6-methylthiopurine has been researched along with 6-thioguanylic acid in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 27 (69.23) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Aarbakke, J; Bentdal, O; Bergan, S; Hartmann, A; Klemetsdal, B; Rugstad, HE; Stokke, O; Sødal, G | 1 |
| Lennard, L; Lilleyman, JS; Morton, GC; Welch, J | 1 |
| Larsen, NE; Reuther, LO; Sonne, J; Vainer, B | 1 |
| Hindorf, U; Lyrenäs, E; Nilsson, A; Schmiegelow, K | 1 |
| Fried, M; Kullak-Ublick, GA; Rammert, C; Rentsch, KM; von Eckardstein, A; Wusk, B | 1 |
| Barclay, ML; Gearry, RB | 1 |
| Barham, R; Barry, M; Boulieu, R; Dervieux, T; Matsutani, M; Meyer, G; Neri, B; Seidman, E | 1 |
| Banerjee, S; Bishop, WP | 1 |
| Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C | 1 |
| de Boer, NK; de Graaf, P; Jharap, B; Mulder, CJ; van Bodegraven, AA; Veldkamp, AI | 1 |
| Barclay, ML; Burt, MJ; Ding, SL; Gardiner, SJ; Gearry, RB | 1 |
| Hart, M; Higgins, PD; Joyce, JC; Saxena, A; Waljee, AK; Wang, S; Zhu, J | 1 |
| Gerich, ME; Henthorn, M; Marcin, JP; Prindiville, TP; Quiros, JA; Tennyson, L | 1 |
| Bartoli, F; Campanozzi, A; Decorti, G; Londero, M; Malusa, N; Marino, S; Martelossi, S; Stocco, G; Ventura, A | 1 |
| Beránek, M; Chládek, J; Dědek, P; Hroch, M; Krásničanová, P; Malý, J; Pozler, O | 1 |
| Armstrong, L; Bishop, J; Galloway, P; McGrogan, P; Russell, RK; Sharif, JA | 1 |
| de Boer, NK; Hanauer, SB; Hoentjen, F; Rubin, DT | 1 |
| Barclay, ML; Chin, P; Sies, CW; van Egmond, R; Zhang, M | 1 |
| Caufield, M; Tom, WL | 1 |
| Andrews, JM; Asser, TL; Bampton, PA; Doogue, MP; Kennedy, NA; Mountifield, RE | 1 |
| de Boer, NK; de Jong, DJ; Dijkstra, G; Hommes, DW; Jharap, B; Mulder, CJ; Oldenburg, B; Stokkers, P; van Bodegraven, AA; van der Woude, CJ; van Elburg, RM | 1 |
| Boulieu, R; Lachaux, A; Nguyen, TM; Nguyen, TV; Vu, DH | 1 |
| Curkovic, I; Frei, P; Fried, M; Jetter, A; Kullak-Ublick, GA; Rentsch, KM; Rogler, G | 1 |
| Kirchherr, H; Shipkova, M; von Ahsen, N | 1 |
| Bernhardt, MB; Brackett, J; Leung, DH; Schafer, ES | 1 |
| Bostrom, B; Gandrud, L; Melachuri, S | 1 |
| Bégin, J; Doré, M; Frenette, AJ; Mansour, AM; Troyanov, Y | 1 |
| Ihekweazu, FD; Kellermayer, R | 1 |
| Amre, D; Deslandres, C; Kopylov, U; Seidman, EG; Theoret, Y | 1 |
| Battat, R; Benmassaoud, A; Kopylov, U; Paradis-Surprenant, L; Seidman, EG | 1 |
| Borowiec, A; Dadlez, M; Hryniewiecka, E; Jazwiec, R; Paczek, L; Samborowska, E; Tszyrsznic, W; Zegarska, J; Zochowska, D | 1 |
| Bruijnzeel-Koomen, CAF; de Bruin-Weller, MS; de Graaf, M; Garritsen, FM; van den Broek, MPH; van der Schaft, J; van Schaik, RH | 1 |
| Bruijnzeel-Koomen, CAF; De Bruin-Weller, MS; de Graaf, M; Garritsen, FM; Hijnen, DJ; van den Broek, MPH; van der Schaft, J | 1 |
| Ainsworth, MA; Brynskov, J; Mogensen, DV; Nersting, J; Schmiegelow, K; Steenholdt, C | 1 |
| Effken, C; Mahajan, PB; Muktar, H; Wall, GC | 1 |
| Andrews, JM; Baird, A; Bampton, P; Barclay, ML; Bell, SJ; Gearry, RB; Grafton, R; Halliwell, J; Jones, GT; Kennedy, MA; Krishnaprasad, K; Lawrance, IC; McHugh, PC; Prosser, R; Radford-Smith, G; Roberts, RL; Seinen, ML; Simms, LA; Studd, C; van Bodegraven, AA; van Rij, AM; Wallace, MC | 1 |
| Bolia, R; Hardikar, W; Rajanayagam, J | 1 |
| Andoh, A; Bamba, S; Inatomi, O; Kawahara, M; Morita, Y; Nishida, A; Sasaki, M; Sugimoto, M; Takahashi, K | 1 |
| Benninga, MA; Buiter, HJC; de Boer, NKH; de Meij, TGJ; Jagt, JZ; Pothof, CD; van Limbergen, JE; van Wijk, MP | 1 |
2 review(s) available for 6-methylthiopurine and 6-thioguanylic acid
| Article | Year |
|---|---|
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Bone Marrow; Erythrocytes; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Inosine Triphosphatase; Mercaptopurine; Methyltransferases; Polymorphism, Genetic; Pyrophosphatases; Thionucleotides | 2005 |
Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease.
Topics: Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Prospective Studies; Retrospective Studies; Thionucleotides | 2018 |
4 trial(s) available for 6-methylthiopurine and 6-thioguanylic acid
| Article | Year |
