6-methyl-1,3,8-trichlorodibenzofuran has been researched along with benzofurans in 23 studies
| Studies (6-methyl-1,3,8-trichlorodibenzofuran) | Trials (6-methyl-1,3,8-trichlorodibenzofuran) | Recent Studies (post-2010) (6-methyl-1,3,8-trichlorodibenzofuran) | Studies (benzofurans) | Trials (benzofurans) | Recent Studies (post-2010) (benzofurans) |
|---|---|---|---|---|---|
| 25 | 0 | 3 | 13,293 | 451 | 4,970 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biegel, L; Harris, M; Merchant, M; Morrison, V; Safe, S; Zacharewski, T | 1 |
| Astroff, B; Harris, M; Morrison, V; Piskorska-Pliszczynska, J; Rosengren, R; Safe, L; Safe, S; Zacharewski, T | 1 |
| Astroff, B; Eldridge, B; Safe, S | 1 |
| Astroff, B; Safe, S | 2 |
| Astroff, B; Harris, M; Safe, S; Zacharewski, T | 1 |
| Safe, S; Yao, C | 1 |
| Arlotto, MP; Astroff, B; Levin, W; Parkinson, A; Safe, S; Thomas, P; Zacharewski, T | 1 |
| Astroff, B; Bannister, R; Biegel, L; Davis, D; Safe, S | 1 |
| Merchant, M; Safe, S | 1 |
| Krishnan, V; Merchant, M; Safe, S | 1 |
| Safe, S; Santostefano, M | 1 |
| McDougal, A; Safe, S; Wilson, C | 1 |
| Castro-Rivera, E; Chen, I; Safe, S; Wormke, M | 1 |
| Calvin, J; McDougal, A; Safe, S; Wormke, M | 1 |
| Morrow, D; Qin, C; Safe, S; Smith, R | 1 |
| Abdelrahim, M; Jordan, VC; Liu, H; Pearce, ST; Radhakrishnan, I; Safe, S | 1 |
| Fretland, AJ; Hankinson, O; Safe, S | 1 |
| Abdelrahim, M; Ariazi, E; Jordan, VC; Khan, S; Liu, S; Safe, S | 1 |
| Fritz, WA; Lin, TM; Moore, RW; Peterson, RE; Safe, S | 1 |
| Kotha, L; Lei, P; Li, X; Liu, X; Rowlands, C; Safe, S; Walker, K; Zhang, S | 1 |
| Amendt, B; Cao, H; Jin, UH; Kim, K; Liu, X; Pfent, C; Safe, S; Wilson-Robles, H; Zhang, S | 1 |
| Chitrala, KN; Yeguvapalli, S | 1 |
23 other study(ies) available for 6-methyl-1,3,8-trichlorodibenzofuran and benzofurans
| Article | Year |
|---|---|
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Topics: Animals; Benzofurans; Breast Neoplasms; Cell Division; Cell Line; Estradiol; Estrogen Antagonists; Female; Humans; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen | 1992 |
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzofurans; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytosol; DNA-Binding Proteins; Enzyme Induction; Kinetics; Microsomes, Liver; Molecular Sequence Data; Oligonucleotides; Oxidoreductases; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; Regulatory Sequences, Nucleic Acid; Transcription Factors | 1991 |
Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus.
Topics: Animals; Benzofurans; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression; Humans; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA, Messenger; Time Factors; Uterus | 1991 |
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
Topics: Animals; Benzofurans; Cell Nucleus; Cytosol; Estradiol; Estrogen Antagonists; Female; Rats; Rats, Inbred Strains; Receptors, Estrogen; Receptors, Progesterone | 1991 |
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Dioxins; Enzyme Induction; Male; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1989 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Drug Antagonism; Female; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Ovariectomy; Oxidoreductases; Polychlorinated Dibenzodioxins; Porphyrias; Porphyrins; Uroporphyrinogen Decarboxylase | 1989 |
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Oxidoreductases; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Structure-Activity Relationship | 1988 |
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzofurans; Dioxins; Dose-Response Relationship, Drug; Enzyme Induction; Estradiol; Estrogen Antagonists; Female; Mesothelin; Microsomes, Liver; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen; Receptors, Progesterone | 1988 |
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
Topics: Abnormalities, Drug-Induced; Animals; Antibody Formation; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzofurans; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Polychlorinated Dibenzodioxins; Species Specificity | 1989 |
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
Topics: Animals; Benzoflavones; Benzofurans; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Mice; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Tumor Cells, Cultured | 1995 |
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Topics: Benzoflavones; Benzofurans; Breast Neoplasms; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Oxidoreductases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen; Tumor Cells, Cultured | 1993 |
Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion.
Topics: Animals; Autoradiography; Base Sequence; Benzofurans; Cells, Cultured; Dioxins; Ligands; Liver Neoplasms, Experimental; Male; Mice; Molecular Sequence Data; Molecular Structure; Polychlorinated Dibenzodioxins; Protein Conformation; Proteins; Rats; Receptors, Aryl Hydrocarbon; Trypsin | 1996 |
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzofurans; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Transcription Factors | 1997 |
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
Topics: Adenocarcinoma; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Benzofurans; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Endometrial Neoplasms; Estradiol; Female; Humans; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Receptors, Progesterone; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Benzofurans; Bone Development; Cysteine Endopeptidases; Drug Synergism; Estrogen Receptor Modulators; Female; Mammary Neoplasms, Experimental; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Tamoxifen; Uterus | 2001 |
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
Topics: Benzofurans; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dihydrotestosterone; Estradiol; Female; Genes, Reporter; Humans; Male; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Receptors, Aryl Hydrocarbon; Time Factors; Transcriptional Activation | 2004 |
Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha.
Topics: Basic Helix-Loop-Helix Transcription Factors; Benzofurans; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estradiol; Estrogen Receptor alpha; Humans; Models, Molecular; Receptor Cross-Talk; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor alpha | 2004 |
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c
Topics: Animals; Benzofurans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Liver Neoplasms; Mice; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2004 |
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
Topics: Benzo(a)pyrene; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Estrogen Receptor alpha; Flavonoids; Humans; Indoles; Ligands; Methylcholanthrene; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Presenilin-2; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Structure-Activity Relationship | 2006 |
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice.
Topics: Animals; Benzofurans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Culture Techniques; Pelvic Neoplasms; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon | 2009 |
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Benzofurans; Breast Neoplasms; Carrier Proteins; Cell Proliferation; Drug Delivery Systems; Female; Humans; Mice; Mice, Nude; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.
Topics: 3' Untranslated Regions; Animals; Benzofurans; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; MicroRNAs; Oligonucleotides; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; RNA Interference; RNA, Messenger; RNA, Small Interfering; SOXC Transcription Factors | 2012 |
Computational prediction and analysis of breast cancer targets for 6-methyl-1, 3, 8-trichlorodibenzofuran.
Topics: Benzofurans; Binding Sites; Breast Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Computer Simulation; Dioxins; Female; Humans; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Proteins | 2014 |