7,8-dichloro-1,2,3,4-tetrahydroisoquinoline has been researched along with clonidine in 9 studies
| Studies (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) | Trials (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) | Recent Studies (post-2010) (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 79 | 0 | 0 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bondiolotti, GP; Cella, SG; De Gennaro, V; Locatelli, V; Loche, S; Müller, EE; Pintor, C; Provezza, M | 1 |
| Crowley, WR; Feder, HH; Nock, B | 1 |
| Goldstein, M; Hieble, JP; Lew, JY; Pendleton, RG; Saito, M | 1 |
| Goldstein, M; Hieble, JP; Kinguasa, K; Pendleton, RG | 1 |
| Gerold, M; Haeusler, G | 1 |
| Crowley, WR; Johnson, MD; Terry, LC | 1 |
| Gerkens, JF; Goldberg, MR; Oates, JA; Ring, M; Robertson, D; Tung, CS | 1 |
| Elam, M; Engberg, G; Svensson, TH | 1 |
| Atobe, M; Kariya, T; Kubota, M; Nakagawara, M | 1 |
9 other study(ies) available for 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline and clonidine
| Article | Year |
|---|---|
Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats.
Topics: Animals; Animals, Newborn; Clonidine; Dopamine beta-Hydroxylase; Epinephrine; Female; Galanin; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Immunization, Passive; Isoquinolines; Male; Norepinephrine; Peptides; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines; Triazoles | 1988 |
Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: mediation by alpha noradrenergic receptors.
Topics: Animals; Brain; Clonidine; Cricetinae; Dose-Response Relationship, Drug; Estradiol; Female; Isoquinolines; Monoamine Oxidase Inhibitors; Ovariectomy; Phenylethanolamine N-Methyltransferase; Progesterone; Receptors, Adrenergic; Sexual Behavior, Animal; Spinal Cord; Tetrahydroisoquinolines | 1989 |
The blockade of alpha 2-adrenoceptors by the PNMT inhibitaor SK&F 64139.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Cerebral Cortex; Clonidine; In Vitro Techniques; Isoquinolines; Phenylethanolamine N-Methyltransferase; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines | 1980 |
Lowering of blood pressure in hypertensive rats by SKF 64139 and SKF 72223.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Heart Rate; Hypertension; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Prazosin; Premedication; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines | 1982 |
The influence of SK & F 64139, a phenylethanolamine-N-methyltransferase inhibitor, on centrally mediated cardiovascular effects of alpha-methyldopa and clonidine.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Clonidine; Heart Rate; Isoquinolines; Male; Methyldopa; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1982 |
Regulation of episodic growth hormone secretion by the central epinephrine system. Studies in the chronically cannulated rat.
Topics: Amines; Animals; Benzylamines; Clonidine; Epinephrine; Growth Hormone; Isoquinolines; Male; Morphine; Periodicity; Phenylethanolamine N-Methyltransferase; Prolactin; Rats; Secretory Rate; Sulfonamides; Tetrahydroisoquinolines | 1982 |
Evidence that alpha-methylepinephrine is an antihypertensive metabolite of alpha-methyldopa.
Topics: Animals; Biotransformation; Blood Pressure; Clonidine; Epinephrine; Heart Rate; Hypertension; Isoquinolines; Male; Methyldopa; Phenylethanolamine N-Methyltransferase; Rats; Tetrahydroisoquinolines | 1982 |
Effect of adrenaline synthesis inhibition on brain noradrenaline neurons in locus coeruleus.
Topics: Action Potentials; Amines; Animals; Benzylamines; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Evoked Potentials; Isoquinolines; Locus Coeruleus; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1981 |
Effect of phenylethanolamine N-methyltransferase inhibitor, CGS19281A, on the alpha-2-adrenoceptor function in the hypothalamus of rats in comparison with SKF29661, SKF64139 and yohimbine.
Topics: Animals; Carbolines; Clonidine; Hypothalamus; Isoquinolines; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tetrahydroisoquinolines; Yohimbine | 1996 |