Page last updated: 2024-08-26

7-ketocholesterol and d-alpha tocopherol

7-ketocholesterol has been researched along with d-alpha tocopherol in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (19.35)18.2507
2000's12 (38.71)29.6817
2010's11 (35.48)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Jensen, C; Nielsen, JH; Olsen, CE; Skibsted, LH1
Guyton, JR; Hughes, H; Karsan, D; Lenz, ML; Mathews, B; Selinger, E; Smith, CV1
Darley-Usmar, VM; Diczfalusy, U; Dzeletovic, S; Patel, RP; Wilson, MT1
Kamei, M; Matsui-Yuasa, I; Miyabara, K; Ohtani, K; Okamoto, E1
Lichtenberg, D; Pinchuk, I; Schnitzer, E1
Cantwell, H; Devery, R1
Besséde, G; Gambert, P; Gueldry, S; Lizard, G; Miguet, C; Monier, S; Neel, D1
Dyduch, A; Hyla-Klekot, L; Kopieczna-Grzebieniak, E; Skrzep-Poloczek, B; Tarnawski, R; Tomasik, A; Wesolowski, W; Widera, E; Wojciechowska, C; Zalejska-Fiolka, J1
Diczfalusy, U; Frati, G; Iuliano, L; Maranghi, M; Micheletta, F; Violi, F1
Kummerow, F; Mahfouz, M1
Bodzek, D; Jagodzińska, J; Jochem, J; Pardela, M; Wielkoszyński, T; Wylezoł, M; Zwirska-Korczala, K1
Fujita, N; Manabe, H; Matsumoto, N; Naito, Y; Ochiai, J; Takagi, T; Uemura, M; Yoshida, N; Yoshikawa, T1
Diczfalusy, U; Iuliano, L; Micheletta, F; Misuraca, M; Natoli, S; Sbarigia, E1
Biro, A; Boaz, M; Friedman, V; Gafter, U; Gvirtz, G; Himmelfarb, J; Iuliano, L; Matas, Z; McMonagle, E; Micheletta, F; Natoli, S; Sabo, G; Smetana, S; Weinstein, T1
Antonini, R; Antonini, TM; Arca, M; Di Angelantonio, E; Diczfalusy, U; Iuliano, L; Micheletta, F; Montali, A; Natoli, S; Riggi, S1
Ameruso, M; Monego, G; Palozza, P; Picci, N; Ranelletti, FO; Serini, S; Trombino, S; Verdecchia, S1
Guyot, S; Kahn, E; Lizard, G; Montange, T; Riedinger, JM; Vejux, A1
Athias, A; Desrumaux, C; Lagrost, L; Lemaire-Ewing, S; Monier, S; Néel, D; Pais de Barros, JP; Royer, MC1
Adams, MR; Croft, KD; Dennis, JM; Kathir, K; Lau, AK; Mori, TA; Stocker, R1
Assunta Dessì, M; Atzeri, A; Corona, G; Deiana, M; Incani, A; Loru, D; Paola Melis, M; Rosa, A1
Athias, A; Baarine, M; Delmas, D; Lizard, G; Nury, T; Ragot, K1
Aires, V; Athias, A; Delmas, D; Jacquin, A; Lizard, G; Mackrill, JJ; Nury, T; Pais de Barros, JP; Ragot, K; Riedinger, JM; Véjux, A; Zarrouk, A1
Delage-Mourroux, R; Doria, M; Lizard, G; Nury, T; Riedinger, JM; Vejux, A; Zarrouk, A1
Delage-Mourroux, R; Delmas, D; Doria, M; Durand, P; Hammami, M; Limagne, E; Lizard, G; Mackrill, JJ; Moreau, T; Nury, T; O'Brien, NM; Prost, M; Riedinger, JM; Samadi, M; Vejux, A; Zarrouk, A1
Davis, BM; Davis, S; O'Shea, P; Petrov, PG; Richens, JL; Vere, KA; Winlove, CP1
Caccia, C; Debbabi, M; Fromont, A; Leoni, V; Lizard, G; Moreau, T; Nury, T; Sghaier, R; Vejux, A; Zarrouk, A1
Aubourg, P; Debbabi, M; Lizard, G; Nury, T; Ragot, K; Riedinger, JM; Vejux, A; Zarrouk, A1
Ammou, SB; Bezine, M; Bretillon, L; Camus, E; Debbabi, M; Durand, P; Grégoire, S; Hammami, M; Jabrane, A; Lizard, G; Martine, L; Mekahli, N; Moreau, T; Nury, T; Prost, M; Sghaier, R; Vejux, A; Zarrouk, A1
Caccia, C; Cherkaoui-Malki, M; Leoni, V; Lizard, G; Meddeb, W; Ménétrier, F; Mihoubi, W; Moreau, T; Namsi, A; Nury, T; Riedinger, JM; Sassi, K; Sghaier, R; Uzun, T; Vejux, A; Zarrouk, A1
Angius, F; Deiana, M; Incani, A; Ingianni, A; Marras, L; Pompei, R; Serreli, G1
de Barros, JP; Ghrairi, T; Ghzaiel, I; Hammami, M; Hammami, S; Jouanny, P; Ksila, M; Lizard, G; Pires, V; Vejux, A; Zarrouk, A1

