7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide has been researched along with benzo(a)pyrene 7,8-dihydrodiol in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (52.94) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jakab, GJ; Mosebrook, DR; Petruska, JM; Trush, MA | 1 |
| Lau, BH; Teel, RW; Wong, BY | 1 |
| Bartley, JC; Levine, GA; Tischler, AN | 1 |
| Strother, A; Teel, RW; Vance, RE | 1 |
| Marnett, LJ; Nimesheim, A; Pruess-Schwartz, D | 1 |
| Alexandrov, K; Rojas, M | 1 |
| Christou, M; Jefcoate, CR; Keller, GM; Pottenger, LH; Wilson, NM | 1 |
| Bagheri, K; Hecht, SS; Melikian, AA | 1 |
| Baird, WM; Harvey, RG; Lee, H; Morgan, SL; Moynihan, CG; Smolarek, TA | 1 |
| Curtis, JF; Eling, TE; Hughes, MF; Mason, RP | 1 |
| Alexandrov, K; Rojas, M; Sala, M | 1 |
| Krolewski, B; Little, JB | 1 |
| Abramovich, M; Harvey, RG; Lebreton, PR; Prakash, AS; Zegar, IS | 1 |
| Jefcoate, CR; Keller, GM; Turner, CR | 1 |
| Dock, L; Jernström, B; Martinez, M | 1 |
| Autrup, H; Eling, TE; Grafstrom, RC; Krauss, RS; Reed, GA | 1 |
| Dock, L; Jernström, B; Martinez, M; Svensson, SA | 1 |
| Connell, JR | 1 |
| Conney, AH; Jerina, DM; Kouri, RE; Levin, W; Mah, HD; Rude, TH; Wood, AW; Yagi, H | 1 |
| Cerniglia, CE; Gibson, DT | 1 |
| Babson, JR; Holmgren, A; Jernström, B; Moldéus, P; Reed, DJ | 1 |
| Culp, SJ; Quan, T; Reiners, JJ; Richter, P; States, JC | 1 |
| Fujita, I; Kikkawa, Y; Rasmussen, RE; Sindhu, RK; Yamamoto, R | 1 |
| Dutchuk, M; Hendricks, JD; Kelly, JD; Reddy, A; Takahashi, N; Williams, DE | 1 |
| Kikkawa, Y; Sindhu, RK | 1 |
| Bleczinski, WF; Burczynski, ME; Flowers, L; Harvey, RG; Penning, TM | 1 |
| Burchiel, SW; Mounho, BJ | 1 |
| Burchiel, SW; Salas, VM | 1 |
| Burchiel, SW; Lane, J; Lauer, FT; Tannheimer, SL | 1 |
| Astlind, T; Dock, L; Ehrenberg, A; Gräslund, A; Jernström, B; Undeman, O | 1 |
| Chen, S; Karin, M; Nguyen, N; Tamura, K; Tukey, RH | 1 |
| Ahmad, S; Doehmer, J; Kabler, SL; Kushman, ME; Morrow, CS; Townsend, AJ | 1 |
| Abedin, Z; Field, J; Sen, S | 1 |
| Chiu, RK; Godschalk, RW; Sanen, K; Schults, MA; Theys, J; van Schooten, FJ | 1 |
34 other study(ies) available for 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide and benzo(a)pyrene 7,8-dihydrodiol
| Article | Year |
|---|---|
Myeloperoxidase-enhanced formation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene-DNA adducts in lung tissue in vitro: a role of pulmonary inflammation in the bioactivation of a procarcinogen.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Bronchoalveolar Lavage Fluid; Dihydroxydihydrobenzopyrenes; DNA; DNA Damage; Inflammation; Kinetics; Lung; Male; Mice; Mice, Inbred DBA; Neutrophils; Peroxidase; Proteus Infections; Proteus mirabilis; Superoxides; Tritium | 1992 |
Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Drugs, Chinese Herbal; Male; Mutagenicity Tests; Rats; Rats, Inbred Strains | 1992 |
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol in human mammary epithelial cells: feedback inhibition by 7-hydroxybenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Biotransformation; Breast; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Epithelium; Female; Humans | 1991 |
Inhibition of liver microsome-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in the rat following glucose administration.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Depression, Chemical; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Glucose; Male; Microsomes, Liver; Mutagenicity Tests; Mutation; Rats; Rats, Inbred Strains | 1990 |
Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Epoxy Compounds; Female; In Vitro Techniques; Mice; NADP; Peroxides; Skin | 1989 |
In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Deoxyguanosine; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Male; Mice; Rats; Rats, Inbred Strains; Skin; Stereoisomerism; Tritium | 1986 |
Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid | 1987 |
Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Topical; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Epidermis; Female; Half-Life; Kinetics; Mice | 1987 |
