Compounds > 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Page last updated: 2024-08-23

7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and oligonucleotides

7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with oligonucleotides in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's13 (48.15)18.2507
2000's11 (40.74)29.6817
2010's1 (3.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dino, JJ; Guenat, CR; Kaufman, DG; Tomer, KB1
Desai, SM; Harvey, RG; Wei, SJ; Weiss, SB1
Amin, S; Geacintov, NE; Hsu, TM; Liu, TM; Santella, RM1
Ariese, F; Geacintov, NE; Jankowiak, R; Liu, TM; Small, GJ; Suh, M1
Birke, S; Geacintov, NE; Li, B; Mao, B; Swenberg, CE; Xu, J; Xu, R1
Gräslund, A; Jernström, B; Kim, SK; Nordén, B; Pontén, I2
Courtney, SH; Geacintov, NE; Li, B; Mao, B; Margulis, LA; Smirnov, S; Xu, J; Ya, NQ1
Ariese, F; Geacintov, NE; Jankowiak, R; Mao, B; Small, GJ; Suh, M1
Dipple, A; Jerina, DM; Lakshman, MK; Oh-hara, T; Page, JE; Sayer, JM; Zajc, B1
Dipple, A; Jerina, DM; Lipinski, LJ; Ross, HL; Sayer, JM; Zajc, B1
Bohr, VA; Cheh, AM; Cullinane, C; Custer, L; Jerina, DM; Mazur, SJ; Phillips, DR; Sayer, JM; Zajc, B1
Dipple, A; Jerina, DM; Page, JE; Pilcher, AS; Sayer, JM; Yagi, H1
Gräslund, A; Jernström, B; Nordén, B; Pradhan, P; Seidel, A1
Gräslund, A; Jernström, B; Pradhan, P; Seidel, A1
Basu, AK; Geacintov, NE; Hoare, S; Krishnasamy, R; Purohit, V; Skorvaga, M; Van Houten, B; Zou, Y1
Gorenstein, DG; Jerina, DM; Liang, C; Luxon, BA; Rice, JS; Sayer, JM; Volk, DE; Xie, G; Yeh, HJ1
Jerina, DM; Liu, X; Pradhan, P; Sayer, JM; Tirumala, S; Yeh, HJ1
Barker, S; Carnelley, TJ; Le, XC; Tan, WG; Wang, H; Weinfeld, M1
Amin, S; Colgate, KC; Geacintov, NE; Huang, X; Kolbanovskiy, A1
Broyde, S; Geacintov, NE; Perlow, RA; Schinecker, TM; Scicchitano, DA1
Cai, M; Cheh, AM; Chiapperino, D; Hanaoka, F; Jerina, DM; Kroth, H; Masutani, C; Sayer, JM; Yagi, H1
Iyer, PC; Jerina, DM; Sayer, JM; Yagi, H1
Feng, YL; Lian, H; Zhu, J1
Glick, J; Lin, Y; Vouros, P; Xiong, W1
Glick, J; Lin, Y; Noronha, AM; Vouros, P; Wilds, CJ; Xiong, W1
Burrows, CJ; Fleming, AM; Johnson, RP; Perera, RT; White, HS1

Other Studies

27 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and oligonucleotides

ArticleYear
Analyses of carcinogen-modified oligonucleotides by fast atom bombardment/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 1987, Volume: 1, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Oligonucleotides; Spectrometry, Mass, Fast Atom Bombardment

1987
Use of short DNA oligonucleotides for determination of DNA sequence modifications induced by benzo[a]pyrene diol epoxide.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:19

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylation; Base Sequence; Benzopyrenes; Carcinogens; Coliphages; DNA Ligases; DNA Restriction Enzymes; DNA, Recombinant; DNA, Viral; Escherichia coli; Oligodeoxyribonucleotides; Oligonucleotides; Transfection

1984
Determination of stereospecificity of benzo[a]pyrene diolepoxide-DNA antisera with site-specifically modified oligonucleotides.
    Carcinogenesis, 1995, Volume: 16, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Binding Sites; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Humans; Immune Sera; Molecular Sequence Data; Oligonucleotides; Sensitivity and Specificity; Stereoisomerism

