7-methoxytacrine has been researched along with tacrine in 50 studies
| Studies (7-methoxytacrine) | Trials (7-methoxytacrine) | Recent Studies (post-2010) (7-methoxytacrine) | Studies (tacrine) | Trials (tacrine) | Recent Studies (post-2010) (tacrine) |
|---|---|---|---|---|---|
| 52 | 1 | 28 | 2,141 | 161 | 643 |
| Protein | Taxonomy | 7-methoxytacrine (IC50) | tacrine (IC50) |
|---|---|---|---|
| Chain A, ACETYLCHOLINESTERASE | Tetronarce californica (Pacific electric ray) | 0.0082 | |
| Solute carrier family 22 member 2 | Homo sapiens (human) | 0.68 | |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.1401 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.1691 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.0456 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.7875 | |
| Cytochrome P450 2E1 | Homo sapiens (human) | 0.075 | |
| Cholinesterase | Homo sapiens (human) | 0.0545 | |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | 0.047 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.517 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 6.6 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 6.6 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 6.6 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.1084 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 6.6 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.0457 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.3 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 6.6 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.0457 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.078 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.1957 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 0.0835 | |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | 0.047 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 0.1143 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.2576 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.1848 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.517 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.1143 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.2097 | |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | 0.042 | |
| Cholinesterase | Equus caballus (horse) | 0.1103 | |
| Histamine N-methyltransferase | Rattus norvegicus (Norway rat) | 0.11 | |
| Cholinesterase | Mus musculus (house mouse) | 0.0625 | |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | 0.044 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 6.3 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 6.3 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.267 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.1 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.0995 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 0.0143 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.00) | 18.7374 |
| 1990's | 16 (32.00) | 18.2507 |
| 2000's | 3 (6.00) | 29.6817 |
| 2010's | 24 (48.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Binder, J; Dohnal, V; Holas, O; Korabecny, J; Kuca, K; Marek, J; Musilek, K; Opletalova, V; Pohanka, M; Zemek, F | 1 |
| Fisar, Z; Holas, O; Horova, A; Hroudova, J; Jung, YS; Korabecny, J; Kuca, K; Musilek, K; Nepovimova, E; Opletalova, V; Zemek, F | 1 |
| Hamulakova, S; Hrabinova, M; Imrich, J; Janovec, L; Korabecny, J; Kristian, P; Kuca, K; Spilovska, K | 1 |
| Andrisano, V; Bartolini, M; Bergamini, C; Bolognesi, ML; Fato, R; Garcia, GE; Korabecny, J; Kuca, K; Lamba, D; Monti, B; Nepovimova, E; Peña-Altamira, LE; Pesaresi, A; Roberti, M; Samez, S; Uliassi, E | 1 |
| Andrs, M; Babkova, K; Bukum, N; Dolezal, R; Horova, A; Hrabinova, M; Jost, P; Jun, D; Kassa, J; Korabecny, J; Kuca, K; Malinak, D; Muckova, L; Nepovimova, E; Ondrejicek, A; Sepsova, V; Soukup, O | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Ibrar, A; Khan, I; Saeed, F; Shehzadi, SA | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Chalupova, K; Gorecki, L; Hepnarova, V; Hrabinova, M; Hroudova, J; Janockova, J; Jun, D; Korabecny, J; Kristofikova, Z; Kucera, T; Kunes, J; Mezeiova, E; Muckova, L; Prchal, L; Soukup, O | 1 |
