6-methylthiopurine has been researched along with mercaptopurine in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.74) | 18.7374 |
| 1990's | 17 (14.78) | 18.2507 |
| 2000's | 33 (28.70) | 29.6817 |
| 2010's | 54 (46.96) | 24.3611 |
| 2020's | 9 (7.83) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, EY; Elion, GB; Inmon, RB; Koszalka, GW; Krenitsky, TA; Latter, VS; Rideout, JL; Williams, RB | 1 |
| Bostrom, BC; Canafax, DM; Carleton, BC; Erdmann, GR; Stafford, RJ; Steury, JC | 1 |
| Bökkerink, JP; De Abreu, RA; Keizer-Garritsen, JJ; Lambooy, LH; Stet, EH; Trijbels, FJ; Vogels-Mentink, TM | 1 |
| Bessa, E; Jacqz-Aigrain, E; Medard, Y; Mircheva, Y; Vilmer, E | 1 |
| Alfieri, AA; Colofiore, JR; Devitt, ML; Koutcher, JA; Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Elfarra, AA; Hwang, IY | 1 |
| Aarbakke, J; Bentdal, O; Bergan, S; Hartmann, A; Klemetsdal, B; Rugstad, HE; Stokke, O; Sødal, G | 1 |
| Colofiore, JR; Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Cadenas, RA; Gelpi, ME; Mosettig, J | 1 |
| Fioravanti, A; Jacomelli, G; Marcolongo, R; Micheli, V; Morozzi, G; Pompucci, G | 1 |
| Lennard, L; Lilleyman, JS; Morton, GC; Welch, J | 1 |
| Alfieri, AA; Colofiore, JR; Koutcher, JA; Martin, DS; Netto, G; Nord, LD; Reuter, V; Sternberg, SS; Stolfi, RL | 1 |
| Jacqz-Aigrain, E; Medard, Y; Nafa, S | 1 |
| Kato, Y; Mawatari, H; Nishimura, S; Sakura, N; Ueda, K | 1 |
| Boulieu, R; Dervieux, T | 1 |
| Chrzanowska, M; Krzymański, M | 1 |
| Belleri, M; Morbidelli, L; Presta, M; Ribatti, D; Rusnati, M; Ziche, M | 1 |
| Chrzanowska, M; Duczmal-Cichocka, B; Fiet, J; Kolecki, P | 1 |
| Belaiche, J; Desager, JP; Horsmans, Y; Louis, E | 1 |
| Franklin, CL; Lipsky, JJ; Lowry, PW; Mays, DC; Pike, MG; Sandborn, WJ | 1 |
| Blanco, JG; Dervieux, T; Krynetski, EY; Relling, MV; Roussel, MF; Vanin, EF | 1 |
| Cara, C; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Menor, C; Román, ID | 1 |
| Dervieux, T; Duval, M; Guigonis, V; Jacqz-Aigrain, E; Lescoeur, B; Médard, Y; Suciu, S; Verpillat, P; Vilmer, E | 1 |
| Dauer, M; Eigler, A; Endres, S; Loher, F; Schulze, J | 1 |
| Bloomfeld, RS; Onken, JE | 1 |
| Bökkerink, JP; Brouwer, C; De Abreu, RA; Keizer-Garritsen, JJ; Lambooy, LH; Ter Riet, P; Trijbels, FJ | 1 |
| de Jong, DJ; Derijks, LJ; Engels, LG; Gilissen, LP; Hooymans, PM; Jansen, JB; Mulder, CJ | 1 |
| Almer, S; Lindqvist, M; Peterson, C; Söderkvist, P | 1 |
| FUJIEDA, T; IKEHARA, M; YAMAZAKI, A | 1 |
| Larsen, NE; Reuther, LO; Sonne, J; Vainer, B | 1 |
| Lennard, L; Lobo, AJ; Sanders, DS; Wright, S | 1 |
| Adeli, K; Banka, T; Stefan, C; Verjee, Z; Walsh, W | 1 |
| Bernstein, CN; Goldenberg, BA; Rawsthorne, P | 1 |
| Hindorf, U; Lyrenäs, E; Nilsson, A; Schmiegelow, K | 1 |
| Fried, M; Kullak-Ublick, GA; Rammert, C; Rentsch, KM; von Eckardstein, A; Wusk, B | 1 |
| Chiou, SS; Wang, CC; Wu, SM | 1 |
| Barclay, ML; Gearry, RB | 1 |
| Barham, R; Barry, M; Boulieu, R; Dervieux, T; Matsutani, M; Meyer, G; Neri, B; Seidman, E | 1 |
| Bu, H; Cheng, JQ; Liang, MZ; Lu, YR; Nan, F; Wang, LN; Zhang, L | 1 |
| Albertioni, F; Fotoohi, AK; Moshfegh, A; Peterson, C; Wrabel, A | 1 |
| Allan, ML; Bornstein, JD; Heneghan, MA; Muir, AJ; Tendler, DA | 1 |
| Banerjee, S; Bishop, WP | 1 |
| Barclay, ML; Begg, EJ; Gardiner, SJ; Gearry, RB; Roberts, RL; Zhang, M | 1 |
| Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C | 1 |
| Barclay, ML; Begg, EJ; Gardiner, SJ; Gearry, RB; Marinaki, A; Sau, A | 1 |
| de Boer, NK; de Graaf, P; Jharap, B; Mulder, CJ; van Bodegraven, AA; Veldkamp, AI | 1 |
| Kornbluth, A; Swaminath, A | 1 |
| Bishop, WP; Rahhal, RM | 1 |
