Compounds > 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
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7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and deoxyguanosine

7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with deoxyguanosine in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199017 (21.25)18.7374
1990's18 (22.50)18.2507
2000's30 (37.50)29.6817
2010's15 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alexandrov, K; Levis, AG; Paleologo, M; Pavanello, S; Rojas, M1
Baird, WM; Merrick, BA; Nikbakht, A; Pruess-Schwartz, D; Selkirk, JK1
Calloway, K; Irigaray, MF; Kaufman, DG; Kulkarni, MS1
Huckle, KR; Smith, RJ; Watson, WP; Wright, AS1
Alexandrov, K; Rojas, M1
Fahl, WE; Iannaccone, P; Warner, MR1
Goodwin, GH; Grover, PL; Lobanenkov, VV; Plumb, M1
Asokan, P; Bickers, DR; Das, M; Mukhtar, H; Santella, RM1
Garner, RC; Martin, CN; Tierney, B1
MacLeod, MC; Zachary, KL1
Anderson, MW; Bend, JR; Horton, JK; Rosenior, JC1
Kakunaga, T; Lo, K1
Alexandrov, K; Bourgeois, Y; Chouroulinkov, I; Rojas, M1
Heisig, V; Jeffrey, AM; McGlade, MJ; Small, GJ1
Broyde, S; Hingerty, B1
Brookes, P; Harvey, RG; Jacobs, S; Osborne, MR1
Baird, WM; Diamond, L; Knowles, BB; Sebti, SM1
Hageman, GJ; Kleinjans, JC; Maas, LM; Stierum, RH; van Herwijnen, MH1
Geacintov, NE; Liu, TM; Van Houten, B; Zou, Y1
Chu, Y; Hurtubise, RJ1
Bowman, ED; Doan, VT; Harrington, AM; Shields, PG; Weston, A1
Harvey, RG; Penning, TM; Shou, M1
Boerrigter, ME; Vijg, J; Wei, JY; Yin, Y1
Broyde, S; Cosman, M; de los Santos, C; Fiala, R; Geacintov, NE; Harvey, R; Hingerty, BE; Ibanez, V; Luna, E; Patel, DJ1
Geacintov, NE; Kolbanovskiy, A; Kuzmin, VA; MacLeod, MC; Powell, KL1
Gorenstein, DG; Jerina, DM; Liu, X; Luxon, BA; Rice, JS; Sayer, JM; Schwartz, JL; Xie, G; Yeh, HJ1
Broyde, S; Feng, B; Geacintov, NE; Gorin, A; Hingerty, BE; Kolbanovskiy, A; Patel, DJ1
Amin, S; Geacintov, NE; Mao, B; Tsao, H; Xu, R; Zhuang, P1
Jang, JJ; Kim, HS; Lee, BM1
Dipple, A; Jerina, DM; Lipinski, LJ; Ross, HL; Sayer, JM; Zajc, B1
Amin, S; Fernandes, A; Geacintov, NE; Grollman, AP; Liu, T; Moriya, M1
Kozack, RE; Loechler, EL1
Kozack, RE; Loechler, EL; Shukla, R1
Chang, RL; Conney, AH; Cui, XX; Dandamudi, N; Jerina, DM; Lu, YP; Merkler, KA; Sayer, JM; Wei, SJ; Wong, CQ1
Gräslund, A; Jernström, B; Pradhan, P; Seidel, A1
Jerina, DM; Kroth, H; Seidel, A; Yagi, H1
Basu, AK; Geacintov, NE; Hoare, S; Krishnasamy, R; Purohit, V; Skorvaga, M; Van Houten, B; Zou, Y1
Jenq, SN; Kang, ZC; Lee, H; Yang, SC1
Jerina, DM; Kroth, H; Ramesha, AR1
Geacintov, NE; Luo, C; Zou, Y1
Amin, S; Geacintov, NE; Kolbanovskiy, A; Zhuang, P1
Meehan, T; Vock, EH; Wolfe, AR1
Dipple, A; Jerina, DM; Kroth, H; Pontén, I; Sayer, JM1
