6-o-palmitoylascorbic-acid and methyl-3-methoxy-4-hydroxystyryl-ketone

Protective effects of recently synthesised dehydrozingerone, M1OH (which is one half of the molecule of curcumin) and dimer of dehydrozingerone, D1(OH)2, as individual compounds (1 mM) and as equimolar binary (1:1) and ternary (1:1:1) mixtures with α-tocopherol (TOH) and/or ascorbyl palmitate (AscPH), were studied during bulk lipid autoxidation at 80 °C. The highest oxidation stability of lipid substrate, in the presence of individual compounds, was found for TOH, followed by D1(OH)2 and M1OH, determined from the main kinetic parameters (antioxidant efficiency, reactivity and capacity). AscPH did not show any protective effect. Synergism was obtained for the binary mixtures of (TOH+AscPH) [42.4%], (M1OH+TOH) [32.4%] and (M1OH+AscPH) [35.6%] and for the ternary mixture of (M1OH+TOH+AscPH) [28.7%]. Different protective effects observed were explained on the basis (of results) of TOH regeneration and its content determined by HPLC. These antioxidant binary and ternary mixtures can be used as functional components of foods with health-promoting effects.

Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Curcumin; Lipids; Molecular Structure; Oxidation-Reduction; Styrenes