| Cairns, C; Collier, PS; Dempsey, S; Hawwa, AF; McCarthy, A; McElnay, JC; Millership, JS | 1 |
| Barclay, ML; Burt, MJ; Ding, SL; Gardiner, SJ; Gearry, RB | 1 |
| Alvarez Beltran, M; Infante Pina, D; Redecillas Ferreiro, S; Segarra Cantón, O; Tormo Carnicé, R | 1 |
| Hart, M; Higgins, PD; Joyce, JC; Saxena, A; Waljee, AK; Wang, S; Zhu, J | 1 |
| Harrison, C | 1 |
| de Boer, NH; de Graaf, P; Jharap, B; Mulder, CJ; Sinjewel, A; van Bodegraven, AA; Veldkamp, AI; Vos, RM | 1 |
| Boulieu, R; Daubard, M; Lachaux, A; Larger, M; Le Gall, C; Nguyen, TM | 1 |
| Almer, S; Carlsson, B; Peterson, C; Vikingsson, S | 1 |
| Ajlouni, Y; Gearry, RB; Gibson, PR; Haines, ML; Irving, PM; Rose, R; Sparrow, MP | 1 |
| Gerich, ME; Henthorn, M; Marcin, JP; Prindiville, TP; Quiros, JA; Tennyson, L | 1 |
| Bartoli, F; Campanozzi, A; Decorti, G; Londero, M; Malusa, N; Marino, S; Martelossi, S; Stocco, G; Ventura, A | 1 |
| Beránek, M; Chládek, J; Dědek, P; Hroch, M; Krásničanová, P; Malý, J; Pozler, O | 1 |
| Chevaux, JB; Oussalah, A; Peyrin-Biroulet, L; Roblin, X; Sparrow, M | 1 |
| Henkel, T; Kiehntopf, M; März, A; Mönch, B; Popp, J; Rösch, P | 1 |
| Armstrong, L; Bishop, J; Galloway, P; McGrogan, P; Russell, RK; Sharif, JA | 1 |
| Bouma, G; de Boer, NK; Peters, GJ; Seinen, ML; Smid, K; van Asseldonk, DP; van Bodegraven, AA | 1 |
| de Boer, NK; Hanauer, SB; Hoentjen, F; Rubin, DT | 1 |
| de Boer, NK; Mulder, CJ; Seinen, ML; van Asseldonk, DP; van Bodegraven, AA | 1 |
| Barclay, ML; Chin, P; Sies, CW; van Egmond, R; Zhang, M | 1 |
| Bradford, K; Ibanez, P; Kwan, LY; Mei, L; Nguyen, M; Shih, DQ; Targan, SR; Ting, C; Vasiliauskas, EA; Zheng, L | 1 |
| Caufield, M; Tom, WL | 1 |
| Andrews, JM; Asser, TL; Bampton, PA; Doogue, MP; Kennedy, NA; Mountifield, RE | 1 |
| Bouma, G; de Boer, NK; de Boer, YS; Mulder, CJ; van Gerven, NM; van Nieuwkerk, CM | 1 |
| de Boer, NK; de Jong, DJ; Dijkstra, G; Hommes, DW; Jharap, B; Mulder, CJ; Oldenburg, B; Stokkers, P; van Bodegraven, AA; van der Woude, CJ; van Elburg, RM | 1 |
| Boulieu, R; Lachaux, A; Nguyen, TM; Nguyen, TV; Vu, DH | 1 |
| Curkovic, I; Frei, P; Fried, M; Jetter, A; Kullak-Ublick, GA; Rentsch, KM; Rogler, G | 1 |
| Kirchherr, H; Shipkova, M; von Ahsen, N | 1 |
| Arenas-Hernandez, M; Blaker, PA; Fairbanks, L; Irving, PM; Marinaki, AM; Sanderson, JD; Shobowale-Bakre, EA; Smith, MA | 1 |
| Boulieu, R; Lachaux, A; Nguyen, TM; Nguyen, TV | 1 |
| Bernhardt, MB; Brackett, J; Leung, DH; Schafer, ES | 1 |
| Bostrom, B; Gandrud, L; Melachuri, S | 1 |
| Bégin, J; Doré, M; Frenette, AJ; Mansour, AM; Troyanov, Y | 1 |
| Ihekweazu, FD; Kellermayer, R | 1 |
| Amre, D; Deslandres, C; Kopylov, U; Seidman, EG; Theoret, Y | 1 |
| de Boer, NK; Tack, GJ; Waayenberg, P | 1 |
| Battat, R; Benmassaoud, A; Kopylov, U; Paradis-Surprenant, L; Seidman, EG | 1 |
| Aitchison, A; Barclay, ML; Chua, EW; Cree, S; Doudney, K; Kennedy, MA; Lehnert, K | 1 |
| Loftus, EV; Moon, W | 1 |
| Borowiec, A; Dadlez, M; Hryniewiecka, E; Jazwiec, R; Paczek, L; Samborowska, E; Tszyrsznic, W; Zegarska, J; Zochowska, D | 1 |
| Coenen, MJ; de Jong, DJ; Derijks, LJ; Engels, LG; Franke, B; Guchelaar, HJ; Hooymans, PM; Klungel, OH; Scheffer, H; van Marrewijk, CJ; Verbeek, AL; Vermeulen, SH; Wong, DR | 1 |
| Aloi, M; Arrigo, S; Barabino, A; Cuzzoni, E; Decorti, G; Favretto, D; Franca, R; Knafelz, D; Martelossi, S; Martinelli, M; Miele, E; Naviglio, S; Romano, C; Stocco, G; Ventura, A | 1 |
| Balis, U; Higgins, PDR; Liu, B; Patel, A; Sauder, K; Segar, S; Stidham, RW; Waljee, AK; Zhang, Y; Zhu, J | 1 |
| Anurathapan, U; Jenjirattithigarn, N; Pakakasama, S; Prommas, S; Puangpetch, A; Santon, S; Sukasem, C; Wiwattanakul, S | 1 |
