Page last updated: 2024-09-02

6-methyl-1,3,8-trichlorodibenzofuran and benzofurans

6-methyl-1,3,8-trichlorodibenzofuran has been researched along with benzofurans in 23 studies

Compound Research Comparison

Studies
(6-methyl-1,3,8-trichlorodibenzofuran)
Trials
(6-methyl-1,3,8-trichlorodibenzofuran)
Recent Studies (post-2010)
(6-methyl-1,3,8-trichlorodibenzofuran)
Studies
(benzofurans)
Trials
(benzofurans)
Recent Studies (post-2010) (benzofurans)
250313,2934514,970

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's8 (34.78)18.2507
2000's8 (34.78)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Biegel, L; Harris, M; Merchant, M; Morrison, V; Safe, S; Zacharewski, T1
Astroff, B; Harris, M; Morrison, V; Piskorska-Pliszczynska, J; Rosengren, R; Safe, L; Safe, S; Zacharewski, T1
Astroff, B; Eldridge, B; Safe, S1
Astroff, B; Safe, S2
Astroff, B; Harris, M; Safe, S; Zacharewski, T1
Safe, S; Yao, C1
Arlotto, MP; Astroff, B; Levin, W; Parkinson, A; Safe, S; Thomas, P; Zacharewski, T1
Astroff, B; Bannister, R; Biegel, L; Davis, D; Safe, S1
Merchant, M; Safe, S1
Krishnan, V; Merchant, M; Safe, S1
Safe, S; Santostefano, M1
McDougal, A; Safe, S; Wilson, C1
Castro-Rivera, E; Chen, I; Safe, S; Wormke, M1
Calvin, J; McDougal, A; Safe, S; Wormke, M1
Morrow, D; Qin, C; Safe, S; Smith, R1
Abdelrahim, M; Jordan, VC; Liu, H; Pearce, ST; Radhakrishnan, I; Safe, S1
Fretland, AJ; Hankinson, O; Safe, S1
Abdelrahim, M; Ariazi, E; Jordan, VC; Khan, S; Liu, S; Safe, S1
Fritz, WA; Lin, TM; Moore, RW; Peterson, RE; Safe, S1
Kotha, L; Lei, P; Li, X; Liu, X; Rowlands, C; Safe, S; Walker, K; Zhang, S1
Amendt, B; Cao, H; Jin, UH; Kim, K; Liu, X; Pfent, C; Safe, S; Wilson-Robles, H; Zhang, S1
Chitrala, KN; Yeguvapalli, S1

Other Studies

23 other study(ies) available for 6-methyl-1,3,8-trichlorodibenzofuran and benzofurans

ArticleYear
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
    Toxicology and applied pharmacology, 1992, Volume: 113, Issue:2

    Topics: Animals; Benzofurans; Breast Neoplasms; Cell Division; Cell Line; Estradiol; Estrogen Antagonists; Female; Humans; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen

1992
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
    Archives of biochemistry and biophysics, 1991, Volume: 284, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzofurans; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytosol; DNA-Binding Proteins; Enzyme Induction; Kinetics; Microsomes, Liver; Molecular Sequence Data; Oligonucleotides; Oxidoreductases; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; Regulatory Sequences, Nucleic Acid; Transcription Factors

1991
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus.
    Toxicology letters, 1991, Volume: 56, Issue:3

    Topics: Animals; Benzofurans; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression; Humans; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA, Messenger; Time Factors; Uterus

1991
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
    Toxicology, 1991, Volume: 69, Issue:2

    Topics: Animals; Benzofurans; Cell Nucleus; Cytosol; Estradiol; Estrogen Antagonists; Female; Rats; Rats, Inbred Strains; Receptors, Estrogen; Receptors, Progesterone

1991
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
    Molecular pharmacology, 1989, Volume: 35, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Dioxins; Enzyme Induction; Male; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug

1989
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
    Toxicology and applied pharmacology, 1989, Sep-01, Volume: 100, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Drug Antagonism; Female; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Ovariectomy; Oxidoreductases; Polychlorinated Dibenzodioxins; Porphyrias; Porphyrins; Uroporphyrinogen Decarboxylase

