7-8-dihydropterin and 7-8-dihydrobiopterin

7-8-dihydropterin has been researched along with 7-8-dihydrobiopterin* in 2 studies

Other Studies

2 other study(ies) available for 7-8-dihydropterin and 7-8-dihydrobiopterin

ArticleYear
Emission properties of dihydropterins in aqueous solutions.
    Physical chemistry chemical physics : PCCP, 2011, Apr-28, Volume: 13, Issue:16

    Pterins belong to a class of heterocyclic compounds present in a wide range of living systems and accumulate in the skin of patients affected by vitiligo, a depigmentation disorder. The study of the emission of 7,8-dihydropterins is difficult because these compounds are more or less unstable in the presence of O(2) and their solutions are contaminated with oxidized pterins which have much higher fluorescence quantum yields (Φ(F)). In this work, the emission properties of six compounds of the dihydropterin family (6-formyl-7,8-dihydropterin (H(2)Fop), sepiapterin (Sep), 7,8-dihydrobiopterin (H(2)Bip), 7,8-dihydroneopterin (H(2)Nep), 6-hydroxymethyl-7,8-dihydropterin (H(2)Hmp), and 6-methyl-7,8-dihydropterin (H(2)Mep)) have been studied in aqueous solution. The fluorescence characteristics (spectra, Φ(F), lifetimes (τ(F))) of the neutral form of these compounds have been investigated using the single-photon-counting technique. Φ(F) and τ(F) values obtained lie in the ranges 3-9 × 10(-3) and 0.18-0.34 ns, respectively. The results are compared to those previously reported for oxidized pterins.

    Topics: Biopterins; Neopterin; Oxidation-Reduction; Oxygen; Pterins; Quantum Theory; Solutions; Spectrometry, Fluorescence; Water

2011
On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates.
    Archives of biochemistry and biophysics, 1987, May-01, Volume: 254, Issue:2

    The substrate specificity of dihydrofolate reductase from cells of different origin has been thought to be quite narrow, and unconjugated dihydropterins such as 6-methyl-dihydropterin are known to be very poor substrates. We have reinvestigated the substrate specificity of several dihydropterins and, in addition, have observed that in a new series of unconjugated dihydropterins of the general structure 6-CH2O(CH2)nCH3 several compounds are excellent substrates for the bovine liver enzyme, but none of them bind as well as dihydrofolate. The substrate activity (apparent Vmax) of these compounds increases from 17 to 110% that of the natural substrate, dihydrofolate, as n is increased from 0 to 3. In contrast, these unconjugated dihydropterins are very poor substrates for the Escherichia coli enzyme.

    Topics: Animals; Biopterins; Cattle; Folic Acid; Kinetics; Liver; Pteridines; Pterins; Substrate Specificity; Tetrahydrofolate Dehydrogenase

1987