Compounds > 7-8-dihydroxy-4-methylcoumarin

7-8-dihydroxy-4-methylcoumarin and quercetin-pentaacetate

7-8-dihydroxy-4-methylcoumarin has been researched along with quercetin-pentaacetate* in 1 studies

Other Studies

1 other study(ies) available for 7-8-dihydroxy-4-methylcoumarin and quercetin-pentaacetate

Article	Year
Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. Bioorganic & medicinal chemistry letters, 2002, Sep-16, Volume: 12, Issue:18 Earlier work carried out in our laboratory highlighted the mode of action of acetoxy 4-methylcoumarins in preventing the genotoxicity of aflatoxin B(1) (AFB(1)). We have in this report extended the observations to quercetin pentaacetate (QPA), which unlike quercetin (Q) has demonstrated time-dependent inhibition of liver microsome catalysed AFB(1) epoxidation as measured by AFB(1) binding to DNA. The action of QPA is similar to that of the acetoxy 4-methylcoumarins in that they are acted upon by microsomal transacetylase leading to modulation of catalytic activities of certain enzymes (such as P-450 enzymes, NADPH cytochrome C reductase and glutathione S-transferase) possibly by way of protein acetylation. In the present work, we have documented the transacetylase-mediated action of QPA in preventing genotoxicity due to AFB(1). Topics: Aflatoxin B1; Animals; Antimutagenic Agents; Bone Marrow Cells; Catalysis; Cytochrome P-450 Enzyme System; Male; Micronucleus Tests; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Quercetin; Rats; Rats, Wistar	2002

Article

Year

Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate.

Bioorganic & medicinal chemistry letters, 2002, Sep-16, Volume: 12, Issue:18

Earlier work carried out in our laboratory highlighted the mode of action of acetoxy 4-methylcoumarins in preventing the genotoxicity of aflatoxin B(1) (AFB(1)). We have in this report extended the observations to quercetin pentaacetate (QPA), which unlike quercetin (Q) has demonstrated time-dependent inhibition of liver microsome catalysed AFB(1) epoxidation as measured by AFB(1) binding to DNA. The action of QPA is similar to that of the acetoxy 4-methylcoumarins in that they are acted upon by microsomal transacetylase leading to modulation of catalytic activities of certain enzymes (such as P-450 enzymes, NADPH cytochrome C reductase and glutathione S-transferase) possibly by way of protein acetylation. In the present work, we have documented the transacetylase-mediated action of QPA in preventing genotoxicity due to AFB(1).

Topics: Aflatoxin B1; Animals; Antimutagenic Agents; Bone Marrow Cells; Catalysis; Cytochrome P-450 Enzyme System; Male; Micronucleus Tests; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Quercetin; Rats; Rats, Wistar

2002