7-ketocholesterol has been researched along with 25-hydroxycholesterol in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.36) | 18.7374 |
| 1990's | 18 (32.14) | 18.2507 |
| 2000's | 14 (25.00) | 29.6817 |
| 2010's | 21 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dodo, K; Hashimoto, Y; Karaki, F; Ohgane, K | 1 |
| Choi, TA; Franzblau, SG; Knölker, HJ; Schmidt, AW; Theumer, G | 1 |
| Dodo, K; Hashimoto, Y; Karaki, F; Noguchi-Yachide, T; Ohgane, K | 1 |
| Hwang, PL | 1 |
| Dorset, DL | 1 |
| Boissonneault, GA; Hennig, B; Ouyang, CM | 1 |
| Hsiao, W; Hu, B; Morin, R; Peng, SK | 1 |
| Avigan, J; Beg, ZH; Reznikov, DC | 1 |
| Melnykovych, G; Ramachandran, CK; Sanders, K | 1 |
| Akiyama, S; Kuwano, M; Masuda, A | 1 |
| Björkhem, I; Breuer, O | 1 |
| Duedahl, C; Nielsen, JH; Olsen, CE; Skibsted, LH | 1 |
| Das, NP; Li, QT | 1 |
| Bellomo, G; Finardi, G; Palladini, G | 2 |
| Nishio, E; Watanabe, Y | 1 |
| Chai, NN; Morin, RJ; Peng, SK; Wan, Y; Zhang, X | 1 |
| Ashraf, K; Dorset, DL; Li, N; McCourt, MP; Miller, R; Pangborn, W; Weeks, CM | 1 |
| Harada, K; Ishibashi, S; Miyashita, T; Ohashi, K; Osuga, J; Yagyu, H; Yamada, N; Yazaki, Y | 1 |
| Dushkin, MI; Konenkov, VI; Kozlov, VA; Musatov, MI; Perminova, OM; Vol'skiĭ, NN | 1 |
| Dushkin, M; Kozlov, V; Musatov, M; Perminova, O; Ragino, J; Schwartz, Y; Vereschagin, E; Volsky, N | 1 |
| Godin, DV; Kitts, DD; Yuan, YV | 1 |
| Dushkin, MI; Grebenshchikov, AIu; Safina, AF; Shvarts, IaSh; Vereshchagin, EI | 1 |
| Kölsch, H; Ludwig, M; Lütjohann, D; Rao, ML | 1 |
| Bernier, L; Blache, D; Bourdon, E; Davignon, J; Loreau, N | 1 |
| Fujimoto, K; Imaizumi, T; JingZhi, G; Matsui, J; Murakami, H; Satoh, K; Suda, T; Tamasawa, N; Yamato, K; Yoshida, H | 1 |
| Geng, YJ; Mason, RP; Phillips, JE | 1 |
| Brachova, L; Hayden, JM; Higgins, K; Khandrika, S; Obermiller, L; Reaven, PD; Sevanian, A | 1 |
| Bolton, KA; Collier, FM; Collier, GR; Ferguson, M; Gregorio-King, CC; Hosking, JB; Kirkland, MA | 1 |
| Aoki, AM; Castellon, R; Kenney, MC; Nesburn, AB; Ong, JM; Sacerio, I; Seigel, GM | 1 |
| Girão, H; Pereira, P; Shang, F | 1 |
| Girão, H; Pereira, P; Prescott, A; Quinlan, R; Ramalho, J | 1 |
| Jo, Y; King, SR; Matassa, AA; Rao, RM; Reyland, ME; Stocco, DM; Walsh, LP; White, EK | 1 |
| Abdalla, DS; Apolinário, E; Bertolami, MC; Calliari, LE; Faludi, A; Ferderbar, S; Gagliardi, AR; Monte, O; Pereira, EC; Sales, JE; Xavier, HT | 1 |
| Erridge, C; Spickett, CM; Webb, DJ | 1 |
| Acar, N; Bretillon, L; Bron, A; Buteau, B; Cabaret, S; Creuzot-Garcher, C; Joffre, C; Leclère, L; Lizard, G; Malvitte, L; Martine, L | 1 |
| Liu, J; Netherland, C; Pickle, T; Sinensky, MS; Thewke, DP | 1 |
| Dushkin, MI; Feofanova, NA; Khoshchenko, OM; Schwartz, YSh | 1 |
| Charles, G; Gordon, S; Mintzer, E | 1 |
| Aye, IL; Keelan, JA; Mark, PJ; Waddell, BJ | 3 |
| Barini, A; Catalano, A; Mele, MC; Monego, G; Palozza, P; Parrone, N; Picci, N; Ranelletti, FO; Simone, R; Trombino, S | 1 |
