7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with benzo(a)pyrene in 256 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (28.13) | 18.7374 |
| 1990's | 69 (26.95) | 18.2507 |
| 2000's | 55 (21.48) | 29.6817 |
| 2010's | 37 (14.45) | 24.3611 |
| 2020's | 23 (8.98) | 2.80 |
| Authors | Studies |
|---|---|
| Levis, AG; Pavanello, S | 1 |
| Alexandrov, K; Bartsch, H; Camus, AM; Castegnaro, M; Geneste, O; Giuntini, C; Petruzzelli, S; Rojas, M | 1 |
| Canella, KA; Dipple, A; Hruszkewycz, AM; Kotrappa, L; Peltonen, K | 1 |
| Kawabata, TT; Ladics, GS; Munson, AE; White, KL | 1 |
| Anderson, JN; Baird, WM; Coffing, SL; Eberhart, J; Gelboin, HV; Kalogeris, TJ; Marcus, C; Park, SS | 1 |
| den Engelse, L; Hillebrand, MJ; Kriek, E; Scherer, E; van Schooten, FJ | 1 |
| Green, JL; Pan, YH; Reed, GA | 1 |
| Bartley, JC; Levine, GA; Tischler, AN | 1 |
| Baer-Dubowska, W; Brauze, D; Mikstacka, R | 1 |
| Butterworth, BE; DiGiovanni, J; Gill, RD; Nettikumara, AN | 1 |
| Earley, K; Erexson, G; Gupta, RC; Kligerman, A; Nelson, G; Nesnow, S; Ross, J | 1 |
| Holz, O; Krause, T; Rüdiger, HW | 1 |
| Atherholt, TB; Ginsberg, GL | 1 |
| Earley, K; Gupta, RC; Kandaswami, C; Kumar, S; Rutkowski, JP; Sikka, HC | 1 |
| DiAugustine, RP; Gallagher, JE; Jahnke, GD; Lucier, GW; Thompson, CL; Walker, MP | 1 |
| Strother, A; Teel, RW; Vance, RE | 1 |
| Ji, C; Marnett, LJ; Pruess-Schwartz, D; Reddy, A | 1 |
| Bevan, DR; Weyand, EH | 1 |
| Dankovic, DA; Mahlum, DD; Mann, DB; Springer, DL; Thomas, BL; Wright, CW | 1 |
| Brylawski, BP; Cordeiro-Stone, M; Kaufman, DG | 1 |
| Le Eberhart, BT; Reichert, WL; Stein, JE; Varanasi, U | 1 |
| Bagheri, K; Hecht, SS; Hoffmann, D; Melikian, AA | 1 |
| Alexandrov, K; Levis, AG; Paleologo, M; Pavanello, S; Rojas, M | 1 |
| Ishikawa, T; Nakagawa, K; Nakatsuru, Y | 1 |
| Gräslund, A; Jernström, B | 1 |
| Braley, J; Hecht, SS; Hoffmann, D; Jordan, KG; Melikian, AA; Meschter, CL; Rigotty, J | 1 |
| Geacintov, NE; Harvey, RG; Ibanez, V; Roche, CJ | 1 |
| Guengerich, FP; Marnett, LJ; Martin, MV; Pruess-Schwartz, D; Shimada, T | 1 |
| Akkaraju, S; Mitchell, CE | 1 |
| Andries, MJ; Lambert, JM; Lucier, GW; McCoy, Z; Thompson, CL | 1 |
| Kurian, P; Lehman, TA; Milo, GE | 1 |
| Teel, RW; Vance, RE | 1 |
| Lambert, ME; Weinstein, IB | 1 |
| Nemoto, N | 1 |
| Baird, WM; Merrick, BA; Nikbakht, A; Pruess-Schwartz, D; Selkirk, JK | 1 |
| Calloway, K; Irigaray, MF; Kaufman, DG; Kulkarni, MS | 1 |
| Billett, MA; Obi, FO; Ryan, AJ | 1 |
| Huckle, KR; Smith, RJ; Watson, WP; Wright, AS | 1 |
| Alexandrov, K; Rojas, M | 1 |
| Krolewski, B; Little, JB; Nagasawa, H | 1 |
| Doerjer, G; Glatt, HR; Oesch, F; Turchi, G | 1 |
| Asokan, P; Bickers, DR; Das, M; Mukhtar, H; Santella, RM | 1 |
| MacLeod, MC; McClay, J; Smith, B | 1 |
| Christou, M; Jefcoate, CR; Keller, GM; Pottenger, LH; Wilson, NM | 1 |
| Baird, WM; Gould, MN; Mauthe, RJ; Moore, CJ; Pruess-Schwartz, D | 1 |
| Garner, RC; Martin, CN; Tierney, B | 1 |
| Bagheri, K; Hecht, SS; Melikian, AA | 1 |
| Baird, WM; Harvey, RG; Lee, H; Morgan, SL; Moynihan, CG; Smolarek, TA | 1 |
| Chen, FM | 1 |
| Baird, WM; Kelley, J; Morgan, SL; Smolarek, TA | 1 |
| Gan, R; Shamsuddin, AK | 1 |
| Aust, AE; Bhattacharyya, N; Maher, VM; McCormick, JJ; Patton, JD; Wang, YY; Yang, JL; Yang, LL | 1 |
| Alexandrov, K; Rojas, M; Sala, M | 1 |
| Dock, L; Eriksson, L; Jernström, B; Martinez, M; Scheu, G; Torndal, UB | 1 |
| Harris, CC; Pelkonen, O; Vähäkangas, K | 1 |
| Pullman, B; Zakrzewska, K | 1 |
| Disher, RM; Lu, LJ; Randerath, K; Reddy, MV | 1 |
| Krolewski, B; Little, JB | 1 |
| Kaufman, DG; Mass, MJ; Paules, RS; Poirier, MC; Yuspa, SH | 1 |
| Brooks, TM; Gonzalez, LP; Watson, WP; Wright, AS | 1 |
| Aalfs, KK; Decina, PC; DiGiovanni, J; Fisher, EP; Prichett, WP | 1 |
| Shugart, L | 1 |
| Anderson, MW; Bend, JR; Horton, JK; Rosenior, JC | 1 |
| Chang, RL; Conney, AH; Huang, MT; Jerina, DM; Newmark, HL; Sayer, JM; Wong, CQ; Wood, AW; Yagi, H | 1 |
| Abramovich, M; Harvey, RG; Lebreton, PR; Prakash, AS; Zegar, IS | 1 |
| Matsunami, R; Shugart, L | 1 |
| Boesch, RR; Harris, CC; Hemminki, K; Shamsuddin, AK; Sinopoli, NT | 1 |
| Callaham, MF; Huberman, E; Jones, CA | 1 |
| Busbee, DL; Joe, CO; Norman, JO; Rankin, PW | 1 |
| Kakunaga, T; Lo, K | 1 |
| Etkin, S; Lavi, S | 1 |
| Jennings, BR; Ridler, PJ | 2 |
| Backer, JM; Weinstein, IB | 1 |
| Grover, PL; Sims, P; Weston, A | 1 |
| Fahl, WE | 1 |
| Jefcoate, CR; Keller, GM; Turner, CR | 1 |
| Chou, MW; Sydor, W; Yang, CS; Yang, SK | 1 |
| Grover, PL; Mironov, NM; Sims, P | 1 |
| Sculley, TB; Zytkovicz, TH | 1 |
| Alexandrov, K; Bourgeois, Y; Chouroulinkov, I; Rojas, M | 1 |
| Billett, MA; Obi, FO | 1 |
| Hosted, TJ; Lavoie, EJ; Rice, JE | 1 |
| Engelhardt, U; Moeroey, T; Schaefer-Ridder, M | 1 |
| Jefcoate, CR; Keller, GM | 1 |
| Bingham, E; Niemeier, RW; Warshawsky, D | 1 |
| Chu, Y; Hurtubise, RJ | 2 |
| Dashwood, R; Dashwood, WM; Guo, D; Larsen, R; Tachino, N; Yamane, S | 1 |
| Baan, RA; Roggeband, R; Van den Berg, PT; Van der Wulp, CJ | 1 |
| Hsu, TM; Santella, RM; Zhang, YJ | 2 |
| Castrén, K; Järvinen, K; Pääkkö, P; Pekkala, K; Rämet, M; Soini, Y; Turpeenniemi-Hujanen, T; Vähäkangas, K | 1 |
| Ariese, F; Geacintov, NE; Jankowiak, R; Liu, TM; Small, GJ; Suh, M | 1 |
| Fujita, I; Kikkawa, Y; Rasmussen, RE; Sindhu, RK; Yamamoto, R | 1 |
| Bowman, ED; Corley, J; Hurtubise, RJ; Weston, A | 1 |
| Ariese, F; Geacintov, NE; Jankowiak, R; Mao, B; Small, GJ; Suh, M | 1 |
| Albertini, RJ; Dickey, C; Hemminki, K; Mooney, LA; O'Neill, JP; Ottman, R; Perera, FP; Santella, R; Savela, K; Tsai, WY | 1 |
| Chang, RL; Conney, AH; Jerina, DM; Wei, SJ | 1 |
| Alexandrov, K; Bartsch, H; Hillebrand, M; Kriek, E; Rojas, M; van Schooten, FJ | 1 |
| Venkatachalam, S; Wani, AA | 1 |
| Bjelogrlic, NM; Mäkinen, M; Stenbäck, F; Vähäkangas, K | 1 |
| Bjelogrlic, N; Gelboin, HV; Honkakoski, P; Park, SS; Pelkonen, O; Peng, R; Vähäkangas, K | 1 |
| Baird, WM; Lau, HH | 1 |
| Dasari, RR; Singh, K; Skipper, PL; Tannenbaum, SR | 1 |
| Beland, FA; Culp, SJ | 1 |
| Balansky, RM; D'Agostini, F; De Flora, S; Izzotti, A; Rossi, GA | 1 |
| Lee, X; Lewtas, J; Mumford, JL; Santella, RM; Young, TL | 1 |
| Hines, RN; Novak, RF; Quan, T; Runge-Morris, M; States, JC | 1 |
| Baer-Dubowska, W; Brauze, D; Gnojkowski, J; Jarmuz, M; Kulińska, A | 1 |
| Harvey, RG; Penning, TM; Shou, M | 1 |
| Boerrigter, ME; Vijg, J; Wei, JY; Yin, Y | 1 |
| Broyde, S; Cosman, M; de los Santos, C; Fiala, R; Geacintov, NE; Harvey, R; Hingerty, BE; Ibanez, V; Luna, E; Patel, DJ | 1 |
| Gonzalez, FF; Holder, GM; McManus, ME; Roberts-Thomson, SJ; Tukey, RH | 1 |
| Bouchard, M; Viau, C | 1 |
| Arimoto, S; Hayatsu, H; Kan-yama, K; Rai, H | 1 |
| Park, KK; Surh, YJ | 1 |
| Kikkawa, Y; Rasmussen, RE; Sindhu, RK | 1 |
| Lee, JW; Shlyankevich, M; Surh, YJ; Yoo, JK | 1 |
| Gupta, RC; Smith, WA | 1 |
| Bjelogrlic, N; Järvinen, K; Pääkko, P; Tapiainen, T; Vähäkangas, K | 1 |
| Hemminki, K; Kohan, MJ; Lewtas, J; Perera, FP; Savela, K; Walsh, D | 1 |
| Myers, SR; Pinorini, MT; Spinnato, JA | 1 |
| Kantoniemi, A; Oikari, A; Vähäkangas, K | 1 |
| Adams, SP; Kort, KL; Laws, GM; Marino, DR; Mittal, LV; Skopek, TR; Umbenhauer, DR | 1 |
| Hanelt, S; Hartmann, A; Helbig, R; Lang, M; Seidel, A; Speit, G | 1 |
| Awasthi, S; Awasthi, YC; Bleicher, RJ; Hu, X; Ji, X; Nanduri, B; O'Donnell, R; Singh, SV; Srivastava, SK; Xia, H; Zimniak, P | 1 |
| Baer-Dubowska, W; Brauze, D; Pawlak, AL; Wielgosz, SM | 1 |
| Broyde, S; Feng, B; Geacintov, NE; Gorin, A; Hingerty, BE; Patel, DJ | 1 |
| Broyde, S; Feng, B; Geacintov, NE; Gorin, A; Hingerty, BE; Kolbanovskiy, A; Patel, DJ | 1 |
| Burchiel, SW; Mounho, BJ | 1 |
| Di Giulio, RT; King, LC; Kohan, MJ; Ploch, SA | 1 |
| Burchiel, SW; Salas, VM | 1 |
| Chary, P; Harris, CM; Harris, TM; Jabil, RJ; Johansen, TN; Lloyd, RS; Stone, MP; Tamura, PJ; Zegar, IS | 1 |
| Arnould, JP; Belegaud, J; Hermant, A; Levi-Valensi, P | 1 |
| de Boer, JG; Glickman, BW; Mazur-Melnyk, M; Yang, H | 1 |
| Bowden, GT; Gudas, JM; Jeffy, BD; Romagnolo, D; Schultz, EU; Selmin, O | 1 |
| El-Bayoumy, K; Hoffmann, D; Melikian, AA; Prokopczyk, B; Sun, P; Waggoner, S; Wang, X | 1 |
| Dipple, A; Harvey, RG; Khalili, H; Zhang, FJ | 1 |
| Kwack, SJ; Lee, BM | 1 |
| Carmella, SG; Christiani, DC; Hecht, SS; Santella, RM; Simpson, CD; Wu, MT | 1 |
