Page last updated: 2024-09-04

7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane and lidocaine

7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane has been researched along with lidocaine in 4 studies

*Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE. [MeSH]

*Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE. [MeSH]

Compound Research Comparison

Studies
(7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane)
Trials
(7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane)
Recent Studies (post-2010)
(7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane)
Studies
(lidocaine)
Trials
(lidocaine)
Recent Studies (post-2010) (lidocaine)
130026,0905,9045,591

Protein Interaction Comparison

ProteinTaxonomy7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane (IC50)lidocaine (IC50)
Sodium channel protein type 4 subunit alphaHomo sapiens (human)2

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berlin, KD; Chen, CL; Fazekas, T; Garrison, GL; Lazzara, R; Patterson, E; Sangiah, S; Scherlag, BJ; Schubot, FD; van der Helm, D1
Bailey, BR; Berlin, KD; Brachmann, J; Holt, EM; Lazzara, R; Pantaleo, NS; Powell, DR; Ruenitz, PC; Scherlag, BJ; van der Helm, D1
Berlin, KD; Lazzara, R; Patterson, E; Scherlag, BJ1
Berlin, KD; Chen, CL; Fazekas, T; Garrison, GL; Lazzara, R; Mabo, P; Patterson, E; Sangiah, S; Scherlag, BJ1

Other Studies

4 other study(ies) available for 7-benzyl 3-thia-7-azabicyclo(3.3.1)nonane and lidocaine

ArticleYear
Novel 3,7-diheterabicyclo[3.3.1]nonanes that possess predominant class III antiarrhythmic activity in 1-4 day post infarction dog models: X-ray diffraction analysis of 3-[4-(1H-imidazol-1-yl)benzoyl]-7-isopropyl-3,7-diazabicyclo[3.3.1]nona ne dihydroperch
    Journal of medicinal chemistry, 1996, Jun-21, Volume: 39, Issue:13

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Dogs; Electrophysiology; Heart Rate; Imidazoles; Lidocaine; Models, Molecular; Molecular Conformation; Molecular Structure; Myocardial Infarction; Tachycardia, Ventricular

1996
Synthesis, conformational analysis, and antiarrhythmic properties of 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one, 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonane hydroperchlorate, and 7-benzyl-9-phenyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ol hydroperchlorate an
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Crystallization; Dogs; Heart Rate; Lidocaine; Magnetic Resonance Spectroscopy; Models, Molecular; Stereoisomerism; X-Ray Diffraction

1984
Electrophysiologic actions of BRB-I-28 in ischemically injured canine myocardium.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Electrophysiology; Heart; Heart Conduction System; Heart Rate; Lidocaine; Myocardial Infarction; Myocardial Ischemia

1993
The comparative antiarrhythmic and proarrhythmic activity of a 3,7-diheterobicyclo[3.3.1]nonane, BRB-I-28, and lidocaine in the 1-4-day-old infarcted dog heart.
    Acta physiologica Hungarica, 1993, Volume: 81, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Electric Stimulation; Electrophysiology; Hemodynamics; Lidocaine; Myocardial Infarction; Tachycardia, Ventricular

1993