| Bruijnzeel-Koomen, CAF; de Bruin-Weller, MS; de Graaf, M; Garritsen, FM; van den Broek, MPH; van der Schaft, J; van Schaik, RH | 1 |
| Bruijnzeel-Koomen, CAF; De Bruin-Weller, MS; de Graaf, M; Garritsen, FM; Hijnen, DJ; van den Broek, MPH; van der Schaft, J | 1 |
| Ainsworth, MA; Brynskov, J; Mogensen, DV; Nersting, J; Schmiegelow, K; Steenholdt, C | 1 |
| Abe, M; Kirchherr, H; Rieger, H; Schaeffeler, E; Schiffhauer, M; Schmidt, P; Schwab, M; Shipkova, M; von Ahsen, N; Wieland, E; Zurek, G | 1 |
| Effken, C; Mahajan, PB; Muktar, H; Wall, GC | 1 |
| Ji, OJ; Lee, K; Lee, SY; Woo, HI; Yoo, IY | 1 |
| Ma, J; Pike, LS; Sies, CW | 1 |
| Barclay, ML; Mulder, CJ; Munnig-Schmidt, E; Zhang, M | 1 |
| Boyle, B; Bricker, J; Crandall, W; Dotson, JL; Kim, SC; Maltz, R; Serpico, MR | 1 |
| Andrews, JM; Baird, A; Bampton, P; Barclay, ML; Bell, SJ; Gearry, RB; Grafton, R; Halliwell, J; Jones, GT; Kennedy, MA; Krishnaprasad, K; Lawrance, IC; McHugh, PC; Prosser, R; Radford-Smith, G; Roberts, RL; Seinen, ML; Simms, LA; Studd, C; van Bodegraven, AA; van Rij, AM; Wallace, MC | 1 |
| Albillos, A; Lopez-Sanroman, A; Mesonero Gismero, F; Ríos León, R; Sánchez Rodríguez, E | 1 |
| Bolia, R; Hardikar, W; Rajanayagam, J | 1 |
| Choi, JY; Hong, CR; Hong, KT; Kang, HJ; Kim, EH; Kim, H; Lee, K; Lee, SY; Lim, JH; Moon, SY; Nam, Y; Shin, HY; Song, J; Song, SH; Yu, KS | 1 |
| Andoh, A; Bamba, S; Inatomi, O; Kawahara, M; Morita, Y; Nishida, A; Sasaki, M; Sugimoto, M; Takahashi, K | 1 |
| Deshayes, S; Echaabi, AK; Illamola, SM; Loriot, MA; Mazeron, C; Pallet, N | 1 |
| Arenas-Hernandez, M; Marinaki, AM | 1 |
| Blasco-Alonso, J; Martín-Masot, R; Navas-López, VM; Ortiz Pérez, MP; Ramos Rueda, N; Serrano Nieto, J | 1 |
| Allin, KH; Burisch, J; Gluud, LL; Hansen, S; Jensen, CB; Jess, T; Kiszka-Kanowitz, M; Nielsen, AM; Theede, K; Thomsen, SB | 1 |
| Han, J; Jin, S; Mei, S; Xu, J; Zhang, D; Zhao, L; Zhao, Z | 1 |
| Beukers, R; Bodelier, A; de Boer, N; de Lima, A; Depla, ACTM; Dijkstra, G; Erler, N; Escher, JC; Gilissen, L; Hoentjen, F; Jansen, JM; Kanis, SL; Kuyvenhoven, J; Mahmmod, N; Mallant-Hent, RC; Modderman, S; Noruzi, A; Oldenburg, B; Oostenbrug, LE; Pierik, M; Romberg-Camps, M; Ter Borg, PCJ; Thijs, W; van der Meulen-de Jong, AE; van der Woude, CJ; van Dijk, ARM; West, R | 1 |
| Benninga, MA; Buiter, HJC; de Boer, NKH; de Meij, TGJ; Jagt, JZ; Pothof, CD; van Limbergen, JE; van Wijk, MP | 1 |
| Bronsky, J; Copova, I; Francova, I; Geryk, M; Gonsorcikova, L; Hradsky, O; Karaskova, E; Lerchova, T; Mihal, V; Pospisilova, K; Siroka, J; Urbanek, L; Velganova-Veghova, M; Zarubova, K | 1 |
| Alexander, TB; Geib, KB; Gold, S; Newcome, J; Thompson, P | 1 |
| Biglin, M; Bishehsari, F; Chouhan, V; Francey, L; Hogenesch, J; Jochum, S; Keshavarzian, A; Raff, H; Shaikh, M; Swanson, GR | 1 |
5 review(s) available for 6-methylthiopurine and mercaptopurine
| Article | Year |
|---|---|
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Bone Marrow; Erythrocytes; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Inosine Triphosphatase; Mercaptopurine; Methyltransferases; Polymorphism, Genetic; Pyrophosphatases; Thionucleotides | 2005 |
Optimizing drug therapy in inflammatory bowel disease.
Topics: Absorptiometry, Photon; Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azathioprine; Colectomy; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Cyclosporine; Humans; Inflammatory Bowel Diseases; Infliximab; Mercaptopurine; Mesalamine; Patient Compliance; Prednisone; Treatment Failure | 2007 |
Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease.