Cheh, AM; Chiapperino, D; Hanaoka, F; Jerina, DM; Kramarczuk, IH; Kroth, H; Masutani, C; Sayer, JM1
Amin, S; Colgate, KC; Geacintov, NE; Huang, X; Kolbanovskiy, A1
Geacintov, NE; Grollman, AP; Kolbanovskiy, A; Ohashi, E; Ohmori, H; Shibutani, S; Suzuki, N1
Hinkle, DC; Jerina, DM; Kramata, P; Sayer, JM; Simhadri, S; Wei, CS; Zajc, B1
Jerina, DM; Kramata, P; Sayer, JM; Wei, CS; Zajc, B1
Amin, R; Jerina, DM; Johnson, AA; Kalena, GP; Pommier, Y; Sayer, JM; Yagi, H1
Jerina, DM; Karle, IL; Sayer, JM; Yagi, H1
Banasiewicz, M; Grubor, N; Jankowiak, R; Jiang, G; Skorvaga, M; Small, GJ; States, JC; Van Houten, B1
Alexandrov, K; Cascorbi, I; Grosdidier, G; Marie, B; Martinet, N; Rojas, M; Siat, J; Vignaud, JM1
Jones, R; Matter, B; Tretyakova, N; Wang, G1
Kim, HS; Kwack, SJ; Lee, BM1
Gao, D; Goldwyn, B; Guevara, D; Lebwohl, M; Lu, Y; Luo, Y; Rui, M; Smith, EC; Wang, Y; Wei, H1
Hilmer, JH; Keeler, JC; Lakshman, MK; Ngassa, FN; Pradhan, P; Thomasson, KA; Zajc, B1
Chang, JH; Cheng, YW; Chiang, CC; Chou, MC; Lai, TJ; Lee, H; Tsai, YY1
Iyer, PC; Jerina, DM; Sayer, JM; Yagi, H1
Chinnappan, R; Dang, NC; Grubor, NM; Jankowiak, R; Matter, B; Miksa, B; Reppert, M; Tretyakova, N1
Jerina, DM; Yagi, H1
Feng, F; Song, M; Wang, H; Yin, J1
Egly, JM; Geacintov, N; Mocquet, V1
Guza, R; Matter, B; Tretyakova, N1
Feng, F; Le, XC; Li, T; Wang, C; Wang, H; Wang, Z1
Feng, F; Wang, H; Wang, X; Yuan, H1
Feng, F; Li, T; Wang, C; Wang, H; Wang, Z1
Bouchard, M; Maître, A; Marie-Desvergne, C; Ravanat, JL; Viau, C1
Fujimoto, H; Grúz, P; Gupta, RC; Johnson, F; Katafuchi, A; Niimi, N; Nohmi, T; Ohta, T; Sassa, A; Yasui, M1
Amin, S; Dissanayake, T; Giambasu, GM; Guza, R; Hudson, RH; Jankowiak, R; Jones, R; Kotandeniya, D; Lad, RR; Lin, C; Murphy, K; Sturla, SJ; Tretyakova, NY; Wojciechowski, F; York, DM1
Akagi, J; Cho, Y; de Wind, N; Hanaoka, F; Hashimoto, K; Moriya, M; Ohashi, E; Ohmori, H; Tateishi, S; Yang, IY1
Deng, Q; Guan, L; Guo, H; Hu, D; Huang, K; Kuang, D; Wu, T; Zhang, W; Zhang, X1
Song, M; Wang, H; Wang, Z; Yin, J; Zhao, C1
Friedberg, E; Guo, C; Liu, Y; Tang, TS; Wang, Z; Yang, W; Yang, Y; Zhang, H1
Adachi, N; Fujimoto, H; Grúz, P; Gupta, RC; Honma, M; Johnson, F; Kanemaru, Y; Katafuchi, A; Niimi, N; Nohmi, T; Ohta, T; Sassa, A; Suzuki, T; Yasui, M1
Farmer, PB; Hedebrant, U; Koukouves, G; Kyrtopoulos, S; Segerbäck, D; Singh, R; Souliotis, VL; Törnqvist, MÅ; Westberg, EA1
Liu, S; Wang, H; Zhang, D1
Geacintov, NE; Kolbanovskiy, A; Lavrik, OI; Lebedeva, NA; Rechkunova, NI; Starostenko, LV1
Barret, JT; Flarakos, C; Glick, J; Klaene, JJ; Vouros, P; Zarbl, H1
Guo, C; Liu, Y; Ma, X1
Abdullatif, MM; Alghobary, HAF; Fathy, MM; Hafez, SF; Rashed, LA; Samir, AM; Shaker, DA1

