6-methylflavone has been researched along with flavone* in 2 studies
2 other study(ies) available for 6-methylflavone and flavone
| Article | Year |
|---|---|
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE
In an effort to identify novel anti-inflammatory compounds, a series of flavone derivatives were synthesized and biologically evaluated for their inhibitory effects on the production of nitric oxide (NO) and prostaglandin E Topics: Animals; Anti-Inflammatory Agents; Dinoprostone; Flavones; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; RAW 264.7 Cells; Structure-Activity Relationship | 2017 |
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors.
In view of the ability of flavones to displace radiolabelled benzodiazepines from brain tissue and the interesting behavioural profile of these compounds, the present study investigated the activity of 6-methylflavone at ionotropic gamma-aminobutyric acid (GABA) receptors expressed in Xenopus laevis oocytes. 6-Methylflavone (1-100 microM) was found to be a positive allosteric modulator at alpha1beta2gamma2L and alpha1beta2 GABAA receptors with no significant difference between the enhancement seen at either receptor subtype. At 100 microM, 6-methylflavone enhanced the response to 5 microM GABA by 183+/-20% at alpha1beta2gamma2L GABAA receptors. The methyl substituent was important since the parent flavone was significantly weaker as a positive modulator (103+/-24% enhancement of 5 microM GABA by 100 microM flavone). This enhancement is not mediated via high-affinity benzodiazepine sites as it was not inhibited by the classical benzodiazepine antagonist flumazenil under conditions where flumazenil inhibits the potentiation of the GABA response to diazepam. 6-Methylflavone (60 microM) did not significantly affect the GABA dose-response curve at rho1 GABAC receptors. 6-Methylflavone acts as a positive modulator of recombinant GABAA receptors at sites independent of flumazenil-sensitive benzodiazepine sites. Topics: Allosteric Regulation; Animals; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; Flavones; Flavonoids; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Membrane Potentials; Microinjections; Molecular Structure; Oocytes; Protein Subunits; Receptors, GABA; Receptors, GABA-A; Recombinant Proteins; RNA; Xenopus laevis | 2004 |