| Bento, CF; Brito, A; Catarino, S; Fernandes, AF; Murteira, E; Pereira, P | 1 |
| Appukuttan, A; Kasseckert, SA; Kumar, S; Ladilov, Y; Reusch, HP | 1 |
| Dasari, B; Ghribi, O; Meiers, C; Prasanthi, JR; Singh, BB | 1 |
| Broncel, M; Chalubinski, M; Gorzelak, P; Skowron, W; Wojdan, K; Zemanek, K | 1 |
| Acilan, C; Adiguzel, Z; Arda, N; Baykal, AT; Baysal, K; Gezer Tas, S; Kacar, O; Serhatli, M | 1 |
| Geng, YJ; Rosales, C; Tang, D | 1 |
| Lee, CS; Lee, DH; Nam, YJ | 1 |
| Liebisch, G; Matysik, S; Pataj, Z; Schmitz, G | 1 |
| Alba, G; Geniz, I; Jiménez, J; Martín-Nieto, J; Pintado, E; Reyes-Quiróz, ME; Sáenz, J; Santa-María, C; Sobrino, F | 1 |
| Ahmad, F; Hasan, GM; Imtaiyaz Hassan, M; Islam, A; Khan, FI; Khan, P; Khan, S; Lobb, KA; Mohammad, T | 1 |
| Ai, M; He, B; Hu, Z; Ma, L; Zeng, B; Zhang, X | 1 |
| Beck, KR; Birk, J; Kanagaratnam, S; Kratschmar, DV; Odermatt, A; Sailer, AW; Seuwen, K; Yamaguchi, H | 1 |
| Bhattacharya, S; Bodziak, ML; Browne, RW; Fellows Maxwell, K; Hagemeier, J; Jakimovski, D; Ramanathan, M; Weinstock-Guttman, B; Zivadinov, R | 1 |
56 other study(ies) available for 7-ketocholesterol and 25-hydroxycholesterol
| Article | Year |
|---|---|
Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.
Topics: Anticholesteremic Agents; Azetidines; Binding Sites; Biological Transport; Carbamates; Ezetimibe; HEK293 Cells; Humans; Ligands; Membrane Proteins; Membrane Transport Proteins; Mutation; Steroids; Structure-Activity Relationship | 2013 |
Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Cholestanols; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxidation-Reduction; Stereoisomerism; Structure-Activity Relationship | 2013 |
Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein.
Topics: Carrier Proteins; Dose-Response Relationship, Drug; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Molecular Structure; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Sterols; Structure-Activity Relationship | 2014 |
Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols.
Topics: Animals; Cell Division; Cycloheximide; Dactinomycin; Emetine; Hydroxycholesterols; Ketocholesterols; Kinetics; Mice; Protein Synthesis Inhibitors; Puromycin; RNA; Tumor Cells, Cultured | 1992 |
Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol.
Topics: Calorimetry, Differential Scanning; Cholestanols; Cholesterol; Hydroxycholesterols; Hypolipidemic Agents; Ketocholesterols; Kinetics; Mathematics; X-Ray Diffraction | 1992 |
Oxysterols, cholesterol biosynthesis, and vascular endothelial cell monolayer barrier function.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cholestanes; Cholestanols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium; Hydroxycholesterols; Hypolipidemic Agents; In Vitro Techniques; Ketocholesterols; Lovastatin; Serum Albumin; Swine; Time Factors | 1991 |
Influence of cholesterol oxides on endocytosis of cultured endothelial and smooth muscle cells.
