7-acetoxycoumarin and coumarin

7-acetoxycoumarin has been researched along with coumarin* in 2 studies

Other Studies

2 other study(ies) available for 7-acetoxycoumarin and coumarin

Article	Year
Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs. European journal of medicinal chemistry, 2014, Apr-22, Volume: 77 Asthma is a chronic inflammatory disorder that causes contraction in the smooth muscle of the airway and blocking of airflow. Reversal the contractile process is a strategy for the search of new drugs that could be used for the treatment of asthma. This work reports the semisynthesis, ex vivo relaxing evaluation and SAR studies of a series of 18 coumarins. The results pointed that the ether derivatives 1-3, 7-9 and 13-15 showed the best activity (Emax = 100%), where compound 2 (42 μM) was the most potent, being 4-times more active than theophylline (positive control). The ether homologation (methyl, ethyl and propyl) in position 7 or positions 6 and 7 of coumarins lead to relaxing effect, meanwhile formation of esters generated less active compounds than ethers. The SAR analysis showed that it is necessary the presence of two small ether groups and the methyl group at position 4 (site 3) encourage biological activity through soft hydrophobic changes in the molecule, without drastically affecting the cLogP. Topics: Animals; Anti-Asthmatic Agents; Coumarins; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Models, Molecular; Molecular Structure; Rats; Rats, Wistar; Structure-Activity Relationship; Trachea	2014
A highly selective fluorescent probe for BO3(-) based on acetate derivatives of coumarin in aqueous solution and thimerosal. The Analyst, 2013, Feb-21, Volume: 138, Issue:3 The acetate derivatives of coumarin exhibited a prominent turn-on type signaling behavior toward BO(3)(-) ions over other common anions. Signaling is based on the selective deprotection of acetate groups by perborate, which resulted in significant fluorogenic signaling in an acetate buffered solution (pH 5.0). Interestingly, the detection process makes the raw material of 7-hydroxycoumarin regenerate, and the probe could be applied for the detection of BO(3)(-) of thimerosal. Furthermore, the optical properties of the probe and its BO(3)(-)-induced product were theoretically studied based on density functional theory (DFT) and the time-dependent DFT (TDDFT) explored at the B3LYP/6-311+G (d, p) level. Topics: Acetates; Borates; Coumarins; Fluorescent Dyes; Hydrogen-Ion Concentration; Ions; Spectrometry, Fluorescence; Thimerosal; Water	2013

Article

Year

Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs.

European journal of medicinal chemistry, 2014, Apr-22, Volume: 77

Asthma is a chronic inflammatory disorder that causes contraction in the smooth muscle of the airway and blocking of airflow. Reversal the contractile process is a strategy for the search of new drugs that could be used for the treatment of asthma. This work reports the semisynthesis, ex vivo relaxing evaluation and SAR studies of a series of 18 coumarins. The results pointed that the ether derivatives 1-3, 7-9 and 13-15 showed the best activity (Emax = 100%), where compound 2 (42 μM) was the most potent, being 4-times more active than theophylline (positive control). The ether homologation (methyl, ethyl and propyl) in position 7 or positions 6 and 7 of coumarins lead to relaxing effect, meanwhile formation of esters generated less active compounds than ethers. The SAR analysis showed that it is necessary the presence of two small ether groups and the methyl group at position 4 (site 3) encourage biological activity through soft hydrophobic changes in the molecule, without drastically affecting the cLogP.

Topics: Animals; Anti-Asthmatic Agents; Coumarins; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Models, Molecular; Molecular Structure; Rats; Rats, Wistar; Structure-Activity Relationship; Trachea

2014

A highly selective fluorescent probe for BO3(-) based on acetate derivatives of coumarin in aqueous solution and thimerosal.

The Analyst, 2013, Feb-21, Volume: 138, Issue:3

The acetate derivatives of coumarin exhibited a prominent turn-on type signaling behavior toward BO(3)(-) ions over other common anions. Signaling is based on the selective deprotection of acetate groups by perborate, which resulted in significant fluorogenic signaling in an acetate buffered solution (pH 5.0). Interestingly, the detection process makes the raw material of 7-hydroxycoumarin regenerate, and the probe could be applied for the detection of BO(3)(-) of thimerosal. Furthermore, the optical properties of the probe and its BO(3)(-)-induced product were theoretically studied based on density functional theory (DFT) and the time-dependent DFT (TDDFT) explored at the B3LYP/6-311+G (d, p) level.

Topics: Acetates; Borates; Coumarins; Fluorescent Dyes; Hydrogen-Ion Concentration; Ions; Spectrometry, Fluorescence; Thimerosal; Water

2013