Other Studies

80 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and deoxyguanosine

ArticleYear
Evidence for substantial formation of r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene- deoxyguanosine in human lymphocytes treated in vitro with benzo[a]pyrene.
    Carcinogenesis, 1989, Volume: 10, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Benzo(a)pyrene; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Humans; Lymphocytes; Tritium

1989
Benzo(a)pyrene:DNA adduct formation in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Breast; Breast Neoplasms; Carcinoma; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA, Neoplasm; Epithelium; Female; Humans; Hydrolysis; Tritium

1986
Species differences in the formation of benzo(a)pyrene-DNA adducts in rodent and human endometrium.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Deoxyguanosine; DNA; DNA Adducts; Endometrium; Female; Humans; Mesocricetus; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity

1986
Comparison of hydrocarbon-DNA adducts formed in mouse skin in vivo and in organ culture in vitro following treatment with benzo[a]pyrene.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carbon Radioisotopes; Deoxyguanosine; DNA; Female; Mice; Mice, Inbred Strains; Organ Culture Techniques; Skin; Stereoisomerism; Tritium

1986
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
    Carcinogenesis, 1986, Volume: 7, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Male; Mice; Rats; Rats, Inbred Strains; Skin; Stereoisomerism; Tritium

1986
Human fibroblast chromatin states as effectors of the DNA-binding characteristics of benzo[a]pyrene anti-7,8-dihydrodiol 9,10-epoxide and two nonalkylating DNA-binding molecules.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Chromatin; Chromomycin A3; Chromomycins; Chromosomes; Deoxyguanosine; DNA; Ethidium; Fibroblasts; Humans; Mitosis; Nucleic Acid Conformation; Tritium

1986
The effect of neighbouring bases on G-specific DNA cleavage mediated by treatment with the anti-diol epoxide of benzo[a]pyrene in vitro.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts

1986
Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of SENCAR mice following topical application of crude coal tar.
    Cancer letters, 1986, Volume: 33, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Coal Tar; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Epidermis; Lung; Male; Mice; Skin Neoplasms

1986
Topical treatment of mice with benzo[a]pyrene or parenteral administration of benzo[a]pyrene diol epoxide-DNA to rats results in faecal excretion of a putative benzo[a]pyrene diol epoxide-deoxyguanosine adduct.
    Carcinogenesis, 1987, Volume: 8, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Environmental Monitoring; Feces; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Smoking

1987
Involvement of the exocyclic amino group of deoxyguanosine in DNA-catalysed carcinogen detoxification.
    Carcinogenesis, 1985, Volume: 6, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Composition; Benzopyrenes; Carcinogens; Deoxyguanosine; DNA; Humans; Hydrolysis; Inactivation, Metabolic; Nucleic Acid Conformation

1985
Quantitation of benzo(a)pyrene metabolite: DNA adducts in selected hepatic and pulmonary cell types isolated from [3H]benzo(a)pyrene-treated rabbits.
    Cancer research, 1985, Volume: 45, Issue:8

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA; Liver; Lung; Male; Protein Binding; Rabbits

1985
Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
    Biochemical and biophysical research communications, 1981, Apr-15, Volume: 99, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Repair; Humans

1981
The persistence of benzo[a]pyrene diol-epoxide deoxyguanosine adduct in mouse skin and its disappearance in rat skin.
    Carcinogenesis, 1983, Volume: 4, Issue:12

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Deoxyguanosine; DNA; Kinetics; Male; Mice; Rats; Rats, Inbred Strains; Skin; Species Specificity; Tritium

1983
Fluorescence-line-narrowed spectra of polycyclic aromatic carcinogen-DNA adducts.
    Science (New York, N.Y.), 1984, Jan-20, Volume: 223, Issue:4633

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; Spectrometry, Fluorescence