| Dolezal, V; Tucek, S | 2 |
| Albrecht, V; Dvorák, I; Dvoráková, J; Filip, V; Fusek, J; Havlůj, J; Vachek, J | 1 |
| Benesová, O; Kristofíková, Z; Tejkalová, H | 1 |
| Musílková, J; Tucek, S | 1 |
| Benesová, O; Binková, B; Dlohozková, N; Kristofíková, Z; Tejkalová, H; Tucek, S | 1 |
| Bielavský, J; Patocka, J | 1 |
| Menini, C; Rektor, I; Silva-Barrat, C; Svejdová, M | 1 |
| Patocka, J | 1 |
| Binková, B; Fojtíková, I; Srám, RJ; Topinka, J | 1 |
| Fusek, J; Hanus, H; Hrdina, V; Zapletálek, M | 2 |
| Herink, J; Hrdina, V; Koupilová, M | 1 |
| Bajgar, J; Fusek, J; Hrdina, V; Patocka, J | 1 |
| Bajgar, J; Bisso, GM; Michalek, H | 1 |
| Fusek, J; Hanus, H; Patocka, J; Tůma, I | 2 |
| Havel, J; Patocka, J; Vargas, MG | 1 |
| Bajgar, J; Herink, J; Kvetina, J; Patocka, J; Skopec, F | 1 |
| Bajgar, J; Herink, J; Krejcová, G | 1 |
| Bajgar, J; Herink, J; Herout, V; Kunes, M; Kvĕtina, J; Svoboda, Z | 1 |
| Fusek, J; Hanus, H; Hrdina, V; Tůtma, I; Zapletálek, M | 1 |
| Kassa, J; Kuca, K; Pohanka, M | 1 |
| Hasan, MY; Kuča, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Shafiullah, M | 1 |
| Fisar, Z; Hroudová, J; Korábečný, J; Kuča, K | 1 |
| Drtinova, L; Gazova, Z; Horova, A; Korabecny, J; Kral, J; Kuca, K; Musilek, K; Siposova, K; Soukup, O; Spilovska, K | 1 |
| Drtinova, L; Jun, D; Kaniakova, M; Korabecny, J; Krusek, J; Kuca, K; Mandikova, J; Musilek, K; Patocka, J; Pavlik, M; Pohanka, M; Sepsova, V; Soukup, O; Tobin, G; Trejtnar, F; Zdarova-Karasova, J | 1 |
| Andrs, M; Cabelova, P; Dolezal, R; Horova, A; Hruba, E; Korabecny, J; Kuca, K; Musilek, K; Nepovimova, E; Opletalova, V; Ricny, J; Ripova, D; Sedlacek, L; Sepsova, V; Spilovska, K | 1 |
| Cabelova, P; Janska, K; Jun, D; Karasova, JZ; Korabecny, J; Krusek, J; Kuca, K; Sepsova, V; Skrenkova, K; Soukup, O; Tobin, G | 1 |
| Bureš, J; Douda, T; Hrabinová, M; Jun, D; Kopáčová, M; Kuča, K; Kuneš, M; Květina, J; Pavlík, M; Rejchrt, S; Tachecí, I | 1 |
| Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J | 1 |
| Drtinova, L; Fedunova, D; Gazova, Z; Hamouda, AK; Horak, M; Jost, P; Kaniakova, M; Korabecny, J; Kuca, K; Nepovimova, E; Sepsova, V; Siposova, K; Soukup, O; Spilovska, K; Wang, ZJ | 1 |
| Korabecny, J; Kristofikova, Z; Kuca, K; Nepovimova, E; Ricny, J; Ripova, D; Soukup, O | 1 |
| Dolezal, R; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Korabecny, J; Kuca, K; Kucera, T; Mezeiova, E; Misik, J; Muckova, L; Pham, NL; Pokrievkova, L; Roh, J; Sepsova, V; Soukup, O; Spilovska, K | 1 |
| Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Korabecny, J; Korinek, M; Krusek, J; Lichnerova, K; Skrenkova, K; Smejkalova, T; Soukup, O; Vales, K | 1 |
| Babkova, K; Brabec, V; Fedorocko, P; Hamulakova, S; Janockova, J; Jendzelovsky, R; Kasparkova, J; Konkolova, E; Korabecny, J; Koval, J; Kozurkova, M; Kuca, K; Kucerova, D; Plsikova, J; Rosocha, J; Soukup, O; Vargova, J | 1 |
| Costa França, TC; da Silva, JAV; Kuca, K; Nepovimova, E; Ramalho, TC | 1 |
| Chalupová, K; Korábečný, J; Mžik, M; Palička, V; Šesták, V; Žďárová-Karasová, J | 1 |
| Bednarikova, Z; Bhunia, A; Gancar, M; Gazova, Z; Ho, K; Li, MS; Mohid, SA; Nepovimova, E; Nguyen, HL; Thai, NQ | 1 |
1 review(s) available for 7-methoxytacrine and tacrine
| Article | Year |
|---|---|
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.
Topics: Aldehyde Reductase; Alkaline Phosphatase; Cholinesterases; Coumarins; Drug Design; Enzymes; Glucosidases; Humans; Molecular Docking Simulation; Monoamine Oxidase | 2018 |
1 trial(s) available for 7-methoxytacrine and tacrine
| Article | Year |
|---|---|
[Treatment of tardive dyskinesias with 7-methoxycrine. II].
Topics: Adult; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Tacrine | 1993 |
48 other study(ies) available for 7-methoxytacrine and tacrine
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Recombinant Proteins; Structure-Activity Relationship; Tacrine | 2010 |
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.