Trials

4 trial(s) available for 7-ketocholesterol and d-alpha tocopherol

ArticleYear
Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:10

    Topics: Adult; Arteriosclerosis; Biomarkers; Eating; Female; Humans; Hydroxycholesterols; Ketocholesterols; Lipid Peroxides; Male; Oxidative Stress; Vitamin E

2001
Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aged; Carotid Stenosis; Cholesterol; Female; Fibrinolytic Agents; Humans; Hydroxycholesterols; Ketocholesterols; Male; Middle Aged; Organ Specificity; Oxidative Stress; Plasma; Treatment Outcome; Vitamin E

2004
Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort.
    Nephron. Clinical practice, 2005, Volume: 100, Issue:4

    Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Double-Blind Method; Female; Humans; Hydroxycholesterols; Inflammation; Ketocholesterols; Kidney Failure, Chronic; Male; Malnutrition; Middle Aged; Oxidative Stress; Renal Dialysis; Tunica Media; Vitamin E

2005
Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy.
    Free radical biology & medicine, 2007, Mar-01, Volume: 42, Issue:5

    Topics: Adult; alpha-Tocopherol; Atorvastatin; Biomarkers; Drug Combinations; Female; Fenofibrate; Heptanoic Acids; Humans; Hydroxycholesterols; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Ketocholesterols; Lipids; Lipoproteins; Male; Middle Aged; Models, Biological; Oxidative Stress; Pyrroles

2007

Other Studies

27 other study(ies) available for 7-ketocholesterol and d-alpha tocopherol

ArticleYear
Cholesterol oxidation in butter and dairy spread during storage.
    The Journal of dairy research, 1996, Volume: 63, Issue:1

    Topics: Butter; Cholesterol; Dairy Products; Food Preservation; Ketocholesterols; Kinetics; Oxidation-Reduction; Temperature; Thiobarbituric Acid Reactive Substances; Vitamin E

1996
Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants.
    Atherosclerosis, 1995, Volume: 118, Issue:2

    Topics: Animals; Antioxidants; Aorta; Butylated Hydroxytoluene; Cell Death; Cells, Cultured; Copper; Culture Media; Deferoxamine; Enzyme Inhibitors; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketocholesterols; Lipid Peroxidation; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Oxidation-Reduction; Probucol; Swine; Thiobarbituric Acid Reactive Substances; Vitamin E

1995
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper.
    Journal of lipid research, 1996, Volume: 37, Issue:11

    Topics: Amidines; Butylated Hydroxytoluene; Copper; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Molsidomine; Molybdenum; Myoglobin; Nitrates; Oxidation-Reduction; Superoxide Dismutase; Vitamin E

1996
Cytotoxicity of 7-ketocholesterol toward cultured rat hepatocytes and the effect of vitamin E.
    Bioscience, biotechnology, and biochemistry, 1996, Volume: 60, Issue:12

    Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Free Radical Scavengers; Indicators and Reagents; Ketocholesterols; L-Lactate Dehydrogenase; Liver; Nitric Oxide; Nitric Oxide Synthase; Oxygen Consumption; Phospholipids; Rats; Rats, Sprague-Dawley; Sterols; Vitamin E

1996
Kinetic analysis of copper-induced peroxidation of LDL.
    Biochimica et biophysica acta, 1998, Jan-15, Volume: 1389, Issue:2

    Topics: Catalysis; Copper; Humans; Ketocholesterols; Kinetics; Lipid Peroxidation; Lipoproteins, LDL; Peroxides; Spectrophotometry; Vitamin E

