7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one has been researched along with cp 96345 in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 40 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cascieri, MA; Fong, TM; Herbert, R; MacIntyre, DE; Merchant, KJ; Owen, SN; Owens, AP; Sabin, V; Seward, EM; Swain, CJ | 1 |
| Bruns, RF; Cho, SS; Crowell, TA; Foreman, MM; Gehlert, DR; Gitter, BD; Hipskind, PA; Howbert, JJ; Iyengar, S; Johnson, KW; Krushinski, JH; Li, DL; Lobb, KL; Mason, NR; Muehl, BS; Nixon, JA; Phebus, LA; Regoli, D; Simmons, RM; Threlkeld, PG; Waters, DC | 1 |
| Fong, TM; Strader, CD; Yu, H | 1 |
| Carruette, A; Champion, A; Cottez, D; Garret, C; Goniot, P; Moussaoui, SM | 1 |
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Longmore, J; Main, MJ; Razzaque, Z; Seabrook, GR | 1 |
| Boccio, D; Carruette, A; Garret, C; Montier, F; Moussaoui, S | 1 |
| Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Goso, C; Manzini, S; Potier, E; Szallasi, A | 1 |
| Buéno, L; Julia, V; Morteau, O | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Couture, R; Picard, P; Prat, A | 1 |
| Brugger, F; Evans, RH; Lepre, M; Olpe, HR | 1 |
| Bollinger, RR; Maggio, JE; Mantyh, CR; Mantyh, PW; Pappas, TN; Vigna, SR | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Delay-Goyet, P; Rinder, J; Stjärne, P | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Nourshargh, S; Walsh, DT; Weg, VB; Williams, TJ | 1 |
| Barr, AJ; Watson, SP | 1 |
| Claing, A; D'Orléans-Juste, P; Jukic, D; Nicolau, M; Regoli, D; Rouissi, N | 1 |
| Saria, A; Troger, J; Zernig, G | 2 |
| Bock, MD; Clerc, F; Fardin, V; Flamand, O; Foucault, F; Garret, C; Jolly, A | 1 |
| Delay-Goyet, P; Lundberg, JM; Rinder, J; Satoh, H; Stjärne, P | 1 |
| Cavero, I; Floch, A; Massa, N; Thiry, C | 1 |
| Doble, A; Heuillet, E; Hubert, JP; Laville, M; Le Guern, S; Pradier, L | 1 |
| Lundberg, JM | 1 |
| Håkanson, R; Strichartz, GR; Tung, SR; Wang, ZY | 1 |
| Cascieri, MA; Fong, TM; Strader, CD; Swain, CJ; Underwood, D; Yu, H | 2 |
| Bian, JT | 1 |
| Brugger, F; Lepre, M; Olpe, HR | 1 |
| Culman, J; Klee, S; Ohlendorf, C; Unger, T | 1 |
| Fox, AJ; Naeem, S; Patel, IA; Urbán, L; Walpole, C | 1 |
| Farley, DM; Kopp, UC; Smith, LA | 1 |
| Gao, XP | 2 |
| McCafferty, DM; Sharkey, KA; Wallace, JL | 1 |
| Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J | 1 |
| Freire-Maia, L; Leite, R; Matos, IM; Teixeira, MM | 1 |
40 other study(ies) available for 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one and cp 96345
| Article | Year |
|---|---|
Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists.
Topics: Animals; Aza Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Guinea Pigs; Humans; Male; Models, Molecular; Molecular Conformation; Mutagenesis; Neurokinin-1 Receptor Antagonists; Structure-Activity Relationship | 1995 |
3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.
Topics: Amides; Analgesics; Animals; Electric Stimulation; Esters; Guinea Pigs; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Neurokinin-1 Receptor Antagonists; Rats; Species Specificity; Stereoisomerism; Structure-Activity Relationship | 1996 |
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cloning, Molecular; Humans; Indoles; Isoindoles; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Protein Conformation; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Recombinant Proteins; Substance P | 1992 |
Comparison in different tissue preparations of the in vitro pharmacological profile of RP 67580, a new non-peptide substance P antagonist.