1989
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
    Molecular pharmacology, 1988, Volume: 33, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Oxidoreductases; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Structure-Activity Relationship

1988
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
    Toxicology and applied pharmacology, 1988, Sep-30, Volume: 95, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Dioxins; Dose-Response Relationship, Drug; Enzyme Induction; Estradiol; Estrogen Antagonists; Female; Mesothelin; Microsomes, Liver; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen; Receptors, Progesterone

1988
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
    Toxicology, 1989, Volume: 54, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Antibody Formation; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzofurans; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Polychlorinated Dibenzodioxins; Species Specificity

1989
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
    Biochemical pharmacology, 1995, Aug-25, Volume: 50, Issue:5

    Topics: Animals; Benzoflavones; Benzofurans; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Mice; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Tumor Cells, Cultured

1995
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
    Toxicology and applied pharmacology, 1993, Volume: 120, Issue:2

    Topics: Benzoflavones; Benzofurans; Breast Neoplasms; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Oxidoreductases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen; Tumor Cells, Cultured

1993
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion.
    Chemico-biological interactions, 1996, May-06, Volume: 100, Issue:3

    Topics: Animals; Autoradiography; Base Sequence; Benzofurans; Cells, Cultured; Dioxins; Ligands; Liver Neoplasms, Experimental; Male; Mice; Molecular Sequence Data; Molecular Structure; Polychlorinated Dibenzodioxins; Protein Conformation; Proteins; Rats; Receptors, Aryl Hydrocarbon; Trypsin

1996
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.
    Cancer letters, 1997, Nov-25, Volume: 120, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzofurans; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Transcription Factors

1997
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2000, Volume: 72, Issue:5

    Topics: Adenocarcinoma; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Benzofurans; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Endometrial Neoplasms; Estradiol; Female; Humans; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Receptors, Progesterone; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2000
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
    Cancer research, 2001, May-15, Volume: 61, Issue:10

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Benzofurans; Bone Development; Cysteine Endopeptidases; Drug Synergism; Estrogen Receptor Modulators; Female; Mammary Neoplasms, Experimental; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Tamoxifen; Uterus

2001
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
    The Journal of steroid biochemistry and molecular biology, 2004, Volume: 88, Issue:1

    Topics: Benzofurans; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dihydrotestosterone; Estradiol; Female; Genes, Reporter; Humans; Male; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Receptors, Aryl Hydrocarbon; Time Factors; Transcriptional Activation

2004
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha.
    Cancer research, 2004, Apr-15, Volume: 64, Issue:8

    Topics: Basic Helix-Loop-Helix Transcription Factors; Benzofurans; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estradiol; Estrogen Receptor alpha; Humans; Models, Molecular; Receptor Cross-Talk; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor alpha

2004
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c
    Chemico-biological interactions, 2004, Nov-20, Volume: 150, Issue:2

    Topics: Animals; Benzofurans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Liver Neoplasms; Mice; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger

2004
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
    Biological chemistry, 2006, Volume: 387, Issue:9

    Topics: Benzo(a)pyrene; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Estrogen Receptor alpha; Flavonoids; Humans; Indoles; Ligands; Methylcholanthrene; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Presenilin-2; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Structure-Activity Relationship

2006
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice.
    Biochemical pharmacology, 2009, Apr-01, Volume: 77, Issue:7

    Topics: Animals; Benzofurans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Culture Techniques; Pelvic Neoplasms; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon

2009
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.
    Endocrine-related cancer, 2009, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzofurans; Breast Neoplasms; Carrier Proteins; Cell Proliferation; Drug Delivery Systems; Female; Humans; Mice; Mice, Nude; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:1

    Topics: 3' Untranslated Regions; Animals; Benzofurans; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; MicroRNAs; Oligonucleotides; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA Interference; RNA, Messenger; RNA, Small Interfering; SOXC Transcription Factors

2012
Computational prediction and analysis of breast cancer targets for 6-methyl-1, 3, 8-trichlorodibenzofuran.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Benzofurans; Binding Sites; Breast Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Computer Simulation; Dioxins; Female; Humans; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Proteins

2014