Compounds > 7-hydroxystaurosporine

Page last updated: 2024-08-25

7-hydroxystaurosporine and alvocidib

7-hydroxystaurosporine has been researched along with alvocidib in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (5.26)	18.2507
2000's	18 (94.74)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Byrd, JC; Grever, MR; Rai, KR; Sausville, EA	1
Sausville, EA; Senderowicz, AM	1
Andreeff, M; Kitada, S; Reed, JC; Zapata, JM	1
Bibb, JA; Biernat, J; Eisenbrand, G; Garnier, M; Greengard, P; Hoessel, R; Leclerc, S; Mandelkow, EM; Marko, D; Meijer, L; Snyder, GL; Wu, YZ	1
Senderowicz, AM	6
Nishio, K	1
Howard, OM; Kim, HH; Lin, TS; Neuberg, DS; Shipp, MA	1
Cheson, BD	1
Sausville, EA	1
Swanton, C	1
Blagden, S; de Bono, J	1
Albanese, C; D'Amico, M; Mani, S; Pestell, RG; Wang, C; Wu, K	1
Chen, XG; Zuo, MX	1

Reviews

14 review(s) available for 7-hydroxystaurosporine and alvocidib

Article	Year
Old and new therapies in chronic lymphocytic leukemia: now is the time for a reassessment of therapeutic goals. Seminars in oncology, 1998, Volume: 25, Issue:1 Topics: Alkaloids; Antineoplastic Agents, Alkylating; Bryostatins; Flavonoids; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Piperidines; Staurosporine; Topoisomerase I Inhibitors	1998
Preclinical and clinical development of cyclin-dependent kinase modulators. Journal of the National Cancer Institute, 2000, Mar-01, Volume: 92, Issue:5 Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine	2000
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia, 2001, Volume: 15, Issue:1 Topics: Alkaloids; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Hematologic Neoplasms; Humans; Piperidines; Retinoblastoma Protein; Signal Transduction; Staurosporine	2001
[CDK inhibitors for therapy of cancer]. Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 4 Topics: Alkaloids; Animals; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Piperidines; Protein Transport; Staurosporine; Stomach Neoplasms	2001
Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene, 2000, Dec-27, Volume: 19, Issue:56 Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Delivery Systems; Enzyme Inhibitors; Flavonoids; Humans; Piperidines; Protein Kinase C; Retinoblastoma Protein; Staurosporine	2000
The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01. The oncologist, 2002, Volume: 7 Suppl 3 Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine	2002
Hematologic malignancies: new developments and future treatments. Seminars in oncology, 2002, Volume: 29, Issue:4 Suppl 13 Topics: Adenine Nucleotides; Alemtuzumab; Alkaloids; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Clofarabine; Cytosine; Dioxolanes; Flavonoids; Hematologic Neoplasms; Humans; Immunoconjugates; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; NF-kappa B; Nitrogen Mustard Compounds; Oligonucleotides, Antisense; Peptide Hydrolases; Piperidines; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Remission Induction; Rituximab; Staurosporine; Thionucleotides	2002
Cyclin-dependent kinases as new targets for the prevention and treatment of cancer. Hematology/oncology clinics of North America, 2002, Volume: 16, Issue:5 Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Clinical Trials, Phase I as Topic; Cyclin-Dependent Kinases; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Humans; Neoplasm Proteins; Neoplasms; Piperidines; Signal Transduction; Staurosporine; Transcription, Genetic	2002
Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies. Current medicinal chemistry. Anti-cancer agents, 2003, Volume: 3, Issue:1 Topics: Alkaloids; Animals; Antineoplastic Agents; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Flavonoids; Humans; National Institutes of Health (U.S.); Piperidines; Staurosporine; United States	2003
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer chemotherapy and pharmacology, 2003, Volume: 52 Suppl 1 Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine; Tumor Cells, Cultured	2003
Cell-cycle targeted therapies. The Lancet. Oncology, 2004, Volume: 5, Issue:1 Topics: Animals; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine	2004
Drugging cell cycle kinases in cancer therapy. Current drug targets, 2005, Volume: 6, Issue:3 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles	2005
Inhibitors of cyclin-dependent kinase modulators for cancer therapy. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2005, Volume: 63 Topics: Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Piperidines; Protein Kinase Inhibitors; Staurosporine	2005
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Neoplasms; Piperidines; Purines; Roscovitine; Staurosporine	2007

Other Studies

5 other study(ies) available for 7-hydroxystaurosporine and alvocidib

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood, 2000, Jul-15, Volume: 96, Issue:2 Topics: Alkaloids; Apoptosis; Carrier Proteins; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; In Situ Nick-End Labeling; Kinetics; Leukemia, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transcription Factors; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein	2000
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1 Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Inhibitory Concentration 50; Mice; Molecular Structure; Neostriatum; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphothreonine; Piperidines; Staurosporine; tau Proteins	2001
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leukemia & lymphoma, 2002, Volume: 43, Issue:4 Topics: Aged; Alkaloids; Antineoplastic Agents; Female; Flavonoids; Humans; Infusions, Intravenous; Lymphoma, Mantle-Cell; Male; Middle Aged; Piperidines; Staurosporine	2002
A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines. Investigational new drugs, 2005, Volume: 23, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Caspase 8; Caspase 9; Caspases; Cell Survival; Collagen Type XI; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Staurosporine; Survivin; Transfection	2005