7-deazapurine has been researched along with adefovir* in 1 studies
1 other study(ies) available for 7-deazapurine and adefovir
| Article | Year |
|---|---|
Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir.
Adefovir based acyclic nucleoside phosphonates were previously shown to modulate bacterial and, to a certain extent, human adenylate cyclases (mACs). In this work, a series of 24 novel 7-substituted 7-deazaadefovir analogues were synthesized in the form of prodrugs. Twelve analogues were single-digit micromolar inhibitors of Bordetella pertussis adenylate cyclase toxin with no cytotoxicity to J774A.1 macrophages. In HEK293 cell-based assays, compound 14 was identified as a potent (IC Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; HEK293 Cells; Humans; Nucleosides; Organophosphonates | 2023 |