1984
A conformational analysis of the (+) anti BPDE adduct to the guanine amino group of dCpdG.
    Journal of biomolecular structure & dynamics, 1983, Volume: 1, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Binding Sites; Deoxycytosine Nucleotides; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; Electrochemistry; Molecular Conformation; Stereoisomerism; Thermodynamics

1983
Minor products from the reaction of (+) and (-) benzo[a]-pyrene-anti-diolepoxide with DNA.
    Carcinogenesis, 1981, Volume: 2, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA; DNA, Bacterial; Escherichia coli; Hydrolysis; Stereoisomerism

1981
Benzo[a]pyrene--DNA adduct formation in target cells in a cell-mediated mutation assay.
    Carcinogenesis, 1982, Volume: 3, Issue:11

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Binding Sites; Biotransformation; Cell Line; Cell Separation; Cricetinae; Cricetulus; Deoxyguanosine; DNA; Embryo, Mammalian; Isomerism; Lung; Mesocricetus; Mutagenicity Tests; Mutagens

1982
Measurement by 32P-postlabeling of (+/-)anti-benzo[a]pyrene-diolepoxide-N2-deoxyguanosine adduct persistence in unstimulated human peripheral blood lymphocytes.
    Mutation research, 1994, Volume: 325, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA Repair; Humans; Lymphocytes; Phosphorus Radioisotopes

1994
Interaction of the UvrABC nuclease system with a DNA duplex containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE.
    Biochemistry, 1995, Oct-17, Volume: 34, Issue:41

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Binding Sites; Deoxyguanosine; DNA; DNA Adducts; DNA Helicases; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Binding; Protein Conformation; Stereoisomerism; Substrate Specificity

1995
Comparison of the solid-matrix luminescence properties and photophysical parameters of two products from benzo(a)pyrene-DNA adducts.
    Photochemistry and photobiology, 1994, Volume: 59, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Deoxyguanosine; DNA; DNA Adducts; Luminescence; Photochemistry; Quantum Theory; Spectrometry, Fluorescence

1994
Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes.
    Cancer research, 1993, Aug-01, Volume: 53, Issue:15

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Cytochrome P-450 Enzyme System; Deoxyguanosine; Disease Susceptibility; DNA; DNA Adducts; Genotype; Glutathione Transferase; Humans; Lung; Molecular Sequence Data; Mutation; Polycyclic Compounds; Polymorphism, Genetic

1993
Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
    Carcinogenesis, 1993, Volume: 14, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cattle; Deoxyguanosine; DNA; DNA Adducts; Estrogens, Catechol

1993
DNA repair in congenic mice: possible influence of a chromosome 4 genetic region on the rate of benzo[a]pyrene-induced DNA adduct removal.
    Journal of gerontology, 1993, Volume: 48, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Chromosomes; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; Genes; Life Expectancy; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Nucleotides

1993
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.
    Biochemistry, 1993, Apr-27, Volume: 32, Issue:16

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Composition; Base Sequence; Benzo(a)pyrene; Deoxyguanosine; DNA; Hydrogen Bonding; Intercalating Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solutions; Thermodynamics

1993
Interference of benzo[a]pyrene diol epoxide-deoxyguanosine adducts in a GC box with binding of the transcription factor Sp1.
    Molecular carcinogenesis, 1996, Volume: 16, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Binding Sites; Deoxyguanosine; DNA Adducts; DNA-Binding Proteins; HeLa Cells; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Protein Binding; Sp1 Transcription Factor

1996
Solution structure of the minor conformer of a DNA duplex containing a dG mismatch opposite a benzo[a]pyrene diol epoxide/dA adduct: glycosidic rotation from syn to anti at the modified deoxyadenosine.
    Biochemistry, 1997, Sep-16, Volume: 36, Issue:37

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens, Environmental; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; Glycosides; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Solutions

1997
Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
    Biochemistry, 1997, Nov-11, Volume: 36, Issue:45

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Composition; Benzo(a)pyrene; Crystallography, X-Ray; Deoxyguanosine; DNA Adducts; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Polydeoxyribonucleotides; Protons; Sequence Deletion; Solutions

