6-ketoprostaglandin-f1-alpha and astragalin

Astragalin, isolated from flowers of Rosa chinensis Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Coagulation; Blood Coagulation Tests; Blood Sedimentation; Blood Viscosity; Drugs, Chinese Herbal; Endothelin-1; Female; Fibrinogen; Flavonoids; Kaempferols; Male; Nitric Oxide Synthase Type III; Partial Thromboplastin Time; Platelet Aggregation; Prothrombin Time; Rabbits; Rats; Rats, Sprague-Dawley; Rosaceae; Thrombin Time; Thromboxane B2