6-ketoprostaglandin-f1-alpha has been researched along with muscone* in 2 studies
2 other study(ies) available for 6-ketoprostaglandin-f1-alpha and muscone
| Article | Year |
|---|---|
[Study on comparative pharmacology of series of Muskone].
To study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats.. Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain.. The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain.. The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain. Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aristolochia; Cycloparaffins; Drug Combinations; Drugs, Chinese Herbal; Endothelins; Female; Inula; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Pain; Plants, Medicinal; Rats; Rats, Wistar; Thromboxane B2 | 2006 |
[Study on therapeutic effects of series of muskone on myocardial infarction canines].
To observe the effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on myocardial ischemia, myocardial infarction and hematological index in experimental canines, and to explain the pharmacological action and characteristic of its therapeutic effect on ischemic heart disease.. The range and degree of myocardial ischemia was evaluated by epicardial electrogram mapping, and the range extent of myocardial infarction was determined by quantitate histology (N-BT staining method). Meanwhile, the changes of ET, TXB2, 6-Keto-PGF1alpha were determined to study the effects of the series of Muskone on myocardial ischemia, myocardial infarction and hematological index in experimental canines.. The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia (Sigma-ST) determined by epicardial electrogram mapping, decrease the range of myocardial ischemia (N-ST) determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto-PGF1alpha and 6-Keto-PGF1alpha/TXB2 induced by myocardial ischemia.. The series of Muskone has significant therapeutic effect on myocardial infarction. Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aristolochia; Cycloparaffins; Dogs; Drug Combinations; Drugs, Chinese Herbal; Endothelins; Female; Inula; Male; Myocardial Infarction; Myocardium; Plants, Medicinal; Thromboxane B2 | 2006 |