Compounds > 7-deoxy-trans-dihydronarciclasine

7-deoxy-trans-dihydronarciclasine and lycoricidine

7-deoxy-trans-dihydronarciclasine has been researched along with lycoricidine* in 1 studies

Other Studies

1 other study(ies) available for 7-deoxy-trans-dihydronarciclasine and lycoricidine

Article	Year
Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70). Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9 The anti hepatitis C virus (HCV) activity of (+)-lycoricidine (1) was evaluated for the first time in this letter, yielding an EC50 value of 0.55 nmol/mL and an selection index (SI) value of 12.72. Further studies indicated that 1 induced this effect by down-regulating host heat-stress cognate 70 (Hsc70) expression. In addition, 20 derivatives were designed and synthesised to investigate the basic structure-activity relationship (SAR) of the title compound. Several of these derivatives exhibit a good inhibition of HCV, such as compound 3 (EC50=0.68 nmol/mL, SI=33.86), compound 2d (EC50=15 nmol/mL, SI=12) and compound 5 (EC50=33 nmol/mL, SI >10.91). Meanwhile, the experimental data suggest that the modification of certain groups of (+)-lycoricidine can reduce the cytotoxicity of the compounds. Topics: Amaryllidaceae Alkaloids; Antiviral Agents; Cell Line; Gene Expression; Hepacivirus; HSC70 Heat-Shock Proteins; Humans; Phenanthridines; Stereoisomerism; Structure-Activity Relationship	2013

Article

Year

Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70).

Bioorganic & medicinal chemistry letters, 2013, May-01, Volume: 23, Issue:9

The anti hepatitis C virus (HCV) activity of (+)-lycoricidine (1) was evaluated for the first time in this letter, yielding an EC50 value of 0.55 nmol/mL and an selection index (SI) value of 12.72. Further studies indicated that 1 induced this effect by down-regulating host heat-stress cognate 70 (Hsc70) expression. In addition, 20 derivatives were designed and synthesised to investigate the basic structure-activity relationship (SAR) of the title compound. Several of these derivatives exhibit a good inhibition of HCV, such as compound 3 (EC50=0.68 nmol/mL, SI=33.86), compound 2d (EC50=15 nmol/mL, SI=12) and compound 5 (EC50=33 nmol/mL, SI >10.91). Meanwhile, the experimental data suggest that the modification of certain groups of (+)-lycoricidine can reduce the cytotoxicity of the compounds.

Topics: Amaryllidaceae Alkaloids; Antiviral Agents; Cell Line; Gene Expression; Hepacivirus; HSC70 Heat-Shock Proteins; Humans; Phenanthridines; Stereoisomerism; Structure-Activity Relationship

2013