | |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 0.06 | |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 8.6 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.3 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SG; Lee, JM; Lee, YH; Lee, YS | 1 |
1 other study(ies) available for 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine and topotecan
| Article | Year |
|---|---|
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor.
Topics: Antineoplastic Agents; Glucose Transporter Type 1; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Pyrazines; Thiones; Thiophenes; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2016 |