|---|---|
Optimization of azathioprine therapy by measuring 6-thioguanine nucleotides and methylated mercaptopurine in renal allograft recipients.
Topics: Azathioprine; Erythrocytes; Graft Rejection; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Methyltransferases; Prospective Studies; Thionucleotides | 1995 |
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Crohn Disease; Dose-Response Relationship, Drug; Erythrocyte Indices; Female; Genotype; Guanine Nucleotides; Humans; Leukopenia; Male; Mercaptopurine; Methyltransferases; Middle Aged; Remission Induction; Thionucleotides; Thrombocytopenia | 2007 |
Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia, Neonatal; Azathioprine; Biomarkers; Female; Fetal Blood; Follow-Up Studies; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infant, Newborn; Inflammatory Bowel Diseases; Mercaptopurine; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Thionucleotides; Treatment Outcome; Young Adult | 2014 |
Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.
Topics: Adult; Aged; Allopurinol; Azathioprine; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides | 2013 |
33 other study(ies) available for 6-methylthiopurine and 6-thioguanylic acid
| Article | Year |
|---|---|
Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Time Factors | 1997 |
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Mutation; Polymerase Chain Reaction; Thionucleotides | 2004 |
Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Drug Monitoring; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Sulfasalazine; Thionucleotides | 2004 |
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Monitoring; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Heterozygote; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Purines; Thioguanine; Thionucleotides | 2004 |
Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
Topics: Adult; Azathioprine; Chromatography, Liquid; Cohort Studies; Drug Therapy, Combination; Erythrocytes; Female; Genetic Variation; Guanine Nucleotides; Humans; Hydrolysis; Inflammatory Bowel Diseases; Male; Mass Spectrometry; Mercaptopurine; Methyltransferases; Purine Nucleotides; Thionucleotides | 2005 |
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Guanine Nucleotides; Heterozygote; Humans; Infant; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prednisone; Remission Induction; Retrospective Studies; Thionucleotides | 2006 |
Stability of thiopurine metabolites: a potential analytical bias.
Topics: Bias; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Prospective Studies; Thionucleotides | 2008 |
Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Middle Aged; Thionucleotides | 2008 |
Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Artificial Intelligence; Child; Child, Preschool; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides; Young Adult | 2010 |
A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Child; Child, Preschool; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Prevalence; Prospective Studies; Thionucleotides; Young Adult | 2010 |
Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Medication Adherence; Mercaptopurine; Thionucleotides; Young Adult | 2010 |
Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides; Treatment Outcome | 2010 |
Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine.
Topics: Adolescent; Azathioprine; Biomarkers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Retrospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2011 |
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.
Topics: Allopurinol; Antimetabolites; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guanine Nucleotides; Humans; Liver; Male; Mercaptopurine; Methyltransferases; Steroids; Thionucleotides; Treatment Outcome; Young Adult | 2012 |
High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Resistance; Erythrocyte Membrane; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Statistics as Topic; Thioguanine; Thionucleotides | 2012 |
Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring.