Topics: Acridines; Cholinergic Agents; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Half-Life; In Vitro Techniques; Models, Molecular; Tacrine | 2011 |
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Coumarins; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Structure-Activity Relationship; Tacrine | 2014 |
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Targeted Therapy; Neurons; Oxidative Stress; Quinones; Rats, Wistar; Tacrine | 2014 |
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood-Brain Barrier; Catalysis; Cholinesterase Inhibitors; Chromans; Drug Design; Free Radical Scavengers; Hepatocytes; Humans; Injections, Intramuscular; Kinetics; Ligands; Male; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Tacrine | 2015 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Tryptophan | 2021 |
Negative effects of tacrine (tetrahydroaminoacridine) and methoxytacrine on the metabolism of acetylcholine in brain slices incubated under conditions stimulating neurotransmitter release.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Brain; Choline; Choline O-Acetyltransferase; Histological Techniques; In Vitro Techniques; Neurotransmitter Agents; Potassium; Rats; Tacrine | 1991 |
Pharmacokinetics and tolerance of 7-methoxytacrine following the single dose administration in healthy volunteers.
Topics: Administration, Oral; Adult; Drug Administration Schedule; Drug Tolerance; Humans; Injections, Intramuscular; Male; Tacrine | 1991 |
Experimental study of long-term administration of cholinesterase inhibitors in aging rats.
Topics: Aging; Animals; Behavior, Animal; Brain; Male; Pyrithioxin; Rats; Rats, Inbred Strains; Tacrine; Time Factors | 1991 |
The binding of cholinesterase inhibitors tacrine (tetrahydroaminoacridine) and 7-methoxytacrine to muscarinic acetylcholine receptors in rat brain in the presence of eserine.
Topics: Animals; Binding, Competitive; Cerebellum; Cerebral Cortex; Cholinesterase Inhibitors; Female; Kinetics; Physostigmine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tacrine | 1991 |
The evaluation of nootropic drug effects in aging rats.
Topics: Aging; Aminoacridines; Animals; Brain; Dose-Response Relationship, Drug; Male; Memory; Neurotransmitter Agents; Psychotropic Drugs; Pyridines; Pyrithioxin; Rats; Rats, Inbred Strains; Tacrine | 1990 |
Positive and negative effects of tacrine (tetrahydroaminoacridine) and methoxytacrine on the metabolism of acetylcholine in brain cortical prisms incubated under "resting" conditions.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Cerebral Cortex; Choline; Cholinesterases; Hemicholinium 3; Histological Techniques; Male; Rats; Rest; Tacrine | 1991 |
[Biotransformation of the anticholinesterase agent, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine].
Topics: Animals; Biotransformation; Male; Rats; Rats, Inbred Strains; Tacrine | 1991 |
Unexpected potentializing effect of a tacrine derivative (9-amino-7-methoxy-1,2,3,4 tetrahydroacridine) upon the non-epileptic myoclonus in baboons Papio papio.
Topics: Animals; Atropine; Drug Synergism; Epilepsies, Myoclonic; Myoclonus; Papio; Physostigmine; Tacrine | 1990 |
[9-amino-7-methoxy-1,2,3,4-tetrahydroacridine, a new substance with indirect cholinomimetic effects].
Topics: Aminoacridines; Animals; Chemical Phenomena; Chemistry; Dogs; Humans; Mice; Rats; Tacrine | 1990 |
Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol.
Topics: Aminoacridines; Animals; Brain; Cerebral Cortex; DNA Repair; Dose-Response Relationship, Drug; Fluphenazine; Hippocampus; Hypothalamus; Lipid Peroxidation; Lithium; Lymphocytes; Male; Rats; Rats, Inbred Strains; Tacrine; Tranquilizing Agents; Vitamin E | 1990 |
First experience with the application of 7-methoxytacrine to psychiatric patients.
Topics: Adult; Aminoacridines; Antipsychotic Agents; Cholinesterase Inhibitors; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Psychotic Disorders; Tacrine | 1989 |
Effects of tetrahydroaminoacridine (tacrine) derivatives and physostigmine in convulsions induced by pentylenetetrazol.
Topics: Aminoacridines; Animals; Cholinesterase Inhibitors; Male; Pentylenetetrazole; Physostigmine; Rats; Rats, Inbred Strains; Seizures; Tacrine | 1989 |
[Initial experience with the administration of 7-methoxyacrine to patients with psychological disorders].
Topics: Adult; Aminoacridines; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Tacrine | 1989 |
Protective effect of 9-amino-7-methoxy-1,2,3,4-tetra-hydroacridine against inhibition of acetylcholinesterase by O-ethyl s-(2-dimethylaminoethyl) methylphosphonotioate in vivo.
Topics: Acetylcholinesterase; Aminoacridines; Animals; Cholinesterase Inhibitors; Male; Organothiophosphates; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Tacrine | 1983 |
Differential inhibition of rat brain acetylcholinesterase molecular forms by 7-methoxytacrine in vitro.
Topics: Acetylcholinesterase; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tacrine | 1995 |
[Treatment of tardive dyskinesias with 7-methoxytacrine. I].
Topics: Adult; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Tacrine | 1993 |
Determination of the anti-Alzheimer's disease drugs tacrine, 7-methoxytacrine, and its metabolites by capillary zone electrophoresis.