Metabolism and DNA adduct formation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in fish cell lines in culture.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fishes | 1987 |
Peroxidase-catalyzed oxidation of (bi)sulfite: reaction of free radical metabolites of (bi)sulfite with (+/-)-7,8-dihydroxy-7, 8-dihydroxy[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Free Radicals; Horseradish Peroxidase; Male; Mass Spectrometry; Microsomes; Oxidation-Reduction; Peroxidases; Seminal Vesicles; Sheep; Sulfites; Sulfonic Acids | 1988 |
Differences in the DNA adducts formed in cultured rabbit and rat dermal fibroblasts by benzo(a)pyrene and (-)benzo(a)pyrene-7,8-diol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Rabbits; Rats; Skin | 1988 |
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetamides; Allylisopropylacetamide; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; Mice; Mice, Inbred C3H | 1985 |
A comparison of the intercalative binding of non-reactive benzo[a]pyrene metabolites and metabolite model compounds to DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; DNA; Humans; Intercalating Agents; Mice; Mice, Inbred ICR; Models, Chemical; Spectrometry, Fluorescence | 1985 |
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Quinones; Rats; Rats, Inbred Strains; Time Factors; Uridine Diphosphate Glucuronic Acid | 1982 |
Metabolic activation of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and the inhibitory effect of glutathione and cysteine.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Biotransformation; Carcinogens; Cysteine; Dihydroxydihydrobenzopyrenes; Glutathione; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1984 |
Prostaglandin H synthase-dependent co-oxygenation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Arachidonic Acid; Arachidonic Acids; Benzopyrenes; Bronchi; Cricetinae; Dihydroxydihydrobenzopyrenes; DNA; Humans; In Vitro Techniques; Male; Prostaglandin Endoperoxides; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Trachea | 1984 |
Metabolism of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and glutathione conjugates in isolated rat hepatocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzoflavones; Benzopyrenes; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Glutathione; Liver; Macromolecular Substances; Male; Maleates; Proteins; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1984 |
Karyotype analysis of carcinogen-treated Chinese hamster cells in vitro evolving from a normal to a malignant phenotype.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Agar; Animals; Benzopyrenes; Carcinogens; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Cricetinae; Cricetulus; Dihydroxydihydrobenzopyrenes; Fetus; Karyotyping; Lung; Sarcoma, Experimental | 1984 |
Carcinogenicity of benzo[a]pyrene and thirteen of its derivatives in C3H/fCum mice.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; Drug Evaluation, Preclinical; Epoxy Compounds; Fibrosarcoma; Male; Mice; Mice, Inbred C3H; Sarcoma, Experimental; Structure-Activity Relationship | 1980 |
Fungal oxidation of benzo[a]pyrene and (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. Evidence for the formation of a benzo[a]pyrene 7,8-diol-9,10-epoxide.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Mass Spectrometry; Mucorales; Oxidation-Reduction; Spectrophotometry | 1980 |
Glutathione conjugation and DNA-binding of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in isolated rat hepatocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA; Glutathione; Glycine; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains | 1982 |
Differential mutagenicity and cytotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol and (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Biotransformation; Cell Line; Cell Survival; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA Adducts; DNA Repair; Humans; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Mutagenesis | 1995 |
Depression of hepatic cytochrome P450 monooxygenases after chronic environmental tobacco smoke exposure of young ferrets.