1997
Sequence dependence and characteristics of bends induced by site-specific polynuclear aromatic carcinogen-deoxyguanosine lesions in oligonucleotides.
    Biochemistry, 1998, Apr-07, Volume: 37, Issue:14

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Carcinogens; Deoxyguanosine; Deoxyribonuclease BamHI; DNA Adducts; Nucleic Acid Conformation; Oligodeoxyribonucleotides

1998
Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma.
    Cancer letters, 1998, Mar-13, Volume: 125, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Deoxyguanosine; DNA Adducts; DNA Damage; Female; Humans; Male; Middle Aged; Stomach Neoplasms

1998
Effect of single benzo[a]pyrene diol epoxide-deoxyguanosine adducts on the action of DNA polymerases in vitro.
    International journal of oncology, 1998, Volume: 13, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Replication; Mutation; Oligonucleotides; Templates, Genetic

1998
Mutagenic potential of stereoisomeric bay region (+)- and (-)-cis-anti-benzo[a]pyrene diol epoxide-N2-2'-deoxyguanosine adducts in Escherichia coli and simian kidney cells.
    Biochemistry, 1998, Jul-14, Volume: 37, Issue:28

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Bay-Region, Polycyclic Aromatic Hydrocarbon; COS Cells; Deoxyguanosine; DNA Adducts; Escherichia coli; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Stereoisomerism; Transformation, Genetic

1998
Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis.
    Carcinogenesis, 1999, Volume: 20, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Deoxyguanosine; DNA Adducts; Mutagenesis; Nucleic Acid Conformation; Point Mutation; Thermodynamics

1999
A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G-->T versus G-->A mutations based upon a correlation between mutagenesis and molecular modeling results.
    Carcinogenesis, 1999, Volume: 20, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Computer Simulation; Deoxyguanosine; DNA Adducts; Models, Molecular; Mutagenesis; Nucleic Acid Conformation; Nucleic Acid Hybridization; Point Mutation; Thermodynamics

1999
The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose.
    International journal of oncology, 1999, Volume: 14, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Carcinogens; Cattle; Cells, Cultured; Cricetinae; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; Thymus Gland

1999
Implications of cytosine methylation on (+)-anti-Benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide N(2)-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
    Chemical research in toxicology, 1999, Volume: 12, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens; Cytosine; Deoxyguanosine; DNA; DNA Adducts; DNA, Single-Stranded; Methylation; Molecular Sequence Data; Oligonucleotides; Thermodynamics

1999
New and highly efficient synthesis of cis- and trans-opened Benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic N(2)-amino group of deoxyguanosine.
    The Journal of organic chemistry, 2000, Sep-08, Volume: 65, Issue:18

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; Spectrum Analysis

2000
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
    Biochemistry, 2000, Oct-10, Volume: 39, Issue:40

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Carcinogens; Chrysenes; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; Oligonucleotides; Protein Binding; Pyrenes; Substrate Specificity; Ultraviolet Rays

2000
Identification of benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine in human lung adenocarcinoma cells exposed to cooking oil fumes from frying fish under domestic conditions.
    Chemical research in toxicology, 2000, Volume: 13, Issue:10

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Air; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Deoxyguanosine; DNA Adducts; Humans; Isotope Labeling; Lung Neoplasms; Mass Spectrometry; Oils; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons; Tumor Cells, Cultured

2000
Solvent-free synthesis of benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the N(2)-position of deoxyguanosine.
    Organic letters, 2001, Feb-22, Volume: 3, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; Molecular Conformation; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2001
Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair.
    Biochemistry, 2001, Mar-06, Volume: 40, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphate; Base Pairing; Base Sequence; Benzo(a)pyrene; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Hydrolysis; Molecular Sequence Data; Mutagens; Substrate Specificity

2001
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
    Biochemistry, 2001, Jun-05, Volume: 40, Issue:22

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Carcinogens, Environmental; Catalysis; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Damage; DNA Polymerase I; DNA Primers; DNA Replication; Guanine; Kinetics; Mutagenesis; Mutagens; Polydeoxyribonucleotides; Pyrimidine Nucleotides; Sequence Analysis, DNA; Templates, Genetic; Thymine Nucleotides