| Dasari, RR; London, SJ; Ozbal, CC; Skipper, PL; Tannenbaum, SR; Yu, MC | 1 |
| Hecht, SS; Kenney, PM; Liang, H; Staretz, ME; Sticha, KR; Wang, M | 1 |
| Jelinsky, SA; Loechler, EL; Seo, KY | 1 |
| Cooper, CS; Ginot, YM; Grover, PL; Kindts, M; Sims, P; Vigny, P | 1 |
| Geacintov, NE; Luo, C; Zou, Y | 1 |
| Jerina, DM; Liu, X; Pradhan, P; Sayer, JM; Tirumala, S; Yeh, HJ | 1 |
| Broyde, S; Perlow, RA | 1 |
| Dipple, A; Jerina, DM; Kroth, H; Pontén, I; Sayer, JM | 1 |
| Godschalk, RW; Neuman, HA; Ostertag, JU; Van Agen, B; Van Schooten, FJ; Van Straaten, H; Zandsteeg, AM | 1 |
| Chipman, JK; Doehmer, J; Edwards, GO; Lautraite, S; Musonda, AC | 1 |
| Chen, EJ; Chirnomas, RB; Gudas, JM; Jeffy, BD; Romagnolo, DF | 1 |
| Chirnomas, RB; Jeffy, BD; Romagnolo, DF | 1 |
| King, LC; Kirlin, WG; Kohan, MJ; Rodriguez, JW | 1 |
| Doehmer, J; Kabler, SL; Morrow, CS; Townsend, AJ | 1 |
| Boysen, G; Hecht, SS | 1 |
| Chen, J; Chen, X; Jiang, Y | 1 |
| Dani, HM; Sharma, S | 1 |
| Dasari, RR; Gurjuar, R; Lafleur, A; Luo, W; Ozbal, C; Taghizadeh, K; Thilly, WG; Zarbl, H | 1 |
| Hurtubise, RJ; Smith, BW | 1 |
| Bartsch, H; Curfs, D; Godschalk, R; Nair, J; Van Schooten, FJ | 1 |
| Brookes, P; Jack, P | 1 |
| Binková, B; Srám, RJ | 1 |
| Chang, JT; Ko, JL; Liao, SH; Lin, P; Lo, WS | 1 |
| Chen, SY; Chen, YM; Darbha, R; Lin, JR; Lin, P; Liu, TY | 1 |
| Brown, BG; Burger, EE; Desiderio, JG; Doolittle, DJ; Fields, WR; Leonard, RM | 1 |
| Amin, S; Chen, H; Costa, M; Feng, Z; Huang, C; Ke, Q; Li, J; Liu, B; Tang, MS | 1 |
| Kisselev, P; Roots, I; Schwarz, D | 1 |
| Holme, JA; Låg, M; Mollerup, S; Nesnow, S; Schwarze, PE; Solhaug, A; Øvrebø, S | 1 |
| Chen, CY; Hsu, CP; Ko, JL; Lai, JC; Lai, WW; Lee, H; Lin, TS; Weng, MW; Yu, KY | 1 |
| Jansson, I; Rusling, JF; Schenkman, JB; Wang, B | 1 |
| Barrios, R; Brayton, C; Gaikwad, A; Iskander, K; Jaiswal, AK; Long, DJ; Paquet, M | 1 |
| Aklillu, E; Botnen, IV; Ingelman-Sundberg, M; Otter, C; Øvrebø, S | 1 |
| Angerer, J; Brüning, T; Engelhardt, B; Kafferlein, HU; Kappler, M; Marczynski, B; Mensing, T; Preuss, R; Scherenberg, M; Seidel, A; Wilhelm, M | 1 |
| Gao, D; Goldwyn, B; Guevara, D; Lebwohl, M; Lu, Y; Luo, Y; Rui, M; Smith, EC; Wang, Y; Wei, H | 1 |
| Byun, SH; Kim, HS; Lee, BM | 1 |
| Abdel-Rahman, SZ; Albrecht, T; Deng, CZ; El-Zein, RA; Fons, MP; Rosenblatt, J | 1 |
| Sibirtsev, VS | 1 |
| Doehmer, J; Fleming, MH; Gupta, RC; Kabler, SL; Kushman, ME; Morrow, CS; Ravoori, S; Townsend, AJ | 1 |
| Ebert, B; Lampen, A; Seidel, A | 1 |
| Abazinge, M; Darling-Reed, SF; Gragg, RD; Harris, C; Nwagbara, O; Thomas, RD; Tucker, A | 1 |
| Chun, YJ; Chung, JY; Hong, YP; Kim, JM; Kim, JY; Kim, WR; Kim, YJ; Lee, SG; Oh, S; Park, JE; Park, YC; Yoo, KS; Yoo, YH | 1 |
| Ahmad, S; Doehmer, J; Kabler, SL; Kushman, ME; Morrow, CS; Townsend, AJ | 1 |
| Cha, MS; Chung, JY; Han, MS; Kim, JM; Kim, JY; Kim, YJ; Lee, HJ; Lee, SG; Park, JE; Yoo, YH | 1 |
| Carrie, D; Farmer, PB; Gaskell, M; Henderson, CJ; Park, K; Ritchie, KJ; Vassieva, O; Wang, XJ; Wolf, CR | 1 |
| Douki, T; Favier, A; Gateau, M; Guiraud, P; Maître, A; Marie, C; Ravanat, JL; Tarantini, A | 1 |
| Arlt, VM; Giddings, I; Hartwig, A; Hockley, SL; Jahnke, G; Phillips, DH | 1 |
| Egly, JM; Geacintov, N; Mocquet, V | 1 |
| Guo, SY; Lin, SJ; Liu, Q; Sun, CJ; Yang, LH | 1 |
| Aarsaether, N; Cajaraville, MP; Goksøyr, A; Gunawickrama, SH; Orbea, A | 1 |
| Chen, L; Chen, W; Ji, W; Lai, Y; Li, D; Li, W; Lin, Y; Ma, R; Pang, Y; Tang, S; Wang, Q; Wei, Q; Xiao, Y; Yang, P; Zheng, Y; Zhuang, Z | 1 |
| Bajak, E; Cotgreave, IA; Jernström, B; Mattsson, A | 1 |
| Awooda, I; Barhoumi, R; Burghardt, RC; Catania, JM; Parrish, AR; Safe, S; Tiffany-Castiglioni, E | 1 |
| Glick, J; Lin, Y; Noronha, AM; Vouros, P; Wilds, CJ; Xiong, W | 1 |
| Garg, R; Maru, G | 1 |
| Duan, H; Jiang, Y; Wu, Y; Zhang, H | 1 |
| Kumar, S; Mukherjee, JJ | 1 |
| Adams, LD; George, MH; King, LC; Moore, T; Nelson, G; Nesnow, S; Padgett, WT; Ross, JA | 1 |
| Anderson, D; Baumgartner, A; Brunborg, G; Cemeli, E; Godschalk, RW; Laubenthal, J; Linschooten, JO; Sipinen, V; Van Schooten, FJ | 1 |
| Bouchard, M; Maître, A; Marie-Desvergne, C; Ravanat, JL; Viau, C | 1 |
| Cao, J; Guo, LH; Lin, Y; Wei, Y; Zhang, AQ | 1 |
| Fujimoto, H; Grúz, P; Gupta, RC; Johnson, F; Katafuchi, A; Niimi, N; Nohmi, T; Ohta, T; Sassa, A; Yasui, M | 1 |
| Huovinen, M; Loikkanen, J; Myllynen, P; Vähäkangas, KH | 1 |
| Abedin, Z; Field, J; Sen, S | 1 |
| Hirakawa, T; Nemoto, N; Takayama, S | 1 |
| Beland, FA; Churchwell, MI; John, K; McMullen, G; Olivero, OA; Pogribny, IP; Poirier, MC; Pratt, MM | 1 |
| Brinkmann, J; Fritsche, E; Genkinger, D; Henkler, F; Hutzler, C; Luch, A; Salzmann, S; Stolpmann, K; Wajant, H | 1 |
| Jain, M; Kumar, M; Sehgal, A; Sharma, VL | 1 |
| Agbo, SO; Akkanen, J; Keinänen, M; Keski-Saari, S; Kukkonen, JV; Lemmetyinen, J; Leppänen, MT; Price, DA; Wang, H; Wang, Z | 1 |
| Högel, J; Kuehner, S; Leibiger, C; Speit, G | 1 |
| An, L; Bao, X; Cai, Y; Jin, C; Liu, Q; Liu, Y; Lu, X; Pan, L; van der Straaten, T; Wu, S; Xiao, S; Yang, J; Yu, T; Zhu, G | 1 |
| Currie, RW; Duan, Y; Gong, Z; Huang, S; Liu, X; Niu, P; Wu, T; Xin, L; Yang, J | 1 |
| Courbiere, B; Einaudi, L; Orsiere, T; Perrin, J; Prevot, C; Sari-Minodier, I; Tassistro, V | 1 |
| Chiu, CY; Liu, SH; Tsai, KS; Yang, RS; Yen, YP | 1 |
| Friedberg, E; Guo, C; Liu, Y; Tang, TS; Wang, Z; Yang, W; Yang, Y; Zhang, H | 1 |
| Andrys, C; Borska, L; Chmelarova, M; Fiala, Z; Hamakova, K; Krejsek, J; Kremlacek, J; Palicka, V | 1 |
| Chiu, RK; Godschalk, RW; Sanen, K; Schults, MA; Theys, J; van Schooten, FJ | 1 |
| Farmer, PB; Hedebrant, U; Koukouves, G; Kyrtopoulos, S; Segerbäck, D; Singh, R; Souliotis, VL; Törnqvist, MÅ; Westberg, EA | 1 |
| Geacintov, NE; Kolbanovskiy, A; Lavrik, OI; Lebedeva, NA; Rechkunova, NI; Starostenko, LV | 1 |
| Burrows, CJ; Fleming, AM; Johnson, RP; Perera, RT; White, HS | 1 |
| Arlt, VM; Kucab, JE; Luijten, M; Phillips, DH; Schmeiser, HH; van Steeg, H; White, PA | 1 |
| Blake, DA; Eriksson, Y; Simon-Friedt, BR; Wickliffe, JK; Wilson, MJ; Yu, H | 1 |
| Chen, G; Chen, L; Fu, K; Gao, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Liu, P; Liu, Y; Pan, X; Yang, C; Zeng, X; Zhang, L; Zhu, J | 1 |
| Bo, Y; Fa-Sheng, L; Gang, C; Hui, L; Jie, Z; Lin, Q; Min, S; Na, L; Xiao-Chen, L | 1 |
| Jennen, D; Kleinjans, J; Kyrtoupolos, S; Souza, T; van Delft, J; van Herwijnen, M | 1 |
| Brancale, A; Lewis, PD; Menzies, GE; Reed, SH | 1 |
| Barret, JT; Flarakos, C; Glick, J; Klaene, JJ; Vouros, P; Zarbl, H | 1 |
| Chen, W; Fan, Y; Wang, W; Yang, J; Zhang, H | 1 |
| Andrys, C; Beranek, M; Borska, L; Chmelarova, M; Fiala, Z; Hamakova, K; Kremlacek, J; Palicka, V | 1 |
| Cai, Y; Jin, C; Lu, X; Straaten, TV; Wu, S; Xiao, M; Xiao, S; Xue, P; Yang, J; Zhang, G; Zhang, Q; Zheng, X; Zhu, G | 1 |
| Mor, G; Wang, R; Wang, W; Zhang, H; Zhang, Q | 1 |
| Ao, L; Cao, J; Chen, H; Han, F; Ling, X; Liu, J; Peng, K; Wang, Z; Yang, W; Zhang, G; Zhang, X; Zou, P | 1 |
| An, H; Ao, L; Cao, J; Chen, Q; Han, F; Jiang, F; Ling, X; Liu, J; Liu, W; Yang, H; Yang, W; Zeng, Y; Zhang, G; Zou, P | 1 |
| Béal, D; Bourgart, E; Douki, T; Giot, JP; Leccia, MT; Maitre, A; Marques, M; Rivier, A; von Koschembahr, A; Youssef, A | 1 |
| Guo, L; Li, B; Li, G; Sang, N; Wei, M; Yun, Y | 1 |
| Jee, SC; Kim, M; Sung, JS | 1 |
| Motwani, HV | 1 |
| Huang, X; Ma, C; Wang, R; Zhang, H | 1 |
| Bai, Y; Feng, Y; Fu, M; Guan, X; Guo, H; He, M; Jie, J; Li, G; Li, H; Li, M; Li, Y; Meng, H; Wang, C; Wei, S; Wei, W; Wu, X; Zhang, X | 1 |
| Chen, W; Dai, M; Huang, W; Liang, T; Mi, C; Tian, P; Xie, J; Xu, Z; Zhang, H; Zhang, S | 1 |
| Feng, F; He, X; Liu, H; Liu, Y; Shang, P; Yang, L; Yu, Q; Zhang, J; Zhang, Q; Zhu, Y | 1 |
| Han, M; Ji, J; Liu, S; Wei, J; Wu, Y; Zhang, J | 1 |
| Chen, X; Ding, Y; Gao, R; Geng, Y; He, J; Li, F; Liu, T; Liu, X; Mu, X; Wang, Y; Xu, H; Yang, J; Zhou, M | 1 |
| Ao, L; Cao, J; Chai, Z; Chen, Q; Cui, H; Ling, X; Liu, J; Shi, F; Yang, B; Yang, H; Yang, W; Zhang, G; Zou, P | 1 |
| Chen, Y; Du, Y; Huang, Z; Liang, L; Liu, J; Liu, Y; Xie, R; Yang, Q; Zhou, J; Zou, H | 1 |
| Bu, KB; Han, DH; Jang, BY; Jee, SC; Kim, M; Lee, SC; Shin, MK; Sung, JS | 1 |
| Guo, CC; Li, ZF; Lyu, Y; Ren, XK; Zheng, JP | 1 |
| Ariga, S; Dosaka-Akita, H; Katabami, M; Kinoshita, I; Shimizu, Y | 1 |
