Page last updated: 2024-08-26

7-chloro-4-aminoquinoline and chloroquine

7-chloro-4-aminoquinoline has been researched along with chloroquine in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	1 (7.69)	18.2507
2000's	2 (15.38)	29.6817
2010's	4 (30.77)	24.3611
2020's	4 (30.77)	2.80

Authors

Authors	Studies
Bhattacharjee, AK; Dorn, A; Ellis, WY; Karle, JM; Matile, H; Ridley, RG; Vennerstrom, JL; Vippagunta, SR	1
Egan, TJ; Hunter, R; Kaschula, CH; Marques, HM; Misplon, A; Walden, J	1
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y	1
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y	1
Combrinck, JM; Egan, TJ; Hunter, R; Smith, PJ; Wicht, KJ	1
Heering, J; Kilu, W; Merk, D; Ohrndorf, J; Willems, S	1
Merk, D; Willems, S	1
Bots, M; de Wit, M; Eggelte, TA; Greenwood, BM; Menon, A; Shenton, FC	1
Brown, ND; Chulay, JD; Poon, BT	1
André-Barrès, C; Mallet-Ladeira, S; Maynadier, M; Ruiz, J; Vial, H	1
Agarwal, P; Ahmad, H; Dola, VR; Dwivedi, AK; Haq, W; Katti, SB; Puri, SK; Raju, KS; Rashid, M; Soni, A; Srivastava, K; Wahajuddin, M	1
Belhassan, A; Bouachrine, M; En-Nahli, F; Lakhlifi, T; Zaki, H	1
Hirayama, K; Hosokawa, M; Huy, NT; Makau, J; Mizukami, S; Mizuta, S; Morita, K; Mosaddeque, F; Nishida, N; Taniguchi, M; Teklemichael, AA; Tun, MMN; Yamaguchi, T	1

Reviews

1 review(s) available for 7-chloro-4-aminoquinoline and chloroquine

Article	Year
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. Journal of medicinal chemistry, 2022, 07-28, Volume: 65, Issue:14 Topics: Chemistry, Pharmaceutical; Humans; Ligands; Nuclear Receptor Subfamily 4, Group A, Member 2; Receptors, Cytoplasmic and Nuclear; Transcription Factors	2022

Other Studies

12 other study(ies) available for 7-chloro-4-aminoquinoline and chloroquine

Article	Year
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. Journal of medicinal chemistry, 1999, Nov-04, Volume: 42, Issue:22 Topics: Animals; Antimalarials; Biopolymers; Chloroquine; Colorimetry; Depression, Chemical; Hemin; Inhibitory Concentration 50; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	1999
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Hemin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Structure-Activity Relationship	2000
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26 Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2008
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061 Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites	2011
Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum. Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13 Topics: Antimalarials; Benzamides; Dose-Response Relationship, Drug; Hemeproteins; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2016
Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms. Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5 Topics: Aminoquinolines; Astrocytes; Gene Expression; HEK293 Cells; Humans; Molecular Structure; Nuclear Receptor Subfamily 4, Group A, Member 2; Structure-Activity Relationship	2021
An ELISA test for detecting chloroquine in urine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:2 Topics: Aminoquinolines; Antibodies, Monoclonal; Child, Preschool; Chloroquine; Colorimetry; Enzyme-Linked Immunosorbent Assay; Humans; Sensitivity and Specificity	1988
Chloroquine metabolism in man: urinary excretion of 7-chloro-4-hydroxyquinoline and 7-chloro-4-aminoquinoline metabolites. Journal of chromatography, 1985, Nov-29, Volume: 345, Issue:1 Topics: Aminoquinolines; Biotransformation; Chloroquine; Chloroquinolinols; Chromatography, High Pressure Liquid; Dealkylation; Humans; Hydroxyquinolines	1985
Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents. Organic & biomolecular chemistry, 2014, Jul-28, Volume: 12, Issue:28 Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Drug Design; Erythrocytes; Free Radicals; Humans; Hypoxanthine; Inhibitory Concentration 50; Iron; Oxidation-Reduction; Peroxides; Plasmodium falciparum; Tritium	2014
Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Administration, Oral; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Erythrocytes; Heme; Hemin; Inhibitory Concentration 50; Macaca mulatta; Malaria; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium cynomolgi; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship; Vero Cells	2017
Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach. Life sciences, 2020, Dec-01, Volume: 262 Topics: Aminoquinolines; Binding Sites; Chloroquine; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Hydroxychloroquine; Imidazoles; Molecular Docking Simulation; Molecular Structure; Pandemics; Protease Inhibitors; SARS-CoV-2	2020
Challenges Based on Antiplasmodial and Antiviral Activities of 7-Chloro-4-aminoquinoline Derivatives. ChemMedChem, 2023, 04-03, Volume: 18, Issue:7 Topics: Antimalarials; Antiviral Agents; Chloroquine; COVID-19; Humans; Malaria; Plasmodium falciparum; SARS-CoV-2	2023