6-methyl-2-(phenylethynyl)pyridine has been researched along with benzothiazole* in 1 studies
1 other study(ies) available for 6-methyl-2-(phenylethynyl)pyridine and benzothiazole
| Article | Year |
|---|---|
Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogues and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC(50) range 60-100 nM) in the quinoline series. Topics: Animals; Benzothiazoles; Brain; Cell Line; Drug Design; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Molecular Structure; Pyridines; Quinolines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2010 |