| Chen, W; Huang, W; Wang, M; Wang, R; Xu, X; Yang, J; Yang, Y; Zhang, H; Zhang, Y; Zhao, J | 1 |
| Chen, Y; Feng, F; He, X; Lei, Y; Lu, P; Mallah, MA; Shang, P; Yang, L; Zhang, Q; Zhou, X; Zhu, Y | 1 |
| Ao, L; Cao, J; Chai, Z; Chen, Q; Cui, H; He, S; Ling, X; Liu, J; Sun, L; Wang, L; Yang, H; Yang, W; Zhang, G; Zou, P | 1 |
| Lei, F; Li, Y; Miao, J; Pan, L; Tong, R; Zhang, N | 1 |
| Li, Y; Liao, Q; Pan, L; Tong, R; Zhang, N | 1 |
| Cao, J; Hao, Z; Li, X; Liang, R; Liu, A; Song, Z; Xia, N; Yan, X; Zhang, H; Zhang, Z; Zhou, L | 1 |
| Chen, W; Mi, C; Shen, Y; Wan, S; Wang, X; Xu, X; Xu, Z; Yang, Y; Zhang, H; Zhang, Y; Zhao, J; Zheng, Z | 1 |
| Aniagu, S; Chen, J; Chen, T; Jiang, Y; Zhang, M; Zou, H | 1 |
6 review(s) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and benzo(a)pyrene
| Article | Year |
|---|---|
DNA-carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides studied by biochemical and biophysical techniques.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts | 1989 |
Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Benzo(a)pyrene; Biotransformation; Cell Line; Dose-Response Relationship, Drug; Humans; Liver; Molecular Sequence Data; Mutagenesis; Mutagens | 1994 |
Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Eukaryotic Cells; Humans; Models, Biological; Mutagenesis; Mutagens; Nucleic Acid Conformation; Point Mutation; Prokaryotic Cells; Structure-Activity Relationship; Temperature | 2000 |
Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Proteins | 2003 |
The RPTEC/TERT1 Cell Line as an Improved Tool for In Vitro Nephrotoxicity Assessments.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cadmium; Cell Line; DNA Adducts; DNA Damage; Drug Synergism; Environmental Pollutants; Healthy Volunteers; Humans; Kidney Neoplasms; Kidney Tubules, Proximal; Male; Models, Biological; Oxidative Stress | 2015 |
Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; ATP-Binding Cassette Transporters; Benzo(a)pyrene; DNA Adducts; DNA Methylation; Epigenome; Humans; Lung Neoplasms; Ubiquitin-Conjugating Enzymes | 2021 |
250 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and benzo(a)pyrene
| Article | Year |
|---|---|
Coal tar therapy does not influence in vitro benzo[a]pyrene metabolism and DNA adduct formation in peripheral blood lymphocytes of psoriatic patients.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Benzo(a)pyrene; Cells, Cultured; Coal Tar; DNA Damage; Drug Interactions; Humans; Lymphocytes; Male; Middle Aged; Psoriasis; Stereoisomerism | 1992 |
An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Fluorometry; Genetic Variation; Humans; Hydrolysis; Isotope Labeling; Lung; Lung Diseases; Lung Neoplasms; Male; Microsomes; Middle Aged; Phosphorus Radioisotopes; Radiometry; Smoking; Thymus Gland | 1992 |
DNA polymerase action on benzo[a]pyrene-DNA adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; DNA Adducts; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Molecular Conformation; Molecular Sequence Data; Oligodeoxyribonucleotides; Spectrophotometry, Ultraviolet; Stereoisomerism; Templates, Genetic | 1992 |
Generation of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by murine splenic macrophages.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Free Radicals; Macrophages; Mice; Oxidation-Reduction; Spleen | 1992 |
The time-dependent increase in the binding of benzo[a]pyrene to DNA through (+)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide in primary rat hepatocyte cultures results from induction of cytochrome P450IA1 by benzo[a]pyrene treatment.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibodies, Monoclonal; Benzo(a)pyrene; Blotting, Western; Carcinogens, Environmental; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Time Factors | 1992 |
Immunocytochemical visualization of DNA adducts in mouse tissues and human white blood cells following treatment with benzo[a]pyrene or its diol epoxide. A quantitative approach.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cells, Cultured; Densitometry; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Kidney; Leukocytes; Lung; Male; Mice; Mice, Inbred Strains; Myocardium; Phosphorus Radioisotopes | 1991 |
Mutagenicity of benzo[a]pyrene bay-region sulfonates.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Mutagens; Salmonella typhimurium; Sulfites; Sulfonic Acids; Sulfur Dioxide | 1991 |
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol in human mammary epithelial cells: feedback inhibition by 7-hydroxybenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Biotransformation; Breast; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Epithelium; Female; Humans | 1991 |
Formation and persistence of benzo[a]pyrene--DNA adducts in different tissues of C57BL/10 and DBA/2 mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Spectrometry, Fluorescence; Tissue Distribution | 1991 |
Relationship between DNA adduct formation and unscheduled DNA synthesis (UDS) in cultured mouse epidermal keratinocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Autoradiography; Benzo(a)pyrene; Cells, Cultured; DNA; DNA Replication; Epidermal Cells; Female; Isomerism; Keratinocytes; Mice; Mice, Inbred Strains; Mutagens; Tritium | 1991 |
DNA adducts in rat lung, liver and peripheral blood lymphocytes produced by i.p. administration of benzo[a]pyrene metabolites and derivatives.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Liver; Lung; Lymphocytes; Male; Rats; Rats, Inbred Strains | 1991 |
Differences in DNA adduct formation between monocytes and lymphocytes after in vivo incubation with benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cells, Cultured; DNA; DNA Adducts; DNA Damage; Humans; In Vitro Techniques; Lymphocytes; Monocytes | 1991 |
DNA adduct formation in mouse tissues in relation to serum levels of benzo(a)pyrene-diol-epoxide after injection of benzo(a)pyrene or the diol-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Female; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Inbred C3H; Mice, Inbred C57BL | 1990 |
Formation and persistence of DNA adducts in the liver of brown bullheads exposed to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biotransformation; Catfishes; DNA; DNA Adducts; Ictaluridae; Liver | 1990 |
Multiple DNA adducts in lymphocytes of smokers and nonsmokers determined by 32P-postlabeling analysis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Adult; Benzo(a)pyrene; Chromatography, Thin Layer; DNA; DNA Adducts; Female; Humans; Lymphocytes; Male; Phosphorus Radioisotopes; Smoking | 1990 |
Inhibition of liver microsome-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in the rat following glucose administration.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Depression, Chemical; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Glucose; Male; Microsomes, Liver; Mutagenicity Tests; Mutation; Rats; Rats, Inbred Strains | 1990 |
Oxidation of polycyclic hydrocarbons by oxygen radicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; DNA; DNA Damage; Female; Free Radicals; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Oxidation-Reduction; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Covalent binding of benzo[a]pyrene to macromolecules in lung and liver of rats following intratracheal instillation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; DNA; DNA Adducts; Injections, Spinal; Liver; Lung; Male; Protein Binding; Rats; Rats, Inbred Strains; RNA | 1987 |
Influences of complex organic mixtures on tumor-initiating activity, DNA binding and adducts of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biotransformation; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Coal; Cocarcinogenesis; DNA Damage; Drug Synergism; Female; Hot Temperature; Mice; Skin Neoplasms | 1989 |
Ferritin-labeled rabbit Fab fragments for the single-step detection of benzo[a]pyrene-diol-epoxide adducts in DNA by electron microscopy.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibody Specificity; Benzo(a)pyrene; Cattle; DNA; DNA Adducts; DNA Damage; Ferritins; Immunoglobulin Fab Fragments; In Vitro Techniques; Microscopy, Electron | 1989 |
Formation and persistence of benzo[a]pyrene-diolepoxide-DNA adducts in liver of English sole (Parophrys vetulus).