Topics: Animals; Aorta; Cells, Cultured; Cholestanols; Cholesterol; Endocytosis; Endothelium, Vascular; Horseradish Peroxidase; Humans; Hydroxycholesterols; Hypolipidemic Agents; Ketocholesterols; Kinetics; Muscle, Smooth, Vascular; Rabbits; Umbilical Veins | 1990 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.
Topics: Acetates; AMP-Activated Protein Kinases; Cells, Cultured; Fibroblasts; Fluorides; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Ketocholesterols; Lipid Metabolism; Lipoproteins, LDL; Mevalonic Acid; Multienzyme Complexes; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Complex; Sterols; Water | 1986 |
Enhancement in the adhesion of tumor cells to endothelial cells by decreased cholesterol synthesis.
Topics: Animals; Anticholesteremic Agents; Cattle; Cell Adhesion; Cells, Cultured; Cholesterol; Dexamethasone; Endothelium; Hydroxycholesterols; Ketocholesterols; Lovastatin; Melanoma; Membrane Fluidity; Membrane Lipids; Mice; Microscopy, Electron, Scanning; Naphthalenes; Retinoids | 1986 |
Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein.
Topics: Acetates; Animals; Cell Line; Clone Cells; Cricetinae; Drug Resistance; Endocytosis; Genes, Regulator; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketocholesterols; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Mutation; Naphthalenes; Sterols | 1982 |
Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol.
Topics: Animals; Cholestanes; Cholestenes; Cholesterol; Hydroxycholesterols; Isotope Labeling; Ketocholesterols; Kinetics; Liver; Oxygen Consumption; Oxygen Isotopes; Rats; Rats, Sprague-Dawley; Respiration; Time Factors | 1995 |
Isolation and quantification of cholesterol oxides in dairy products by selected ion monitoring mass spectrometry.
Topics: Cholestanols; Cholesterol; Cholesterol Esters; Chromatography, High Pressure Liquid; Dairy Products; Gas Chromatography-Mass Spectrometry; Hydroxycholesterols; Ketocholesterols; Mass Spectrometry; Oxidation-Reduction; Oxides; Triglycerides | 1995 |
Comparison of the effects of cholesterol and oxysterols on phospholipid bilayer microheterogeneity: a study of fluorescence lifetime distributions.
Topics: Cholesterol; Diphenylhexatriene; Hydroxycholesterols; Ketocholesterols; Lipid Bilayers; Membrane Fluidity; Membrane Lipids; Phosphatidylcholines; Spectrometry, Fluorescence | 1994 |
Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells.
Topics: Actin Cytoskeleton; Actinin; Actins; Animals; Apoptosis; Cattle; Cell Adhesion; Cell Line; Cholestanols; Endothelium, Vascular; Hydroxycholesterols; Ketocholesterols; Microscopy, Confocal; Microscopy, Fluorescence; Vinculin | 1996 |
Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells.
Topics: Animals; Cattle; Cell Line; Cell Nucleus; Cholestanols; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Hydroxycholesterols; Intermediate Filaments; Ketocholesterols; Microscopy, Confocal; Microtubules; Oxides; Vimentin | 1996 |
Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation.
Topics: Animals; Aorta, Thoracic; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Enzyme Activation; Enzyme Precursors; Gene Expression Regulation; Hydroxycholesterols; Ketocholesterols; Kinetics; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-bcl-2; Rabbits | 1996 |
Inhibitory effect of cholesterol oxides on low density lipoprotein receptor gene expression.
Topics: Animals; Blotting, Northern; Cells, Cultured; Cholestanols; Cholesterol; Gene Expression Regulation; Hydroxycholesterols; Ketocholesterols; Muscle, Smooth, Vascular; Rabbits; Receptors, Lipoprotein; RNA, Messenger | 1996 |
X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol.