1995
Conformational studies of the (+)-trans, (-)-trans, (+)-cis, and (-)-cis adducts of anti-benzo[a]pyrene diolepoxide to N2-dG in duplex oligonucleotides using polyacrylamide gel electrophoresis and low-temperature fluorescence spectroscopy.
    Biophysical chemistry, 1995, Volume: 56, Issue:3

    Topics: Base Sequence; Benzo(a)pyrene; Benzopyrenes; Biophysical Phenomena; Biophysics; Chemical Phenomena; Chemistry, Physical; DNA Adducts; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Oligonucleotides; Spectrometry, Fluorescence; Stereoisomerism; Temperature

1995
Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions.
    Nucleic acids research, 1995, Jun-25, Volume: 23, Issue:12

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphate; Base Sequence; DNA Damage; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides; Spectrum Analysis; Stereoisomerism

1995
Synthesis and characterization of a (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide-oligonucleotide adduct.
    IARC scientific publications, 1994, Issue:125

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; DNA Adducts; Drug Stability; Molecular Sequence Data; Oligonucleotides

1994
Synthesis and characterization of covalent adducts derived from the binding of benzo[a]pyrene diol expoxide to a -GGG- sequence in a deoxyoligonucleotide.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Electrophoresis; Molecular Sequence Data; Oligonucleotides; Spectrometry, Fluorescence

1995
Spectroscopic studies of the trans adducts derived from (+)- and (-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC).
    Carcinogenesis, 1994, Volume: 15, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Binding Sites; DNA Adducts; Drug Stability; Hot Temperature; Molecular Sequence Data; Oligonucleotides; Osmolar Concentration; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship

1994
Flanking base effects on the structural conformation of the (+)-trans-anti-benzo[a]pyrene diolepoxide adduct to N2-dG in sequence-defined oligonucleotides.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Cold Temperature; DNA Adducts; DNA Damage; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Mutation; Nucleic Acid Conformation; Oligonucleotides

1994
Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies.
    Biochemistry, 1998, Jun-23, Volume: 37, Issue:25

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bacteriophage M13; Base Sequence; DNA Adducts; Genetic Vectors; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Mutagens; Oligonucleotides; Purine Nucleosides; Stereoisomerism; Transfection

1998
Effect of single benzo[a]pyrene diol epoxide-deoxyguanosine adducts on the action of DNA polymerases in vitro.
    International journal of oncology, 1998, Volume: 13, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Replication; Mutation; Oligonucleotides; Templates, Genetic

1998
Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence.
    Biochemistry, 1999, Jan-12, Volume: 38, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bacteriophage T3; Base Sequence; Cell Line, Transformed; Cell Nucleus; Codon; DNA Adducts; DNA Repair; DNA-Directed RNA Polymerases; Genes, ras; Humans; Lymphocytes; Molecular Sequence Data; Oligonucleotides; Stereoisomerism; Transcription, Genetic

1999
Mutational consequences of replication of M13mp7L2 constructs containing cis-opened benzo[a]pyrene 7,8-diol 9, 10-epoxide-deoxyadenosine adducts.
    Chemical research in toxicology, 1999, Volume: 12, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bacteriophage M13; Circular Dichroism; Coliphages; Deoxyadenosines; DNA Adducts; Escherichia coli; Mutation; Oligonucleotides; Spectrophotometry, Ultraviolet; Transfection; Ultraviolet Rays

1999
Studies on the adduct heterogeneity of benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.
    Chemical research in toxicology, 1999, Volume: 12, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Binding Sites; Circular Dichroism; Deoxyribonucleotides; DNA Adducts; Nucleic Acid Conformation; Oligonucleotides; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature

1999
Implications of cytosine methylation on (+)-anti-Benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide N(2)-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
    Chemical research in toxicology, 1999, Volume: 12, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens; Cytosine; Deoxyguanosine; DNA; DNA Adducts; DNA, Single-Stranded; Methylation; Molecular Sequence Data; Oligonucleotides; Thermodynamics