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Flatfishes; Liver; Male; Salmon; Spectrometry, Fluorescence; Spermatozoa | 1989 |
Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aging; Animals; Animals, Newborn; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Kinetics; Liver; Lung; Mice; Organ Specificity | 1989 |
Evidence for substantial formation of r-7,t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene- deoxyguanosine in human lymphocytes treated in vitro with benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Benzo(a)pyrene; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Humans; Lymphocytes; Tritium | 1989 |
Immunohistochemical detection of carcinogen-DNA adducts and DNA repair in mouse skin.
Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aminoquinolines; Animals; Antibodies; Benzo(a)pyrene; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Repair; Female; Immunohistochemistry; Mice; Mice, Inbred ICR; Nitroquinolines; Skin | 1989 |
Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Catechols; Dihydroxydihydrobenzopyrenes; Female; Mice; Mice, Inbred Strains; Reference Values; Skin Neoplasms | 1989 |
Linear dichroism properties and orientations of different ultraviolet transition moments of benzo[a]pyrene derivatives bound noncovalently and covalently to DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Chemical Phenomena; Chemistry; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Pyrenes; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 1989 |
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA Damage; Gene Expression; Genes; Humans; Isoenzymes; Kinetics; Lung; Microsomes; Microsomes, Liver; Polycyclic Compounds; Rats | 1989 |
Binding of polycyclic and nitropolycyclic aromatic hydrocarbons to specific fractions of rat lung chromatin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Fractionation; Chromatin; DNA Damage; Dose-Response Relationship, Drug; In Vitro Techniques; Lung; Nuclear Matrix; Polycyclic Compounds; Pyrenes; Rats; Structure-Activity Relationship | 1989 |
Relationships among benzo(a)pyrene metabolism, benzo(a)pyrene-diol-epoxide:DNA adduct formation, and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Benzo(a)pyrene; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA Damage; Female; Humans; Lymphocytes; Male; Oxidoreductases; Sister Chromatid Exchange; Smoking | 1989 |
Metabolism of and DNA adduct formation by benzo[alpha]pyrene in human skin epithelial cells in vitro pretreated with cytochrome P450 modulators.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Biotransformation; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Humans; Infant, Newborn; Keratinocytes; Male | 1989 |
Effect of tannic acid on rat liver S9 mediated mutagenesis, metabolism and DNA binding of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; DNA; DNA Adducts; Hydrolyzable Tannins; Liver; Male; Mutagens; Rats; Rats, Inbred Strains; Tannins | 1989 |
Nitropyrenes are inducers of polyoma viral DNA synthesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; DNA Damage; DNA, Viral; Polyomavirus; Pyrenes; Rats; Structure-Activity Relationship; Virus Replication | 1987 |
Marked activation of benzo[a]pyrene to protein-binding forms in the presence of unsaturated fatty acids and heme-compounds.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Blood Proteins; Fatty Acids, Unsaturated; Female; Heme; Humans; Porphyrins; Protein Binding; Rats; Rats, Inbred Strains; Serum Albumin, Bovine | 1986 |
Benzo(a)pyrene:DNA adduct formation in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Breast; Breast Neoplasms; Carcinoma; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA, Neoplasm; Epithelium; Female; Humans; Hydrolysis; Tritium | 1986 |
Species differences in the formation of benzo(a)pyrene-DNA adducts in rodent and human endometrium.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Deoxyguanosine; DNA; DNA Adducts; Endometrium; Female; Humans; Mesocricetus; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Preferential binding of the carcinogen benzo[a]pyrene to DNA in active chromatin and the nuclear matrix.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Cell Nucleus; Chromatin; DNA; DNA Repair; DNA Replication; Epoxide Hydrolases; In Vitro Techniques; Rats; Rats, Inbred Strains; Tritium | 1986 |
Comparison of hydrocarbon-DNA adducts formed in mouse skin in vivo and in organ culture in vitro following treatment with benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carbon Radioisotopes; Deoxyguanosine; DNA; Female; Mice; Mice, Inbred Strains; Organ Culture Techniques; Skin; Stereoisomerism; Tritium | 1986 |
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Male; Mice; Rats; Rats, Inbred Strains; Skin; Stereoisomerism; Tritium | 1986 |
Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; Mutation; Pyrenes; Sister Chromatid Exchange | 1986 |
A benzo[a]pyrene metabolite-DNA adduct occurring in the activating cell but not in exogenous DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; DNA; Liver; Rats; Salmon | 1987 |
Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of SENCAR mice following topical application of crude coal tar.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Coal Tar; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Epidermis; Lung; Male; Mice; Skin Neoplasms | 1986 |
Equilibrium binding of derivatives of the carcinogen, benzo(a)pyrene, to DNA. Thermodynamic analysis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; Osmolar Concentration; Spectrophotometry; Thermodynamics | 1987 |
Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid | 1987 |
Interspecies differences in the major DNA adducts formed from benzo(a)pyrene but not 7,12-dimethylbenz(a)anthracene in rat and human mammary cell cultures.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Breast; Cells, Cultured; DNA; DNA Adducts; Female; Humans; Mammary Glands, Animal; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Topical treatment of mice with benzo[a]pyrene or parenteral administration of benzo[a]pyrene diol epoxide-DNA to rats results in faecal excretion of a putative benzo[a]pyrene diol epoxide-deoxyguanosine adduct.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Environmental Monitoring; Feces; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Smoking | 1987 |
Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Epidermis; Female; Half-Life; Kinetics; Mice | 1987 |
Metabolism and DNA adduct formation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in fish cell lines in culture.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fishes | 1987 |
Denaturation and renaturation studies of benzo[a]pyrene metabolite modified DNAs.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Circular Dichroism; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Isomerism; Nucleic Acid Conformation; Nucleic Acid Denaturation; Nucleic Acid Renaturation; Polydeoxyribonucleotides; Spectrometry, Fluorescence | 1987 |
Effects of pretreatment with benzo[a]pyrene on the stereochemical selectivity of metabolic activation of benzo[a]pyrene to DNA-binding metabolites in hamster embryo cell cultures.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cells, Cultured; Cricetinae; Dactinomycin; DNA; Guanosine; Stereoisomerism | 1987 |
Immunocytochemical localization of benzo(a)pyrene-DNA adducts in human tissue.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cervix Uteri; Dihydroxydihydrobenzopyrenes; DNA; Female; Humans; Immunohistochemistry; Lung; Ovary; Placenta; Smoking | 1988 |
Mutations and homologous recombination induced in mammalian cells by metabolites of benzo[a]pyrene and 1-nitropyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Survival; Cells, Cultured; Humans; Mice; Mutagens; Plasmids; Pyrenes; Recombination, Genetic | 1987 |
Differences in the DNA adducts formed in cultured rabbit and rat dermal fibroblasts by benzo(a)pyrene and (-)benzo(a)pyrene-7,8-diol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Rabbits; Rats; Skin | 1988 |
Benzo[a]pyrene metabolism and induction of enzyme-altered foci in regenerating rat liver.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Glutathione; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Rats; Rats, Inbred Strains; Regeneration | 1988 |
Synchronous fluorescence spectrophotometry of benzo[a]pyrene diol epoxide-DNA adducts: a tool for detection of in-vitro and in-vivo DNA damage by exposure to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; DNA Damage; Humans; Mice; Spectrometry, Fluorescence | 1988 |
Sequence selectivity, a test of the nature of the covalent adduct formed between benzo[a]pyrene and DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Carcinogens; Chemical Phenomena; Chemistry, Physical; DNA; Guanine; Intercalating Agents; Models, Molecular; Thermodynamics | 1987 |
32P-postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aminobiphenyl Compounds; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens, Environmental; Dioxoles; DNA; DNA Adducts; Female; Fetus; Kidney; Liver; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Phosphorus Radioisotopes; Placenta; Pregnancy; Safrole | 1986 |
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; Mice; Mice, Inbred C3H | 1985 |
Quantitation by electron microscopy of the binding of highly specific antibodies to benzo[a]pyrene-DNA adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibodies; Benzo(a)pyrene; Benzopyrenes; DNA; Enzyme-Linked Immunosorbent Assay; Mice; Microscopy, Electron | 1985 |
Genotoxicity studies with mineral oils; effects of oils on the microbial mutagenicity of precursor mutagens and genotoxic metabolites.
Topics: 2-Naphthylamine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Mineral Oil; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium | 1985 |
Formation and disappearance of benzo[a]pyrene DNA-adducts in mouse epidermis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; DNA; Female; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Tritium | 1985 |
Covalent binding of benzo[a]pyrene diol epoxide to DNA of mouse skin: in vivo persistence of adducts formation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Benzopyrenes; DNA; Female; Half-Life; Male; Mice; Mice, Inbred C3H; Sex Factors; Skin; Species Specificity; Time Factors | 1985 |
Quantitation of benzo(a)pyrene metabolite: DNA adducts in selected hepatic and pulmonary cell types isolated from [3H]benzo(a)pyrene-treated rabbits.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA; Liver; Lung; Male; Protein Binding; Rabbits | 1985 |
Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; Ellagic Acid; Female; Flavonoids; Lung Neoplasms; Mice; Mice, Inbred Strains; Quercetin; Skin Neoplasms | 1985 |
A comparison of the intercalative binding of non-reactive benzo[a]pyrene metabolites and metabolite model compounds to DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; DNA; Humans; Intercalating Agents; Mice; Mice, Inbred ICR; Models, Chemical; Spectrometry, Fluorescence | 1985 |
Adduct formation in hemoglobin of the newborn mouse exposed in utero to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Body Burden; Female; Hemoglobins; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Pregnancy | 1985 |
Detection of benzo(a)pyrene:DNA adducts in human white blood cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Line; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Humans; Industry; Kinetics; Leukocytes; Lymphocytes; Metals; Reference Values | 1985 |
Enhancement of chemical-carcinogen-induced cell transformation in hamster embryo cells by 1 alpha,25-dihydroxycholecalciferol, the biologically active metabolite of vitamin D3.
