6-methylthiopurine has been researched along with thioguanine anhydrous in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 16 (41.03) | 29.6817 |
| 2010's | 14 (35.90) | 24.3611 |
| 2020's | 5 (12.82) | 2.80 |
| Authors | Studies |
|---|---|
| Bostrom, BC; Canafax, DM; Carleton, BC; Erdmann, GR; Stafford, RJ; Steury, JC | 1 |
| Kato, Y; Mawatari, H; Nishimura, S; Sakura, N; Ueda, K | 1 |
| Chrzanowska, M; Krzymański, M | 1 |
| Chrzanowska, M; Duczmal-Cichocka, B; Fiet, J; Kolecki, P | 1 |
| Belaiche, J; Desager, JP; Horsmans, Y; Louis, E | 1 |
| Franklin, CL; Lipsky, JJ; Lowry, PW; Mays, DC; Pike, MG; Sandborn, WJ | 1 |
| Blanco, JG; Dervieux, T; Krynetski, EY; Relling, MV; Roussel, MF; Vanin, EF | 1 |
| Cara, C; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Menor, C; Román, ID | 1 |
| Dervieux, T; Duval, M; Guigonis, V; Jacqz-Aigrain, E; Lescoeur, B; Médard, Y; Suciu, S; Verpillat, P; Vilmer, E | 1 |
| Bloomfeld, RS; Onken, JE | 1 |
| de Jong, DJ; Derijks, LJ; Engels, LG; Gilissen, LP; Hooymans, PM; Jansen, JB; Mulder, CJ | 1 |
| Lennard, L; Lobo, AJ; Sanders, DS; Wright, S | 1 |
| Bernstein, CN; Goldenberg, BA; Rawsthorne, P | 1 |
| Fried, M; Kullak-Ublick, GA; Rammert, C; Rentsch, KM; von Eckardstein, A; Wusk, B | 1 |
| Chiou, SS; Wang, CC; Wu, SM | 1 |
| Albertioni, F; Fotoohi, AK; Moshfegh, A; Peterson, C; Wrabel, A | 1 |
| Allan, ML; Bornstein, JD; Heneghan, MA; Muir, AJ; Tendler, DA | 1 |
| Barclay, ML; Begg, EJ; Gardiner, SJ; Gearry, RB; Roberts, RL; Zhang, M | 1 |
| Alvarez Beltran, M; Infante Pina, D; Redecillas Ferreiro, S; Segarra Cantón, O; Tormo Carnicé, R | 1 |
| Harrison, C | 1 |
| de Boer, NH; de Graaf, P; Jharap, B; Mulder, CJ; Sinjewel, A; van Bodegraven, AA; Veldkamp, AI; Vos, RM | 1 |
| Boulieu, R; Daubard, M; Lachaux, A; Larger, M; Le Gall, C; Nguyen, TM | 1 |
| Almer, S; Carlsson, B; Peterson, C; Vikingsson, S | 1 |
| Ajlouni, Y; Gearry, RB; Gibson, PR; Haines, ML; Irving, PM; Rose, R; Sparrow, MP | 1 |
| de Boer, NK; Mulder, CJ; Seinen, ML; van Asseldonk, DP; van Bodegraven, AA | 1 |
| Barclay, ML; Chin, P; Sies, CW; van Egmond, R; Zhang, M | 1 |
| Bouma, G; de Boer, NK; de Boer, YS; Mulder, CJ; van Gerven, NM; van Nieuwkerk, CM | 1 |
| Boulieu, R; Lachaux, A; Nguyen, TM; Nguyen, TV | 1 |
| Borowiec, A; Dadlez, M; Hryniewiecka, E; Jazwiec, R; Paczek, L; Samborowska, E; Tszyrsznic, W; Zegarska, J; Zochowska, D | 1 |
| Aloi, M; Arrigo, S; Barabino, A; Cuzzoni, E; Decorti, G; Favretto, D; Franca, R; Knafelz, D; Martelossi, S; Martinelli, M; Miele, E; Naviglio, S; Romano, C; Stocco, G; Ventura, A | 1 |
| Ji, OJ; Lee, K; Lee, SY; Woo, HI; Yoo, IY | 1 |
| Barclay, ML; Mulder, CJ; Munnig-Schmidt, E; Zhang, M | 1 |
| Albillos, A; Lopez-Sanroman, A; Mesonero Gismero, F; Ríos León, R; Sánchez Rodríguez, E | 1 |
| Choi, JY; Hong, CR; Hong, KT; Kang, HJ; Kim, EH; Kim, H; Lee, K; Lee, SY; Lim, JH; Moon, SY; Nam, Y; Shin, HY; Song, J; Song, SH; Yu, KS | 1 |
| Blasco-Alonso, J; Martín-Masot, R; Navas-López, VM; Ortiz Pérez, MP; Ramos Rueda, N; Serrano Nieto, J | 1 |
| Allin, KH; Burisch, J; Gluud, LL; Hansen, S; Jensen, CB; Jess, T; Kiszka-Kanowitz, M; Nielsen, AM; Theede, K; Thomsen, SB | 1 |
| Han, J; Jin, S; Mei, S; Xu, J; Zhang, D; Zhao, L; Zhao, Z | 1 |
| Alexander, TB; Geib, KB; Gold, S; Newcome, J; Thompson, P | 1 |
| Biglin, M; Bishehsari, F; Chouhan, V; Francey, L; Hogenesch, J; Jochum, S; Keshavarzian, A; Raff, H; Shaikh, M; Swanson, GR | 1 |
4 trial(s) available for 6-methylthiopurine and thioguanine anhydrous
| Article | Year |
|---|---|