1998
The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox.
    Cell biology and toxicology, 1998, Volume: 14, Issue:6

    Topics: Animals; Antioxidants; Catalase; Cholestanols; Enzyme Induction; Glutathione Peroxidase; Ketocholesterols; Lipid Peroxidation; Liver; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E

1998
Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis.
    Free radical biology & medicine, 2000, Mar-01, Volume: 28, Issue:5

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Ascorbic Acid; Cytochrome c Group; Cytosol; Free Radicals; Glutathione; Humans; Intracellular Membranes; Ketocholesterols; Kinetics; Melatonin; Membrane Potentials; Microscopy, Electron; Mitochondria; Superoxides; U937 Cells; Vitamin E

2000
Nephrotic origin hyperlipidemia, relative reduction of vitamin E level and subsequent oxidative stress may promote atherosclerosis.
    Nephron, 2001, Volume: 89, Issue:1

    Topics: Adult; Antioxidants; Arteriosclerosis; Child; Child, Preschool; Female; Humans; Hyperlipidemias; Ketocholesterols; Lipoproteins, LDL; Male; Nephrotic Syndrome; Oxidative Stress; Triglycerides; Vitamin E

2001
Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: a key role of lysolecithin.
    Prostaglandins & other lipid mediators, 2001, Volume: 66, Issue:4

    Topics: Animals; Antioxidants; Aorta; Catalase; Epoprostenol; Humans; In Vitro Techniques; Ketocholesterols; Lipoproteins, LDL; Lysophosphatidylcholines; Oxidation-Reduction; Rats; Solutions; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E

2001
[Assessment of plasma lipid profile oxysterols and vitamin E concentration in morbidity obese patients with coexisting arterial hypertension and non-insulin dependent diabetes mellitus].
    Polskie Archiwum Medycyny Wewnetrznej, 2002, Volume: 107, Issue:2

    Topics: Adult; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Ketocholesterols; Male; Middle Aged; Vitamin E

2002
Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation.
    European journal of pharmacology, 2002, Dec-05, Volume: 456, Issue:1-3

    Topics: alpha-Tocopherol; Antioxidants; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Necrosis; Reactive Oxygen Species; Time Factors

2002
Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages.
    Free radical biology & medicine, 2007, May-15, Volume: 42, Issue:10

    Topics: alpha-Tocopherol; Apoptosis; Apoptosis Regulatory Proteins; beta Carotene; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Humans; Ketocholesterols; Macrophages; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 4; NADPH Oxidases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering

2007
Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.
    The Journal of nutritional biochemistry, 2009, Volume: 20, Issue:1

    Topics: Apoptosis; Benzimidazoles; Down-Regulation; Humans; Ketocholesterols; Microscopy, Electron, Transmission; Oxazines; Phosphatidylinositol 3-Kinases; Phospholipids; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidinones; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; U937 Cells; Vitamin E

2009
7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.
    The Journal of biological chemistry, 2009, Jun-05, Volume: 284, Issue:23

    Topics: alpha-Tocopherol; Aorta; Cell Death; Cell Line; Cell Membrane Permeability; Cholesterol; Humans; Hydrogen Peroxide; Ketocholesterols; Membrane Microdomains; Membrane Potentials; Mitochondrial Membranes; Muscle, Smooth, Vascular; Oxidation-Reduction; Sphingolipids; Tocopherols; Vitamin E

2009
Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects.
    Free radical biology & medicine, 2010, Aug-01, Volume: 49, Issue:3

    Topics: Aged; Aged, 80 and over; alpha-Tocopherol; Antioxidants; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Female; Humans; Isoprostanes; Ketocholesterols; Lipid Metabolism; Lipid Peroxides; Male; Middle Aged

2010
Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:10

    Topics: alpha-Tocopherol; Antioxidants; Caco-2 Cells; Cell Survival; Cholesterol; Fatty Acids; Free Radical Scavengers; Humans; Ketocholesterols; Linoleic Acid; Lipid Peroxidation; Malondialdehyde; Olive Oil; Oxidation-Reduction; Phenols; Phenylethyl Alcohol; Plant Oils

2010
α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.
    Chemistry and physics of lipids, 2011, Volume: 164, Issue:6

    Topics: alpha-Tocopherol; Animals; Apoptosis; Caspase 3; Cell Proliferation; Cell Survival; Cytochromes c; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Ketocholesterols; Membrane Microdomains; Membrane Potential, Mitochondrial; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Oligodendroglia; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Time Factors