Topics: 7-Alkoxycoumarin O-Dealkylase; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analysis of Variance; Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Dose-Response Relationship, Drug; Down-Regulation; Environmental Exposure; Female; Ferrets; Immunoblotting; Liver; Male; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Pregnancy; Tobacco Smoke Pollution | 1995 |
Covalent binding of (+) 7S-trans-7,8-dihydrobenzo [a]pyrene-7,8-diol to trout DNA: P-450- and peroxidation-dependent pathways.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Analysis of Variance; Animals; Benzoflavones; beta-Naphthoflavone; Binding Sites; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Damage; Embryo, Nonmammalian; Enzyme Induction; Hydrogen Peroxide; Lipid Peroxidation; Oxidation-Reduction; Oxidoreductases; Peroxidases; Trout | 1993 |
Metabolism of (+)-trans-benzo[a]pyrene-7,8-dihydrodiol by 3-methylcholanthrene-induced rat liver homogenates.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetates; Animals; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Glutathione; In Vitro Techniques; Liver; Methylcholanthrene; Oxidoreductases; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Spectrophotometry, Ultraviolet | 1995 |
Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Benzoquinones; Cells, Cultured; Dihydroxydihydrobenzopyrenes; DNA Adducts; DNA Damage; DNA Fragmentation; DNA, Superhelical; DNA, Viral; Liver; Male; Mutagenicity Tests; Mutagens; Oxidoreductases; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 1996 |
Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; B-Lymphocytes; Benzo(a)pyrene; Benzoflavones; Benzoquinones; Calcium; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Humans; Lactams, Macrocyclic; Protein-Tyrosine Kinases; Quinones; Rifabutin | 1998 |
Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Apoptosis; Atrial Natriuretic Factor; B-Lymphocytes; bcl-2-Associated X Protein; Benzo(a)pyrene; Cell Line; Dihydroxydihydrobenzopyrenes; DNA Fragmentation; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 1998 |
Factors influencing elevation of intracellular Ca2+ in the MCF-10A human mammary epithelial cell line by carcinogenic polycyclic aromatic hydrocarbons.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzoflavones; Benzopyrenes; Breast; Calcium; Carcinogens; Cell Line; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA-Binding Proteins; Egtazic Acid; Epithelial Cells; Humans; Methylcholanthrene; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; RNA, Messenger; Time Factors; Transcription Factors | 1999 |
Fluorescence measurements of DNA-bound metabolites of benzo(a)pyrene derivatives with different carcinogenic effects.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Carcinogens; Dihydroxydihydrobenzopyrenes; DNA Adducts; Fluorescence; Microsomes, Liver; Rats | 1984 |
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Aryl Hydrocarbon Receptor Nuclear Translocator; bcl-X Protein; Carcinogens; Carcinoma, Hepatocellular; Caspases; Cytochrome c Group; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA Damage; DNA-Binding Proteins; Enzyme Activation; Fibroblasts; Humans; Liver Neoplasms; Luciferases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Mutagenicity Tests; Mutagens; Mutation; Stereoisomerism; Transfection | 2007 |
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenocarcinoma; Adenocarcinoma of Lung; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Benzo(a)pyrene; Cell Line, Tumor; Dihydroxydihydrobenzopyrenes; Epithelial Cells; Heme Oxygenase-1; Humans; Lung Neoplasms; Quinones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzo(a)pyrene; Cell Hypoxia; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Media; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dihydroxydihydrobenzopyrenes; DNA Adducts; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Kinetics; Mutagens; Oxygen; Time Factors | 2014 |