Topics: Crystallization; Crystallography, X-Ray; Hydroxycholesterols; Ketocholesterols | 1997 |
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydroxycholesterols; Ketocholesterols; Macrophages; Mice; Oligopeptides; Proto-Oncogene Proteins c-bcl-2 | 1997 |
[Effect of oxidized cholesterol derivatives on lymphokine stimulated differentiation of macrophages and primary allogenic mixed human lymphocyte culture].
Topics: Adult; Antigen-Presenting Cells; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Female; HLA-DR Antigens; Humans; Hydroxycholesterols; Ketocholesterols; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Lymphokines; Macrophages; Male; Middle Aged | 1997 |
Effects of oxysterols upon macrophage and lymphocyte functions in vitro.
Topics: Animals; Cholesterol; Culture Media, Conditioned; Erythrocytes; Growth Inhibitors; Humans; Hydroxycholesterols; Immunosuppressive Agents; Interleukin-1; Ketocholesterols; Lipopolysaccharides; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Macrophage Activation; Macrophage-Activating Factors; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Neopterin; Phagocytosis; Reactive Oxygen Species; Receptors, Fc; Sheep; Spleen; Thymus Gland | 1998 |
Interactive effects of increased intake of saturated fat and cholesterol on atherosclerosis in the Japanese quail (Coturnix japonica).
Topics: Analysis of Variance; Animals; Aorta; Arteriosclerosis; Bird Diseases; Cholestanols; Cholesterol; Cholesterol, Dietary; Coturnix; Dietary Fats; Disease Models, Animal; Energy Intake; Hydroxycholesterols; Hypolipidemic Agents; Ketocholesterols; Lipids; Lipoproteins; Male; Regression Analysis | 1998 |
[Effects of hydroxysterols on expression of inflammatory cytokine genes and their level in macrophages tolerant to endotoxin].
Topics: Animals; Cells, Cultured; Gene Expression; Hydroxycholesterols; Inflammation; Interleukin-1; Ketocholesterols; Lipopolysaccharides; Macrophages, Peritoneal; Male; Rats; Rats, Wistar; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides.
Topics: Apoptosis; Calcium; Calpain; Cell Survival; Cholesterol; Humans; Hydroxycholesterols; Ketocholesterols; L-Lactate Dehydrogenase; Lipid Peroxides; Necrosis; Neuroblastoma; Reactive Oxygen Species; Tumor Cells, Cultured | 1999 |
Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells.
Topics: Antioxidants; Diabetes Mellitus; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hydroxycholesterols; Hypercholesterolemia; Ketocholesterols; Leucine; Lipoproteins, LDL; Liver; Lysophosphatidylcholines; RNA, Messenger; Serum Albumin; Time Factors; Tritium; Tumor Cells, Cultured | 2000 |
An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture.
Topics: Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Ketocholesterols; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2001 |
7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells.
Topics: Animals; Aorta; Cell Line; Cell Membrane; Cholesterol; Crystallization; Hydroxycholesterols; Ketocholesterols; Membranes, Artificial; Mice; Muscle, Smooth, Vascular; X-Ray Diffraction | 2001 |
Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol.
Topics: CD36 Antigens; Cell Adhesion; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Foam Cells; Humans; Hydroxycholesterols; Ketocholesterols; Lipoproteins, LDL; Macrophages; Membrane Proteins; Models, Biological; Monocytes; Protein Biosynthesis; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B | 2002 |
Effect of oxysterols on hematopoietic progenitor cells.
Topics: Adult; Apoptosis; Blood Cells; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Colony-Forming Units Assay; Fetal Blood; Hematopoietic Stem Cells; HL-60 Cells; Humans; Hydroxycholesterols; Infant, Newborn; Ketocholesterols | 2002 |
Oxysterol-induced toxicity in R28 and ARPE-19 cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydroxycholesterols; Hydroxysteroids; Ketocholesterols; Kinetics; Rats; Retina | 2003 |
7-ketocholesterol stimulates differentiation of lens epithelial cells.