1999
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
    Biochemistry, 2000, Oct-10, Volume: 39, Issue:40

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Carcinogens; Chrysenes; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; Oligonucleotides; Protein Binding; Pyrenes; Substrate Specificity; Ultraviolet Rays

2000
NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex.
    Biochemistry, 2000, Nov-21, Volume: 39, Issue:46

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chrysenes; Crystallography, X-Ray; Deoxyadenosines; DNA Adducts; Intercalating Agents; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Oligonucleotides; Protein Conformation; Protons; Stereoisomerism; Thermodynamics

2000
Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.
    Biochemistry, 2001, May-22, Volume: 40, Issue:20

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Deoxyadenosines; DNA; DNA Adducts; Hydrocarbons; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Oligonucleotides; Protons; Solutions; Spectrophotometry, Ultraviolet; Stereoisomerism; Thermodynamics

2001
Synthesis, characterization, and applications of a fluorescent probe of DNA damage.
    Chemical research in toxicology, 2001, Volume: 14, Issue:11

    Topics: Antibodies; Benzopyrenes; DNA Damage; Electrophoresis; Fluorescent Dyes; Humans; Immunoassay; Lung Neoplasms; Oligonucleotides; Sensitivity and Specificity; Tumor Cells, Cultured

2001
Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: 5-Methylcytosine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; CpG Islands; Cytosine; Deoxyguanosine; DNA Adducts; Electrophoretic Mobility Shift Assay; Fluorescence; Hot Temperature; Methylation; Molecular Conformation; Oligonucleotides; Stereoisomerism

2002
Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.
    Nucleic acids research, 2003, Oct-15, Volume: 31, Issue:20

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Catalytic Domain; DNA Adducts; Humans; Models, Molecular; Molecular Structure; Oligonucleotides; Protein Conformation; RNA Polymerase II; Templates, Genetic; Time Factors; Transcription, Genetic

2003
Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
    The Journal of biological chemistry, 2005, Dec-02, Volume: 280, Issue:48

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Pair Mismatch; Deoxyadenosines; DNA; DNA Adducts; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Humans; Hydrocarbons; Hydrogen; Kinetics; Models, Chemical; Mutation; Nucleic Acid Conformation; Oligonucleotides; Sequence Analysis, DNA

2005
3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
    Chemical research in toxicology, 2007, Volume: 20, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chromatography, High Pressure Liquid; Deoxyguanosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Oligonucleotides; Organophosphonates; Sensitivity and Specificity; Stereoisomerism; Time Factors

2007
Application of pressure assisted electrokinetic injection technique in the measurements of DNA oligonucleotides and their adducts using capillary electrophoresis-mass spectrometry.
    Journal of chromatography. A, 2007, May-04, Volume: 1148, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; DNA; DNA Adducts; Electrophoresis, Capillary; Mass Spectrometry; Oligonucleotides; Reproducibility of Results

2007
Separation and sequencing of isomeric oligonucleotide adducts using monolithic columns by ion-pair reversed-phase nano-HPLC coupled to ion trap mass spectrometry.
    Analytical chemistry, 2007, Jul-15, Volume: 79, Issue:14

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Humans; Nanotechnology; Oligonucleotides; Polystyrenes; Sequence Analysis, DNA; Spectrometry, Mass, Electrospray Ionization

2007
The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS.
    Journal of mass spectrometry : JMS, 2009, Volume: 44, Issue:8

    Topics: 5-Methylcytosine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analytic Sample Preparation Methods; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Codon; Cytosine; DNA; DNA Adducts; DNA Methylation; Genes, p53; Guanine; Humans; Microchemistry; Mutagens; Oligonucleotides; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2009
Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore.
    Nanotechnology, 2015, Feb-20, Volume: 26, Issue:7

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Benzo(a)pyrene; DNA Adducts; DNA, Single-Stranded; Genome; Glass; Guanine; Hemolysin Proteins; Humans; Ions; Lipid Bilayers; Metals; Mutagenesis; Mutagens; Nanopores; Nanotechnology; Neoplasms; Oligonucleotides

2015