Topics: Azathioprine; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Pharmacogenetics; Thioinosine; Thionucleotides | 2016 |
Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease.
Topics: Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Prospective Studies; Retrospective Studies; Thionucleotides | 2018 |
Reducing risk in thiopurine therapy.
Topics: Azathioprine; Drug Hypersensitivity; Erythrocytes; Female; Genotype; Humans; Male; Mercaptopurine; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine-Pyrimidine Metabolism, Inborn Errors; Purines | 2020 |
10 trial(s) available for 6-methylthiopurine and mercaptopurine
| Article | Year |
|---|---|
Optimization of azathioprine therapy by measuring 6-thioguanine nucleotides and methylated mercaptopurine in renal allograft recipients.
Topics: Azathioprine; Erythrocytes; Graft Rejection; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Methyltransferases; Prospective Studies; Thionucleotides | 1995 |
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 1999 |
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Genotype; Humans; Infant; Infections; Leukocyte Count; Male; Mercaptopurine; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2001 |
6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Monitoring; Erythrocytes; Female; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thioguanine | 2003 |
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Crohn Disease; Dose-Response Relationship, Drug; Erythrocyte Indices; Female; Genotype; Guanine Nucleotides; Humans; Leukopenia; Male; Mercaptopurine; Methyltransferases; Middle Aged; Remission Induction; Thionucleotides; Thrombocytopenia | 2007 |
Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.
Topics: Adolescent; Adult; Allopurinol; Azathioprine; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Young Adult | 2011 |
Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia, Neonatal; Azathioprine; Biomarkers; Female; Fetal Blood; Follow-Up Studies; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infant, Newborn; Inflammatory Bowel Diseases; Mercaptopurine; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Thionucleotides; Treatment Outcome; Young Adult | 2014 |
Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.
Topics: Adult; Aged; Allopurinol; Azathioprine; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides | 2013 |
Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Early Diagnosis; Female; Genotype; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Prognosis; Risk Factors; Thioinosine; Thionucleotides; Treatment Outcome; Young Adult | 2017 |
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial.
Topics: Azathioprine; Chronotherapy; Cross-Over Studies; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Pilot Projects; Prospective Studies; Thioguanine | 2023 |
100 other study(ies) available for 6-methylthiopurine and mercaptopurine
| Article | Year |
|---|---|
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines.
Topics: Animals; Chickens; Coccidiostats; Eimeria; Pyrimidine Nucleosides; Structure-Activity Relationship | 1982 |
Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Humans; Lymphocytes; Mercaptopurine; Thioguanine | 1991 |
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.
Topics: Adenine; Adenosine; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Guanosine; Humans; Inosine; Mercaptopurine; Methylthioinosine; Nucleosides; Nucleotides; Purine Nucleosides; Ribonucleosides; T-Lymphocytes; Thioinosine; Thionucleotides | 1995 |
Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.
