7-deoxypancratistatin has been researched along with pancratistatin* in 5 studies
*pancratistatin: an isocarbostyril from Amaryllidaceae [MeSH]
*pancratistatin: an isocarbostyril from Amaryllidaceae [MeSH]
1 review(s) available for 7-deoxypancratistatin and pancratistatin
| Article | Year |
|---|---|
Chemistry, biology, and medicinal potential of narciclasine and its congeners.
Topics: Amaryllidaceae Alkaloids; Antineoplastic Agents; Antiviral Agents; Humans; Isoquinolines; Molecular Structure; Phenanthridines; Stereoisomerism | 2008 |
4 other study(ies) available for 7-deoxypancratistatin and pancratistatin
| Article | Year |
|---|---|
Synthesis of (+)-Pancratistatins via Catalytic Desymmetrization of Benzene.
A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core. Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and seven operations. Topics: Amaryllidaceae Alkaloids; Antineoplastic Agents; Benzene; Biological Products; Catalysis; Chemistry Techniques, Synthetic; Hydroxylation; Isoquinolines; Stereoisomerism | 2017 |
Synthesis and biological activity of some structural modifications of pancratistatin.
Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies. Topics: Amaryllidaceae Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Mice; Structure-Activity Relationship | 2004 |
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives.
Biocatalytic approaches have yielded efficient total syntheses of the major Amaryllidaceae alkaloids, all based on the key enzymatic dioxygenation of suitable aromatic precursors. This paper discusses the logic of general synthetic design for lycoricidine, narciclasine, pancratistatin, and 7-deoxypancratistatin. Experimental details are provided for the recently accomplished syntheses of narciclasine, ent-7-deoxypancratistatin, and 10b-epi-deoxypancratistatin via a new and selective opening of a cyclic sulfate over aziridines followed by aza-Payne rearrangement. The structural core of 7-deoxypancratistatin has also been degraded to a series of intermediates in which the amino inositol unit is cleaved and deoxygenated in a homologous fashion. These truncated derivatives and the compounds from the synthesis of the unnatural derivatives have been tested against six important human cancer cell lines in an effort to further develop the understanding of the mode of action for the most active congener in this group, pancratistatin. The results of the biological activity testing as well as experimental, spectral, and analytical data are provided in this manuscript for all relevant compounds. Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Catalysis; Cyclization; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Leukemia P388; Magnoliopsida; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenanthridines; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Total synthesis of (+)-7-deoxypancratistatin from furan.
A new total synthesis of (+)-7-deoxypancratistatin 1 has been accomplished in 19 steps (8% overall yield) from two readly available compounds, furan and trans-1,2-bis(phenylsulfonyl)ethylene. Topics: Amaryllidaceae Alkaloids; Antineoplastic Agents, Phytogenic; Furans; Indicators and Reagents; Isoquinolines; Magnetic Resonance Spectroscopy; Plants, Medicinal | 2000 |