2001
Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin.
    Mutation research, 2001, Jul-01, Volume: 478, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Deoxyadenosines; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Epidermis; Male; Mice; Mice, Inbred C57BL; Mutagens; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Skin; Stereoisomerism

2001
Differences between the mutational consequences of replication of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyguanosine adducts in M13mp7L2 constructs.
    Chemical research in toxicology, 2001, Volume: 14, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Sequence; Amino Acid Substitution; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Escherichia coli; Humans; Isomerism; Molecular Sequence Data; Mutagenicity Tests; Transfection

2001
Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts.
    The Journal of biological chemistry, 2002, Apr-05, Volume: 277, Issue:14

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Binding Sites; Deoxyguanosine; DNA Adducts; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Purines; Stereoisomerism

2002
Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: 5-Methylcytosine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; CpG Islands; Cytosine; Deoxyguanosine; DNA Adducts; Electrophoretic Mobility Shift Assay; Fluorescence; Hot Temperature; Methylation; Molecular Conformation; Oligonucleotides; Stereoisomerism

2002
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).
    Biochemistry, 2002, May-14, Volume: 41, Issue:19

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Deoxyguanosine; DNA; DNA Damage; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Humans; In Vitro Techniques; Proteins; Recombinant Proteins; Stereoisomerism; Substrate Specificity

2002
Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase zeta in vitro.
    Mutation research, 2002, Oct-31, Volume: 508, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; DNA-Directed DNA Polymerase; Fungal Proteins; Hypoxanthine Phosphoribosyltransferase; Templates, Genetic; Yeasts

2002
A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA.
    The Journal of biological chemistry, 2003, Apr-25, Volume: 278, Issue:17

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Cell Line; Cricetinae; Deoxyguanosine; DNA; DNA Adducts; DNA Mutational Analysis; DNA Repair; Genetic Vectors; Hypoxanthine Phosphoribosyltransferase; Mutagenesis; Mutation; Stereoisomerism; Transfection

2003
Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.
    The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Binding Sites; Deoxyguanosine; DNA; DNA, Viral; HIV Integrase; Magnetic Resonance Spectroscopy; Recombinant Proteins

2004
Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformation.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Feb-10, Volume: 101, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Circular Dichroism; Deoxyguanosine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation

2004
Supercoiled DNA promotes formation of intercalated cis-N2-deoxyguanine adducts and base-stacked trans-N2-deoxyguanine adducts by (+)-7R,8S-dihydrodiol-9S,10R-epoxy-7,8,9,10-tetra- hydrobenzo[a]pyrene.
    Chemical research in toxicology, 2004, Volume: 17, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; DNA, Superhelical; Intercalating Agents; Mutagens; Oligonucleotide Probes

2004
High DNA damage by benzo[a]pyrene 7,8-diol-9,10-epoxide in bronchial epithelial cells from patients with lung cancer: comparison with lung parenchyma.
    Cancer letters, 2004, Apr-30, Volume: 207, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Bronchi; Carcinogens; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Epithelial Cells; Female; Humans; Lung Neoplasms; Male; Middle Aged

2004
Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences.
    Chemical research in toxicology, 2004, Volume: 17, Issue:6

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Genes, p53; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Stereoisomerism

2004
Age-related changes in oxidative DNA damage and benzo(a)pyrene diolepoxide-I (BPDE-I)-DNA adduct levels in human stomach.
    Journal of toxicology and environmental health. Part A, 2005, Oct-08, Volume: 68, Issue:19

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Benzopyrenes; Child; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; DNA Damage; Female; Gastric Mucosa; Humans; Linear Models; Male; Middle Aged; Stomach Neoplasms

2005
Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2'-deoxyguanosine via reactive oxygen species.
    Free radical biology & medicine, 2005, Nov-01, Volume: 39, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzo(a)pyrene; Benzopyrenes; Deoxyguanosine; DNA; DNA Damage; Female; Mice; Mice, Inbred Strains; Microsomes; Reactive Oxygen Species; Singlet Oxygen; Superoxides; Ultraviolet Rays