Topics: 24,25-Dihydroxyvitamin D 3; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Calcitriol; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cholecalciferol; Cricetinae; Dihydroxycholecalciferols; Embryo, Mammalian; Female; Mesocricetus; Methylnitronitrosoguanidine; Pregnancy | 1984 |
Inhibition of DNA synthesis by an electrophilic metabolite of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell-Free System; DNA Polymerase II; DNA Replication; Humans; Kinetics; Lymphocytes | 1984 |
Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Repair; Humans | 1981 |
Carcinogen-mediated induction of SV40 DNA synthesis in SV40 transformed Chinese hamster embryo cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Viral; Clone Cells; Cricetinae; Cricetulus; DNA, Viral; Embryo, Mammalian; Female; Pregnancy; Simian virus 40 | 1981 |
Electrically induced fluorescence as a method for studying benzo[a]pyrene binding to DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cattle; DNA; Fluorescence; Mutagens; Proflavine | 1982 |
Interaction of benzo(a)pyrene and its dihydrodiol-epoxide derivative with nuclear and mitochondrial DNA in C3H10T 1/2 cell cultures.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Nucleus; Cells, Cultured; DNA; DNA, Mitochondrial; Liposomes; Mice | 1982 |
Formation of the 11,12-diol as a metabolite of benzo(a)pyrene by rat skin in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Male; Mice; Rats; Rats, Inbred Strains; Skin; Tritium | 1982 |
The kinetics of benzo(a)pyrene anti-7,8-dihydrodiol 9, 10-epoxide formation from benzo(a)pyrene and regulatory membrane effects.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Kinetics; Male; Microscopy, Fluorescence; Microsomes, Liver; Rats; Rats, Inbred Strains; Stereoisomerism | 1982 |
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Quinones; Rats; Rats, Inbred Strains; Time Factors; Uridine Diphosphate Glucuronic Acid | 1982 |
Regioselective inhibition of benzo[a]pyrene metabolism by butylated hydroxyanisole.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anisoles; Benzo(a)pyrene; Benzopyrenes; Butylated Hydroxyanisole; Carcinogens; Chromatography, High Pressure Liquid; Female; Kinetics; Mice; Microsomes, Liver | 1983 |
Preferential binding of polycyclic hydrocarbons to matrix-bound DNA in rat-liver nuclei.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Nucleus; Chromatin; DNA; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Binding of benzo(a)pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9, 10-tetrahydrobenzo(a)pyrene to histones.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Histones; Mice; Mice, Inbred AKR; Molecular Weight; Protein Binding; Tritium | 1983 |
Electro-optical fluorescence studies on the DNA binding of medically active drugs.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Berberine; Carcinogens; DNA; Fluorescence Polarization; Pharmaceutical Preparations; Quinacrine; Stilbamidines | 1983 |
The persistence of benzo[a]pyrene diol-epoxide deoxyguanosine adduct in mouse skin and its disappearance in rat skin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Deoxyguanosine; DNA; Kinetics; Male; Mice; Rats; Rats, Inbred Strains; Skin; Species Specificity; Tritium | 1983 |
Binding of benzo[a]pyrene to different chromatin domains following activation at the nuclear membrane.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Chromatin; Deoxyribonuclease I; DNA; In Vitro Techniques; Liver; Micrococcal Nuclease; Nuclear Envelope; Nucleic Acid Conformation; Rats; Rats, Inbred Strains | 1984 |
Fluoranthene and pyrene enhance benzo[a]pyrene--DNA adduct formation in vivo in mouse skin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; DNA; Female; Fluorenes; Mice; Mice, Inbred Strains; Pyrenes; Skin; Tritium | 1984 |
Inactivation of the thymidine kinase gene after in vitro modification with benzo(a)pyrene-diol-epoxide and transfer to LTK- cells as a eukaryotic test for carcinogens.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; DNA, Recombinant; Genes; L Cells; Mice; Nucleic Acid Hybridization; Plasmids; Thymidine Kinase | 1984 |
Benzo(a)pyrene activation to 7,8-dihydrodiol 9,10-oxide by rat liver microsomes. Control by selective product inhibition.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amines; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Kinetics; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1984 |
The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cocarcinogenesis; Ferric Compounds; In Vitro Techniques; Iron; Lung; Male; Methylcholanthrene; Rabbits | 1984 |
Comparison of the solid-matrix luminescence properties of benzo(a)pyrene-DNA adducts on alpha-cyclodextrin/NaCl and trehalose/NaCl matrices.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; alpha-Cyclodextrins; Benzo(a)pyrene; Chemical Phenomena; Chemistry, Physical; Cyclodextrins; DNA Adducts; Luminescence; Sodium Chloride; Trehalose | 1995 |
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antimutagenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Chlorophyllides; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; DNA; DNA Adducts; Hydrolysis; Male; Microsomes, Liver; Mixed Function Oxygenases; Mutagenicity Tests; Oxidoreductases; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 1994 |
Detection of DNA adducts in basal and non-basal cells of the hamster trachea exposed to benzo(a)pyrene in organ culture.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cricetinae; DNA Adducts; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Humans; Keratins; Leukocytes; Mesocricetus; Methylcholanthrene; Organ Culture Techniques; Time Factors; Trachea | 1994 |
Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in oral mucosa cells of smokers and nonsmokers.
Topics: Adult; Benzo(a)pyrene; Benzopyrenes; Case-Control Studies; Cells, Cultured; DNA Adducts; DNA Damage; DNA Repair; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mouth Mucosa; Polycyclic Compounds; Smoking; Staining and Labeling | 1995 |
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Benzo(a)pyrene; Biotransformation; Carcinogens, Environmental; DNA Adducts; DNA Mutational Analysis; Female; Fibroblasts; Humans; Immunohistochemistry; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Conformational studies of the (+)-trans, (-)-trans, (+)-cis, and (-)-cis adducts of anti-benzo[a]pyrene diolepoxide to N2-dG in duplex oligonucleotides using polyacrylamide gel electrophoresis and low-temperature fluorescence spectroscopy.
Topics: Base Sequence; Benzo(a)pyrene; Benzopyrenes; Biophysical Phenomena; Biophysics; Chemical Phenomena; Chemistry, Physical; DNA Adducts; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Oligonucleotides; Spectrometry, Fluorescence; Stereoisomerism; Temperature | 1995 |
Depression of hepatic cytochrome P450 monooxygenases after chronic environmental tobacco smoke exposure of young ferrets.
Topics: 7-Alkoxycoumarin O-Dealkylase; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analysis of Variance; Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Dose-Response Relationship, Drug; Down-Regulation; Environmental Exposure; Female; Ferrets; Immunoblotting; Liver; Male; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Pregnancy; Tobacco Smoke Pollution | 1995 |
Solid matrix, room temperature phosphorescence identification and quantitation of the tetrahydrotetrols derived from the acid hydrolysis of benzo[a]pyrene-DNA adducts from human lung.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; Humans; Hydrolysis; Luminescent Measurements; Lung; Temperature | 1995 |
Flanking base effects on the structural conformation of the (+)-trans-anti-benzo[a]pyrene diolepoxide adduct to N2-dG in sequence-defined oligonucleotides.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Cold Temperature; DNA Adducts; DNA Damage; Electrophoresis, Polyacrylamide Gel; Guanine; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Mutation; Nucleic Acid Conformation; Oligonucleotides | 1994 |
Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Benzo(a)pyrene; Biomarkers; Cohort Studies; DNA; DNA Adducts; DNA Damage; Female; Finland; Genes; Humans; Hypoxanthine Phosphoribosyltransferase; Iron; Lymphocytes; Male; Metallurgy; Middle Aged; Mutagenesis; Occupational Exposure; Polycyclic Compounds; Risk Assessment; Smoking | 1994 |
Comparison of the solid-matrix luminescence properties and photophysical parameters of two products from benzo(a)pyrene-DNA adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Deoxyguanosine; DNA; DNA Adducts; Luminescence; Photochemistry; Quantum Theory; Spectrometry, Fluorescence | 1994 |
Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA.
Topics: Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Enzyme-Linked Immunosorbent Assay; Fluorescence; Humans; Leukocytes; Lung Neoplasms; Phosphorus Radioisotopes; Sensitivity and Specificity | 1994 |
Differential recognition of stereochemically defined base adducts by antibodies against anti-benzo[a]pyrene diol-epoxide-modified DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibody Specificity; Benzo(a)pyrene; DNA; DNA Damage; Osmolar Concentration; Stereoisomerism | 1994 |
Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts and increased p53 protein in mouse skin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; DNA; DNA Damage; Male; Mice; Mice, Inbred C57BL; Skin; Tumor Suppressor Protein p53 | 1994 |
Involvement of P450 1A1 in benzo(a)pyrene but not in benzo(a)pyrene-7,8-dihydrodiol activation by 3-methylcholanthrene-induced mouse liver microsomes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; DNA Repair; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Spectrometry, Fluorescence | 1993 |
Separation and characterization of post-labeled DNA adducts of stereoisomers of benzo[a]pyrene-7,8-diol-9,10-epoxide by immobilized boronate chromatography and HPLC analysis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Boron Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; DNA; DNA Adducts; Embryo, Mammalian; Mesocricetus; Stereoisomerism; Sulfur Radioisotopes | 1994 |
Fluorescence line-narrowing studies of antibody-benzo[a]pyrene tetrol complexes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antibodies, Monoclonal; Antigen-Antibody Reactions; Benzo(a)pyrene; Cold Temperature; Dihydroxydihydrobenzopyrenes; Fluorescent Dyes; Quantum Theory; Spectrometry, Fluorescence; Ultraviolet Rays | 1993 |
Comparison of DNA adduct formation in mice fed coal tar or benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Coal Tar; DNA; DNA Damage; Gastric Mucosa; Liver; Lung; Male; Mice | 1994 |
Pulmonary alveolar macrophages in molecular epidemiology and chemoprevention of cancer.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Adolescent; Adult; Aged; Animals; Benzo(a)pyrene; DNA; DNA Adducts; Female; Humans; Macrophages, Alveolar; Male; Micronuclei, Chromosome-Defective; Middle Aged; Neoplasms; Rats; Rats, Sprague-Dawley; Smoking | 1993 |
DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Air Pollutants; Benzo(a)pyrene; Biomarkers; China; Coal; DNA; DNA Damage; Environmental Exposure; Environmental Monitoring; Female; Humans; Lung Neoplasms; Male; Polycyclic Compounds; Pregnancy | 1993 |
Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Base Sequence; Benzo(a)pyrene; Benzoflavones; Biotransformation; Cadmium; Cadmium Compounds; Chimera; Cytochrome P-450 Enzyme System; DNA Repair; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; Isoenzymes; Mice; Molecular Sequence Data; Plasmids; RNA, Messenger; Sulfates; Transfection; Transformation, Genetic; Xeroderma Pigmentosum | 1993 |
DNA adducts detected by synchronous fluorescence spectrophotometry in rat liver, kidney, lung and spleen after intraperitoneal administration of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens, Environmental; DNA; DNA Adducts; DNA Damage; Injections, Intraperitoneal; Kidney; Liver; Lung; Male; Rats; Rats, Wistar; Spectrometry, Fluorescence; Spleen | 1993 |
Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Cattle; Deoxyguanosine; DNA; DNA Adducts; Estrogens, Catechol | 1993 |
DNA repair in congenic mice: possible influence of a chromosome 4 genetic region on the rate of benzo[a]pyrene-induced DNA adduct removal.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Chromosomes; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; Genes; Life Expectancy; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Nucleotides | 1993 |
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Composition; Base Sequence; Benzo(a)pyrene; Deoxyguanosine; DNA; Hydrogen Bonding; Intercalating Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solutions; Thermodynamics | 1993 |
The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Cloning, Molecular; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Isomerism; Kinetics; Substrate Specificity; Transfection | 1993 |
Benzo(a)pyrenediolepoxide-hemoglobin adducts and 3-hydroxy-benzo(a)pyrene urinary excretion profiles in rats subchronically exposed to benzo(a)pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Carcinogens; Drug Administration Schedule; Half-Life; Hemoglobins; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley | 1995 |
Inhibitory effect of hemin, chlorophyllin and related pyrrole pigments on the mutagenicity of benzo[a]pyrene and its metabolites.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Chlorophyllides; DNA Adducts; Ferric Compounds; Hemin; Metalloporphyrins; Mutagenicity Tests; Mutagens; Pigments, Biological; Pyrroles; Salmonella typhimurium | 1995 |
Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Chlorophyllides; Female; Mice; Mice, Inbred ICR; Skin; Skin Neoplasms; Tissue Distribution | 1996 |
Exposure to environmental tobacco smoke results in an increased production of (+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide in juvenile ferret lung homogenates.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; DNA; Environmental Exposure; Female; Ferrets; Lung; Male; Pregnancy; Sex Characteristics; Stereoisomerism; Tobacco Smoke Pollution | 1996 |
Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Benzo(a)pyrene; Biotransformation; DNA; DNA Adducts; Liver; Microsomes, Liver; Molecular Structure; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Thiazoles | 1996 |
Use of a microsome-mediated test system to assess efficacy and mechanisms of cancer chemopreventive agents.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cattle; DNA; DNA Adducts; Drug Evaluation, Preclinical; Male; Microsomes; Rats; Rats, Sprague-Dawley | 1996 |
TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; DNA Damage; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Skin; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1996 |
In vitro characterization of DNA adducts formed by foundry air particulate matter.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Air Pollution, Indoor; Animals; Benzo(a)pyrene; Biomarkers; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA Adducts; Humans; In Vitro Techniques; Iron; Leukocytes; Metallurgy; Occupational Exposure; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons; Pyrenes; Thymus Gland | 1996 |
Chromatographic characterization of hemoglobin benzo[a]pyrene-7,8-diol-9,10-epoxide adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hemoglobins; Humans; Hydrogen-Ion Concentration; Kinetics; Oxygen | 1996 |
The capacity of liver microsomes to form benzo[a]pyrene-diolepoxide-DNA adducts and induction of cytochrome P450 1A in feral fish exposed to pulp mill effluents.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA Adducts; Finland; Fishes; Industrial Waste; Microsomes, Liver; Paper; Water Pollutants, Chemical | 1996 |
Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Bacterial Proteins; Base Composition; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 Enzyme System; DNA Adducts; Dose-Response Relationship, Drug; Escherichia coli Proteins; Ethylnitrosourea; Female; Genetic Vectors; Hypoxanthine Phosphoribosyltransferase; Lac Repressors; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenicity Tests; Mutagens; Repressor Proteins; Spleen; Transgenes | 1996 |
Immunoperoxidase quantitation of 4-aminobiphenyl- and polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral and urothelial cells of smokers and nonsmokers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aminobiphenyl Compounds; Animals; Antibodies, Monoclonal; Benzo(a)pyrene; Biomarkers; Carcinogens; Case-Control Studies; Cell Count; Cells, Cultured; Coloring Agents; DNA Adducts; DNA Repair; Female; Humans; Immunoenzyme Techniques; Liver; Male; Mice; Mice, Inbred BALB C; Molecular Epidemiology; Mouth Mucosa; Polycyclic Compounds; Smoking; Urothelium | 1997 |
A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (+/-)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cells, Cultured; DNA; DNA Adducts; DNA Damage; Electrophoresis; Fibroblasts; Genetic Techniques; Humans; Hypoxanthine Phosphoribosyltransferase; Mutagenicity Tests; Mutagens; Mutation; Phosphorus Radioisotopes | 1997 |
Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyre
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Binding Sites; Carcinogens; Gene Expression; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Isoenzymes; Kinetics; Models, Molecular; Molecular Conformation; Polymorphism, Genetic; Protein Binding; Stereoisomerism | 1997 |
Effect of the route of benzo[a]pyrene administration on sister chromatid exchange and DNA binding in bone marrow of mice differing with respect to cytochrome P450 1A1 induction.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Bone Marrow; Cytochrome P-450 CYP1A1; DNA; DNA Adducts; Drug Administration Routes; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagens; Sister Chromatid Exchange | 1997 |
Structural alignment of the (+)-trans-anti-benzo[a]pyrene-dG adduct positioned opposite dC at a DNA template-primer junction.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Crystallography, X-Ray; DNA Adducts; DNA Primers; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Phosphorus; Polydeoxyribonucleotides; Protons; Stereoisomerism; Templates, Genetic | 1997 |
Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Composition; Benzo(a)pyrene; Crystallography, X-Ray; Deoxyguanosine; DNA Adducts; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Polydeoxyribonucleotides; Protons; Sequence Deletion; Solutions | 1997 |
Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; B-Lymphocytes; Benzo(a)pyrene; Benzoflavones; Benzoquinones; Calcium; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Humans; Lactams, Macrocyclic; Protein-Tyrosine Kinases; Quinones; Rifabutin | 1998 |
Comparative in vitro and in vivo benzo[a]pyrene-DNA adduct formation and its relationship to CYP1A activity in two species of ictalurid catfish.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; beta-Naphthoflavone; Carcinogens, Environmental; Cytochrome P-450 Enzyme System; DNA Adducts; Ictaluridae; Liver; Microsomes, Liver; Species Specificity | 1998 |
Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Atrial Natriuretic Factor; B-Lymphocytes; bcl-2-Associated X Protein; Benzo(a)pyrene; Cell Line; Dihydroxydihydrobenzopyrenes; DNA Fragmentation; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 1998 |
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenine; Base Sequence; Benzo(a)pyrene; Codon; DNA; DNA Adducts; Genes, ras; Humans; Intercalating Agents; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protons | 1998 |
Detection of benzo[a]pyrene-DNA adducts from leukocytes from heavy smokers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Adult; Aged; Benzo(a)pyrene; Carcinogens; Cotinine; DNA Adducts; DNA Damage; Female; Humans; Leukocytes; Male; Middle Aged; Smoking | 1998 |
A comparison of mutational specificity of mutations induced by S9-activated B[a]P and benzo[a]pyrene-7,8-diol-9,10-epoxide at the endogenous aprt gene in CHO cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenine Phosphoribosyltransferase; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; CHO Cells; Cricetinae; DNA Mutational Analysis; Humans; Liver Extracts; Mutagenesis, Site-Directed; Mutagens; Proto-Oncogene Mas; Rats | 1999 |
Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Blotting, Western; Breast Neoplasms; Carcinogens; Dose-Response Relationship, Drug; Down-Regulation; Exons; Female; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Ovarian Neoplasms; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Ribosomal; Time Factors; Tumor Cells, Cultured; Up-Regulation | 1999 |
Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cervix Mucus; Cervix Uteri; DNA Adducts; Female; Gas Chromatography-Mass Spectrometry; Humans; Smoking | 1999 |
Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Carcinogens; Codon; Deoxyadenosines; DNA Adducts; DNA Replication; Escherichia coli; Exons; Female; Genes, p53; Humans; Mutagenicity Tests; Mutagens; Mutation; Neoplasms | 2000 |
Correlation between DNA or protein adducts and benzo[a]pyrene diol epoxide I-triglyceride adduct detected in vitro and in vivo.
Topics: Adult; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Humans; Lipid Metabolism; Male; Proteins; Rats; Rats, Sprague-Dawley; Triglycerides | 2000 |
Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Gas Chromatography-Mass Spectrometry; Humans | 2000 |
Quantification of (7S,8R)-dihydroxy-(9R,10S)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene adducts in human serum albumin by laser-induced fluorescence: implications for the in vivo metabolism of benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Benzo(a)pyrene; Case-Control Studies; Chromatography, High Pressure Liquid; DNA Adducts; Fluorescence; Humans; Male; Middle Aged; Sensitivity and Specificity; Serum Albumin | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorometry; Inhibitory Concentration 50; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes, Liver | 2000 |
Fluorescence spectral evidence that benzo[a]pyrene is activated by metabolism in mouse skin to a diol-epoxide and a phenol-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Chromatography, High Pressure Liquid; DNA Adducts; Male; Mice; Mice, Inbred C57BL; Skin; Spectrometry, Fluorescence | 1980 |
Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphate; Base Pairing; Base Sequence; Benzo(a)pyrene; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Hydrolysis; Molecular Sequence Data; Mutagens; Substrate Specificity | 2001 |
Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Deoxyadenosines; DNA; DNA Adducts; Hydrocarbons; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Oligonucleotides; Protons; Solutions; Spectrophotometry, Ultraviolet; Stereoisomerism; Thermodynamics | 2001 |
Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bacteriophage T7; Base Pair Mismatch; Base Pairing; Benzo(a)pyrene; Binding Sites; Carcinogens, Environmental; Computer Simulation; Deoxyadenine Nucleotides; DNA Adducts; DNA Damage; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Genes, p53; Guanine; Hydrogen Bonding; Magnesium; Models, Molecular; Mutagenesis; Protein Conformation; Software; Stereoisomerism; Templates, Genetic | 2001 |
Differences between the mutational consequences of replication of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyguanosine adducts in M13mp7L2 constructs.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Sequence; Amino Acid Substitution; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Escherichia coli; Humans; Isomerism; Molecular Sequence Data; Mutagenicity Tests; Transfection | 2001 |
Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Benzo(a)pyrene; Dermatitis, Atopic; DNA Adducts; Female; Glutathione Transferase; Humans; Lymphocytes; Male; Skin; Tumor Suppressor Protein p53 | 2001 |
Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Apigenin; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Comet Assay; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; DNA Adducts; DNA Damage; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Liver; Lung; Male; Mutagenicity Tests; Prodrugs; Quercetin; Quinolines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Species Specificity | 2002 |
Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Biotransformation; BRCA1 Protein; Breast Neoplasms; Carcinogens; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzoflavones; Blotting, Western; BRCA1 Protein; Breast Neoplasms; Carcinogens; DNA Damage; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Detection of DNA adducts in developing CD4+ CD8+ thymocytes and splenocytes following in utero exposure to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens, Environmental; CD4 Antigens; CD8 Antigens; DNA Adducts; Female; Fetus; Humans; Immune Tolerance; Male; Mice; Mice, Inbred C3H; Neoplasms; Pregnancy; Smoking; Spleen; T-Lymphocytes | 2002 |
Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Cell Survival; Cytochrome P-450 CYP1A1; Enzyme Activation; Glutathione Transferase; Humans; Isoenzymes; Rats; Transfection | 2002 |
[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Humans | 2001 |
In vitro formation of organ specific proximate carcinogen of benzo(a)pyrene by rat homogenates.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Brain; Carcinogens; Chromatography, Thin Layer; In Vitro Techniques; Intestinal Mucosa; Intestines; Kidney; Liver; Lung; Organ Specificity; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet | 2002 |
Quantitative detection of benzo[alpha]pyrene diolepoxide-DNA adducts by cryogenic laser induced fluorescence.
Topics: Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; DNA; DNA Adducts; Freezing; Humans; Lasers; Sensitivity and Specificity; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2003 |
Characterization of tetrol I-1 and (+/-)-anti-BPDE-DNA adducts with solid-matrix fluorescence quenching.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; DNA Adducts; Spectrometry, Fluorescence | 2003 |
Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Aorta; Apolipoproteins E; Benzo(a)pyrene; Body Weight; Carcinogens; Disease Models, Animal; DNA; DNA Adducts; DNA Damage; Lipid Peroxidation; Lipids; Lipoproteins; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout | 2003 |
The binding of benzo(a)pyrene to DNA components of differing sequence complexity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Chromatography; Cricetinae; DNA; DNA Adducts; Durapatite; Kinetics; Nucleic Acid Renaturation | 1980 |
The genotoxic effect of carcinogenic PAHs, their artificial and environmental mixtures (EOM) on human diploid lung fibroblasts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Diploidy; DNA; DNA Adducts; Dose-Response Relationship, Drug; Environmental Exposure; Fibroblasts; Humans; Lung; Polycyclic Aromatic Hydrocarbons; Structure-Activity Relationship; Time Factors | 2004 |
Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Drug Interactions; Estrogen Antagonists; Fibroblasts; Gene Expression; Humans; Lung Neoplasms; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Receptors, Androgen; Testosterone; Tumor Cells, Cultured | 2004 |
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Active Transport, Cell Nucleus; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cytochrome P-450 CYP1A1; DNA Adducts; Enzyme Induction; Genetic Predisposition to Disease; Glycine N-Methyltransferase; Humans; Inactivation, Metabolic; Liver Neoplasms; Methyltransferases; Models, Molecular; Transfection | 2004 |
Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Air Pollutants; Benzo(a)pyrene; Benzopyrenes; Bronchi; Cell Cycle; Cell Division; Cells, Cultured; Coloring Agents; DNA Adducts; Epithelial Cells; Gene Expression Regulation; Humans; Mutagens; Neutral Red; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Reference Values; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Chrysenes; Enzyme Inhibitors; Epidermal Cells; Epidermis; Flavonoids; I-kappa B Proteins; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Polycyclic Aromatic Hydrocarbons; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation | 2004 |
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Genotype; Humans; Lung Neoplasms; Quercetin | 2005 |
Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.