Topics: Acetonitriles; Alzheimer Disease; Blood Proteins; Chemical Precipitation; Cholinesterase Inhibitors; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Tacrine | 1998 |
Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase.
Topics: Animals; Basal Ganglia; Carnitine; Choline O-Acetyltransferase; Female; Hippocampus; Kinetics; Neurons; Rats; Rats, Wistar; Tacrine | 1999 |
Antiacetylcholinesterase activity of cyclosporine--a comparison of single and repeated administration and effect of 7-methoxytacrine.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cyclosporine; Male; Rats; Rats, Wistar; Tacrine | 2002 |
Intestinal single-pass in situ perfusion technique in rat: the influence of L-carnitine on absorption of 7-methoxytacrine.
Topics: Animals; Carnitine; Cholinesterase Inhibitors; Intestinal Absorption; Perfusion; Rats; Rats, Wistar; Tacrine; Vitamin B Complex | 2005 |
Treatment of tardive dyskinesia by single and repeated application of 7-methoxytacrin.
Topics: Adult; Anti-Dyskinesia Agents; Antipsychotic Agents; Chronic Disease; Dyskinesia, Drug-Induced; Euphoria; Female; Humans; Liver Function Tests; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Tacrine | 1991 |
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.
Topics: Acetylcholinesterase; Algorithms; Alzheimer Disease; Biosensing Techniques; Cholinesterase Inhibitors; Electrochemistry; Enzymes, Immobilized; Humans; Kinetics; Nootropic Agents; Tacrine | 2008 |
Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors.
Topics: Amiloride; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Inhibitory Concentration 50; Isoflurophate; Male; Methylene Blue; Metoclopramide; Oximes; Physostigmine; Proportional Hazards Models; Pyridinium Compounds; Pyridostigmine Bromide; Ranitidine; Rats; Tacrine; Tiapride Hydrochloride | 2011 |
In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain.
Topics: Animals; Brain Chemistry; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electron Transport; Electron Transport Chain Complex Proteins; Electron Transport Complex I; Energy Metabolism; In Vitro Techniques; Mitochondria; Oximes; Swine; Tacrine | 2011 |
7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Amantadine; Cholinesterase Inhibitors; Dimerization; Enzyme Assays; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Reference Standards; Tacrine; Thiourea | 2013 |
A resurrection of 7-MEOTA: a comparison with tacrine.
Topics: Animals; Cholinesterase Inhibitors; Male; Oxidative Stress; Rats; Rats, Wistar; Tacrine | 2013 |
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship; Recombinant Proteins; Tacrine | 2014 |
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Topics: Animals; Cells, Cultured; Cholinergic Antagonists; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Muscarinic Antagonists; Muscle Fibers, Skeletal; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Tacrine | 2015 |
Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs.
Topics: Animals; Cholinesterase Inhibitors; Electromyography; Female; Muscle, Smooth; Stomach; Sus scrofa; Tacrine | 2015 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry | 2016 |
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amantadine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; CHO Cells; Cholinesterases; Cricetulus; Dimerization; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Targeted Therapy; Receptor, Muscarinic M1; Receptors, Cholinergic; Receptors, N-Methyl-D-Aspartate; Tacrine; Xenopus | 2017 |
Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1.
Topics: Alkylation; Amyloid beta-Peptides; Animals; Cation Transport Proteins; Cerebral Cortex; Cholesterol; Choline; Cholinesterase Inhibitors; Hippocampus; Male; Membrane Fluidity; Membrane Microdomains; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Stereoisomerism; Synaptosomes; Tacrine | 2017 |
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrolysis; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Permeability; Protein Binding; Structure-Activity Relationship; Tacrine | 2017 |
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Humans; Locomotion; Male; Memantine; Mutation; Neurons; Neuroprotective Agents; Prepulse Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Tacrine | 2018 |
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers.
Topics: A549 Cells; Acridines; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; HL-60 Cells; Humans; Structure-Activity Relationship; Tacrine; Thiourea | 2019 |
Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths.
Topics: Acetylcholinesterase; Binding Sites; Cholinesterase Inhibitors; Humans; Ligands; Molecular Docking Simulation; Organothiophosphorus Compounds; Oximes; Protein Structure, Tertiary; Tacrine; Thermodynamics | 2019 |
UHPLC-HRMS study of anti-Alzheimer's drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Hydrolysis; Male; Rats; Rats, Wistar; Tacrine; Tandem Mass Spectrometry; Tryptophan | 2019 |
7-Methoxytacrine and 2-Aminobenzothiazole Heterodimers: Structure-Mechanism Relationship of Amyloid Inhibitors Based on Rational Design.
Topics: Amyloid; Amyloidogenic Proteins; Amyloidosis; Humans; Prospective Studies; Tacrine | 2020 |