6-ketoprostaglandin-f1-alpha and propionic-acid

To determine glucogenic and hormonal responses in ruminants to indomethacin, a prostaglandin synthetase inhibitor, four lactating Toggenburg goats were used in a crossover design. Fifteen milligrams of indomethacin or 3 ml of saline were injected subcutaneously twice daily with propionate infused intrajugularly at a rate of 2 mM/min for 75 min as a challenge. Plasma glucose concentrations were increased by indomethacin injections. Plasma concentrations of insulin, glucagon, and 6-keto-prostaglandin F1 alpha were not affected by indomethacin injections. Propionate infusion elevated plasma glucose, insulin, and glucagon concentrations. A decreased insulin release in response to propionate challenge was observed with indomethacin injections.

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Glucose; Female; Glucagon; Gluconeogenesis; Goats; Homeostasis; Indomethacin; Insulin; Lactation; Pancreatic Hormones; Pregnancy; Propionates; Sodium Chloride