Topics: Adult; Chromatography, High Pressure Liquid; Female; France; Gallic Acid; Humans; Male; Mercaptopurine; Methyltransferases; Phenotype; Polymorphism, Genetic | 1994 |
Potentiation of a three drug chemotherapy regimen by radiation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Combined Modality Therapy; Female; Mercaptopurine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Phosphonoacetic Acid | 1993 |
Detection and mechanisms of formation of S-(6-purinyl)glutathione and 6-mercaptopurine in rats given 6-chloropurine.
Topics: Animals; Bile; Biliary Tract; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione; Glutathione Transferase; Kidney; Liver; Male; Mercaptopurine; Microsomes; Proteins; Purines; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid | 1993 |
Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Doxorubicin; Fluorouracil; Mammary Neoplasms, Animal; Mercaptopurine; Mice; Niacinamide; Phosphonoacetic Acid | 1996 |
Nucleosteroids: reaction of activated purine bases with steroidal reactive centers.
Topics: Acetylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mercaptopurine; Molecular Structure; Pregnenes; Purines; Steroids | 1996 |
Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Male; Mercaptopurine; Methyltransferases | 1997 |
Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Time Factors | 1997 |
Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aspartic Acid; Female; Mammary Neoplasms, Experimental; Mercaptopurine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphonoacetic Acid; Time Factors | 1997 |
Thiopurine methyltransferase activity: new high-performance liquid chromatographic assay conditions.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Humans; Mercaptopurine; Methyltransferases | 1997 |
Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Erythrocytes; Hemoglobins; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Control; Reproducibility of Results; Thioguanine | 1998 |
Identification of 6-methylmercaptopurine derivative formed during acid hydrolysis of thiopurine nucleotides in erythrocytes, using liquid chromatography-mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance assay.
Topics: Azathioprine; Chromatography, Liquid; Erythrocytes; Humans; Hydrolysis; Imidazoles; Immunosuppressive Agents; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mercaptopurine; Perchlorates; Spectrophotometry, Infrared; Thionucleotides | 1998 |
Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine.
Topics: Adult; Allopurinol; Antimetabolites; Azathioprine; Erythrocytes; Female; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mercaptopurine; Middle Aged; Thioguanine | 1999 |
Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process.
Topics: 2-Aminopurine; Adenocarcinoma; Adenosine; Allantois; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aorta; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chick Embryo; Chorion; Cornea; Depression, Chemical; Endometrial Neoplasms; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Humans; Mercaptopurine; Methylthioinosine; Mice; Mitogen-Activated Protein Kinase 1; Neoplasm Transplantation; Neovascularization, Physiologic; Phosphorylation; Protein Processing, Post-Translational; Rabbits; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1999 |
Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.
Topics: Adult; Azathioprine; Case-Control Studies; Crohn Disease; Drug Monitoring; Drug Therapy, Combination; Erythrocytes; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Prospective Studies; Thioguanine; Time Factors | 2001 |
Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.
Topics: Chromatography, High Pressure Liquid; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Reproducibility of Results; Spectrometry, Fluorescence; Thioguanine | 2001 |
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cytosol; Deoxyguanosine; DNA, Neoplasm; Gene Transfer Techniques; HeLa Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Mercaptopurine; Methyltransferases; Mice; Purine Nucleotides; Purines; Retroviridae; Thioguanine; Thionucleosides; Thionucleotides; Tumor Cells, Cultured | 2001 |
Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Monitoring; Erythrocytes; Humans; Linear Models; Mercaptopurine; Methyltransferases; Radiochemistry; S-Adenosylmethionine; Thioguanine | 2001 |
Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.
Topics: Carbon Radioisotopes; Chromatography, Thin Layer; Humans; Indicators and Reagents; Mercaptopurine; Methyltransferases; Phenotype | 2002 |
Mercaptopurine metabolite results in clinical gastroenterology practice.
Topics: Azathioprine; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Patient Compliance; Risk Factors; Thioguanine | 2003 |
Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.
Topics: Bone Marrow; Child; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Kinetics; Leukocytes, Mononuclear; Mercaptopurine; Methyltransferases; Reference Values; Reproducibility of Results; Time Factors | 2003 |
Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression.
Topics: Erythrocytes; Gene Expression; Humans; Mercaptopurine; Methyltransferases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2003 |
Studies on coenzyme analogs. XIII. Oxidation of methylmercaptopurine and its nucleoside by means of N-chloro-and N-bromosuccinimide.
Topics: Bromosuccinimide; Coenzymes; Mercaptopurine; Nucleosides; Oxidation-Reduction; Pyrrolidinones | 1962 |
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Mutation; Polymerase Chain Reaction; Thionucleotides | 2004 |
Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antimetabolites, Antineoplastic; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Patient Compliance; Thioguanine; Treatment Outcome | 2004 |
Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy.
