Compounds > 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine
Page last updated: 2024-09-03

7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and rolipram

7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine has been researched along with rolipram in 4 studies

Compound Research Comparison

Studies
(7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine)		Trials
(7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine)		Recent Studies (post-2010)
(7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine)		Studies
(rolipram)		Trials
(rolipram)		Recent Studies (post-2010) (rolipram)
10011,60417401

Protein Interaction Comparison

ProteinTaxonomy7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine (IC50)rolipram (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.2233
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)1.2233
Retina-specific copper amine oxidaseHomo sapiens (human)0.0003
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.0975
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)3.63
ReninHomo sapiens (human)3.5
Tumor necrosis factorHomo sapiens (human)0.35
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.8447
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.1942
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.095
Delta-type opioid receptorMus musculus (house mouse)1.5
Delta-type opioid receptorRattus norvegicus (Norway rat)1.5
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.7287
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)1.1005
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)1.61
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.0794
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.835
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.835
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.835

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Augusti-Tocco, G; Campagnolo, L; Giorgi, M1
Eisenbrand, G; Fürstenberger, G; Marko, D; Romanakis, K; Steinbauer, B; Zankl, H1
Gasbarri, A; Giorgi, M; Modica, A; Pacitti, C; Pompili, A1
Biagioni, S; Cardarelli, S; Cifone, MG; Cinque, B; Galli, F; Giardi, MF; Giorgi, M; Massimi, M; Panera, N; Ragusa, F1

Other Studies

4 other study(ies) available for 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and rolipram

ArticleYear
Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line.
    Journal of neuro-oncology, 1997, Volume: 31, Issue:1-2

    Topics: Cell Division; Humans; Neuroectodermal Tumors, Primitive, Peripheral; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Purinones; Pyrrolidinones; Rolipram; Tumor Cells, Cultured

1997
Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts.
    Cell biochemistry and biophysics, 1998, Volume: 28, Issue:2-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Carcinoma; Cell Cycle; Cell Division; Cell Size; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA Fragmentation; Isoenzymes; Keratinocytes; Mice; Papilloma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Pteridines; Pyrrolidinones; Rolipram; Skin Neoplasms; Tumor Cells, Cultured

1998
The induction of cyclic nucleotide phosphodiesterase 4 gene (PDE4D) impairs memory in a water maze task.
    Behavioural brain research, 2004, Sep-23, Volume: 154, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Corpus Striatum; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation; Hippocampus; Isoenzymes; Male; Maze Learning; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Rats; Rats, Wistar; Retention, Psychology; RNA, Messenger; Rolipram; Second Messenger Systems

2004
Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival.
    Journal of cellular biochemistry, 2017, Volume: 118, Issue:6

    Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Cyclic AMP; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Phosphodiesterase 4 Inhibitors; Piperazines; Pteridines; Rolipram

2017