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 1999 |
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Genotype; Humans; Infant; Infections; Leukocyte Count; Male; Mercaptopurine; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2001 |
6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Monitoring; Erythrocytes; Female; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thioguanine | 2003 |
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial.
Topics: Azathioprine; Chronotherapy; Cross-Over Studies; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Pilot Projects; Prospective Studies; Thioguanine | 2023 |
35 other study(ies) available for 6-methylthiopurine and thioguanine anhydrous
| Article | Year |
|---|---|
Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Humans; Lymphocytes; Mercaptopurine; Thioguanine | 1991 |
Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Erythrocytes; Hemoglobins; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Reproducibility of Results; Thioguanine | 1998 |
Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine.
Topics: Adult; Allopurinol; Antimetabolites; Azathioprine; Erythrocytes; Female; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mercaptopurine; Middle Aged; Thioguanine | 1999 |
Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.
Topics: Adult; Azathioprine; Case-Control Studies; Crohn Disease; Drug Monitoring; Drug Therapy, Combination; Erythrocytes; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Prospective Studies; Thioguanine; Time Factors | 2001 |
Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.
Topics: Chromatography, High Pressure Liquid; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Reproducibility of Results; Spectrometry, Fluorescence; Thioguanine | 2001 |
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cytosol; Deoxyguanosine; DNA, Neoplasm; Gene Transfer Techniques; HeLa Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Mercaptopurine; Methyltransferases; Mice; Purine Nucleotides; Purines; Retroviridae; Thioguanine; Thionucleosides; Thionucleotides; Tumor Cells, Cultured | 2001 |
Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Monitoring; Erythrocytes; Humans; Linear Models; Mercaptopurine; Methyltransferases; Radiochemistry; S-Adenosylmethionine; Thioguanine | 2001 |
Mercaptopurine metabolite results in clinical gastroenterology practice.
Topics: Azathioprine; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Patient Compliance; Risk Factors; Thioguanine | 2003 |
Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antimetabolites, Antineoplastic; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Patient Compliance; Thioguanine; Treatment Outcome | 2004 |
The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.
Topics: Adult; Azathioprine; Biomarkers; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Inflammatory Bowel Diseases; Male; Maximum Tolerated Dose; Mercaptopurine; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Assessment; Severity of Illness Index; Thioguanine; Treatment Outcome | 2004 |
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Monitoring; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Heterozygote; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Purines; Thioguanine; Thionucleotides | 2004 |
Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Guanosine; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Thioguanine; Thionucleosides; Xanthines | 2005 |
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.