2005
Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis.
    Journal of the American Chemical Society, 2007, Jan-10, Volume: 129, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Carcinogens; Deoxyadenosines; Deoxyguanosine; DNA Adducts; Mathematical Computing; Nucleosides; Stereoisomerism

2007
An association between BPDE-like DNA adduct levels and P53 gene mutation in pterygium.
    Molecular vision, 2006, Dec-24, Volume: 12

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Aged, 80 and over; Deoxyguanosine; DNA Adducts; Female; Genes, p53; Guanine; Humans; Immunohistochemistry; Male; Middle Aged; Mutation; Pterygium; Staining and Labeling; Thymine; Tissue Distribution; Tumor Suppressor Protein p53

2006
3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
    Chemical research in toxicology, 2007, Volume: 20, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chromatography, High Pressure Liquid; Deoxyguanosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Oligonucleotides; Organophosphonates; Sensitivity and Specificity; Stereoisomerism; Time Factors

2007
Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts.
    Chemical research in toxicology, 2007, Volume: 20, Issue:8

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies, Monoclonal; Base Sequence; Benzopyrenes; Binding Sites; Deoxyguanosine; DNA Adducts; Electrophoresis, Capillary; Immunoassay; Molecular Conformation; Spectrometry, Fluorescence; Stereoisomerism; Time Factors

2007
Fluorinated alcohol mediated displacement of the C10 acetoxy group of benzo[a]pyrene-7,8,9,10-tetrahydrotetraol tetraacetates: a new route to diol epoxide-deoxyguanosine adducts.
    The Journal of organic chemistry, 2007, Dec-21, Volume: 72, Issue:26

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Deoxyguanosine; DNA Adducts; Hydrolysis; Molecular Conformation; Organosilicon Compounds; Propanols; Stereoisomerism; Trifluoroethanol

2007
Preparation, identification and analysis of stereoisomeric anti-benzo[a]pyrene diol epoxide-deoxyguanosine adducts using phenyl liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection.
    Journal of chromatography. A, 2008, Mar-07, Volume: 1183, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chromatography, High Pressure Liquid; Circular Dichroism; Deoxyguanosine; DNA Adducts; Spectrometry, Fluorescence; Stereoisomerism; Tandem Mass Spectrometry

2008
[A cigarette, an aromatic...and a cancer].
    Medecine sciences : M/S, 2008, Volume: 24, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Hot Temperature; Humans; Lung Neoplasms; Smoking; Structure-Activity Relationship; Substrate Specificity

2008
Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts.
    Nucleic acids symposium series (2004), 2008, Issue:52

    Topics: 5-Methylcytosine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Pairing; Carcinogens; CpG Islands; Cytosine; Deoxyguanosine; DNA Adducts; DNA Methylation; Genes, p53; Guanine; Stereoisomerism

2008
Synthesis and characterization of DNA fluorescent probes containing a single site-specific stereoisomer of anti-benzo[a]pyrene diol epoxide-N2-dG.
    Chemical research in toxicology, 2009, Volume: 22, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies, Monoclonal; Deoxyguanosine; DNA Probes; Fluorescent Dyes; Stereoisomerism

2009
Ultra-performance liquid chromatography-tandem mass spectrometry for rapid and highly sensitive analysis of stereoisomers of benzo[a]pyrene diol epoxide-DNA adducts.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Jul-15, Volume: 877, Issue:22

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Cell Line, Tumor; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Humans; Mutagens; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry

2009
Quantitative study of stereospecific binding of monoclonal antibody to anti-benzo(a)pyrene diol epoxide-N(2)-dG adducts by capillary electrophoresis immunoassay.
    Journal of chromatography. A, 2010, Apr-09, Volume: 1217, Issue:15

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies, Monoclonal; Binding, Competitive; Cell Line, Tumor; Deoxyguanosine; DNA Adducts; Electrophoresis, Capillary; Fluorescence; Genome, Human; Humans; Immunoassay; Lasers; Linear Models; Rhodamines; Stereoisomerism

2010
Evaluation of DNA adducts, DNA and RNA oxidative lesions, and 3-hydroxybenzo(a)pyrene as biomarkers of DNA damage in lung following intravenous injection of the parent compound in rats.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Injections, Intravenous; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; RNA; Tandem Mass Spectrometry; Time Factors