Topics: Animals; Apoptosis; Benzo(a)pyrene; Benzopyrenes; Caspase 3; Caspases; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA Fragmentation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Lung; Male; Mice; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aged; Alternative Splicing; Benzo(a)pyrene; Carcinoma; Cell Line; Enzyme Inhibitors; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Evaluating enzymes that generate genotoxic benzo[a]pyrene metabolites using sensor arrays.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biosensing Techniques; Camphor 5-Monooxygenase; Chromatography, Liquid; Cytochrome P-450 CYP1A2; DNA; DNA Damage; Electrochemistry; Electrodes; Enzymes; Guanine; Horses; Humans; Hydrogen Peroxide; Kinetics; Mass Spectrometry; Mutagens; Myoglobin; Organometallic Compounds; Oxidation-Reduction; Polyethylenes; Pseudomonas putida; Quaternary Ammonium Compounds | 2005 |
Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Benzo(a)pyrene; Carcinogens; Female; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; NAD; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Oxidation-Reduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2005 |
Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chromosome Mapping; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Haplotypes; Humans; Isoenzymes; Mutation, Missense; Polymorphism, Single Nucleotide | 2005 |
DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Coke; DNA Adducts; Germany; Humans; Occupational Exposure | 2005 |
Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2'-deoxyguanosine via reactive oxygen species.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzo(a)pyrene; Benzopyrenes; Deoxyguanosine; DNA; DNA Damage; Female; Mice; Mice, Inbred Strains; Microsomes; Reactive Oxygen Species; Singlet Oxygen; Superoxides; Ultraviolet Rays | 2005 |
Effects of chemical carcinogens and physicochemical factors on the UV spectrophotometric determination of DNA.
Topics: Aflatoxin B1; Base Composition; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chloroform; DNA; Ethanol; Hydrogen-Ion Concentration; Nucleosides; Nucleotides; Pentanols; Phenol; Proteins; RNA; Spectrophotometry, Ultraviolet; Temperature | 2005 |
Nickel potentiates the genotoxic effect of benzo[a]pyrene in Chinese hamster lung V79 cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Line; Chromium; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Male; Microsomes, Liver; Models, Statistical; Nickel; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Time Factors | 2006 |
Analysis of benzo[a]pyrene deactivation mechanisms in rats.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Male; Mathematics; Rats; Regression Analysis | 2006 |
Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylation; Animals; Benzo(a)pyrene; Cells, Cultured; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Damage; Glutathione S-Transferase pi; Humans; Hypoxanthine Phosphoribosyltransferase; Mutagenesis; Mutagens; Transfection | 2007 |
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Biological Transport; Caco-2 Cells; Catechin; Cell Line, Tumor; Chalcones; Flavonoids; Gene Expression; Humans; Hydroquinones; Indoles; Isothiocyanates; Maleates; Molecular Structure; Neoplasm Proteins; Plant Extracts; Quercetin; Receptors, Aryl Hydrocarbon; Resveratrol; RNA, Messenger; Silymarin; Stilbenes; Sulfoxides; Thiocyanates; Transfection | 2007 |
Induction of cell death, DNA strand breaks, and cell cycle arrest in DU145 human prostate carcinoma cell line by benzo[a]pyrene and benzo[a]pyrene-7,8-diol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Carcinoma; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Breaks; Humans; Male; Prostatic Neoplasms; Toxicity Tests | 2007 |
Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Benzoflavones; Carcinogens; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Down-Regulation; Ellipticines; Enzyme Induction; Enzyme Inhibitors; Liver Neoplasms, Experimental; Mice; Phosphorylation; Receptors, Aryl Hydrocarbon; Tumor Suppressor Protein p53 | 2007 |
Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Mutagenicity Tests; Mutagens; Mutation; Stereoisomerism; Transfection | 2007 |
Benzo[a]pyrene induces apoptosis in RL95-2 human endometrial cancer cells by cytochrome P450 1A1 activation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Benzo(a)pyrene; Blotting, Western; Caspases; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Endometrial Neoplasms; Enzyme Activation; Female; Humans; Immunohistochemistry; Microscopy, Electron; Mitochondria; Receptors, Aryl Hydrocarbon; Up-Regulation | 2007 |
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoma; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Female; Gene Expression Profiling; Glutathione S-Transferase pi; Lung; Lung Neoplasms; Male; MAP Kinase Kinase 4; Nicotiana; RNA, Messenger; Urethane | 2007 |
Influence of the metabolic properties of human cells on the kinetic of formation of the major benzo[a]pyrene DNA adducts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Survival; Cells; Chromatography, High Pressure Liquid; DNA Adducts; DNA Repair; Electrochemistry; Environmental Pollutants; Humans; Indicators and Reagents; Keratinocytes; Kinetics; Online Systems; Tandem Mass Spectrometry; Tetrazolium Salts; Thiazoles | 2008 |
Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Tumor Suppressor Protein p53 | 2008 |
[A cigarette, an aromatic...and a cancer].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Hot Temperature; Humans; Lung Neoplasms; Smoking; Structure-Activity Relationship; Substrate Specificity | 2008 |
[The formation of BPDE-DNA adduct in rat and its determination by high performance liquid chromatography].
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; DNA; DNA Adducts; DNA Damage; Electrophoresis, Agar Gel; Female; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
PCB77 (3,3',4,4'-tetrachlorobiphenyl) co-exposure prolongs CYP1A induction, and sustains oxidative stress in B(a)P-exposed turbot, Scophthalmus maximus, in a long-term study.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antioxidants; Benzo(a)pyrene; Bile; Blotting, Western; Cytochrome P-450 CYP1A1; DNA Adducts; Drug Synergism; Enzyme Induction; Female; Flatfishes; Gills; Liver; Male; Metabolic Detoxication, Phase II; Oxidative Stress; Polychlorinated Biphenyls; Water Pollutants, Chemical | 2008 |
Development of human cell models for assessing the carcinogenic potential of chemicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Aflatoxin B1; Animals; Benzo(a)pyrene; Bronchi; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Cytochrome P-450 CYP1A1; Genes, myc; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Nickel | 2008 |
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Bay-Region, Polycyclic Aromatic Hydrocarbon; Benzo(a)pyrene; Benzopyrenes; Blotting, Western; Cell Line, Tumor; Comet Assay; DNA Adducts; DNA Damage; DNA Fragmentation; Epoxy Compounds; Histones; Humans; Immunohistochemistry; Phosphorylation; Time Factors | 2009 |
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Cell Line, Tumor; Cyclosporine; Cytochrome P-450 CYP1A1; Humans; Microscopy, Fluorescence, Multiphoton; Time Factors | 2009 |
The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS.
Topics: 5-Methylcytosine; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analytic Sample Preparation Methods; Benzo(a)pyrene; Carcinogens; Chromatography, High Pressure Liquid; Codon; Cytosine; DNA; DNA Adducts; DNA Methylation; Genes, p53; Guanine; Humans; Microchemistry; Mutagens; Oligonucleotides; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Dietary curcumin enhances benzo(a)pyrene-induced apoptosis resulting in a decrease in BPDE-DNA adducts in mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Blotting, Western; Caspase 3; Curcumin; Diet; DNA Adducts; Male; Mice; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2009 |
MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Bronchi; Carcinogens; Cell Cycle; Cell Separation; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase 6; Environmental Pollutants; Epithelial Cells; Female; Flow Cytometry; Male; Mice; MicroRNAs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2010 |
Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Drug Synergism; Humans; NF-kappa B; Protein Kinase C; Tobacco Smoke Pollution; Transcription Factor AP-1 | 2010 |
Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Free Radical Scavengers; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Models, Biological; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons | 2010 |
In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; DNA Adducts; DNA Damage; DNA Fragmentation; Humans; Male; Mutagens; Spermatozoa | 2010 |
Evaluation of DNA adducts, DNA and RNA oxidative lesions, and 3-hydroxybenzo(a)pyrene as biomarkers of DNA damage in lung following intravenous injection of the parent compound in rats.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 8-Hydroxy-2'-Deoxyguanosine; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Injections, Intravenous; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; RNA; Tandem Mass Spectrometry; Time Factors | 2010 |
Evaluation of the noncovalent binding interactions between polycyclic aromatic hydrocarbon metabolites and human p53 cDNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; DNA Damage; DNA, Complementary; Environmental Pollutants; Humans; Mutagens; Polycyclic Aromatic Hydrocarbons; Pyrenes; Tumor Suppressor Protein p53 | 2010 |
Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amino Acid Substitution; Base Sequence; Benzo(a)pyrene; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Escherichia coli Proteins; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Substrate Specificity | 2011 |
Characterization of human breast cancer cell lines for the studies on p53 in chemical carcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; Exons; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Immunoblotting; Mutation; Phosphorylation; Polymerase Chain Reaction; Receptors, Estrogen; Receptors, Progesterone; Sequence Analysis, DNA; Tumor Suppressor Protein p53 | 2011 |
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Benzo(a)pyrene; Cell Line, Tumor; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Heme Oxygenase-1; Humans; Lung Neoplasms; Quinones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Effect of UDP-glucuronic acid on the microsome-mediated binding of benzo(a)pyrene metabolites to calf thymus DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dextrans; DNA; Glucuronosyltransferase; Indicators and Reagents; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Uridine Diphosphate Glucuronic Acid | 1980 |
Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carcinogens; Chlorophyllides; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; DNA Repair; Female; Haploinsufficiency; Humans; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Tandem Mass Spectrometry; Tumor Suppressor Protein p53; Xeroderma Pigmentosum Group A Protein | 2012 |
Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; beta-Naphthoflavone; Caspase 8; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adducts; Fas Ligand Protein; Humans; Keratinocytes; Receptors, Aryl Hydrocarbon; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; RNA, Small Interfering; Signal Transduction | 2012 |
Modulation of CYP1A1, CYP1B1 and DNA adducts level by green and white tea in Balb/c mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adducts; Erythrocytes; Glutathione Transferase; Inactivation, Metabolic; Liver; Lung; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; NAD(P)H Dehydrogenase (Quinone); Tea | 2012 |
Response of Lumbriculus variegatus transcriptome and metabolites to model chemical contaminants.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; alpha-Tocopherol; Animals; Antioxidants; Benzo(a)pyrene; Cadmium; Cholecalciferol; Cluster Analysis; DNA Adducts; Electrophoresis, Capillary; Energy Metabolism; Gas Chromatography-Mass Spectrometry; Immunoassay; Oligochaeta; Oligonucleotide Array Sequence Analysis; Pentachlorophenol; Reverse Transcriptase Polymerase Chain Reaction; Transcriptome; Water Pollutants, Chemical | 2013 |
Further investigations on the modified comet assay for measuring aphidicolin-block nucleotide excision repair.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Adult; Aphidicolin; Benzo(a)pyrene; Comet Assay; DNA Damage; DNA Repair; Enzyme Inhibitors; Female; Humans; Leukocytes, Mononuclear; Male; Reproducibility of Results; Young Adult | 2013 |