Topics: Administration, Oral; Adolescent; Azathioprine; Child; Child, Preschool; Dermatitis, Atopic; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides | 2013 |
Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease.
Topics: Adult; Biomarkers; Disease Management; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Thionucleotides | 2013 |
Relationship between azathioprine dosage and thiopurine metabolites in pediatric IBD patients: identification of covariables using multilevel analysis.
Topics: Adolescent; Age Factors; Azathioprine; Child; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Multilevel Analysis; Retrospective Studies; Thionucleotides | 2013 |
Improved method for therapeutic drug monitoring of 6-thioguanine nucleotides and 6-methylmercaptopurine in whole-blood by LC/MSMS using isotope-labeled internal standards.
Topics: Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Erythrocytes; Guanine Nucleotides; Humans; Limit of Detection; Mercaptopurine; Tandem Mass Spectrometry; Thionucleotides; Time Factors | 2013 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase | 2014 |
The association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Blood Glucose; Child; Child, Preschool; Dexamethasone; Dietary Carbohydrates; Drug Administration Schedule; Fasting; Female; Guanine Nucleotides; Humans; Hyperglycemia; Hypoglycemia; Hypoxanthine Phosphoribosyltransferase; Infant; Liver Glycogen; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methylation; Methyltransferases; Polymorphism, Genetic; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Retrospective Studies; Thionucleotides | 2014 |
Febuxostat as a novel option to optimize thiopurines' metabolism in patients with inadequate metabolite levels.
Topics: Adult; Azathioprine; Drug Interactions; Enzyme Inhibitors; Febuxostat; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Muscular Diseases; Thiazoles; Thionucleotides; Xanthine Oxidase | 2014 |
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era.
Topics: Adolescent; Allopurinol; Antimetabolites; Child; Colitis, Ulcerative; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Thionucleotides | 2014 |
Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease.
Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Crohn Disease; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Odds Ratio; Thionucleotides; Treatment Failure | 2014 |
Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD.
Topics: Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; Erythrocyte Indices; Female; Guanine Nucleotides; Hematologic Tests; Hemoglobins; Humans; Lymphocyte Count; Male; Mercaptopurine; Platelet Count; Predictive Value of Tests; Retrospective Studies; Thionucleotides; Treatment Outcome | 2015 |
Determination of Concentrations of Azathioprine Metabolites 6-Thioguanine and 6-Methylmercaptopurine in Whole Blood With the Use of Liquid Chromatography Combined With Mass Spectrometry.
Topics: Adult; Azathioprine; Chromatography, Liquid; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Male; Mercaptopurine; Organ Transplantation; Tandem Mass Spectrometry; Thioguanine; Thionucleotides | 2016 |
Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine.
Topics: Adult; Azathioprine; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Eczema; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Thionucleotides; Treatment Outcome | 2018 |
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema.
Topics: Adult; Allopurinol; Azathioprine; Chronic Disease; Dermatitis, Atopic; Drug Therapy, Combination; Eczema; Female; Foot Dermatoses; Guanine Nucleotides; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2018 |
A Role for Thiopurine Metabolites in the Synergism Between Thiopurines and Infliximab in Inflammatory Bowel Disease.
Topics: Adult; Antibodies; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Male; Mercaptopurine; Methyltransferases; Middle Aged; Retrospective Studies; Thionucleotides | 2018 |
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Topics: Adult; Azathioprine; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cohort Studies; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thionucleotides; Young Adult | 2018 |
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis.
Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Liver Function Tests; Maintenance Chemotherapy; Male; Mercaptopurine; Retrospective Studies; Thionucleotides; Treatment Outcome | 2018 |
pH-Dependent 5-Aminosalicylates Releasing Preparations Do Not Affect Thiopurine Metabolism.
Topics: Administration, Oral; Adolescent; Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug Liberation; Female; Guanine Nucleotides; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Mesalamine; Middle Aged; Retrospective Studies; Thionucleotides; Time Factors; Young Adult | 2019 |
Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Topics: Adolescent; Antimetabolites; Azathioprine; Biomarkers, Pharmacological; Child; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Netherlands; Retrospective Studies; Thionucleotides; Withholding Treatment | 2022 |