6-o-palmitoylascorbic-acid has been researched along with hydroquinone* in 2 studies
2 other study(ies) available for 6-o-palmitoylascorbic-acid and hydroquinone
| Article | Year |
|---|---|
Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II).
Literature data are scarce on the activities of analogous pairs of hydrophilic and lipophilic antioxidants related to the 'polar paradox' distinguishing antioxidants based on their partitioning between lipids and water. The peroxidation of linoleic acid (LA) in the presence of either Cu(II) ions alone or Cu(II) ions combined with Trolox (TR), ascorbic acid (AA), hydroquinone (HQ) and gallic acid (GA), as hydrophilic antioxidants, or with α-tocopherol (TocH), ascorbyl palmitate (AP), tert-butyl hydroquinone (TBHQ) and propyl gallate (PG), as their respective lipophilic analogues, was investigated in aerated and incubated emulsions at 37 °C and pH 7.. LA peroxidation induced by Cu(II) followed pseudo-first-order kinetics with respect to the formation of primary (hydroperoxides) and secondary (aldehyde- and ketone-like) oxidation products, which were determined by ferric thiocyanate (Fe(III)-SCN) and thiobarbituric acid-reactive substances (TBARS) methods respectively. With the exception of TocH at certain concentrations, the tested compounds showed antioxidant behaviour depending on their polarities. The results were evaluated in the light of structure-activity relationships and the polar paradox.. The results of this study partly confirm the hypothesis that the polar paradox experiences limitations in oil-in-water emulsions and that its validity is also dependent on the concentrations of the antioxidants employed. Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Chromans; Copper; Emulsions; Gallic Acid; Hydrophobic and Hydrophilic Interactions; Hydroquinones; Iron; Kinetics; Linoleic Acid; Lipid Peroxidation; Peroxides; Propyl Gallate; Structure-Activity Relationship; Thiobarbituric Acid Reactive Substances; Thiocyanates | 2013 |
Acylated ascorbate stimulates collagen synthesis in cultured human foreskin fibroblasts at lower doses than does ascorbic acid.
Acylated derivatives of ascorbic acid were found to be active in a number of biochemical and physiological processes. In the present study we investigated the effects of 6-O-palmitoyl ascorbate on collagen synthesis by cultured foreskin human fibroblasts. Our observations indicate a marked stimulatory effect on collagen synthesis by 6-O-palmitoyl ascorbate in the concentration range of 5-20 microM, while the synthesis stimulated by ascorbic acid was maximal at concentrations of 20-100 microM. Cells treated with 10 microM palmitoyl ascorbate for 36 h exhibited a production of collagen threefold greater than those in the presence of 10 microM ascorbic acid, and it was about the same as in cells treated with 100 microM ascorbic acid. By 48 h differences were not significant. Acylated ascorbate impaired vitality of the treated fibroblasts at concentrations exceeding 20 microM in media supplemented with 0.5% FCS. However, most of the cytotoxic effect was neutralized by FCS at a concentration of 10%. The resistance of acylated ascorbate against oxidative degradation as well as the role of free radicals in the modulation of collagen synthesis by ascorbic acid and by its derivatives is discussed. Topics: Acylation; Antioxidants; Ascorbate Oxidase; Ascorbic Acid; Cells, Cultured; Collagen; Deferoxamine; DNA; Dose-Response Relationship, Drug; Fibroblasts; Humans; Hydroquinones; Oxidation-Reduction; Serum Albumin, Bovine; Skin; Time Factors | 1998 |