ERCC1 and ERCC2 haplotype modulates induced BPDE-DNA adducts in primary cultured lymphocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Benzo(a)pyrene; Carcinogens; Cells, Cultured; DNA Adducts; DNA Damage; DNA-Binding Proteins; Endonucleases; Female; Haplotypes; Humans; Lymphocytes; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Xeroderma Pigmentosum Group D Protein; Young Adult | 2013 |
HspA1A facilitates DNA repair in human bronchial epithelial cells exposed to Benzo[a]pyrene and interacts with casein kinase 2.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Casein Kinase II; Cell Line; Cell Nucleus; Cytoprotection; DNA Adducts; DNA Damage; DNA Repair; Epithelial Cells; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Protein Binding; Protein Transport; Transfection | 2014 |
In vivo exposure to benzo(a)pyrene induces significant DNA damage in mouse oocytes and cumulus cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cumulus Cells; DNA Adducts; DNA Damage; Female; Mice; Oocytes | 2014 |
Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Cell Differentiation; Cell Survival; Cells, Cultured; Creatine Kinase, MM Form; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Male; Middle Aged; Muscle Development; Muscle, Skeletal; Primary Cell Culture; Stem Cells | 2014 |
Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biocatalysis; Deoxyguanosine; DNA Primers; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Embryo, Mammalian; Fibroblasts; Kinetics; Mice; Models, Molecular; Mutant Proteins | 2014 |
Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adolescent; Benzo(a)pyrene; Child; Child, Preschool; Chromosome Aberrations; Coal Tar; Cohort Studies; DNA; DNA Adducts; DNA Damage; Female; Humans; Keratolytic Agents; Lymphocytes; Male; Ointments; Oxidative Stress; Prospective Studies; Psoriasis; Ultraviolet Rays | 2014 |
Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cell Hypoxia; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Media; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dihydroxydihydrobenzopyrenes; DNA Adducts; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Kinetics; Mutagens; Oxygen; Time Factors | 2014 |
Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Biomarkers; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; Histidine; Humans; Male; Mice; Protein Binding; Risk Assessment; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Human DNA polymerases catalyze lesion bypass across benzo[a]pyrene-derived DNA adduct clustered with an abasic site.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Catalysis; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA Polymerase I; DNA Repair; DNA-Directed DNA Polymerase; Humans; Molecular Sequence Data | 2014 |
Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Benzo(a)pyrene; DNA Adducts; DNA, Single-Stranded; Genome; Glass; Guanine; Hemolysin Proteins; Humans; Ions; Lipid Bilayers; Metals; Mutagenesis; Mutagens; Nanopores; Nanotechnology; Neoplasms; Oligonucleotides | 2015 |
TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Survival; Cells, Cultured; Codon; DNA Adducts; DNA Repair; Fibroblasts; Genes, p53; Humans; Mice; Mutagens; Mutation; Oxygen; Xeroderma Pigmentosum Group A Protein | 2015 |
PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lung Neoplasms; Mice; MicroRNAs; Phosphoprotein Phosphatases | 2015 |
Quantitative analysis of 3-OHB[a]P and (+)-anti-BPDE as biomarkers of B[a]P exposure in rats.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Oral; Animals; Benzo(a)pyrene; Benzopyrenes; Biomarkers; Chromatography, High Pressure Liquid; Environmental Exposure; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2016 |
New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Environmental; Dihydroxydihydrobenzopyrenes; DNA Adducts; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; Transcriptome | 2016 |
Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; Benzo(a)pyrene; Carcinogens; Codon; DNA; DNA Adducts; DNA Damage; Genes, p53; Humans; Hydrogen Bonding; Lung Neoplasms; Molecular Dynamics Simulation; Mutation; Smoking | 2015 |
Tracking matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; Humans; Mass Spectrometry; Polycyclic Aromatic Hydrocarbons | 2016 |
Ubiquitin Protein Ligase Ring2 Is Involved in S-phase Checkpoint and DNA Damage in Cells Exposed to Benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Bronchi; Cell Line; Cell Proliferation; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Epithelial Cells; Fibroblasts; Gene Expression Regulation; Humans; Proliferating Cell Nuclear Antigen; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Signal Transduction; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2016 |
Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Benzo(a)pyrene; Biotransformation; Coal Tar; Cytochrome P-450 CYP1B1; DNA Adducts; DNA Damage; Epoxide Hydrolases; Female; Gene Frequency; Glucuronosyltransferase; Glutathione Transferase; Heterozygote; Homozygote; Humans; Keratolytic Agents; Male; Middle Aged; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Psoriasis; Real-Time Polymerase Chain Reaction; Risk Assessment; Ultraviolet Therapy; Young Adult | 2016 |
Genetic polymorphisms in 19q13.3 genes associated with alteration of repair capacity to BPDE-DNA adducts in primary cultured lymphocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Aged; Alleles; Benzo(a)pyrene; Carcinogens, Environmental; Cells, Cultured; Chromosomes, Human, Pair 19; Comet Assay; DNA; DNA Adducts; DNA Damage; DNA Repair; Female; Genotype; Humans; Lymphocytes; Male; Middle Aged; Polymorphism, Single Nucleotide | 2016 |
Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Benzo(a)pyrene; Carcinogens; Cell Line; Cytochromes c; Drosophila Proteins; Epoxy Compounds; Humans; Mitochondria; Mitochondrial Dynamics; Naphthalenes; Nerve Tissue Proteins; Nuclear Proteins; Toxicity Tests; Transcription Factors; Trophoblasts | 2018 |
TERT regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to BPDE in vitro and to B[a]P in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Benzo(a)pyrene; Cell Survival; Cells, Cultured; Cellular Senescence; DNA Damage; Gene Knockdown Techniques; Male; Mice; Rats; Spermatocytes; Telomerase; Telomere | 2018 |
BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Benzo(a)pyrene; Benzopyrenes; Cell Line; DNA, Mitochondrial; Gene Knockdown Techniques; Male; Mice; Mitochondria; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirtuin 1; Spermatocytes; Spermatozoa; Telomerase; Testis | 2019 |
Metabolism and genotoxicity of polycyclic aromatic hydrocarbons in human skin explants: mixture effects and modulation by sunlight.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Complex Mixtures; Cytochrome P-450 Enzyme System; DNA Adducts; Female; Gene Expression Regulation; Humans; Inactivation, Metabolic; Mutagenicity Tests; Organ Culture Techniques; Polycyclic Aromatic Hydrocarbons; Skin; Sunlight | 2020 |
The Role of Cyclooxygenases-2 in Benzo(
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Environmental Pollutants; Male; Mice, Inbred C57BL; Neurons; Neurotoxicity Syndromes; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype | 2020 |
Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Chemical and Drug Induced Liver Injury; DNA Adducts; DNA Damage; Hep G2 Cells; Humans; Mutagens; Protective Agents; Signal Transduction; Silymarin | 2020 |
DNA as an in vitro trapping agent for detection of bulky genotoxic metabolites.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Chromatography, Liquid; DNA; DNA Adducts; Linear Models; Mass Spectrometry; Microsomes, Liver; Models, Chemical; Mutagens; Rats; Reproducibility of Results; Sensitivity and Specificity | 2020 |
Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; DNA Adducts; Female; Humans; Pregnancy; Trophoblasts | 2021 |
Lnc-HZ05 regulates BPDE-inhibited human trophoblast cell proliferation and affects the occurrence of miscarriage by directly binding with miR-hz05.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Abortion, Spontaneous; Benzo(a)pyrene; Cell Line; Cell Movement; Cell Proliferation; Female; Humans; MicroRNAs; Pregnancy; RNA, Long Noncoding; Trophoblasts | 2022 |
Endoplasmic reticulum stress regulates pyroptosis in BPDE-induced BEAS-2B cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Caspase 1; Endoplasmic Reticulum Stress; Humans; Interleukin-18; Pyroptosis | 2022 |
Interactions between Benzo(a)pyrene exposure and genetic polymorphisms of AhR signaling pathway on missed abortion.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Abortion, Missed; Benzo(a)pyrene; DNA Adducts; Female; Humans; Polymorphism, Genetic; Pregnancy; Signal Transduction | 2023 |
Exposure to Benzo(a)pyrene damages mitochondrial function via suppressing mitochondrial melatonin receptors in ovarian corpus luteum during early pregnancy.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenosine Triphosphate; Animals; Benzo(a)pyrene; Corpus Luteum; Environmental Pollutants; Female; Mammals; Mice; Mitochondria; Pregnancy; Progesterone; Rats; Receptors, Melatonin; Sirtuin 3 | 2022 |
Benzo[a]pyrene inhibits testosterone biosynthesis via NDUFA10-mediated mitochondrial compromise in mouse Leydig cells: Integrating experimental and in silico toxicological approaches.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Leydig Cells; Male; Mice; Mitochondria; NADH Dehydrogenase; PPAR alpha; Testosterone | 2022 |
Acute cytotoxicity test of PM
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogens; Coculture Techniques; Cytokines; Epithelial Cells; Epoxy Compounds; Humans; Ketones; Macrophages; Nicotine; Nitrosamines; Particulate Matter; Sincalide | 2022 |
Quercetin and Isorhamnetin Reduce Benzo[a]pyrene-Induced Genotoxicity by Inducing RAD51 Expression through Downregulation of miR-34a.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; DNA Adducts; DNA Damage; Down-Regulation; MicroRNAs; Mutagens; Quercetin | 2022 |
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Epoxy Compounds; Ferroptosis; Humans; Lipid Peroxides; Neuroblastoma; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidation-Reduction | 2022 |
Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Carcinogenesis; Culture Media, Conditioned; Enhancer of Zeste Homolog 2 Protein; Epidermal Growth Factor; Epithelial Cells; Epoxy Compounds; Humans; Lung; Nuclear Proteins; Transcription Factors; Tumor Microenvironment; Tumor Necrosis Factor-alpha | 2023 |
BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Abortion, Spontaneous; Animals; Benzo(a)pyrene; Female; Humans; Methyltransferases; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Placenta; Pregnancy; Pyroptosis; RNA-Binding Proteins; Trophoblasts | 2023 |
The activation of SIRT1 ameliorates BPDE-induced inflammatory damage in BEAS-2B cells via HMGB1/TLR4/NF-κB pathway.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acute Lung Injury; Benzo(a)pyrene; Cytokines; HMGB1 Protein; Humans; Inflammation; NF-kappa B; Signal Transduction; Sirtuin 1; Toll-Like Receptor 4 | 2023 |
TERT transcription and translocation into mitochondria regulate benzo[a]pyrene/BPDE-induced senescence and mitochondrial damage in mouse spermatocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Male; Mice; Mice, Inbred ICR; Mitochondria; Sirtuin 1; Spermatocytes | 2023 |
Potential pathway and mechanisms underlining the immunotoxicity of benzo[a]pyrene to Chlamys farreri.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Oxidative Stress; Pectinidae; Protein-Tyrosine Kinases; Signal Transduction | 2023 |
Potential molecular mechanism underlying the harmed haemopoiesis upon Benzo[a]pyrene exposure in Chlamys farreri.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Hemocytes; Pectinidae | 2023 |
BPDE-DNA adduct formation and alterations of mRNA, protein, and DNA methylation of CYP1A1, GSTP1, and GSTM1 induced by benzo[a]pyrene and the intervention of aspirin in mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Aspirin; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Methylation; Glutathione S-Transferase pi; Glutathione Transferase; Mice | 2023 |
BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Abortion, Spontaneous; Animals; Benzo(a)pyrene; Endothelial Cells; Female; Ferroptosis; Humans; Mice; Placenta; Pregnancy; Proteins | 2023 |
AHR-mediated DNA damage contributes to BaP-induced cardiac malformations in zebrafish.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Damage; Heart Defects, Congenital; Receptors, Aryl Hydrocarbon; Sirtuin 1; Spironolactone; Zebrafish | 2024 |