Topics: Animals; Biphenyl Compounds; Female; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Structure; Muscle, Smooth; Muscle, Smooth, Vascular; Organ Specificity; Rabbits; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1992 |
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
Differences in the effects of tachykinin NK1 receptor antagonists: neuronal versus smooth muscle tissues.
Topics: Animals; Biphenyl Compounds; Electrophysiology; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Locus Coeruleus; Male; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P; Superior Cervical Ganglion; Urinary Bladder | 1993 |
Antagonism of substance P and related peptides by RP 67580 and CP-96,345, at tachykinin NK1 receptor sites, in the rat urinary bladder.
Topics: Animals; Biphenyl Compounds; Blood Proteins; Female; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Urinary Bladder | 1994 |
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains.
Topics: Airway Resistance; Animals; Atropine; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Methysergide; Neurokinin A; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Tachykinin; Serotonin; Substance P; Thiorphan | 1994 |
Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding.
Topics: Astrocytoma; Biphenyl Compounds; Dipeptides; Humans; Indoles; Isoindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Cardiovascular and behavioural effects of centrally administered neuropeptide K in the rat: receptor characterization.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neuropeptide; Substance P; Tachykinins | 1994 |
Physiological and pharmacological characterization of the spinal tachykinin NK2 receptor.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gerbillinae; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-2; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.
Topics: Binding Sites; Biphenyl Compounds; Blood Vessels; Humans; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Isoindoles; Lymphoid Tissue; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Effects of NK1 receptor antagonists on vasodilation induced by chemical and electrical activation of sensory C-fibre afferents in different organs.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Bronchial Arteries; Electric Stimulation; Indoles; Isoindoles; Laser-Doppler Flowmetry; Nasal Mucosa; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Organ Specificity; Regional Blood Flow; Skin; Substance P; Swine; Vasodilation | 1994 |
Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Indoles; Isoindoles; Male; Methacholine Chloride; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
Topics: Animals; Antibodies, Monoclonal; Biphenyl Compounds; Chlorpheniramine; Dihydropyridines; Dose-Response Relationship, Drug; Edema; Female; Guinea Pigs; Imidazoles; Indoles; Inflammation; Isoindoles; Neurokinin-1 Receptor Antagonists; Pyrans; Quinolones; Skin; Substance P; Time Factors | 1995 |
Non-peptide antagonists, CP-96,345 and RP 67580, distinguish species variants in tachykinin NK1 receptors.
Topics: Animals; Binding Sites; Biphenyl Compounds; Carbachol; Cell Line; Female; Guinea Pigs; Humans; Hydrolysis; Ileum; Indoles; Inositol Phosphates; Isoindoles; Male; Muscle, Smooth; Neurokinin B; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1993 |
Substance P (NK-1 receptor) antagonists: in vivo and in vitro activities in rats and guinea pigs.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Muscle, Smooth; Oligopeptides; Peptides; Rabbits; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
Different behavioral profiles of the non-peptide substance P (NK1) antagonists CP-96,345 and RP 67580 in Swiss albino mice in the black-and-white box.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Exploratory Behavior; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Mice; Psychomotor Performance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septide.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Cell Line; Dogs; Guinea Pigs; Humans; Indoles; Isoindoles; Mice; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Submandibular Gland; Substance P | 1993 |
Differences in the potency of CP-96345 and RP-67580, two new non-peptide antagonists selective for NK1 receptors, in inhibiting responses evoked by stimulation of sensory nerves.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Capsaicin; Electric Stimulation; Guanethidine; Guinea Pigs; Indoles; Isoindoles; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Regional Blood Flow; Skin; Substance P; Ureter | 1993 |
Evidence for NK-1 receptor subtypes from in vivo bronchopulmonary and cardiovascular studies.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Bronchoconstriction; Guinea Pigs; Indoles; Isoindoles; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Different behavioral profiles of the non-peptide substance P (NK-1) antagonists CP-96,345 and RP 67580.
