7-methoxytacrine has been researched along with donepezil in 6 studies
| Studies (7-methoxytacrine) | Trials (7-methoxytacrine) | Recent Studies (post-2010) (7-methoxytacrine) | Studies (donepezil) | Trials (donepezil) | Recent Studies (post-2010) (donepezil) |
|---|---|---|---|---|---|
| 52 | 1 | 28 | 3,193 | 557 | 1,594 |
| Protein | Taxonomy | 7-methoxytacrine (IC50) | donepezil (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.4231 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.0265 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.022 | |
| Cholinesterase | Homo sapiens (human) | 4.5742 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 7.42 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 5 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 7.4 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 1.5489 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.3257 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.1644 | |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | 0.0053 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.0182 | |
| Beta-secretase 1 | Homo sapiens (human) | 0.8666 | |
| Cholinesterase | Equus caballus (horse) | 3.7325 | |
| Cholinesterase | Mus musculus (house mouse) | 1.992 | |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | 0.0324 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.7844 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 4.715 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 4.5551 | |
| Histamine H3 receptor | Homo sapiens (human) | 0.35 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Andrs, M; Cabelova, P; Dolezal, R; Horova, A; Hruba, E; Korabecny, J; Kuca, K; Musilek, K; Nepovimova, E; Opletalova, V; Ricny, J; Ripova, D; Sedlacek, L; Sepsova, V; Spilovska, K | 1 |
| Cabelova, P; Janska, K; Jun, D; Karasova, JZ; Korabecny, J; Krusek, J; Kuca, K; Sepsova, V; Skrenkova, K; Soukup, O; Tobin, G | 1 |
| Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J | 1 |
6 other study(ies) available for 7-methoxytacrine and donepezil
| Article | Year |
|---|---|
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship; Recombinant Proteins; Tacrine | 2014 |
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Topics: Animals; Cells, Cultured; Cholinergic Antagonists; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Muscarinic Antagonists; Muscle Fibers, Skeletal; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Tacrine | 2015 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry | 2016 |