Topics: Chromatography, High Pressure Liquid; Dithiothreitol; Drug Monitoring; Humans; Linear Models; Mercaptopurine | 2004 |
The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.
Topics: Adult; Azathioprine; Biomarkers; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Inflammatory Bowel Diseases; Male; Maximum Tolerated Dose; Mercaptopurine; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Assessment; Severity of Illness Index; Thioguanine; Treatment Outcome | 2004 |
Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Drug Monitoring; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Sulfasalazine; Thionucleotides | 2004 |
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Monitoring; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Heterozygote; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Purines; Thioguanine; Thionucleotides | 2004 |
Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
Topics: Electrophoresis, Capillary; Guanosine; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Thioguanine; Thionucleosides; Xanthines | 2005 |
Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
Topics: Adult; Azathioprine; Chromatography, Liquid; Cohort Studies; Drug Therapy, Combination; Erythrocytes; Female; Genetic Variation; Guanine Nucleotides; Humans; Hydrolysis; Inflammatory Bowel Diseases; Male; Mass Spectrometry; Mercaptopurine; Methyltransferases; Purine Nucleotides; Thionucleotides | 2005 |
[HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig].
Topics: Animals; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Mercaptopurine; Methyltransferases; Species Specificity; Swine; Swine, Miniature | 2006 |
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.
Topics: Adenosine Kinase; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Gene Silencing; Humans; Inhibitory Concentration 50; Mercaptopurine; Polymerase Chain Reaction; Purines; Ribonucleotides; RNA, Messenger; RNA, Small Interfering; Sodium; T-Lymphocytes; Thioguanine | 2006 |
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Drug Monitoring; Female; Genotype; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Prednisone; Thioguanine | 2006 |
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Guanine Nucleotides; Heterozygote; Humans; Infant; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prednisone; Remission Induction; Retrospective Studies; Thionucleotides | 2006 |
Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.
Topics: Adult; Azathioprine; Breast Feeding; Female; Humans; Immunosuppressive Agents; Infant; Male; Mercaptopurine; Methyltransferases; Mothers; Thioguanine | 2006 |
Thiopurine treatment in inflammatory bowel disease.
Topics: Adult; Antimetabolites; Breast Feeding; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newborn; Inflammatory Bowel Diseases; Mercaptopurine; Milk, Human | 2007 |
Stability of thiopurine metabolites: a potential analytical bias.
Topics: Bias; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Prospective Studies; Thionucleotides | 2008 |
Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.
Topics: Adolescent; Allopurinol; Antimetabolites; Child; Child, Preschool; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Mercaptopurine; Prognosis; Remission Induction; Retrospective Studies; Treatment Outcome | 2008 |
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genotype; Humans; Male; Mercaptopurine; Metabolic Clearance Rate; Methyltransferases; Models, Biological; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2008 |
Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Middle Aged; Thionucleotides | 2008 |
[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].
Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Retrospective Studies; Thioguanine | 2009 |
Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Artificial Intelligence; Child; Child, Preschool; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides; Young Adult | 2010 |
Patent watch. Drug metabolite claims are patentable.
Topics: Humans; Mercaptopurine; Patents as Topic; Pharmaceutical Preparations; Purines; Thioguanine | 2009 |
Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Reproducibility of Results; Specimen Handling; Statistics, Nonparametric; Thioguanine | 2010 |
Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Biotransformation; Blood Cell Count; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver Function Tests; Male; Mercaptopurine; Thioguanine | 2010 |
How should thiopurine treatment be monitored?--methodological aspects.
Topics: Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Purines; Thioguanine | 2010 |
Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Azathioprine; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Crohn Disease; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thioguanine; Treatment Failure; Young Adult | 2011 |
A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Child; Child, Preschool; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Prevalence; Prospective Studies; Thionucleotides; Young Adult | 2010 |
Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Medication Adherence; Mercaptopurine; Thionucleotides; Young Adult | 2010 |
Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides; Treatment Outcome | 2010 |
Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts.
Topics: Azathioprine; Biomarkers; Cross-Sectional Studies; Gastroenterology; Genetic Testing; Genotype; Global Health; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Phenotype; Practice Patterns, Physicians'; Surveys and Questionnaires | 2011 |
Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS).
Topics: Erythrocytes; Humans; Lab-On-A-Chip Devices; Mercaptopurine; Methyltransferases; Spectrum Analysis, Raman | 2011 |
Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine.
Topics: Adolescent; Azathioprine; Biomarkers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Retrospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2011 |
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.
Topics: Allopurinol; Antimetabolites; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guanine Nucleotides; Humans; Liver; Male; Mercaptopurine; Methyltransferases; Steroids; Thionucleotides; Treatment Outcome; Young Adult | 2012 |
Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Retrospective Studies; Thioguanine; Treatment Outcome | 2012 |
High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Resistance; Erythrocyte Membrane; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Statistics as Topic; Thioguanine; Thionucleotides | 2012 |
Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism.