Topics: Animals; Biphenyl Compounds; Indoles; Isoindoles; Mice; Motor Activity; Naloxone; Neurokinin-1 Receptor Antagonists; Stereotyped Behavior; Substance P | 1993 |
Substance P-evoked calcium mobilization and ionic current activation in the human astrocytoma cell line U 373 MG: pharmacological characterization.
Topics: Astrocytoma; Biphenyl Compounds; Calcium; Cell Line; Cytosol; Fluorescent Dyes; Humans; Indoles; Ion Channels; Isoindoles; Membrane Potentials; Quinuclidines; Receptors, Neurokinin-1; Receptors, Tachykinin; Spectrometry, Fluorescence; Substance P; Tumor Cells, Cultured | 1993 |
[Effects of tachykinin antagonists on inflammation].
Topics: Analgesics; Animals; Biphenyl Compounds; Humans; Hypnotics and Sedatives; Indoles; Inflammation; Isoindoles; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Trachea | 1995 |
Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission.
Topics: Action Potentials; Anesthetics, Local; Animals; Benzamides; Biphenyl Compounds; Bupivacaine; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Iris; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Procaine; Rabbits; Rana catesbeiana; Receptors, Tachykinin; Sciatic Nerve; Synaptic Transmission; Vas Deferens | 1994 |
Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.
Topics: Amino Acid Sequence; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Glutamine; Humans; Hydrogen Bonding; Indoles; Isoindoles; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Conformation; Quinuclidines; Receptors, Neurokinin-1 | 1994 |
The role of histidine 265 in antagonist binding to the neurokinin-1 receptor.
Topics: Amino Acid Sequence; Analgesics; Animals; Binding Sites; Biphenyl Compounds; Cell Line; Conserved Sequence; Histidine; Humans; Hydrogen Bonding; Hypnotics and Sedatives; Indoles; Isoindoles; Models, Molecular; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Point Mutation; Protein Conformation; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Transfection | 1994 |
[Study on a role of substance P in the spinal mechanisms of electroacupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Biphenyl Compounds; Electroacupuncture; Hypnotics and Sedatives; Indoles; Isoindoles; Naloxone; Narcotic Antagonists; Rats; Spinal Cord; Substance P | 1995 |
The effects of neurokinin-1 receptor agonists on spinal motoneurones of the neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Biphenyl Compounds; Electric Conductivity; Electric Stimulation; Evoked Potentials; Indoles; Isoindoles; Motor Neurons; Neurokinin-1 Receptor Antagonists; Physalaemin; Rats; Reaction Time; Receptors, Neurokinin-1; Spinal Cord | 1996 |
Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress.
Topics: Animals; Behavior, Animal; Benzamides; Biphenyl Compounds; Blood Pressure; Brain; Heart Rate; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Periaqueductal Gray; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Stress, Physiological | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P.
Topics: Animals; Biphenyl Compounds; Bradykinin; Indoles; Indomethacin; Isoindoles; Kidney; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Prostaglandins; Prostaglandins E; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
Tannic acid elicits neurogenic plasma exudation from the in situ hamster cheek pouch.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Biphenyl Compounds; Cheek; Cricetinae; Dextrans; Exudates and Transudates; Fluorescein-5-isothiocyanate; Hydrolyzable Tannins; Indoles; Isoindoles; Male; Mesocricetus; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Plasma; Stereoisomerism | 1998 |
Grain sorghum dust increases macromolecular efflux from the in situ nasal mucosa.
Topics: Animals; Biphenyl Compounds; Cricetinae; Dextrans; Dust; Edible Grain; Fluorescein-5-isothiocyanate; Indoles; Isoindoles; Male; Microcirculation; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Substance P | 1998 |
Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis.
Topics: Analgesics; Animals; Biphenyl Compounds; Colitis; Granulocytes; Guinea Pigs; Indoles; Isoindoles; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin | 1998 |
Effect of tachykinin receptor antagonists in experimental neuropathic pain.
Topics: Analgesics; Animals; Benzamides; Biphenyl Compounds; Denervation; Diabetes Mellitus, Experimental; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Sciatic Nerve | 1998 |
Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Isoindoles; Muscarinic Antagonists; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neuropeptides; Scorpion Venoms; Stereoisomerism; Substance P | 1999 |