Topics: Animals; Aquaporins; Biomarkers; Blotting, Western; Cattle; Cell Differentiation; Cell Division; Cholesterol; Cyclin-Dependent Kinase Inhibitor p57; Enzyme Inhibitors; Epithelial Cells; Eye Proteins; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; gamma-Crystallins; Hydroxycholesterols; Intermediate Filament Proteins; Ketocholesterols; Lens, Crystalline; Membrane Glycoproteins; Nuclear Proteins; Proliferating Cell Nuclear Antigen | 2003 |
Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.
Topics: Actin Cytoskeleton; Cell Adhesion; Cell Line; Cell Movement; Cholesterol; Cytoskeletal Proteins; Cytoskeleton; Epithelial Cells; Humans; Hydroxycholesterols; Ketocholesterols; rho GTP-Binding Proteins | 2003 |
Oxysterols regulate expression of the steroidogenic acute regulatory protein.
Topics: Adrenal Cortex Neoplasms; Animals; Gene Expression Regulation; Hydroxycholesterols; Ketocholesterols; Leydig Cell Tumor; Mice; Phosphoproteins; Promoter Regions, Genetic; Sterols; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Child; Cholestanols; Cholesterol; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Humans; Hydroxycholesterols; Hypoglycemic Agents; Insulin; Ketocholesterols; Male; Middle Aged; Oxidative Stress | 2007 |
25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.
Topics: Cells, Cultured; Epithelial Cells; Humans; Hydroxycholesterols; Interleukin-8; Ketocholesterols; Macrophages; Signal Transduction; Toll-Like Receptor 1; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 6; Toll-Like Receptors; Transfection; Up-Regulation | 2007 |
Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells.
Topics: Animals; Chromatography, Gas; Enzyme-Linked Immunosorbent Assay; Fluoresceins; Fluorescent Dyes; Hydroxycholesterols; Inflammation; Interleukin-8; Ketocholesterols; Mitochondria; Oxidative Stress; Pigment Epithelium of Eye; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine | 2007 |
Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.
Topics: Animals; Apoptosis; Base Sequence; Cell Line, Tumor; Hydroxycholesterols; Ketocholesterols; Leukemia P388; Leupeptins; Macrophages; Mice; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Transfection; Ubiquitination | 2009 |
Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.
Topics: Alitretinoin; Animals; Cells, Cultured; Cholesterol; Farnesol; Hydroxycholesterols; Hydroxysteroids; Ketocholesterols; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Transforming Growth Factor beta; Tretinoin | 2009 |
Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes.
Topics: Hydroxycholesterols; Ketocholesterols; Lipid Bilayers; Models, Molecular; Phosphatidylcholines; Solubility; Sphingomyelins; Surface-Active Agents | 2010 |
Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.
Topics: ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Western; Cell Proliferation; Cholesterol; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Hydroxycholesterols; Immunoenzyme Techniques; Ketocholesterols; Placenta; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Trophoblasts | 2010 |
Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression.
Topics: Carotenoids; Cell Line; Cytokines; Humans; Hydroxycholesterols; Interleukin-1beta; Interleukin-6; Interleukin-8; Ketocholesterols; Lycopene; Macrophages; Mitogen-Activated Protein Kinases; NADPH Oxidases; NF-kappa B; Phosphorylation; Plaque, Atherosclerotic; PPAR gamma; Protein Binding; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.
Topics: Alkaline Phosphatase; Cell Differentiation; Cell Fusion; Chorionic Gonadotropin; DNA-Binding Proteins; Female; Gene Products, env; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ketocholesterols; Liver X Receptors; Nuclear Proteins; Orphan Nuclear Receptors; Placenta; Pregnancy; Pregnancy Proteins; RNA, Messenger; Sulfonamides; Transcription Factors; Trophoblasts | 2011 |
Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB.
Topics: Cells, Cultured; Chemokine CCL4; Female; Humans; Hydroxycholesterols; Immunohistochemistry; Interleukin-6; Ketocholesterols; Lipopolysaccharides; NF-kappa B; Pregnancy; Trophoblasts; Tumor Necrosis Factor-alpha | 2012 |
Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells.
