Page last updated: 2024-09-02

6-methyl-1,3,8-trichlorodibenzofuran and alpha-naphthoflavone

6-methyl-1,3,8-trichlorodibenzofuran has been researched along with alpha-naphthoflavone in 3 studies

Compound Research Comparison

Studies
(6-methyl-1,3,8-trichlorodibenzofuran)
Trials
(6-methyl-1,3,8-trichlorodibenzofuran)
Recent Studies (post-2010)
(6-methyl-1,3,8-trichlorodibenzofuran)
Studies
(alpha-naphthoflavone)
Trials
(alpha-naphthoflavone)
Recent Studies (post-2010) (alpha-naphthoflavone)
25036651142

Protein Interaction Comparison

ProteinTaxonomy6-methyl-1,3,8-trichlorodibenzofuran (IC50)alpha-naphthoflavone (IC50)
Carboxylic ester hydrolase Sus scrofa (pig)0.0478
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.3034
Cytochrome P450 1A1Homo sapiens (human)0.1921
Cytochrome P450 1A2Homo sapiens (human)0.1698
AromataseHomo sapiens (human)1.035
Substance-K receptorHomo sapiens (human)5.8471
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.01
Thromboxane-A synthase Homo sapiens (human)6.7608
Adenosine receptor A1Homo sapiens (human)1.1325
Aryl hydrocarbon receptorMus musculus (house mouse)0.025
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.05
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)4.98
Cytochrome P450 1B1Homo sapiens (human)0.0449
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.355

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Ballarotto, M; Dolciami, D; Fallarino, F; Gargaro, M; López-Cara, LC; Macchiarulo, A1
Merchant, M; Safe, S1
Krishnan, V; Merchant, M; Safe, S1

Reviews

1 review(s) available for 6-methyl-1,3,8-trichlorodibenzofuran and alpha-naphthoflavone

ArticleYear
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs).
    European journal of medicinal chemistry, 2020, Jan-01, Volume: 185

    Topics: Animals; Humans; Immune System Diseases; Immunotherapy; Ligands; Molecular Structure; Receptors, Aryl Hydrocarbon

2020

Other Studies

2 other study(ies) available for 6-methyl-1,3,8-trichlorodibenzofuran and alpha-naphthoflavone

ArticleYear
In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.
    Biochemical pharmacology, 1995, Aug-25, Volume: 50, Issue:5

    Topics: Animals; Benzoflavones; Benzofurans; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Mice; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Tumor Cells, Cultured

1995
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
    Toxicology and applied pharmacology, 1993, Volume: 120, Issue:2

    Topics: Benzoflavones; Benzofurans; Breast Neoplasms; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Oxidoreductases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Receptors, Estrogen; Tumor Cells, Cultured

1993