Compounds > 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid
Page last updated: 2024-09-05

7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid and indomethacin

7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid)		Trials
(7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid)		Recent Studies (post-2010)
(7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
39151429,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomy7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mayatepek, E; Nützenadel, W; Seyberth, HW1
Hoffmann, GF; Linderkamp, O; Mayatepek, E; Meyburg, J; Seyberth, HW1
Frölich, JC; Stichtenoth, DO; Wagner, B1
Frölich, JC; Gutzki, FM; Marhauer, V; Stichtenoth, DO; Tsikas, D1

Trials

2 trial(s) available for 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid and indomethacin

ArticleYear
Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1997, Volume: 45, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Meloxicam; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Therapeutic Equivalency; Thiazines; Thiazoles; Thromboxane B2

1997
Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers.
    Kidney international, 2005, Volume: 68, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Body Weight; Celecoxib; Creatinine; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Diuretics; Female; Furosemide; Humans; Indomethacin; Kidney; Potassium; Prostaglandins; Pyrazoles; Renin; Sodium; Sulfonamides; Thromboxane B2

2005

Other Studies

2 other study(ies) available for 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid and indomethacin

ArticleYear
Effects of indomethacin in congenital chloride diarrhea.
    Journal of pediatric gastroenterology and nutrition, 1992, Volume: 14, Issue:3

    Topics: 18-Hydroxycorticosterone; Aldosterone; Chlorine; Diarrhea; Dinoprost; Dinoprostone; Humans; Indomethacin; Infant; Male; Potassium Chloride; Prostaglandins; Renin; Sodium Chloride; Water-Electrolyte Balance

1992
Severe hyperchloriduria-hyperkaliuria: a new congenital renal tubular abnormality?
    The Journal of pediatrics, 1996, Volume: 128, Issue:3

    Topics: Bartter Syndrome; Calcium; Chlorides; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Infant; Potassium; Prostaglandins; Renal Tubular Transport, Inborn Errors; Syndrome

1996