Topics: Blotting, Western; Cell Line; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genes, Reporter; Humans; Hydroxycholesterols; Interleukin-8; Ketocholesterols; NF-kappa B; Phosphatidylinositol 3-Kinases; Real-Time Polymerase Chain Reaction; Retinal Pigment Epithelium; RNA, Messenger; Transcription Factor AP-1 | 2012 |
Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Hydroxycholesterols; Ketocholesterols; Membrane Potential, Mitochondrial; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Reactive Oxygen Species | 2013 |
Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.
Topics: Cell Line; Chemokine CCL2; Drug Interactions; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Hydroxycholesterols; Interleukin-6; Interleukin-8; Ketocholesterols; Liver X Receptors; Macular Degeneration; Orphan Nuclear Receptors; Oxidation-Reduction; Platelet-Derived Growth Factor; Retinal Pigment Epithelium; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers.
Topics: Aorta; Apoptosis; Caco-2 Cells; Cell Survival; Cells, Cultured; Endothelial Cells; Epithelial Cells; Humans; Hydroxycholesterols; Intestinal Mucosa; Ketocholesterols | 2013 |
Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols.
Topics: Aortic Aneurysm, Thoracic; Apoptosis; Caspase 3; Cells, Cultured; Cholesterol; Humans; Hydroxycholesterols; Ketocholesterols; Myocytes, Smooth Muscle; Reactive Oxygen Species; Signal Transduction | 2014 |
CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ.
Topics: Animals; Antigens, CD1d; Atherosclerosis; Cell Membrane; Cholesterol; DNA Primers; HEK293 Cells; Humans; Hydroxycholesterols; Immunoglobulin G; Ketocholesterols; Lipids; Macrophages; Mice; Mice, Knockout; Microscopy, Fluorescence; Oxygen; PPAR gamma; Protein Binding; Sterols | 2015 |
Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Death; Cell Survival; DNA Fragmentation; Glutathione; Hydroxycholesterols; Ketocholesterols; Membrane Potential, Mitochondrial; NF-kappa B; Oxidation-Reduction; PC12 Cells; Quercetin; Rats; Reactive Oxygen Species | 2015 |
Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.
Topics: Biomarkers; Chromatography, Liquid; Erythrocytes; Humans; Hydroxycholesterols; Ketocholesterols; Niemann-Pick Disease, Type C; Plasma; Stereoisomerism; Tandem Mass Spectrometry; Xanthomatosis, Cerebrotendinous | 2016 |
7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils.
Topics: Cell Membrane; Heme Oxygenase-1; Humans; Hydroxycholesterols; Ketocholesterols; Muramidase; NADPH Oxidases; Neutrophils; Phosphoproteins; Reactive Oxygen Species | 2016 |
Exploring molecular insights into the interaction mechanism of cholesterol derivatives with the Mce4A: A combined spectroscopic and molecular dynamic simulation studies.
Topics: Bacterial Proteins; Binding Sites; Cholesterol; Host-Pathogen Interactions; Humans; Hydroxycholesterols; Ketocholesterols; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Protein Binding; Tuberculosis | 2018 |
Heterologous expression and functional characterization of the ligand-binding domain of oxysterol-binding protein from Aspergillus oryzae.
Topics: Aspergillus oryzae; Biological Transport; Carrier Proteins; Ergosterol; Gene Expression; Hydroxycholesterols; Ketocholesterols; Protein Binding; Protein Domains; Receptors, Steroid; Spores, Fungal; Stigmasterol | 2019 |
Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; HEK293 Cells; Humans; Hydroxycholesterols; Hydroxylation; Ketocholesterols; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Oxidation-Reduction; RAW 264.7 Cells | 2019 |
Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study.
Topics: Adolescent; Adult; Aged; Apolipoproteins; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Ketocholesterols; Longitudinal Studies; Male; Mass Spectrometry; Middle Aged; Multiple Sclerosis; Oxysterols; Prospective Studies; Young Adult | 2019 |