Topics: Adolescent; Adult; Azathioprine; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2012 |
Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring.
Topics: Administration, Oral; Adolescent; Azathioprine; Child; Child, Preschool; Dermatitis, Atopic; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides | 2013 |
Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease.
Topics: Adult; Biomarkers; Disease Management; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Thionucleotides | 2013 |
Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis.
Topics: Adult; Aged; Alanine Transaminase; Allopurinol; Antimetabolites; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Salvage Therapy; Thioguanine | 2013 |
Relationship between azathioprine dosage and thiopurine metabolites in pediatric IBD patients: identification of covariables using multilevel analysis.
Topics: Adolescent; Age Factors; Azathioprine; Child; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Multilevel Analysis; Retrospective Studies; Thionucleotides | 2013 |
Improved method for therapeutic drug monitoring of 6-thioguanine nucleotides and 6-methylmercaptopurine in whole-blood by LC/MSMS using isotope-labeled internal standards.
Topics: Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Erythrocytes; Guanine Nucleotides; Humans; Limit of Detection; Mercaptopurine; Tandem Mass Spectrometry; Thionucleotides; Time Factors | 2013 |
Mechanism of allopurinol induced TPMT inhibition.
Topics: Adult; Allopurinol; Azathioprine; Case-Control Studies; Drug Therapy, Combination; Erythrocytes; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Oxypurinol; Prospective Studies; Xanthines | 2013 |
Usefulness of thiopurine metabolites in predicting azathioprine resistance in pediatric IBD patients.
Topics: Adolescent; Antimetabolites; Azathioprine; Child; Child, Preschool; Drug Resistance; Female; Humans; Inflammatory Bowel Diseases; Leukopenia; Male; Mercaptopurine; Thioguanine | 2013 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase | 2014 |
The association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Blood Glucose; Child; Child, Preschool; Dexamethasone; Dietary Carbohydrates; Drug Administration Schedule; Fasting; Female; Guanine Nucleotides; Humans; Hyperglycemia; Hypoglycemia; Hypoxanthine Phosphoribosyltransferase; Infant; Liver Glycogen; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methylation; Methyltransferases; Polymorphism, Genetic; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Retrospective Studies; Thionucleotides | 2014 |
Febuxostat as a novel option to optimize thiopurines' metabolism in patients with inadequate metabolite levels.
Topics: Adult; Azathioprine; Drug Interactions; Enzyme Inhibitors; Febuxostat; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Muscular Diseases; Thiazoles; Thionucleotides; Xanthine Oxidase | 2014 |
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era.
Topics: Adolescent; Allopurinol; Antimetabolites; Child; Colitis, Ulcerative; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Thionucleotides | 2014 |
Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease.
Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Crohn Disease; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Odds Ratio; Thionucleotides; Treatment Failure | 2014 |
Beneficial pharmacological interaction between thiopurine and mesalazine—never change a winning team.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Interactions; Erythrocytes; Feces; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte L1 Antigen Complex; Mercaptopurine; Mesalamine | 2014 |
Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD.
Topics: Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; Erythrocyte Indices; Female; Guanine Nucleotides; Hematologic Tests; Hemoglobins; Humans; Lymphocyte Count; Male; Mercaptopurine; Platelet Count; Predictive Value of Tests; Retrospective Studies; Thionucleotides; Treatment Outcome | 2015 |
Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Comparative Genomic Hybridization; Crohn Disease; DNA Copy Number Variations; Drug Resistance; Exome; Female; Genome-Wide Association Study; Hepatitis, Autoimmune; High-Throughput Nucleotide Sequencing; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methyltransferases; Middle Aged; Mutation | 2015 |
Determination of Concentrations of Azathioprine Metabolites 6-Thioguanine and 6-Methylmercaptopurine in Whole Blood With the Use of Liquid Chromatography Combined With Mass Spectrometry.
Topics: Adult; Azathioprine; Chromatography, Liquid; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Male; Mercaptopurine; Organ Transplantation; Tandem Mass Spectrometry; Thioguanine; Thionucleotides | 2016 |
Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease.
Topics: Adolescent; Age of Onset; Antimetabolites; Azathioprine; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Thioguanine | 2017 |
Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines.
Topics: Adolescent; Adult; Algorithms; Area Under Curve; Azathioprine; Drug Prescriptions; Female; Hospitalization; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Machine Learning; Male; Medication Adherence; Mercaptopurine; Middle Aged; Remission Induction; Retrospective Studies; ROC Curve; Treatment Outcome; Young Adult | 2017 |
Development and validation of a reliable method for thiopurine methyltransferase (TPMT) enzyme activity in human whole blood by LC-MS/MS: An application for phenotypic and genotypic correlations.
Topics: Chromatography, Liquid; Genotype; Humans; Mercaptopurine; Methyltransferases; Phenotype; Tandem Mass Spectrometry | 2017 |
Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine.
