7-hydroxystaurosporine has been researched along with fluorouracil in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Tsuchida, E; Urano, M | 1 |
| Hsueh, CT; Kelsen, D; Schwartz, GK | 1 |
| Abe, S; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M | 1 |
| Abe, S; Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Kubota, T; Migita, T | 1 |
| Comijn, EM; Kamphuis, JA; Peters, GJ; Sigmond, J | 1 |
| Gonen, M; Ilson, DI; Kaubisch, A; Kelsen, DP; Kemeny, N; Kortmansky, J; Maki, RG; O'reilly, E; Saltz, LB; Schwartz, GK; Shah, MA; Sowers, R; Tong, W; Weyerbacher, A; Yi, S | 1 |
| Fujinaka, Y; Gillespie, DA; Iimori, M; Kakeji, Y; Kitao, H; Maehara, Y; Matsuoka, K; Morita, M; Saeki, H; Sakasai, R; Takata, M; Tuul, M; Yamamoto, K; Yoshinaga, K | 1 |
1 trial(s) available for 7-hydroxystaurosporine and fluorouracil
| Article | Year |
|---|---|
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2005 |
7 other study(ies) available for 7-hydroxystaurosporine and fluorouracil
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Fibrosarcoma; Fluorouracil; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Stem Cell Assay | 1997 |
UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carrier Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinases; DNA-Binding Proteins; Down-Regulation; Drug Administration Schedule; Drug Synergism; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Fluorouracil; Gene Expression; Humans; Protein Kinase C; Retinoblastoma-Binding Protein 1; Staurosporine; Stomach Neoplasms; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1998 |
UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
Topics: Alkaloids; Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Estrogens; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Separation; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Humans; Inhibitory Concentration 50; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Time Factors | 2004 |
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Nucleus; Checkpoint Kinase 1; Chickens; Cytoprotection; DNA Breaks, Double-Stranded; Fanconi Anemia Complementation Group D2 Protein; Fluorouracil; Histones; Lymphoma, B-Cell; Mutation; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Recombinational DNA Repair; Signal Transduction; Staurosporine; Time Factors | 2012 |