2010
Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa.
    Mutation research, 2011, Jan-10, Volume: 718, Issue:1-2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Substitution; Base Sequence; Benzo(a)pyrene; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Escherichia coli Proteins; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Substrate Specificity

2011
Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA.
    Nucleic acids research, 2011, Volume: 39, Issue:9

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Pairing; Chromatography, High Pressure Liquid; Cytosine; Deoxyguanosine; DNA Adducts; Genes, p53; Guanine; Isotope Labeling; Models, Molecular; Oligodeoxyribonucleotides; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2011
The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.
    The Journal of biological chemistry, 2012, Mar-16, Volume: 287, Issue:12

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Sequence; Animals; Cell Cycle Proteins; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Humans; Mad2 Proteins; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutation; Nuclear Proteins; Nucleotidyltransferases; Protein Binding; Protein Structure, Tertiary; Proteins; Sequence Alignment

2012
Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers.
    Environmental science & technology, 2013, Jul-02, Volume: 47, Issue:13

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Adult; Air Pollutants, Occupational; Biomarkers; Coke; Deoxyguanosine; Dinoprost; DNA Damage; Dose-Response Relationship, Drug; Environmental Monitoring; Humans; Lipids; Male; Middle Aged; Occupational Exposure; Oxidative Stress; Polycyclic Aromatic Hydrocarbons; Pyrenes; Serum Albumin; Young Adult

2013
Plastic antibody for DNA damage: fluorescent imaging of BPDE-dG adducts in genomic DNA.
    The Analyst, 2013, Sep-07, Volume: 138, Issue:17

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies; Base Sequence; Biomimetic Materials; Cell Line, Tumor; Deoxyguanosine; DNA Adducts; DNA Damage; DNA, Single-Stranded; Genome, Human; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Imprinting; Nanocomposites

2013
Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Feb-04, Volume: 111, Issue:5

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biocatalysis; Deoxyguanosine; DNA Primers; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Embryo, Mammalian; Fibroblasts; Kinetics; Mice; Models, Molecular; Mutant Proteins

2014
In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ.
    DNA repair, 2014, Volume: 15

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Substitution; Base Sequence; Catalytic Domain; Cell Line; Deoxyguanosine; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Mutagenesis, Site-Directed; Mutation Rate; Phenylalanine

2014
Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.
    Toxicology letters, 2015, Jan-05, Volume: 232, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biomarkers; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; Histidine; Humans; Male; Mice; Protein Binding; Risk Assessment; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
Transient isotachophoresis focusing of DNA and DNA-protein complexes is essentially enhanced by spontaneously dissolved aerial carbon dioxide in electrolytes.
    Analytical chemistry, 2015, Jan-06, Volume: 87, Issue:1

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aerosols; Carbon Dioxide; Deoxyguanosine; DNA; DNA-Binding Proteins; Electrolytes; Electrophoresis, Capillary; Humans; Isotachophoresis

2015
Human DNA polymerases catalyze lesion bypass across benzo[a]pyrene-derived DNA adduct clustered with an abasic site.
    DNA repair, 2014, Volume: 24

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Catalysis; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA Polymerase I; DNA Repair; DNA-Directed DNA Polymerase; Humans; Molecular Sequence Data

2014
Tracking matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons.
    Journal of chromatography. A, 2016, Mar-25, Volume: 1439

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; Humans; Mass Spectrometry; Polycyclic Aromatic Hydrocarbons

2016
Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct.
    Journal of biochemistry, 2016, Volume: 159, Issue:4

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Catalytic Domain; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Enzyme Assays; Kinetics; Mice; Mutagenesis

2016
Urinary and Genetic Biomonitoring of Polycyclic Aromatic Hydrocarbons in Egyptian Coke Oven Workers: Associations between Exposure, Effect, and Carcinogenic Risk Assessment.
    The international journal of occupational and environmental medicine, 2019, Volume: 10, Issue:3

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Coke; Cytochrome P-450 CYP2E1; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; Egypt; Environmental Monitoring; Humans; Male; Middle Aged; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Pyrenes; Risk Assessment; X-ray Repair Cross Complementing Protein 1; Young Adult

2019