Topics: Adult; Azathioprine; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Eczema; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Thionucleotides; Treatment Outcome | 2018 |
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema.
Topics: Adult; Allopurinol; Azathioprine; Chronic Disease; Dermatitis, Atopic; Drug Therapy, Combination; Eczema; Female; Foot Dermatoses; Guanine Nucleotides; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2018 |
A Role for Thiopurine Metabolites in the Synergism Between Thiopurines and Infliximab in Inflammatory Bowel Disease.
Topics: Adult; Antibodies; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Male; Mercaptopurine; Methyltransferases; Middle Aged; Retrospective Studies; Thionucleotides | 2018 |
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate.
Topics: Chromatography, High Pressure Liquid; Genotype; Healthy Volunteers; Humans; Mercaptopurine; Methyltransferases; Phenotype; Substrate Specificity | 2018 |
Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS/MS Method.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Humans; Mercaptopurine; Tandem Mass Spectrometry; Temperature; Thioguanine | 2018 |
Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP.
Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Mercaptopurine; Methyltransferases | 2018 |
Late-onset Rise of 6-MMP Metabolites in IBD Patients on Azathioprine or Mercaptopurine.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; New Zealand; Thioguanine; Young Adult | 2018 |
Thiopurine Optimization Through Combination With Allopurinol in Children With Inflammatory Bowel Diseases.
Topics: Adolescent; Adult; Allopurinol; Azathioprine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Retrospective Studies; Treatment Outcome; Young Adult | 2018 |
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Topics: Adult; Azathioprine; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cohort Studies; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thionucleotides; Young Adult | 2018 |
Clinical experience of optimising thiopurine use through metabolite measurement in inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Biotransformation; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Thioguanine; Young Adult | 2018 |
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis.
Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Liver Function Tests; Maintenance Chemotherapy; Male; Mercaptopurine; Retrospective Studies; Thionucleotides; Treatment Outcome | 2018 |
Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, Liquid; Erythrocytes; Female; Humans; Male; Mercaptopurine; Nucleotides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry; Thioguanine | 2019 |
pH-Dependent 5-Aminosalicylates Releasing Preparations Do Not Affect Thiopurine Metabolism.
Topics: Administration, Oral; Adolescent; Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug Liberation; Female; Guanine Nucleotides; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Mesalamine; Middle Aged; Retrospective Studies; Thionucleotides; Time Factors; Young Adult | 2019 |
Development and validation of a UPLC-UV method for the quantification of thiopurine methyltransferase enzyme activity in human erythrocytes.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Enzyme Assays; Erythrocytes; Humans; Limit of Detection; Linear Models; Mercaptopurine; Methyltransferases; Reproducibility of Results; S-Adenosylmethionine | 2019 |
[Laboratory determination of thiopurine levels in paediatric patients with inflammatory bowel disease].
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Male; Mercaptopurine; Retrospective Studies; Thioguanine; Treatment Outcome | 2020 |
Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease: A nationwide Danish cohort study.
Topics: Adult; Allopurinol; Azathioprine; Colitis, Ulcerative; Crohn Disease; Denmark; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Remission Induction; Severity of Illness Index; Signal Transduction; Thioguanine; Treatment Outcome | 2020 |
Simultaneous UPLC-MS/MS Determination of 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine in Plasma: Application to the Pharmacokinetic Evaluation of Novel Dosage forms in Beagle Dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dogs; Mercaptopurine; Plasma; Tandem Mass Spectrometry; Thioguanine | 2020 |
Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life.
Topics: Adalimumab; Adult; Anti-Bacterial Agents; Autoimmune Diseases; Cesarean Section; Child Development; Child, Preschool; Congenital Abnormalities; Drug Prescriptions; Drug Therapy, Combination; Female; Gastrointestinal Agents; Humans; Infant; Infant, Newborn; Infant, Small for Gestational Age; Infections; Inflammatory Bowel Diseases; Infliximab; Mercaptopurine; Neoplasms; Netherlands; Patient Admission; Pregnancy; Pregnancy Complications; Premature Birth; Prenatal Exposure Delayed Effects; Retrospective Studies; Tumor Necrosis Factor Inhibitors; Vaccines | 2021 |
Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Topics: Adolescent; Antimetabolites; Azathioprine; Biomarkers, Pharmacological; Child; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Netherlands; Retrospective Studies; Thionucleotides; Withholding Treatment | 2022 |
Is It Useful to Monitor Thiopurine Metabolites in Pediatric Patients with Crohn's Disease on Combination Therapy? A Multicenter Prospective Observational Study.
Topics: Adolescent; Azathioprine; Biomarkers; Child; Crohn Disease; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Infliximab; Longitudinal Studies; Male; Mercaptopurine; Prospective Studies | 2021 |
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia.
Topics: Allopurinol; Burkitt Lymphoma; Child; Exanthema; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2022 |