Page last updated: 2024-08-17

6-methylthiopurine and allopurinol

6-methylthiopurine has been researched along with allopurinol in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (5.56)	18.2507
2000's	1 (5.56)	29.6817
2010's	14 (77.78)	24.3611
2020's	2 (11.11)	2.80

Authors

Authors	Studies
Chrzanowska, M; Krzymański, M	1
Bishop, WP; Rahhal, RM	1
Gerich, ME; Henthorn, M; Marcin, JP; Prindiville, TP; Quiros, JA; Tennyson, L	1
Bouma, G; de Boer, NK; Peters, GJ; Seinen, ML; Smid, K; van Asseldonk, DP; van Bodegraven, AA	1
de Boer, NK; Hanauer, SB; Hoentjen, F; Rubin, DT	1
Bouma, G; de Boer, NK; de Boer, YS; Mulder, CJ; van Gerven, NM; van Nieuwkerk, CM	1
Curkovic, I; Frei, P; Fried, M; Jetter, A; Kullak-Ublick, GA; Rentsch, KM; Rogler, G	1
Arenas-Hernandez, M; Blaker, PA; Fairbanks, L; Irving, PM; Marinaki, AM; Sanderson, JD; Shobowale-Bakre, EA; Smith, MA	1
Bernhardt, MB; Brackett, J; Leung, DH; Schafer, ES	1
Bégin, J; Doré, M; Frenette, AJ; Mansour, AM; Troyanov, Y	1
Ihekweazu, FD; Kellermayer, R	1
Bruijnzeel-Koomen, CAF; De Bruin-Weller, MS; de Graaf, M; Garritsen, FM; Hijnen, DJ; van den Broek, MPH; van der Schaft, J	1
Effken, C; Mahajan, PB; Muktar, H; Wall, GC	1
Boyle, B; Bricker, J; Crandall, W; Dotson, JL; Kim, SC; Maltz, R; Serpico, MR	1
Bolia, R; Hardikar, W; Rajanayagam, J	1
Andoh, A; Bamba, S; Inatomi, O; Kawahara, M; Morita, Y; Nishida, A; Sasaki, M; Sugimoto, M; Takahashi, K	1
Allin, KH; Burisch, J; Gluud, LL; Hansen, S; Jensen, CB; Jess, T; Kiszka-Kanowitz, M; Nielsen, AM; Theede, K; Thomsen, SB	1
Alexander, TB; Geib, KB; Gold, S; Newcome, J; Thompson, P	1

Reviews

1 review(s) available for 6-methylthiopurine and allopurinol

Article	Year
Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease. Pharmacotherapy, 2018, Volume: 38, Issue:2 Topics: Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Prospective Studies; Retrospective Studies; Thionucleotides	2018

Article

Year

Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease.

Pharmacotherapy, 2018, Volume: 38, Issue:2

Topics: Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Prospective Studies; Retrospective Studies; Thionucleotides

2018

Trials

2 trial(s) available for 6-methylthiopurine and allopurinol

Article	Year
Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series. Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12 Topics: Adolescent; Adult; Allopurinol; Azathioprine; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Young Adult	2011
Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations. European journal of clinical pharmacology, 2013, Volume: 69, Issue:8 Topics: Adult; Aged; Allopurinol; Azathioprine; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides	2013

Article

Year

Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.

Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12

Topics: Adolescent; Adult; Allopurinol; Azathioprine; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Young Adult

2011

Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.

European journal of clinical pharmacology, 2013, Volume: 69, Issue:8

Topics: Adult; Aged; Allopurinol; Azathioprine; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides

2013

Other Studies

15 other study(ies) available for 6-methylthiopurine and allopurinol

Article	Year
Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine. Therapeutic drug monitoring, 1999, Volume: 21, Issue:2 Topics: Adult; Allopurinol; Antimetabolites; Azathioprine; Erythrocytes; Female; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mercaptopurine; Middle Aged; Thioguanine	1999
Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease. Inflammatory bowel diseases, 2008, Volume: 14, Issue:12 Topics: Adolescent; Allopurinol; Antimetabolites; Child; Child, Preschool; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Mercaptopurine; Prognosis; Remission Induction; Retrospective Studies; Treatment Outcome	2008
A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine. Journal of Crohn's & colitis, 2010, Volume: 4, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Child; Child, Preschool; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Prevalence; Prospective Studies; Thionucleotides; Young Adult	2010
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction. Digestive diseases and sciences, 2012, Volume: 57, Issue:1 Topics: Allopurinol; Antimetabolites; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guanine Nucleotides; Humans; Liver; Male; Mercaptopurine; Methyltransferases; Steroids; Thionucleotides; Treatment Outcome; Young Adult	2012
Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis. Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:6 Topics: Adult; Aged; Alanine Transaminase; Allopurinol; Antimetabolites; Drug Interactions; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Salvage Therapy; Thioguanine	2013
Mechanism of allopurinol induced TPMT inhibition. Biochemical pharmacology, 2013, Aug-15, Volume: 86, Issue:4 Topics: Adult; Allopurinol; Azathioprine; Case-Control Studies; Drug Therapy, Combination; Erythrocytes; Female; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Oxypurinol; Prospective Studies; Xanthines	2013
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism. Pediatric blood & cancer, 2014, Volume: 61, Issue:6 Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase	2014
Febuxostat as a novel option to optimize thiopurines' metabolism in patients with inadequate metabolite levels. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:5 Topics: Adult; Azathioprine; Drug Interactions; Enzyme Inhibitors; Febuxostat; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Muscular Diseases; Thiazoles; Thionucleotides; Xanthine Oxidase	2014
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. Journal of pediatric gastroenterology and nutrition, 2014, Volume: 59, Issue:1 Topics: Adolescent; Allopurinol; Antimetabolites; Child; Colitis, Ulcerative; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Thionucleotides	2014
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema. Acta dermato-venereologica, 2018, Mar-13, Volume: 98, Issue:3 Topics: Adult; Allopurinol; Azathioprine; Chronic Disease; Dermatitis, Atopic; Drug Therapy, Combination; Eczema; Female; Foot Dermatoses; Guanine Nucleotides; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thionucleotides; Time Factors; Treatment Outcome	2018
Thiopurine Optimization Through Combination With Allopurinol in Children With Inflammatory Bowel Diseases. Journal of pediatric gastroenterology and nutrition, 2018, Volume: 67, Issue:3 Topics: Adolescent; Adult; Allopurinol; Azathioprine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Retrospective Studies; Treatment Outcome; Young Adult	2018
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis. Journal of pediatric gastroenterology and nutrition, 2018, Volume: 67, Issue:6 Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Liver Function Tests; Maintenance Chemotherapy; Male; Mercaptopurine; Retrospective Studies; Thionucleotides; Treatment Outcome	2018
pH-Dependent 5-Aminosalicylates Releasing Preparations Do Not Affect Thiopurine Metabolism. Digestion, 2019, Volume: 100, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug Liberation; Female; Guanine Nucleotides; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Mesalamine; Middle Aged; Retrospective Studies; Thionucleotides; Time Factors; Young Adult	2019
Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease: A nationwide Danish cohort study. United European gastroenterology journal, 2020, Volume: 8, Issue:1 Topics: Adult; Allopurinol; Azathioprine; Colitis, Ulcerative; Crohn Disease; Denmark; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Remission Induction; Severity of Illness Index; Signal Transduction; Thioguanine; Treatment Outcome	2020
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia. Journal of pediatric hematology/oncology, 2022, 10-01, Volume: 44, Issue:7 Topics: Allopurinol; Burkitt Lymphoma; Child; Exanthema; Humans; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine	2022