6-ketoprostaglandin-f1-alpha and alpha-naphthoflavone

Human amnion, trophoblast and umbilical vein endothelial cells synthesise an arachidonic acid metabolite which is neither a lipoxygenase nor a cyclo-oxygenase product. It is sensitive to stimulants and inhibitors of the cytochrome-P450-dependent epoxygenase system and co-migrates on HPLC with 14,15-epoxyeicosatrienoic acid (14,15-EET), which is an epoxygenase product. The function of 14,15-EET in these reproductive tissues is unknown, but it may be involved in the maintenance of vascular function.

Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Benzoflavones; Dinoprost; Endothelium; Fatty Acids, Unsaturated; Female; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Trophoblasts; Umbilical Veins