7-methoxytacrine has been researched along with 6-chlorotacrine in 7 studies
| Studies (7-methoxytacrine) | Trials (7-methoxytacrine) | Recent Studies (post-2010) (7-methoxytacrine) | Studies (6-chlorotacrine) | Trials (6-chlorotacrine) | Recent Studies (post-2010) (6-chlorotacrine) |
|---|---|---|---|---|---|
| 52 | 1 | 28 | 28 | 0 | 20 |
| Protein | Taxonomy | 7-methoxytacrine (IC50) | 6-chlorotacrine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.051 | |
| Cholinesterase | Homo sapiens (human) | 0.8458 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 6.09 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 0.0198 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.0535 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.31 | |
| Cholinesterase | Equus caballus (horse) | 0.0165 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Andrisano, V; Bartolini, M; Bergamini, C; Bolognesi, ML; Fato, R; Garcia, GE; Korabecny, J; Kuca, K; Lamba, D; Monti, B; Nepovimova, E; Peña-Altamira, LE; Pesaresi, A; Roberti, M; Samez, S; Uliassi, E | 1 |
| Andrs, M; Babkova, K; Bukum, N; Dolezal, R; Horova, A; Hrabinova, M; Jost, P; Jun, D; Kassa, J; Korabecny, J; Kuca, K; Malinak, D; Muckova, L; Nepovimova, E; Ondrejicek, A; Sepsova, V; Soukup, O | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Chalupova, K; Gorecki, L; Hepnarova, V; Hrabinova, M; Hroudova, J; Janockova, J; Jun, D; Korabecny, J; Kristofikova, Z; Kucera, T; Kunes, J; Mezeiova, E; Muckova, L; Prchal, L; Soukup, O | 1 |
7 other study(ies) available for 7-methoxytacrine and 6-chlorotacrine
| Article | Year |
|---|---|
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Targeted Therapy; Neurons; Oxidative Stress; Quinones; Rats, Wistar; Tacrine | 2014 |
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood-Brain Barrier; Catalysis; Cholinesterase Inhibitors; Chromans; Drug Design; Free Radical Scavengers; Hepatocytes; Humans; Injections, Intramuscular; Kinetics; Ligands; Male; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Tacrine | 2015 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Tryptophan | 2021 |