2011
Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.
    Biochemical pharmacology, 2013, Jul-01, Volume: 86, Issue:1

    Topics: alpha-Tocopherol; Animals; Apoptosis; Calcium; Cell Line; Cell Proliferation; Cell Survival; Glycogen Synthase Kinase 3; Hydroxycholesterols; Ketocholesterols; Membrane Microdomains; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Oligodendroglia; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sterols

2013
Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by α-tocopherol.
    Biochemical and biophysical research communications, 2014, Apr-11, Volume: 446, Issue:3

    Topics: alpha-Tocopherol; Animals; Apoptosis; Autophagy; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Ketocholesterols; Mice; Microscopy, Phase-Contrast; Microtubule-Associated Proteins; Oligodendroglia; Oxidative Stress

2014
Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3).
    Steroids, 2015, Volume: 99, Issue:Pt B

    Topics: alpha-Tocopherol; Animals; Anions; Apoptosis; Autophagy; Biomarkers; Cell Proliferation; Docosahexaenoic Acids; Hydrogen Peroxide; Hydroxycholesterols; Ketocholesterols; Mice; Microscopy, Phase-Contrast; Mitochondria; Oligodendroglia; Oxidation-Reduction; Protective Agents; Superoxides

2015
α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein.
    Journal of lipid research, 2015, Volume: 56, Issue:8

    Topics: alpha-Tocopherol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Fluoresceins; Fluorescent Dyes; Humans; Jurkat Cells; Ketocholesterols; Ligands; Membrane Potentials; Models, Molecular; Molecular Conformation; Phosphatidylethanolamines; Protein Binding; Pyridinium Compounds; Saquinavir; Unilamellar Liposomes

2015
Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, chole
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169

    Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Cell Nucleus; Cholesterol; Citric Acid Cycle; Fatty Acids, Unsaturated; Flow Cytometry; Inflammation; Ketocholesterols; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipids; Mass Spectrometry; Membrane Potential, Mitochondrial; Mice; Mitochondria; Multiple Sclerosis; NAD; Oligodendroglia; Oxidation-Reduction; Oxidative Stress; Oxysterols; Reactive Oxygen Species

2017
7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169

    Topics: Acyl-CoA Oxidase; Adolescent; Adrenoleukodystrophy; Adult; alpha-Tocopherol; Animals; Apoptosis; ATP-Binding Cassette Transporters; Brain; Case-Control Studies; Catalase; Cell Survival; Child; Disease Progression; Docosahexaenoic Acids; Glutathione; Humans; Hydrogen Peroxide; Ketocholesterols; Linoleic Acid; Male; Membrane Proteins; Mice; Microglia; Middle Aged; Oxidative Stress; Peroxisomes; Reactive Oxygen Species; Repressor Proteins; Young Adult

2017
Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.
    International journal of molecular sciences, 2016, Nov-25, Volume: 17, Issue:12

    Topics: alpha-Tocopherol; Animals; Antioxidants; Cell Line; gamma-Tocopherol; Ketocholesterols; Membrane Potential, Mitochondrial; Mice; Microglia; Mitochondria; Oleic Acid; Olive Oil; Peroxisomes

2016
Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol.
    Biochimie, 2018, Volume: 153

    Topics: alpha-Tocopherol; Animals; Apoptosis; Dose-Response Relationship, Drug; Fatty Acids; Fibroblasts; Humans; Ketocholesterols; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mitochondria; Oligodendroglia; Peroxisomes; Plasmalogens; Tocotrienols; Zellweger Syndrome

2018
Human Herpesvirus 8 infection may contribute to oxidative stress in diabetes type 2 patients.
    BMC research notes, 2020, Feb-13, Volume: 13, Issue:1

    Topics: Adult; Aged; alpha-Tocopherol; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Ketocholesterols; Male; Malondialdehyde; Middle Aged; Oxidative Stress

2020
7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes.
    The Journal of steroid biochemistry and molecular biology, 2023, Volume: 232

    Topics: Aged; alpha-Tocopherol; Animals; Antioxidants; Apelin; Biomarkers; Case-Control Studies; Catalase; Glutathione Peroxidase; Humans; Hydroxycholesterols; Interleukin-6; Interleukin-8; Ketocholesterols; Leukotriene B4; Mice; Muscle Fibers, Skeletal; Myoblasts; Oxidative Stress; Plant Oils; Sarcopenia; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2023