Topics: Adenosine Kinase; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Gene Silencing; Humans; Inhibitory Concentration 50; Mercaptopurine; Polymerase Chain Reaction; Purines; Ribonucleotides; RNA, Messenger; RNA, Small Interfering; Sodium; T-Lymphocytes; Thioguanine | 2006 |
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Drug Monitoring; Female; Genotype; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Prednisone; Thioguanine | 2006 |
Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.
Topics: Adult; Azathioprine; Breast Feeding; Female; Humans; Immunosuppressive Agents; Infant; Male; Mercaptopurine; Methyltransferases; Mothers; Thioguanine | 2006 |
[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].
Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Retrospective Studies; Thioguanine | 2009 |
Patent watch. Drug metabolite claims are patentable.
Topics: Humans; Mercaptopurine; Patents as Topic; Pharmaceutical Preparations; Purines; Thioguanine | 2009 |
Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Reproducibility of Results; Specimen Handling; Statistics, Nonparametric; Thioguanine | 2010 |
Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Biotransformation; Blood Cell Count; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver Function Tests; Male; Mercaptopurine; Thioguanine | 2010 |
How should thiopurine treatment be monitored?--methodological aspects.
Topics: Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Purines; Thioguanine | 2010 |
Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Azathioprine; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Crohn Disease; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thioguanine; Treatment Failure; Young Adult | 2011 |
Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Retrospective Studies; Thioguanine; Treatment Outcome | 2012 |
High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Resistance; Erythrocyte Membrane; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Statistics as Topic; Thioguanine; Thionucleotides | 2012 |
Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis.
Topics: Adult; Aged; Alanine Transaminase; Allopurinol; Antimetabolites; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Salvage Therapy; Thioguanine | 2013 |
Usefulness of thiopurine metabolites in predicting azathioprine resistance in pediatric IBD patients.
Topics: Adolescent; Antimetabolites; Azathioprine; Child; Child, Preschool; Drug Resistance; Female; Humans; Inflammatory Bowel Diseases; Leukopenia; Male; Mercaptopurine; Thioguanine | 2013 |
Determination of Concentrations of Azathioprine Metabolites 6-Thioguanine and 6-Methylmercaptopurine in Whole Blood With the Use of Liquid Chromatography Combined With Mass Spectrometry.
Topics: Adult; Azathioprine; Chromatography, Liquid; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Male; Mercaptopurine; Organ Transplantation; Tandem Mass Spectrometry; Thioguanine; Thionucleotides | 2016 |
Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease.
Topics: Adolescent; Age of Onset; Antimetabolites; Azathioprine; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Thioguanine | 2017 |
Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS/MS Method.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Humans; Mercaptopurine; Tandem Mass Spectrometry; Temperature; Thioguanine | 2018 |
Late-onset Rise of 6-MMP Metabolites in IBD Patients on Azathioprine or Mercaptopurine.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; New Zealand; Thioguanine; Young Adult | 2018 |
Clinical experience of optimising thiopurine use through metabolite measurement in inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Biotransformation; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Thioguanine; Young Adult | 2018 |
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, Liquid; Erythrocytes; Female; Humans; Male; Mercaptopurine; Nucleotides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry; Thioguanine | 2019 |
[Laboratory determination of thiopurine levels in paediatric patients with inflammatory bowel disease].
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Male; Mercaptopurine; Retrospective Studies; Thioguanine; Treatment Outcome | 2020 |
Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease: A nationwide Danish cohort study.
Topics: Adult; Allopurinol; Azathioprine; Colitis, Ulcerative; Crohn Disease; Denmark; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Remission Induction; Severity of Illness Index; Signal Transduction; Thioguanine; Treatment Outcome | 2020 |
Simultaneous UPLC-MS/MS Determination of 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine in Plasma: Application to the Pharmacokinetic Evaluation of Novel Dosage forms in Beagle Dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dogs; Mercaptopurine; Plasma; Tandem Mass Spectrometry; Thioguanine | 2020 |
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia.
Topics: Allopurinol; Burkitt Lymphoma; Child; Exanthema; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2022 |